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The enteric nervous system (ENS, shown in blue) is embedded in the digestive tract

The Enteric Nervous System​—Your Body’s “Second Brain”?

The Enteric Nervous System​—Your Body’s “Second Brain”?

HOW many brains do you have? If you answer “one,” you are correct. Yet, there are other nervous systems in your body. One network of neurons is so extensive that some scientists have referred to it as a “second brain.” It is the enteric nervous system (ENS) and is located, not in your head, but mostly in your belly.

It takes an enormous amount of coordination and effort for the body to transform food into fuel. Hence, it is fitting that the brain is designed to delegate, as it were, most digestive control to the ENS.

While much simpler than the brain, the ENS is immensely complex. In humans, it is made up of an estimated 200 to 600 million neurons. This complex network of neurons is built into the digestive system. Scientists believe that if the function of the ENS were to take place in the brain, the needed nerves would be too thick. According to the book The Second Brain, “it is thus both safer and more convenient to let the [digestive system] look after itself.”


Food digestion requires a variety of very precise chemical mixtures produced at the right times and delivered to the right locations. Professor Gary Mawe aptly describes the digestive system as “a chemical workshop.” The sophistication of this chemical operation is mind-boggling. For instance, the intestinal wall is lined with specialized cells that act as chemical detectors, or taste receptors, identifying chemicals present in the food you eat. This data helps the ENS enlist the right digestive enzymes to break the food down into particles that the body can absorb. Also, the ENS plays a vital role in monitoring the acidity and other chemical properties of food particles and in adjusting the digestive enzymes accordingly.

Think of the digestive tract as a factory line managed mostly by the ENS. Your “second brain” moves food through the digestive system by directing the muscles along the wall of the digestive tract to contract. The ENS varies the strength and frequency of these muscle contractions as needed to make the system function like a line of conveyor belts.

The ENS also supervises safety functions. The food you swallow is likely to contain potentially harmful bacteria. It is no wonder that about 70 to 80 percent of your body’s lymphocyte cells​—a vital component of your immune defense system—​are housed inside your belly! If you ingest high levels of harmful organisms, the ENS protects the body by triggering powerful contractions that expel most of the toxic matter through vomiting or diarrhea.


While the ENS seems to function independently of the brain, these two nerve  centers engage in constant communication. For example, the ENS plays a role in the regulation of hormones that tell the brain when you should eat and how much you should eat. ENS nerve cells signal the brain when you are full and may possibly trigger nausea if you eat too much.

Even before reading this article, you may have suspected that there is a communication link between your digestive tract and your brain. Have you noticed, for instance, that eating some fatty foods seems to improve your mood? Research suggests that this happens when your ENS sends ‘happy signals’ to your brain, starting a chain reaction that makes you feel better. This may explain why people tend to eat so-called comfort food when feeling stressed. Scientists are exploring the possibility of artificially stimulating the ENS as a treatment for depression.

Another example of communication between the brain and the digestive system is what has been described as having butterflies in one’s stomach. This feeling may be the result of the ENS diverting blood away from the stomach when the brain experiences tension or stress. Nausea can be another result, as during stress the brain triggers the ENS to change the gut’s normal contractions. According to experts, this brain-gut connection might also be the basis for so-called gut instincts.

While the ENS may generate such gut feelings, it cannot think for you or direct your decisions. In other words, the ENS is not really a brain. It cannot help you to compose a song, balance your bank account, or do your homework. Still, this marvelous system continues to amaze scientists for its complexity​—much of it perhaps still undiscovered. So the next time you are about to eat a meal, pause and think about all the monitoring, data processing, coordination, and communication that is about to take place in your digestive system!