Multimodality, Interdisciplinary, and Individualized Approach

Anemia Management

Autoimmune Hemolytic Anemia

Iron Deficiency Anemia

Aplastic Anemia

Neutropenia Management

Thrombocytopenia Management

Immune Thrombocytopenia (ITP)

Thrombotic Thrombocytopenic Purpura (TTP)

Management and Optimization of Hemostasis

• Recombinant Activated Factor VII (rFVIIa)

Therapeutic Plasma Exchange Using Replacement Alternatives

Restricted Diagnostic Phlebotomy to Avoid Iatrogenic Anemia

Acceptance of Normovolemic Anemia

Clinical Outcomes

Economic Outcomes

Multimodality, Interdisciplinary, Planned, and Individualized Approach

Thrombocytopenia Management

Anticoagulation Management and Reversal

Restricted Diagnostic Phlebotomy to Avoid Iatrogenic Anemia

Management and Optimization of Hemostasis

• Antifibrinolytic Agents

• Recombinant Activated Factor VII (rFVIIa)

• Coagulation Factor Concentrates

• Desmopressin

• Other Agents

• Topical Hemostatic Agents

• Viscoelastic Tests to Identify Surgical or Coagulopathic Bleeding

Thermal Management (Prevention of Hypothermia)

Prevention of Drug-Induced Anemia or Thrombocytopenia

Optimization of Oxygen Delivery and Minimization of Oxygen Consumption

Damage Control Strategy

Blood Cell Salvage

Anemia Management

Optimization of Patients’ Tolerance of Anemia

Acceptance of Normovolemic Anemia

Adverse Effects of Substantial Bleeding

Transfusion Risks and Uncertainties

Clinical Outcomes

Economic Outcomes

Preoperative Patient Evaluation and Transfusion Risk Assessment

Preoperative Planning and Patient Optimization

Multimodality, Interdisciplinary, and Individualized Approach

Preoperative Anemia Management and Optimization of Red Cell Mass

Anticoagulation Management and Reversal

Restricted Nondiagnostic Blood Loss

Angiographic Embolization or Vascular Occlusion

Surgical Blood Conservation Techniques

Minimally Invasive Approaches

Management and Optimization of Hemostasis

• Antifibrinolytic Agents

• Recombinant Activated Factor VII (rFVIIa)

• Coagulation Factor Concentrates

• Desmopressin

• Topical Hemostatic Agents

• Viscoelastic Tests to Identify Surgical or Coagulopathic Bleeding

Thermal Management (Prevention of Hypothermia)

Judicious Fluid and Volume Management

Intraoperative Autologous Blood Management

• Blood Cell Salvage

• Acute Normovolemic Hemodilution

• Retrograde Autologous Priming

• Ultrafiltration

• Miniaturized Cardiopulmonary Bypass (Perfusion) Circuits

Postoperative Blood Cell Salvage

Restricted Diagnostic Phlebotomy to Avoid Iatrogenic Anemia

Postoperative Anemia Management

Optimization of Patients’ Tolerance of Anemia

Acceptance of Normovolemic Anemia

Resource-Limited Settings

Adverse Effects of Substantial Bleeding

Transfusion Risks and Uncertainties

Clinical Outcomes

Economic Outcomes

Pretreatment Patient Evaluation and Transfusion Risk Assessment

Pretreatment Planning and Patient Optimization

Multimodality, Interdisciplinary, and Individualized Approach

Anemia Management

• Erythropoiesis-Stimulating Agents

• Intravenous Iron

Thrombocytopenia Management

Angiographic Embolization or Vascular Occlusion

Surgical Blood Conservation Techniques

Management and Optimization of Hemostasis

• Antifibrinolytic Agents

• Recombinant Activated Factor VII (rFVIIa)

• Coagulation Factor Concentrates

• Desmopressin

Intraoperative Autologous Blood Management

• Blood Cell Salvage

• Acute Normovolemic Hemodilution

Neutropenia Management

Intensive Therapy Using Transfusion-Alternative Strategies

Individualized or Modified Chemotherapy (Dose Adjustment or Delay)

Hematopoietic Stem Cell Transplantation Without Blood Transfusion

Restricted Diagnostic Phlebotomy to Avoid Iatrogenic Anemia

Restricted Nondiagnostic Blood Loss

Acceptance of Normovolemic Anemia

Adverse Effects of Substantial Bleeding

Transfusion Risks and Uncertainties

Clinical Outcomes

Economic Outcomes

Preoperative Planning and Patient Optimization

Multimodality, Interdisciplinary, and Individualized Approach

Anticoagulation Management and Reversal

Angiographic Embolization or Vascular Occlusion

Management and Optimization of Hemostasis

• Antifibrinolytic Agents

• Desmopressin

• Other Agents

• Topical Hemostatic Agents

Intraoperative Autologous Blood Management

• Blood Cell Salvage

• Acute Normovolemic Hemodilution

Anesthetic Blood Conservation Techniques

• Controlled (Induced) Hypotension

Postoperative Anemia Management

Optimization of Patients’ Tolerance of Anemia

Clinical Outcomes

Economic Outcomes

Preoperative Patient Evaluation and Transfusion Risk Assessment

Preoperative Planning and Patient Optimization

Multimodality, Interdisciplinary, and Individualized Approach

Preoperative Anemia Management and Optimization of Red Cell Mass

Angiographic Embolization or Vascular Occlusion

Surgical Blood Conservation Techniques

Minimally Invasive Approaches

Management and Optimization of Hemostasis

• Antifibrinolytic Agents

• Recombinant Activated Factor VII (rFVIIa)

• Topical Hemostatic Agents

Thermal Management (Prevention of Hypothermia)

Intraoperative Autologous Blood Management

• Blood Cell Salvage

• Acute Normovolemic Hemodilution

Anesthetic Blood Conservation Techniques

• Controlled (Induced) Hypotension

• Regional Anesthesia

Postoperative Blood Cell Salvage

Restricted Diagnostic Phlebotomy to Avoid Iatrogenic Anemia

Acceptance of Normovolemic Anemia

Clinical Outcomes

Economic Outcomes

Preoperative Patient Evaluation and Transfusion Risk Assessment

Preoperative Planning and Patient Optimization

Multimodality, Interdisciplinary, and Individualized Approach

Preoperative Anemia Management and Optimization of Red Cell Mass

Angiographic Embolization or Vascular Occlusion

Surgical Blood Conservation Techniques

Management and Optimization of Hemostasis

• Antifibrinolytic Agents

• Desmopressin

• Other Agents

• Topical Hemostatic Agents

Intraoperative Autologous Blood Management

• Blood Cell Salvage

• Acute Normovolemic Hemodilution

Anesthetic Blood Conservation Techniques

• Controlled (Induced) Hypotension

Transfusion Risks and Uncertainties

Preoperative Patient Evaluation and Transfusion Risk Assessment

Preoperative Planning and Patient Optimization

Multimodality, Interdisciplinary, and Individualized Approach

Preoperative Anemia Management and Optimization of Red Cell Mass

Thrombocytopenia Management

Anticoagulation Management and Reversal

Management and Optimization of Hemostasis

• Antifibrinolytic Agents

• Recombinant Activated Factor VII (rFVIIa)

• Coagulation Factor Concentrates

• Desmopressin

• Viscoelastic Tests to Identify Surgical or Coagulopathic Bleeding

Thermal Management (Prevention of Hypothermia)

Judicious Fluid and Volume Management

Intraoperative Autologous Blood Management

• Blood Cell Salvage

• Acute Normovolemic Hemodilution

Anesthetic Blood Conservation Techniques

• Controlled (Induced) Hypotension

• Regional Anesthesia

Restricted Diagnostic Phlebotomy to Avoid Iatrogenic Anemia

Postoperative Anemia Management

Optimization of Patients’ Tolerance of Anemia

Acceptance of Normovolemic Anemia

Adverse Effects of Substantial Bleeding

Transfusion Risks and Uncertainties

Clinical Outcomes

Economic Outcomes

Antenatal Evaluation, Hospital Preparedness, and Clinical Experience

Multimodality, Interdisciplinary, Planned, and Individualized Approach

Anemia Management

• During Early Pregnancy

• During Third Trimester

• Delayed Cord Clamping to Prevent Neonatal Anemia

Thrombocytopenia Management

Inhibition or Delay of Preterm Birth

Acceleration of Fetal Lung Maturation for Women at Risk of Preterm Delivery

Prophylactic Perioperative Vascular Occlusion

Intraoperative Autologous Blood Management

• Blood Cell Salvage

• Acute Normovolemic Hemodilution

Active Management of the Third Stage of Labor

Uterotonic Agents

Surgical Control of Postpartum Hemorrhage

Temporizing Measures

Management and Optimization of Hemostasis

• Antifibrinolytic Agents

• Recombinant Activated Factor VII (rFVIIa)

• Coagulation Factor Concentrates

• Desmopressin

• Topical Hemostatic Agents

• Viscoelastic Tests to Identify Surgical or Coagulopathic Bleeding

Close Surveillance for Evidence of Postpartum Bleeding

Early Recourse to Hysterectomy for Persistent Bleeding

Restricted Diagnostic Phlebotomy to Avoid Iatrogenic Anemia

Postpartum Anemia Management

Optimization of Patients’ Tolerance of Anemia

Acceptance of Normovolemic Anemia

Adjuncts to Prevent Neonatal and Maternal Complications

Resource-Limited Settings

Clinical Outcomes

Economic Outcomes

Preoperative Patient Evaluation and Transfusion Risk Assessment

Preoperative Planning and Patient Optimization

Multimodality, Interdisciplinary, and Individualized Approach

Preoperative Anemia Management and Optimization of Red Cell Mass

Thrombocytopenia Management

Anticoagulation Management and Reversal

Surgical Blood Conservation Techniques

Management and Optimization of Hemostasis

• Antifibrinolytic Agents

• Recombinant Activated Factor VII (rFVIIa)

• Coagulation Factor Concentrates

• Viscoelastic Tests to Identify Surgical or Coagulopathic Bleeding

Thermal Management (Prevention of Hypothermia)

Judicious Fluid and Volume Management

Intraoperative Autologous Blood Management

• Blood Cell Salvage

• Acute Normovolemic Hemodilution

Anesthetic Blood Conservation Techniques

• Controlled (Induced) Hypotension

• Regional Anesthesia

Restricted Diagnostic Phlebotomy to Avoid Iatrogenic Anemia

Postoperative Anemia Management

Optimization of Patients’ Tolerance of Anemia

Acceptance of Normovolemic Anemia

Adverse Effects of Substantial Bleeding

Transfusion Risks and Uncertainties

Clinical Outcomes

Economic Outcomes

Multimodality, Interdisciplinary, and Individualized Approach

Prehospital

• Aggressive Hemorrhage Control

• Management of Shock

• Rapid Transport to Hospital

Anticoagulation Management and Reversal

Expeditious Arterial Embolization or Mechanical Vascular Occlusion

Restricted Diagnostic Phlebotomy to Avoid Iatrogenic Anemia

Management and Optimization of Hemostasis

• Antifibrinolytic Agents

• Recombinant Activated Factor VII (rFVIIa)

• Coagulation Factor Concentrates

• Desmopressin

• Viscoelastic Tests to Identify Surgical or Coagulopathic Bleeding

Thermal Management (Prevention of Hypothermia)

Optimization of Oxygen Delivery

Hypotensive Resuscitation

Damage Control Strategy

Blood Cell Salvage

Early Anemia Management

Acceptance of Normovolemic Anemia

Clinical Outcomes

Economic Outcomes

Preoperative Patient Evaluation and Transfusion Risk Assessment

Preoperative Planning and Patient Optimization

Multimodality, Interdisciplinary, and Individualized Approach

Preoperative Anemia Management and Optimization of Red Cell Mass

Surgical Blood Conservation Techniques

Management and Optimization of Hemostasis

• Antifibrinolytic Agents

• Recombinant Activated Factor VII (rFVIIa)

Thermal Management (Prevention of Hypothermia)

Intraoperative Autologous Blood Management

• Blood Cell Salvage

• Acute Normovolemic Hemodilution

Anesthetic Blood Conservation Techniques

• Controlled (Induced) Hypotension

Restricted Diagnostic Phlebotomy to Avoid Iatrogenic Anemia

Acceptance of Normovolemic Anemia

Clinical Outcomes