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Medical Information for Clinicians

The medical literature contains numerous reports of complex medical and surgical procedures performed successfully without transfusion of allogeneic whole blood or its primary components. Avoiding blood transfusion involves the optimal use of clinical strategies to minimize blood loss, conserve autologous blood, enhance hematopoiesis, and augment tolerance of anemia. This section contains citations of peer-reviewed articles from leading medical journals, presenting evidence in support of the use of autologous blood conservation and alternatives to blood transfusion.


Medicine and Surgery

Clinical strategies for managing hemorrhage and anemia without allogeneic blood transfusion.


Clinical strategies for managing neonatal and pediatric patients without allogeneic blood transfusion.

Diseases and Conditions

Clinical strategies for managing specific diseases or conditions without allogeneic blood transfusion.

Bioethics and Law

Ethical, legal, and social factors for health-care professionals to consider when treating Jehovah’s Witnesses.

Featured Articles

Association of umbilical cord management strategies with outcomes of preterm infants: a systematic review and network meta-analysis. (opens new window)

Jasani B, Torgalkar R, Ye XY, Syed S, Shah PS

Source‎: JAMA Pediatr 2021;175(4):e210102.

Indexed‎: PubMed 33683307

DOI‎: 10.1001/jamapediatrics.2021.0102 (opens new window)

Perioperative management of patients for whom transfusion is not an option. (opens new window)

Guinn NR, Resar LMS, Frank SM

Source‎: Anesthesiology 2021;134(6):939-48.

Indexed‎: PubMed 33857295

DOI‎: 10.1097/ALN.0000000000003763 (opens new window)

Heart transplant in Jehovah's Witness patients: a case-control study. (opens new window)

Sander S, Singer-Englar T, Nishihara K, Esmailian F, Patel JK, Kobashigawa JA, Kittleson MM

Source‎: J Heart Lung Transplant 2021;40(7):575-9.

Indexed‎: PubMed 33839007

DOI‎: 10.1016/j.healun.2021.03.014 (opens new window)

A multicenter study of romiplostim for chemotherapy-induced thrombocytopenia in solid tumors and hematologic malignancies. (opens new window)

Al-Samkari H, Parnes AD, Goodarzi K, Weitzman JI, Connors JM, Kuter DJ

Source‎: Haematologica 2021;106(4):1148-57.

Indexed‎: PubMed 32499239

DOI‎: 10.3324/haematol.2020.251900 (opens new window)

Preoperative blood transfusions and morbidity in neonates undergoing surgery. (opens new window)

Dukleska K, Vinocur CD, Brenn BR, Lim DJ, Keith SW, Dirnberger DR, Berman L

Source‎: Pediatrics 2020;146(5):e20193718.

Indexed‎: PubMed 33087550

DOI‎: 10.1542/peds.2019-3718 (opens new window)

Voxelotor in adolescents and adults with sickle cell disease (HOPE): long-term follow-up results of an international, randomised, double-blind, placebo-controlled, phase 3 trial. (opens new window)

Howard J, Ataga KI, Brown RC, Achebe M, Nduba V, El-Beshlawy A, Hassab H, Agodoa I, Tonda M, Gray S, Lehrer-Graiwer J, Vichinsky E

Source‎: Lancet Haematol 2021;8(5):e323-33.

Indexed‎: PubMed 33838113

DOI‎: 10.1016/S2352-3026(21)00059-4 (opens new window)

Efficacy and safety of intravenous ferric carboxymaltose compared with oral iron for the treatment of iron deficiency anaemia in women after childbirth in Tanzania: a parallel-group, open-label, randomised controlled phase 3 trial. (opens new window)

Vanobberghen F, Lweno O, Kuemmerle A, Mwebi KD, Asilia P, Issa A, Simon B, Mswata S, Schmidlin S, Glass TR, Abdulla S, Daubenberger C, Tanner M, Meyer-Monard S.

Source‎: Lancet Glob Health 2021;9(2):e189-98

Indexed‎: PubMed 33245866

DOI‎: 10.1016/S2214-109X(20)30448-4 (opens new window)