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臨床医のための医学情報
定評のある医学雑誌の査読された論文。この論文には,さまざまな治療や手術における同種血輸血に代わる治療ストラテジーと,そのストラテジーを支持するエビデンスが示されています。
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治療前の患者の評価と輸血リスクの評価
Predictive factors for perioperative blood transfusions in partial nephrectomy for renal masses.
Drug interactions with phytotherapeutics in oncology.
Factors associated with the avoidance of red blood cell transfusion after hematopoietic stem cell transplantation.
Clinical factors affecting engraftment and transfusion needs in SCT: a single-center retrospective analysis.
Trends and risk factors for transfusion in hepatopancreatobiliary surgery.
Potential interactions with anticancer agents: a cross-sectional study.
治療前の計画と患者の状態の最適化
Preoperative anaemia is associated with poor clinical outcome in non-cardiac surgery patients.
Intraoperative bleeding and haemostasis during pelvic surgery for locally advanced or recurrent rectal cancer: a prospective evaluation.
A cohort investigation of anaemia, treatment and the use of allogeneic blood transfusion in colorectal cancer surgery.
The theory and practice of bloodless surgery.
Non-blood medical care in gynecologic oncology: a review and update of blood conservation management schemes.
Effects of trilaciclib on chemotherapy-induced myelosuppression and patient-reported outcomes in patients with extensive-stage small cell lung cancer: Pooled results from three phase ii randomized, double-blind, placebo-controlled studies.
Adverse effects on hemostatic function of drugs used in hematologic malignancies.
集学的,職種横断的な,個別化されたアプローチ
Pancreaticoduodenectomy without homologous blood transfusion in an anemic Jehovah's Witness.
Complex liver resection for a large intrahepatic cholangiocarcinoma in a Jehovah's Witness: a strategy to avoid transfusion.
Long-lasting extreme anemia during the therapy of acute lymphoblastic leukemia in a Jehovah's Witness patient.
Leczenie ostrej białaczki u Świadków Jehowy—opis przypadku i przegląd piśmiennictwa. [Treatment of acute leukemia in Jehovah's Witnesses—a case report and review of the literature.] [Polish, English abstract]
Autologous stem-cell transplantation without hematopoietic support for the treatment of hematologic malignancies in Jehovah's Witnesses.
Impact of a patient blood management program and an outpatient anemia management protocol on red cell transfusions in oncology inpatients and outpatients.
A multidisciplinary approach to gastrointestinal bleeding in cancer patients.
エホバの証人に対して無輸血手術を行った褐色細胞腫の 1 例 [Surgery without blood transfusion for pheocromocytoma in a Jehovah's Witness patient: a case report.] [Japanese]
Pancreas and liver resection in Jehovah's Witness patients: feasible and safe.
Pancreaticoduodenectomy after neoadjuvant therapy in a Jehovah's Witness with locally advanced pancreatic cancer: case report and approach to avoid transfusion.
The treatment of acute lymphoblastic leukemia in Jehovah's Witnesses and patients who cannot accept blood products.
Transplante autólogo de células-tronco hematopoiéticas sem uso de hemocomponentes. [Autologous hematopoietic stem cell transplantation without the use of blood transfusions.] [Portuguese, English abstract]
貧血の管理
Management of anaemia and iron deficiency in patients with cancer: ESMO clinical practice guidelines.
Use of platelet and erythroid growth factors during induction chemotherapy for acute lymphoblastic leukaemia in a Jehovah's Witness.
Intravenous iron in oncology.
High-dose (40,000 IU twice/week) alpha recombinant human erythropoietin as single agent in low/intermediate risk myelodysplastic syndromes: a retrospective investigation on 133 patients treated in a single institution.
Recombinant human erythropoietin is associated with increased overall survival in patients with multiple myeloma.
Darbepoetin-alfa and intravenous iron administration after autologous hematopoietic stem cell transplantation: a prospective multicenter randomized trial.
Randomized phase III trial of sequential adjuvant chemoradiotherapy with or without erythropoietin alfa in patients with high-risk cervical cancer: results of the NOGGO-AGO intergroup study.
Intravenous iron supplementation for the treatment of chemotherapy-induced anemia: a systematic review and meta-analysis of randomized controlled trials.
Epoetin alpha decreases the number of erythrocyte transfusions in patients with acute lymphoblastic leukemia, lymphoblastic lymphoma, and Burkitt leukemia/lymphoma: results of a randomized clinical trial.
Management of anemia in cancer patients.
Ferric carboxymaltose reduces transfusions and hospital stay in patients with colon cancer and anemia.
Leczenie ostrej białaczki u Świadków Jehowy—opis przypadku i przegląd piśmiennictwa. [Treatment of acute leukemia in Jehovah's Witnesses—a case report and review of the literature.] [Polish, English abstract]
Hemoglobin level at initiation of darbepoetin alfa: impact on need for transfusion and associated costs in chemotherapy-induced anemia treatment in Europe.
Luspatercept versus epoetin alfa in erythropoiesis-stimulating agent-naive, transfusion-dependent, lower-risk myelodysplastic syndromes (COMMANDS): primary analysis of a phase 3, open-label, randomised, controlled trial.
The short-term use of erythropoetin-stimulating agents: impact on the biochemical recurrence of prostate cancer.
Epoetin alfa in patients with advanced-stage Hodgkin's lymphoma: results of the randomized placebo-controlled GHSG HD15EPO trial.
Autologous stem-cell transplantation without hematopoietic support for the treatment of hematologic malignancies in Jehovah's Witnesses.
Randomised, phase III trial of epoetin-β to treat chemotherapy-induced anaemia according to the EU regulation.
Erythropoiesis-stimulating agents significantly delay the onset of a regular transfusion need in nontransfused patients with lower-risk myelodysplastic syndrome.
How I treat cancer-associated anemia.
Total dose iron dextran infusion in cancer patients: is it SaFe2+?
Update on safety of ESAs in cancer-induced anemia.
Thrombocytosis and venous thromboembolism in cancer patients with chemotherapy induced anemia may be related to ESA induced iron restricted erythropoiesis and reversed by administration of IV iron.
Iron or vitamin B12 deficiency in anemic cancer patients prior to erythropoiesis-stimulating agent therapy.
Biosimilar erythropoiesis-stimulating agents are an effective and safe option for the management of myelofibrosis-related anemia.
A randomized controlled trial comparing darbepoetin alfa doses in red blood cell transfusion-dependent patients with low- or intermediate-1 risk myelodysplastic syndromes.
Intravenous iron therapy to treat anemia in oncology: a mapping review of randomized controlled trials.
The role of iron in the management of chemotherapy-induced anemia in cancer patients receiving erythropoiesis-stimulating agents.
Prospective study of erythropoietin use on quality of life and cost effectiveness in acute myeloid leukemia and allogeneic hematopoietic stem cell transplantation patients.
Adding epoetin alfa to intense dose-dense adjuvant chemotherapy for breast cancer: randomized clinical trial.
Perioperative anemia management in colorectal cancer patients: a pragmatic approach.
Meta-analysis of epoetin beta and darbepoetin alfa treatment for chemotherapy-induced anemia and mortality: Individual patient data from Japanese randomized, placebo-controlled trials.
Peri-operative blood management of Jehovah's Witnesses undergoing cytoreductive surgery for advanced ovarian cancer.
Practical clinical consensus guidelines for the management of cancer associated anemia in low- and middle-income countries.
Clinical effectiveness and safety of erythropoietin-stimulating agents for the treatment of low- and intermediate-1-risk myelodysplastic syndrome: a systematic literature review.
Outcomes of erythropoiesis-stimulating agents in cancer patients with chemotherapy-induced anemia.
Randomized trial of intravenous iron supplementation in patients with chemotherapy-related anemia without iron deficiency treated with darbepoetin alpha.
High-dose chemotherapy without transfusion for Philadelphia chromosome negative B-cell acute lymphoblastic leukemia in two Jehovah's Witnesses patients: a feasible option in the age of hematopoietic growth factors.
Addition of iron to erythropoiesis-stimulating agents in cancer patients: a meta-analysis of randomized trials.
Imetelstat in patients with lower-risk myelodysplastic syndromes who have relapsed or are refractory to erythropoiesis-stimulating agents (IMerge): a multinational, randomised, double-blind, placebo-controlled, phase 3 trial.
Epoetin alfa improves anemia and anemia-related, patient-reported outcomes in patients with breast cancer receiving myelotoxic chemotherapy: results of a European, multicenter, randomized, controlled trial.
Clinical experience with ferric carboxymaltose in the treatment of cancer- and chemotherapy-associated anaemia.
The effect of erythropoiesis-stimulating agents on lung cancer patients: a meta-analysis.
Expert consensus guidelines: intravenous iron uses, formulations, administration, and management of reactions.
Benefits and risks of using erythropoiesis-stimulating agents (ESAs) in lung cancer patients: study-level and patient-level meta-analyses.
Response to erythropoietic-stimulating agents in patients with chronic myelomonocytic leukemia.
赤血球造血刺激因子製剤
鉄静注
血小板減少症の治療管理
Autologous stem cell transplantation in patients who object to a blood transfusion: contribution of new pharmacological haematopoiesis support.
A multicenter study of romiplostim for chemotherapy-induced thrombocytopenia in solid tumors and hematologic malignancies.
The effect of interleukin 11 on thrombocytopenia associated with tyrosine kinase inhibitor therapy in patients with chronic myeloid leukemia.
Use of platelet and erythroid growth factors during induction chemotherapy for acute lymphoblastic leukaemia in a Jehovah's Witness.
Romiplostim efficacy in an acute myeloid leukemia patient with transfusion refractory thrombocytopenia.
The role of interleukin-11 to prevent chemotherapy-induced thrombocytopenia in patients with solid tumors, lymphoma, acute myeloid leukemia and bone marrow failure syndromes.
Results of a phase I dose escalation study of eltrombopag in patients with advanced soft tissue sarcoma receiving doxorubicin and ifosfamide.
Efficacy of romiplostim in the treatment of chemotherapy induced thrombocytopenia (CIT) in a patient with mantle cell lymphoma.
Eltrombopag for radiation-induced thrombocytopenia in a glioblastoma patient.
Recombinant human interleukin 11 and bacterial infection in patients with haematological malignant disease undergoing chemotherapy: a double-blind placebo-controlled randomised trial.
Autologous stem-cell transplantation without hematopoietic support for the treatment of hematologic malignancies in Jehovah's Witnesses.
Effect of avatrombopag in the management of severe and refractory chemotherapy-induced thrombocytopenia (CIT) in patients with solid tumors.
Results of a randomized, double-blind study of romiplostim versus placebo in patients with low/intermediate-1-risk myelodysplastic syndrome and thrombocytopenia.
A randomized controlled trial of romiplostim in patients with low- or intermediate-risk myelodysplastic syndrome receiving decitabine.
Thrombopoietin-receptor agonists in haematological disorders: the Danish experience.
Recombinant human thrombopoietin promotes platelet engraftment after haploidentical hematopoietic stem cell transplantation: a prospective randomized controlled trial.
The non-peptide thrombopoietin receptor agonist eltrombopag stimulates megakaryopoiesis in bone marrow cells from patients with relapsed multiple myeloma.
Safety and efficacy of romiplostim in patients with lower-risk myelodysplastic syndrome and thrombocytopenia.
The use of simple patient blood management strategies as an alternative to platelet and red cell transfusion in autologous stem cell transplant.
The effect of recombinant human erythropoietin on platelet counts is strongly modulated by the adequacy of iron supply.
A single center experience with romiplostim for the management of chemotherapy-induced thrombocytopenia.
Pharmacological therapies to minimise platelet transfusion.
Romiplostim for management of chemotherapy-induced thrombocytopenia.
Eltrombopag for the treatment of thrombocytopenia in patients with malignant and non-malignant hematologic disorders.
High-dose chemotherapy without transfusion for Philadelphia chromosome negative B-cell acute lymphoblastic leukemia in two Jehovah's Witnesses patients: a feasible option in the age of hematopoietic growth factors.
Safety and tolerability of eltrombopag versus placebo for treatment of thrombocytopenia in patients with advanced myelodysplastic syndromes or acute myeloid leukaemia: a multicentre, randomised, placebo-controlled, double-blind, phase 1/2 trial.
Romiplostim for delayed platelet recovery and secondary thrombocytopenia following allogeneic stem cell transplantation.
Safety and efficacy of eltrombopag in post-hematopoietic stem cell transplantation (HSCT) thrombocytopenia.
Identifying drugs that cause acute thrombocytopenia: an analysis using 3 distinct methods.
Eltrombopag inhibits the proliferation of leukemia cells via reduction of intracellular iron and induction of differentiation.
Subcutaneous or intravenous administration of romiplostim in thrombocytopenic patients with lower risk myelodysplastic syndromes.
Romiplostim treatment of chemotherapy-induced thrombocytopenia.
Effects of erythropoietin on platelet reactivity and thrombopoiesis in humans.
A pilot phase I dose finding safety study of the thrombopoietin-receptor agonist, eltrombopag, in patients with myelodysplastic syndrome treated with azacitidine.
Eltrombopag for treatment of thrombocytopenia after allogeneic hematopoietic cell transplantation.
Low-dose interleukin-11 in patients with bone marrow failure: update of the M. D. Anderson Cancer Center experience.
A randomized, double-blind, placebo-controlled phase 2 study evaluating the efficacy and safety of romiplostim treatment of patients with low or intermediate-1 risk myelodysplastic syndrome receiving lenalidomide.
Romiplostim for chemotherapy-induced thrombocytopenia: efficacy and safety of extended use.
Effect of the nonpeptide thrombopoietin receptor agonist eltrombopag on bone marrow cells from patients with acute myeloid leukemia and myelodysplastic syndrome.
血管造影による塞栓術または血管閉塞
Hypervascular lesion in the head of the pancreas. Preoperative angiography and selective embolization results in bloodless operation.
Transcutaneous arterial embolization to control massive tumor bleeding in head and neck cancer: 63 patients' experiences from a single medical center.
Preoperative and therapeutic embolization of extremities of bone and soft tissue tumors.
Optimal schedule of preoperative embolization for spinal metastasis surgery.
Case report: octreotide as an adjunct to embolisation in the management of recurrent bleeding upper gastrointestinal metastases from primary renal cell cancer.
Role of embolization in the treatment of renal masses.
Surgery without blood transfusion for giant paraganglioma in a Jehovah's Witness patient.
Embolization of hypervascular bone metastases reduces intraoperative blood loss: a case-control study.
Management of bleeding in patients with advanced cancer.
Preoperative embolization of hypervascular spinal tumors: current practice and center experience.
Is preoperative embolization a prerequisite for spinal metastases surgical management?
外科的血液温存法
Pancreaticoduodenectomy without homologous blood transfusion in an anemic Jehovah's Witness.
Blood loss in surgical oncology: neglected quality indicator?
Transfusion requirements in microsurgical reconstruction in maxillofacial surgery: ethical and legal problems of patients who are Jehovah's Witnesses.
The theory and practice of bloodless surgery.
止血の管理と最適化
Use of Novoseven for arsenic trioxide-induced bleeding in PML.
Epsilon aminocaproic acid prevents bleeding in severely thrombocytopenic patients with hematological malignancies.
Tranexamic acid for control of haemorrhage in acute promyelocytic leukaemia.
Tranexamic acid therapy in acute myeloid leukemia: possible reduction of platelet transfusions.
Control of bleeding caused by thrombocytopenia associated with hematologic malignancy: an audit of the clinical use of recombinant activated Factor VII.
Pilot study on the safety and efficacy of desmopressin for the treatment or prevention of bleeding in patients with hematologic malignancies.
Fibrinolytic inhibitors for cancer-associated bleeding problems.
The off-label use of recombinant FVIIa in the treatment of a patient with T-cell non-Hodgkin lymphoma who developed intra-abdominal and intra-pleural hemorrhages followed by high-dose methotreaxate therapy.
Autologous stem-cell transplantation without hematopoietic support for the treatment of hematologic malignancies in Jehovah's Witnesses.
The potential role of recombinant activated FVII in the management of critical hemato-oncological bleeding: a systematic review.
Anti-fibrinolytic therapy with aminocaproic acid for the control of bleeding in thrombocytopenic patients.
Effective hemostasis with rFVIIa treatment in two patients with severe thrombocytopenia and life-threatening hemorrhage.
Desmopressin and other synthetic vasopressin analogues in cancer treatment.
Management of bleeding complications of hematologic malignancies.
Vitamin K deficiency in cancer patients referred to a hospital palliative care team with bleeding and the impact of vitamin K replacement on laboratory indicators of vitamin K status.
Use of recombinant activated factor VII in a Jehovah's Witness patient.
Epsilon aminocaproic acid reduces transfusion requirements in patients with thrombocytopenic hemorrhage.
Clinical experience with recombinant factor VIIa in patients with thrombocytopenia.
Aminocaproic acid use in hospitalized patients with hematological malignancy: a case series.
Successful treatment of severe gastrointestinal bleeding after chemotherapy in acute myeloblastic leukemia with recombinant activated factor VII: report on one case and review of other uses in acute leukemias.
Management of bleeding in patients with advanced cancer.
Tranexamic acid to treat life-threatening hemorrhage in prostate cancer associated disseminated intravascular coagulation with excessive fibrinolysis.
A controlled trial of tranexamic acid therapy for the reduction of bleeding during treatment of acute myeloid leukemia.
Recombinant factor VIIa for bleeding in refractory thrombocytopenia.
Acute promyelocytic leukaemia and acquired alpha-2-plasmin inhibitor deficiency: a retrospective look at the use of epsilon-aminocaproic acid (Amicar) in 30 patients.
Effective treatment of life-threatening bleeding with recombinant activated factor VII in a patient with acute promyelocytic leukaemia.
抗線溶薬
遺伝子組換え活性型血液凝固第Ⅶ因子製剤(rFVIIa)
濃縮凝固因子製剤
デスモプレシン
術中の自己血管理
Safety of intraoperative blood salvage during liver transplantation in patients with hepatocellular carcinoma: A systematic review and meta-analysis.
Effect of autotransfusion system on tumor recurrence and survival in hepatocellular carcinoma patients.
Does autologous blood transfusion during liver transplantation for hepatocellular carcinoma increase risk of recurrence?
Phase II comparison study of intraoperative autotransfusion for major oncologic procedures.
Cerebral effect of acute normovolemic hemodilution during brain tumor resection.
Oncologic outcomes following radical prostatectomy with intraoperative cell salvage.
Effects of standardized acute normovolemic hemodilution on intraoperative allogeneic blood transfusion in patients undergoing major maxillofacial surgery.
Safety of the use of blood salvage and autotransfusion during liver transplantation for hepatocellular carcinoma.
A prospective randomized trial of acute normovolemic hemodilution compared to standard intraoperative management in patients undergoing major hepatic resection.
Impact of autologous blood transfusion on survival and recurrence among patients undergoing partial hepatectomy for colorectal cancer liver metastases.
Transfusion-free strategies in liver and pancreatic surgery: a predictive model of blood conservation for transfusion avoidance in mainstream populations.
Use of intraoperative cell-salvage for autologous blood transfusions in metastatic spine tumour surgery: a systematic review.
Metastatic efficiency of tumour cells can be impaired by intraoperative cell salvage process: truth or conjecture?
Acute normovolemic hemodilution in a Jehovah's Witness patient: a case report.
Pancreaticoduodenectomy after neoadjuvant therapy in a Jehovah's Witness with locally advanced pancreatic cancer: case report and approach to avoid transfusion.
Effectiveness of acute normovolemic hemodilution to minimize allogeneic blood transfusion in major liver resections.
The impact of intraoperative autologous blood transfusion during type III radical hysterectomy for early-stage cervical cancer.
悪性腫瘍手術における術中回収式自己血輸血[Intraoperative, salvaged, autologous blood transfusion in oncologic surgery.] [Japanese]
Intraoperative cell salvage during radical cystectomy does not affect long-term survival.
Intraoperative cell salvage in radical prostatectomy does not appear to increase long-term biochemical recurrence, metastases, or mortality.
Should intraoperative cell-salvaged blood be used in patients with suspected or known malignancy?
Blood salvage and cancer surgery: a meta-analysis of available studies.
血液回収法
急性等容量性血液希釈
好中球減少症の治療管理
2010 update of EORTC guidelines for the use of granulocyte-colony stimulating factor to reduce the incidence of chemotherapy-induced febrile neutropenia in adult patients with lymphoproliferative disorders and solid tumours.
Clinical practice guideline for the use of antimicrobial agents in neutropenic patients with cancer: 2010 Update by the Infectious Diseases Society of America.
High-dose chemotherapy without transfusion for Philadelphia chromosome negative B-cell acute lymphoblastic leukemia in two Jehovah's Witnesses patients: a feasible option in the age of hematopoietic growth factors.
Recommendations for the use of WBC growth factors: American Society of Clinical Oncology Clinical Practice Guideline Update.
輸血代替療法を用いた集中治療
Acute leukaemia in Jehovah's Witnesses.
Leczenie ostrej białaczki u Świadków Jehowy—opis przypadku i przegląd piśmiennictwa. [Treatment of acute leukemia in Jehovah's Witnesses—a case report and review of the literature.] [Polish, English abstract]
Treatment of acute leukaemia in adult Jehovah's Witnesses.
Autologous stem-cell transplantation without hematopoietic support for the treatment of hematologic malignancies in Jehovah's Witnesses.
Should Jehovah's Witnesses be denied intensive chemotherapy for acute leukemia?
Myeloablative therapy and bone marrow transplantation in Jehovah's Witnesses with malignancies: single center experience.
Developing a blood conservation care plan for Jehovah's Witness patients with malignant disease.
High-dose chemotherapy without transfusion for Philadelphia chromosome negative B-cell acute lymphoblastic leukemia in two Jehovah's Witnesses patients: a feasible option in the age of hematopoietic growth factors.
Bloodless chimeric antigen receptor (CAR) T-cell therapy in Jehovah's Witnesses.
個別化または変法化学療法
Combined lenalidomide, low-dose dexamethasone, and rituximab achieves durable responses in rituximab-resistant indolent and mantle cell lymphomas.
Autologous stem-cell transplantation can be performed safely without the use of blood-product support.
Leucemia aguda en los Testigos de Jehová. [Acute leukemia in Jehovah's Witnesses.] [Spanish]
The use of blood conservation methods in addition to erythropoietin allows myeloablative allogeneic stem cell transplantation without the use of blood products.
Oral azacitidine (CC-486) for the treatment of myelodysplastic syndromes and acute myeloid leukemia.
Hematologic improvement and response in elderly AML/RAEB patients treated with valproic acid and low-dose Ara-C.
Arsenic trioxide during consolidation for patients with previously untreated low/intermediate risk acute promyelocytic leukaemia may eliminate the need for maintenance therapy.
Low-dose cytosine arabinoside as an alternative treatment for acute leukemia in Jehovah's Witnesses.
Dose-dense rituximab-CHOP compared with standard rituximab-CHOP in elderly patients with diffuse large B-cell lymphoma (the LNH03-6B study): a randomised phase 3 trial.
Azacitidine and venetoclax in previously untreated acute myeloid leukemia.
Treatment of acute leukaemia in adult Jehovah's Witnesses.
Minimally-myelosuppressive asparaginase-containing induction regimen for treatment of a Jehovah's Witness with mutant IDH1/NPM1/NRAS acute myeloid leukemia.
Bevacizumab alone and in combination with irinotecan in recurrent glioblastoma.
Successful treatment of a Jehovah's Witness with acute promyelocytic leukemia.
Induction with azacytidine followed by allogeneic hematopoietic stem cell transplantation in a Jehovah's Witness with acute monocytic leukemia.
Immediate or delayed therapy with 2-CdA for hairy cell leukemia in Jehova's Witness?
Tailored therapy of adult acute leukaemia in Jehovah's Witnesses: unjustified reluctance to treat.
Successful treatment of acute promyelocytic leukemia in a pregnant Jehovah's Witness with all-trans retinoic acid, rhG-CSF, and erythropoietin.
Long-term efficacy of low-dose all-trans retinoic acid plus minimal chemotherapy induction followed by the addition of intravenous arsenic trioxide post-remission therapy in newly diagnosed acute promyelocytic leukaemia.
Cytarabine dose for acute myeloid leukemia.
Myeloablative therapy and bone marrow transplantation in Jehovah's Witnesses with malignancies: single center experience.
Ivosidenib and azacitidine in IDH1-mutated acute myeloid leukemia.
Effect of chemotherapy delays and dose reductions on progression free and overall survival in the treatment of epithelial ovarian cancer.
The treatment of acute lymphoblastic leukemia in Jehovah's Witnesses and patients who cannot accept blood products.
Developing a blood conservation care plan for Jehovah's Witness patients with malignant disease.
High-dose chemotherapy without transfusion for Philadelphia chromosome negative B-cell acute lymphoblastic leukemia in two Jehovah's Witnesses patients: a feasible option in the age of hematopoietic growth factors.
Hematopoietic growth factors: personalization of risks and benefits.
Bloodless chimeric antigen receptor (CAR) T-cell therapy in Jehovah's Witnesses.
Ivosidenib induces deep durable remissions in patients with newly diagnosed IDH1-mutant acute myeloid leukemia.
Bloodless (transfusion-free) hematopoietic stem cell transplants: the Mexican experience.
A Mexican way to cope with stem cell grafting.
Management of acute promyelocytic leukemia: recommendations from an expert panel on behalf of the European LeukemiaNet.
SCT in Jehovah's Witnesses: the bloodless transplant.
Treatment of acute myelogenous leukemia with outpatient azacitidine.
Isolated limb perfusion for an irresectable melanoma recurrence in a Jehovah's Witness.
Management of cytopenias in patients with myelofibrosis treated with ruxolitinib and effect of dose modifications on efficacy outcomes.
Bevacizumab plus irinotecan in recurrent glioblastoma multiforme.
Venetoclax plus LDAC for newly diagnosed AML ineligible for intensive chemotherapy: a phase 3 randomized placebo-controlled trial.
Decreased transfusion requirements for patients receiving nonmyeloablative compared with conventional peripheral blood stem cell transplants from HLA-identical siblings.
A Jehovah's Witness with acute myeloid leukemia successfully treated with an epigenetic drug, azacitidine: a clue for development of anti-AML therapy requiring minimum blood transfusions.
Acute lymphoblastic leukaemia in a Jehovah's Witness: a management dilemma.
Oral tetra-arsenic tetra-sulfide formula versus intravenous arsenic trioxide as first-line treatment of acute promyelocytic leukemia: a multicenter randomized controlled trial.
無輸血での造血幹細胞移植
Autologous stem cell transplantation in patients who object to a blood transfusion: contribution of new pharmacological haematopoiesis support.
Autologous stem-cell transplantation can be performed safely without the use of blood-product support.
Safety of bloodless autologous stem cell transplantation in Jehovah's Witness patients.
The use of blood conservation methods in addition to erythropoietin allows myeloablative allogeneic stem cell transplantation without the use of blood products.
Hematopoietic stem cell transplantation without the use of blood components by the patient's choice: experience of 2 Brazilian centers.
Transfusion challenges in hematology oncology and hematopoietic stem cell transplant - literature review and local experience.
Autologous stem-cell transplantation without hematopoietic support for the treatment of hematologic malignancies in Jehovah's Witnesses.
Myeloablative chemotherapy and autologous stem cell transplantation without the use of blood products.
Safety and survival outcomes for bloodless transplantation in patients with myeloma.
Bloodless tandem autologous transplant in Jehovah's Witness patients.
Myeloablative therapy and bone marrow transplantation in Jehovah's Witnesses with malignancies: single center experience.
Bloodless (transfusion-free) hematopoietic stem cell transplants: the Mexican experience.
SCT in Jehovah's Witnesses: the bloodless transplant.
医原性貧血を避けるための採血量の制限
Phlebotomy—a minimalist approach.
Savoring every drop—vampire or mosquito?
Hospital-acquired anemia: prevalence, outcomes, and healthcare implications.
Twenty-five million liters of blood into the sewer.
Reduction of blood loss from laboratory testing in hospitalized adult patients using small-volume (pediatric) tubes.
Iatrogenic anemia (can it be prevented?).
診断目的以外の失血の抑制
Stress ulcer prophylaxis.
Management of menorrhagia associated with chemotherapy-induced thrombocytopenia in women with hematologic malignancy.
Stress-related mucosal bleeding in critically ill oncology patients.
Menstrual suppression in special circumstances.
Prevention of severe menorrhagia in oncology patients with treatment-induced thrombocytopenia by luteinizing hormone-releasing hormone agonist and depo-medroxyprogesterone acetate.
Management of uterine bleeding during hematopoietic stem cell transplantation.
等容量性貧血の許容
Compliance rates and outcomes associated with a restrictive transfusion policy in gynecologic oncology patients.
Liberal or restrictive transfusion in high-risk patients after hip surgery.
Long-lasting extreme anemia during the therapy of acute lymphoblastic leukemia in a Jehovah's Witness patient.
Autologous stem-cell transplantation without hematopoietic support for the treatment of hematologic malignancies in Jehovah's Witnesses.
Do basic laboratory tests or clinical observations predict bleeding in thrombocytopenic oncology patients? A reevaluation of prophylactic platelet transfusions.
A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care.
Red blood cell transfusion in non-bleeding critically ill patients with moderate anemia: is there a benefit?
How low should we go: A systematic review and meta-analysis of the impact of restrictive red blood cell transfusion strategies in oncology.
Trends in red blood cell transfusion and 30-day mortality among hospitalized patients.
Liberal versus restrictive red blood cell transfusion thresholds in hematopoietic cell transplantation: a randomized, open label, phase III, noninferiority trial.
Transfusion indications for patients with cancer.
Restrictive blood transfusion protocol in malignant upper gastrointestinal and pancreatic resections patients reduces blood transfusions with no increase in patient morbidity.
大量出血の有害作用
Association between perioperative blood transfusions and clinical outcomes in patients undergoing bladder cancer surgery: a systematic review and meta-analysis study.
Impact of intraoperative blood loss on long-term survival after lung cancer resection.
Acute bleeding after bone marrow transplantation (BMT)—incidence and effect on survival. A quantitative analysis in 1,402 patients.
Financial and clinical outcomes associated with surgical bleeding complications.
Elective surgery without transfusion: influence of preoperative hemoglobin level and blood loss on mortality.
輸血のリスクと不確実性
Effects of allogeneic red blood cell transfusions on clinical outcomes in patients undergoing colorectal cancer surgery: a systematic review and meta-analysis.
Blood transfusion and cancer surgery outcomes: a continued reason for concern.
Perioperative blood transfusions promote pancreas cancer progression.
Impact of allogeneic and autologous transfusion on immune function in patients with tumors.
A cohort investigation of anaemia, treatment and the use of allogeneic blood transfusion in colorectal cancer surgery.
Blood transfusions, thrombosis, and mortality in hospitalized patients with cancer.
Perioperative blood transfusion, age at surgery, and prognosis in a database of 526 upper gastrointestinal cancers.
Perioperative allogenenic blood transfusion is associated with worse clinical outcome for patients undergoing gastric carcinoma surgery: a meta-analysis.
Perioperative allogenenic blood transfusion is associated with worse clinical outcomes for hepatocellular carcinoma: a meta-analysis.
Correlations between neoadjuvant treatment, anemia, and perioperative complications in patients undergoing esophagectomy for cancer.
How low should we go: A systematic review and meta-analysis of the impact of restrictive red blood cell transfusion strategies in oncology.
Impact of perioperative allogeneic red blood cell transfusion on recurrence and overall survival after resection of colorectal liver metastases.
Current perspectives in transfusion-transmitted infectious diseases: emerging and re-emerging infections.
臨床成績
Liberal versus restrictive red blood cell transfusion thresholds in hematopoietic cell transplantation: a randomized, open label, phase III, noninferiority trial.
経済効果
Impact of a patient blood management monitoring and feedback programme on allogeneic blood transfusions and related costs.
術前の患者の評価と輸血リスクの評価
Transfusion and coagulation management in liver transplantation.
The beneficial effects of minimizing blood loss in pancreatoduodenectomy.
術前の計画と患者の状態の最適化
Short-term preoperative diet decreases bleeding after partial hepatectomy: results from a multi-institutional randomized controlled trial.
Recommendations from the international consensus conference on anemia management in surgical patients (ICCAMS).
集学的,職種横断的な,個別化されたアプローチ
Multimodal patient blood management program based on a three-pillar strategy: a systematic review and meta-analysis.
Liver transplantation in a Jehovah's Witness with ankylosing spondylitis.
Liver transplantation in Jehovah's Witnesses: 13 consecutive cases at a single institution.
Pancreatic resections in patients who refuse blood transfusions. The application of a perioperative protocol for a true bloodless surgery.
Patient blood management: a patient-orientated approach to blood replacement with the goal of reducing anemia, blood loss and the need for blood transfusion in elective surgery.
Bloodless surgery in geriatric surgery.
Transfusion-free strategies in liver and pancreatic surgery: a predictive model of blood conservation for transfusion avoidance in mainstream populations.
The theory and practice of bloodless surgery.
Obiettivi di un programma di chirurgia senza sangue. Studio comparativo (chirurgia maggiore vs chirurgia minore-media) su 51 pazienti testimoni di Geova. [Objectives of a bloodless surgery program. A comparative study (major surgery vs. minor-medium surgery) in 51 Jehovah's Witnesses patients.] [Italian, English abstract]
Strategies to minimize intraoperative blood loss during major surgery.
Blood-management programs: a clinical and administrative model with program implementation strategies.
術前貧血管理と赤血球数の最適化
The role of intravenous iron in anemia management and transfusion avoidance.
Impact of preoperative erythropoietin on allogeneic blood transfusions in surgical patients: results from a systematic review and meta-analysis.
A propensity-matched cohort study of intravenous iron versus red cell transfusions for preoperative iron-deficiency anemia.
Liver transplantation in Jehovah's Witnesses: 13 consecutive cases at a single institution.
The important role for intravenous iron in perioperative patient blood management in major abdominal surgery: a randomized controlled trial.
Identification and management of preoperative anaemia in adults: a British Society for Haematology Guideline update.
Efficacy and safety of erythropoietin and intravenous iron in perioperative blood management: a systematic review.
Penny-wise and pound-foolish: the challenges of preoperative anaemia management.
Recommendations from the international consensus conference on anemia management in surgical patients (ICCAMS).
Expert consensus guidelines: intravenous iron uses, formulations, administration, and management of reactions.
Blood conservation in pediatric anesthesia.
血小板減少症の治療管理
Eltrombopag before procedures in patients with cirrhosis and thrombocytopenia.
Preoperative use of romiplostim in thrombocytopenic patients with chronic hepatitis C and liver cirrhosis.
抗凝固療法の管理と中和
Emergency reversal of anticoagulation: from theory to real use of prothrombin complex concentrates. A retrospective Italian experience.
Perioperative management of antithrombotic therapy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines.
Four-factor prothrombin complex concentrate versus plasma for rapid vitamin K antagonist reversal in patients needing urgent surgical or invasive interventions: a phase 3b, open-label, non-inferiority, randomised trial.
Long-term safety and efficacy of a pasteurized nanofiltrated prothrombin complex concentrate (Beriplex P/N): a pharmacovigilance study.
Emergency reversal of warfarin anticoagulation.
Recent advances in the development of specific antidotes for target-specific oral anticoagulants.
Idarucizumab for dabigatran reversal - full cohort analysis.
Oral anticoagulation in surgical procedures: risks and recommendations.
外科的血液温存法
The theory and practice of bloodless surgery.
止血の管理と最適化
Tranexamic acid demonstrates efficacy without increased risk for venous thromboembolic events in cranial neurosurgery: systematic review of the evidence and current applications in nontraumatic pathologies.
Fibrinogen replacement therapy: a critical review of the literature.
Anti-fibrinolytic use for minimising perioperative allogeneic blood transfusion.
Effect of tranexamic acid on surgical bleeding: systematic review and cumulative meta-analysis.
Systematic review, meta-analysis and meta-regression of the effect of tranexamic acid on surgical blood loss.
Management of severe perioperative bleeding: Guidelines from the European Society of Anaesthesiology.
Fibrinogen as a therapeutic target for bleeding: a review of critical levels and replacement therapy.
Recombinant factor VIIa as last-resort treatment of desperate haemorrhage.
Association of intravenous tranexamic acid with thromboembolic events and mortality: a systematic review, meta-analysis, and meta-regression.
抗線溶薬
遺伝子組換え活性型血液凝固第Ⅶ因子製剤(rFVIIa)
濃縮凝固因子製剤
外科的出血か凝固異常による出血かを同定するための血液粘弾性試験
体温管理(低体温の回避)
Consequences of inadvertent perioperative hypothermia.
Comparison of resistive heating and forced-air warming to prevent inadvertent perioperative hypothermia.
Effectiveness of strategies for the management and/or prevention of hypothermia within the adult perioperative environment.
The effects of mild perioperative hypothermia on blood loss and transfusion requirement.
A systematic review of intraoperative warming to prevent postoperative complications.
Intraoperative core temperature patterns, transfusion requirement, and hospital duration in patients warmed with forced air.
Randomized clinical trial of perioperative systemic warming in major elective abdominal surgery.
注意深い輸液・体液管理
Perioperative fluid management strategies in major surgery: a stratified meta-analysis.
Major hepatectomy in children: approaching blood transfusion-free.
Restrictive strategy of intraoperative fluid maintenance during optimization of oxygen delivery decreases major complications after high-risk surgery.
Choice of fluid in acute illness: what should be given? An international consensus.
Impact of goal-directed perioperative fluid management in high-risk surgical procedures: a literature review.
Safety of modern starches used during surgery.
術中の自己血管理
Does autologous blood transfusion during liver transplantation for hepatocellular carcinoma increase risk of recurrence?
Cell salvage as part of a blood conservation strategy in anaesthesia.
Phase II comparison study of intraoperative autotransfusion for major oncologic procedures.
Very low rate of patient-related adverse events associated with the use of intraoperative cell salvage.
Intra-operative cell salvage: a fresh look at the indications and contraindications.
Safety of the use of blood salvage and autotransfusion during liver transplantation for hepatocellular carcinoma.
Blood salvage and autotransfusion during orthotopic liver transplantation for hepatocellular carcinoma: a systematic review and meta-analysis.
A case of thoracic esophageal cancer undergone esophagectomy after induction chemotherapy in a Jehovah's Witness.
A prospective randomized trial of acute normovolemic hemodilution compared to standard intraoperative management in patients undergoing major hepatic resection.
Association of Anaesthetists guidelines: cell salvage for peri-operative blood conservation 2018.
Transfusion-free strategies in liver and pancreatic surgery: a predictive model of blood conservation for transfusion avoidance in mainstream populations.
Use of intraoperative cell-salvage for autologous blood transfusions in metastatic spine tumour surgery: a systematic review.
Metastatic efficiency of tumour cells can be impaired by intraoperative cell salvage process: truth or conjecture?
A prospective randomized study comparing two techniques of perioperative blood conservation: isovolemic hemodilution and hypervolemic hemodilution.
Blood transfusion risks and alternative strategies in pediatric patients.
Acute normovolemic hemodilution.
Is cell salvage safe in liver resection? A pilot study.
Acute normovolemic hemodilution.
Should intraoperative cell-salvaged blood be used in patients with suspected or known malignancy?
Blood salvage and cancer surgery: a meta-analysis of available studies.
血液回収法
急性等容量性血液希釈
麻酔学的血液温存法
Controlled hypotension: a guide to drug choice.
Influence of controlled hypotension versus normotension on amount of blood loss during breast reduction.
Does neuraxial anesthesia reduce intraoperative blood loss? A meta-analysis.
Reduction of postoperative mortality and morbidity with epidural or spinal anaesthesia: results from overview of randomised trials.
低血圧法
局所麻酔
医原性貧血を避けるための採血量の制限
Savoring every drop—vampire or mosquito?
Surgical vampires and rising health care expenditure: reducing the cost of daily phlebotomy.
術後貧血の管理
Recombinant human erythropoietin therapy in critically ill Jehovah's Witnesses.
Severe acute anemia after liver transplantation in an elderly Jehovah's Witness treated with high-dose erythropoietin and ferric carboxymaltose: a case report.
Intravenous ferric carboxymaltose versus standard care in the management of postoperative anaemia: a prospective, open-label, randomised controlled trial.
How do we treat life-threatening anemia in a Jehovah's Witness patient?
Transfusion-free management of gastrointestinal bleeding: the experience of a Bloodless Institute.
患者の貧血に対する許容力の最適化
The influence of volume management on outcome.
Prophylactic hypothermia and neuromuscular blockade to limit myocardial oxygen demand in a critically anemic Jehovah's Witness after emergency surgery.
Pillar III—optimisation of anaemia tolerance.
等容量性貧血の許容
Patient blood management: a patient-orientated approach to blood replacement with the goal of reducing anemia, blood loss and the need for blood transfusion in elective surgery.
Restrictive blood transfusion practices are associated with improved patient outcomes.
A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care.
Restrictive versus liberal transfusion strategy for red blood cell transfusion: systematic review of randomised trials with meta-analysis and trial sequential analysis.
Anemia and perioperative red blood cell transfusion: a matter of tolerance.
Pillar III—optimisation of anaemia tolerance.
Trends in red blood cell transfusion and 30-day mortality among hospitalized patients.
Impact of more restrictive blood transfusion strategies on clinical outcomes: a meta-analysis and systematic review.
大量出血の有害作用
The beneficial effects of minimizing blood loss in pancreatoduodenectomy.
輸血のリスクと不確実性
Blood transfusion and cancer surgery outcomes: a continued reason for concern.
Surgical outcomes and transfusion of minimal amounts of blood in the operating room.
Adverse blood transfusion outcomes: establishing causation.
Efficacy of red blood cell transfusion in the critically ill: a systematic review of the literature.
Survival rate changes with transfusion of blood products during liver transplantation.
臨床成績
Peri-operative blood transfusion increases length of hospital stay and number of postoperative complications in non-cardiac surgical patients.
Association between the use of blood components and the five-year mortality after liver transplant. [Associação entre Uso de Hemocomponentes e Mortalidade em Cinco Anos após Transplante Hepático.] [English, Portuguese]
Risk-adjusted clinical outcomes in patients enrolled in a bloodless program.
The important role for intravenous iron in perioperative patient blood management in major abdominal surgery: a randomized controlled trial.
Association between intraoperative blood transfusion and mortality and morbidity in patients undergoing noncardiac surgery.
Restrictive blood transfusion practices are associated with improved patient outcomes.
Intraoperative cardiac arrests in adults undergoing noncardiac surgery: incidence, risk factors, and survival outcome.
Review article: Risks of anemia and related management strategies: can perioperative blood management improve patient safety?
Trends in red blood cell transfusion and 30-day mortality among hospitalized patients.
Impact of more restrictive blood transfusion strategies on clinical outcomes: a meta-analysis and systematic review.
Blood-management programs: a clinical and administrative model with program implementation strategies.
Implementation of a comprehensive patient blood management program for hospitalized patients at a large united states medical center.
Safety and efficacy of methods for reducing perioperative allogeneic transfusion: a critical review of the literature.
経済効果
Cost-effectiveness of cell salvage and alternative methods of minimising perioperative allogeneic blood transfusion: a systematic review and economic model.
Estimating the epidemiological and economic impact of implementing preoperative anaemia measures in the German healthcare system: the health economic footprint of patient blood management.
Greater than sevenfold return on investment for a comprehensive patient blood management program with equivalent or improved outcomes.
Risk-adjusted clinical outcomes in patients enrolled in a bloodless program.
Economic considerations on transfusion medicine and patient blood management.
From blood transfusion to patient blood management: a new paradigm for patient care and cost assessment of blood transfusion practice.
Safety, cost savings, simplicity back broader use of bloodless surgery.
Associations between preoperative anaemia and hospital costs following major abdominal surgery: cohort study.
A prospective study investigating the cost effectiveness of intraoperative blood salvage during liver transplantation.
Effective reduction of blood product use in a community teaching hospital: when less is more.
Prospective monitoring of plasma and platelet transfusions in a large teaching hospital results in significant cost reduction.
Activity-based costs of blood transfusions in surgical patients at four hospitals.
Intra-operative cell salvage in South Africa: feasible, beneficial and economical.
Randomized trial comparing packed red cell blood transfusion with and without leukocyte depletion for gastrointestinal surgery.
Implementation of a comprehensive patient blood management program for hospitalized patients at a large united states medical center.
The volume of returned red blood cells in a large blood salvage program: where does it all go?
An economic analysis of costs associated with development of a cell salvage program.
術前の計画と患者の状態の最適化
Preparing a Jehovah's Witness for major elective surgery.
Preoperative evaluation of the adult patient undergoing non-cardiac surgery: guidelines from the European Society of Anaesthesiology.
Avoiding blood transfusion in surgical patients (including Jehovah's Witnesses).
Patient blood management is key before elective surgery.
Bloodless medicine: clinical care without allogeneic blood transfusion.
Blood transfusion and orthognathic surgery--a thing of the past?
The effect of preoperative recombinant erythropoietin on postoperative hematocrit level after orthognathic surgery.
集学的,職種横断的な,個別化されたアプローチ
No increased bleeding risk for oral surgery in patients with severe congenital bleeding disorders due to intense perioperative management.
Case report: The management of advanced oral cancer in a Jehovah's Witness using the Ultracision Harmonic Scalpel.
Blood transfusion and orthognathic surgery--a thing of the past?
The use of erythropoietin in a patient having major oral and maxillofacial surgery and refusing blood transfusion.
Multimodal strategy for reduction of homologous transfusions in cranio-maxillofacial surgery.
Treatment of individuals who cannot receive blood products for religious or other reasons.
抗凝固療法の管理と中和
Risk of bleeding after dentoalveolar surgery in patients taking anticoagulants.
Bleeding risk and reversal strategies for old and new anticoagulants and antiplatelet agents.
Emergency reversal of warfarin anticoagulation.
Effect of non-specific reversal agents on anticoagulant activity of dabigatran and rivaroxaban: a randomised crossover ex vivo study in healthy volunteers.
Reversal of clopidogrel-induced bleeding with rFVIIa in healthy subjects: a randomized, placebo-controlled, double-blind, exploratory study.
血管造影による塞栓術または血管閉塞
Transarterial embolization of the external carotid artery in the treatment of life-threatening haemorrhage following blunt maxillofacial trauma.
Transarterial embolization in the management of life-threatening hemorrhage after maxillofacial trauma: a case report and review of literature.
Endovascular preoperative embolization for temporomandibular joint replacement surgery.
止血の管理と最適化
The effect of tranexamic acid on blood loss during orthognathic surgery: a randomized controlled trial.
The effect of nasal application of cocaine/adrenaline on blood loss in Le Fort I osteotomies.
Effect of tranexamic acid irrigation on perioperative blood loss during orthognathic surgery: a double-blind, randomized controlled clinical trial.
Clinical applications of fibrin sealants.
Surgical removal of intra- and extraoral cavernous lymphangiomas using intraoperative-assisted intralesional fibrin glue injections.
Hemostasis of oral surgery wounds with the HemCon Dental Dressing.
The efficacy and safety of tranexamic acid in cranio-maxillofacial and plastic surgery.
Prevention of bleeding in orthognathic surgery--a systematic review and meta-analysis of randomized controlled trials.
Evaluation of the efficacy of tranexamic acid on blood loss in orthognathic surgery. A prospective, randomized clinical study.
Tranexamic acid is associated with improved operative field in orthognathic surgery.
Effectiveness of intravenous haemocoagulase on haemorrhage control in bi-maxillary orthognathic surgery-a prospective, randomised, controlled, double-blind study.
The role of antifibrinolytics in reducing blood loss during craniofacial or orthognathic surgical procedures: a meta-analysis.
Aprotinin reduces blood loss and the need for transfusion in orthognathic surgery.
Topical hemostatic agents: what the oral and maxillofacial surgeon needs to know.
Evaluation of hemorrhage depressors on blood loss during orthognathic surgery: a retrospective study.
抗線溶薬
デスモプレシン
他の薬剤
局所止血剤
術中の自己血管理
Effects of standardized acute normovolemic hemodilution on intraoperative allogeneic blood transfusion in patients undergoing major maxillofacial surgery.
Intraoperative red cell salvage in head and neck surgery.
Acute perioperative normovolaemic haemodilution in major maxillofacial surgery.
血液回収法
急性等容量性血液希釈
麻酔学的血液温存法
Orthognathic surgery with or without induced hypotension.
Effect of induced hypotensive anaesthesia vs isovolaemic haemodilution on blood loss and transfusion requirements in orthognathic surgery: a prospective, single-blinded, randomized, controlled clinical study.
Effects of hypotensive anesthesia on reducing intraoperative blood loss, duration of operation, and quality of surgical field during orthognathic surgery: a systematic review and meta-analysis of randomized controlled trials.
Hypotensive anaesthesia and blood loss in orthognathic surgery: a clinical study.
Induced hypotensive anesthesia for adolescent orthognathic surgery patients.
Anesthetic considerations for orthognathic surgery with evaluation of difficult intubation and technique for hypotensive anesthesia.
High Le Fort I and bilateral split sagittal osteotomy in Crouzon syndrome.
Comparative evaluation of hypotensive and normotensive anesthesia on Lefort I osteotomies: a randomized, double-blind, prospective clinical study.
低血圧法
術後貧血の管理
Recombinant human erythropoietin in severe anaemia: issues of dosing and duration.
Intravenous ferric carboxymaltose versus standard care in the management of postoperative anaemia: a prospective, open-label, randomised controlled trial.
患者の貧血に対する許容力の最適化
Anemia and perioperative red blood cell transfusion: a matter of tolerance.
Recombinant human erythropoietin in the treatment of head and neck tumour anaemia.
Effect of transfusion guidelines on postoperative transfusion in children undergoing craniofacial reconstruction surgery.
臨床成績
Multimodal patient blood management program based on a three-pillar strategy: a systematic review and meta-analysis.
経済効果
Effects of standardized acute normovolemic hemodilution on intraoperative allogeneic blood transfusion in patients undergoing major maxillofacial surgery.
Patient blood management is associated with a substantial reduction of red blood cell utilization and safe for patient's outcome: a prospective, multicenter cohort study with a noninferiority design.
Acute perioperative normovolaemic haemodilution in major maxillofacial surgery.
Impact of bleeding-related complications and/or blood product transfusions on hospital costs in inpatient surgical patients.
術前の患者の評価と輸血リスクの評価
Perioperative analgesia and the effects of dietary supplements.
Herbal medicines and perioperative care.
Perioperative use of selective serotonin reuptake inhibitors and risks for adverse outcomes of surgery.
Risk associated with preoperative anemia in noncardiac surgery: a single-center cohort study.
Identifying, monitoring and reducing preventable major bleeds in the hospital setting.
Guidelines on the assessment of bleeding risk prior to surgery or invasive procedures. British Committee for Standards in Haematology.
Clinical herbal interactions with conventional drugs: from molecules to maladies.
Transfusion and coagulation management in liver transplantation.
Preoperative assessment of coagulation disorders.
Preparing a Jehovah's Witness for major elective surgery.
Aspirin in patients undergoing noncardiac surgery.
Antiplatelet drugs: a review of their pharmacology and management in the perioperative period.
Prediction of transfusion requirements in surgical patients: a review.
In the clinic. Preoperative evaluation.
Pre-operative haematological assessment in patients scheduled for major surgery.
Preoperative anaemia and postoperative outcomes in non-cardiac surgery: a retrospective cohort study.
Preoperative assessment of the older patient: a narrative review.
The beneficial effects of minimizing blood loss in pancreatoduodenectomy.
Preoperative hematocrit levels and postoperative outcomes in older patients undergoing noncardiac surgery.
術前の計画と患者の状態の最適化
Short-term preoperative diet decreases bleeding after partial hepatectomy: results from a multi-institutional randomized controlled trial.
Detection, evaluation, and management of preoperative anaemia in the elective orthopaedic surgical patient: NATA guidelines.
Optimizing postoperative outcomes with efficient preoperative assessment and management.
Merits of exercise therapy before and after major surgery.
Effect of timing of chronic preoperative aspirin discontinuation on morbidity and mortality in patients having combined coronary artery bypass grafting and valve surgery.
Romiplostim in the management of the thrombocytopenic surgical patient.
Bloodless medicine: what to do when you can't transfuse.
Preparation of the patient for surgery.
Recommendations from the international consensus conference on anemia management in surgical patients (ICCAMS).
Essential role of patient blood management in a pandemic: a call for action.
集学的,職種横断的な,個別化されたアプローチ
Multimodal patient blood management program based on a three-pillar strategy: a systematic review and meta-analysis.
Liver transplantation in a Jehovah's Witness with ankylosing spondylitis.
Perioperative management of four anaemic female Jehovah's Witnesses undergoing urgent complex cardiac surgery.
Preparing a Jehovah's Witness for major elective surgery.
Liver transplantation in Jehovah's Witnesses: 13 consecutive cases at a single institution.
Pancreatic resections in patients who refuse blood transfusions. The application of a perioperative protocol for a true bloodless surgery.
Patient blood management: a patient-orientated approach to blood replacement with the goal of reducing anemia, blood loss and the need for blood transfusion in elective surgery.
Bloodless medicine: clinical care without allogeneic blood transfusion.
Bloodless surgery in geriatric surgery.
Perioperative management of patients for whom transfusion is not an option.
Anesthesia management of a Jehovah's Witness patient with pheochromocytoma undergoing off pump coronary artery bypass graft surgery—a case report.
Effect of a patient blood management programme on preoperative anaemia, transfusion rate, and outcome after primary hip or knee arthroplasty: a quality improvement cycle.
Blood conservation strategies in Jehovah's Witness patients undergoing complex aortic surgery: a report of three cases.
Aortic arch replacement and elephant trunk procedure: an interdisciplinary approach to surgical reconstruction, perfusion strategies and blood management.
Multidisciplinary management of a Jehovah's Witness patient for the removal of a renal cell carcinoma extending into the right atrium.
Update on blood conservation for cardiac surgery.
Anesthetic management for ascending aorta replacement in a patient who refused autologous transfusion for religious reasons.
Obiettivi di un programma di chirurgia senza sangue. Studio comparativo (chirurgia maggiore vs chirurgia minore-media) su 51 pazienti testimoni di Geova. [Objectives of a bloodless surgery program. A comparative study (major surgery vs. minor-medium surgery) in 51 Jehovah's Witnesses patients.] [Italian, English abstract]
Thoraco-abdominal aneurysm repair in a Jehovah's Witness: maximising blood conservation.
Programmatic blood conservation in cardiac surgery.
Allogeneic blood transfusion reduction by risk-based protocol in total joint arthroplasty.
Bloodless medicine: what to do when you can't transfuse.
Strategies to minimize intraoperative blood loss during major surgery.
Patient blood management in Europe.
2011 update to the Society of Thoracic Surgeons and the Society of Cardiovascular Anesthesiologists blood conservation clinical practice guidelines.
The pillars of patient blood management: key to successful implementation.
Blood-management programs: a clinical and administrative model with program implementation strategies.
A standardized multidisciplinary approach reduces the use of allogeneic blood products in patients undergoing cardiac surgery.
The perfusionist's role in a collaborative multidisciplinary approach to blood transfusion reduction in cardiac surgery.
Hypotensive anesthesia combined with tranexamic acid reduces perioperative blood loss in simultaneous bilateral total hip arthroplasty: a retrospective cohort study.
術前貧血管理と赤血球数の最適化
The role of intravenous iron in anemia management and transfusion avoidance.
The safety of intravenous iron preparations: systematic review and meta-analysis.
Impact of preoperative erythropoietin on allogeneic blood transfusions in surgical patients: results from a systematic review and meta-analysis.
A propensity-matched cohort study of intravenous iron versus red cell transfusions for preoperative iron-deficiency anemia.
Liver transplantation in Jehovah's Witnesses: 13 consecutive cases at a single institution.
The important role for intravenous iron in perioperative patient blood management in major abdominal surgery: a randomized controlled trial.
Detection, evaluation, and management of preoperative anaemia in the elective orthopaedic surgical patient: NATA guidelines.
Treatment through a preoperative anemia clinic is associated with a reduction in perioperative red blood cell transfusion in patients undergoing orthopedic and gynecologic surgery.
Identification and management of preoperative anaemia in adults: a British Society for Haematology Guideline update.
Practice advisory on the implementation of preoperative anemia management: the Society of Cardiovascular Anesthesiologists and the Society for the Advancement of Patient Blood Management.
Efficacy and safety of erythropoietin and intravenous iron in perioperative blood management: a systematic review.
International consensus statement on the peri-operative management of anaemia and iron deficiency.
'Fit to fly': overcoming barriers to preoperative haemoglobin optimization in surgical patients.
Effects of intravenous iron combined with low-dose recombinant human erythropoietin on transfusion requirements in iron-deficient patients undergoing bilateral total knee replacement arthroplasty.
Penny-wise and pound-foolish: the challenges of preoperative anaemia management.
Recommendations from the international consensus conference on anemia management in surgical patients (ICCAMS).
Iron absorption from oral iron supplements given on consecutive versus alternate days and as single morning doses versus twice-daily split dosing in iron-depleted women: two open-label, randomised controlled trials.
Effect of single recombinant human erythropoietin injection on transfusion requirements in preoperatively anemic patients undergoing valvular heart surgery.
血小板減少症の治療管理
Eltrombopag before procedures in patients with cirrhosis and thrombocytopenia.
Romiplostim treatment allows for platelet transfusion-free liver transplantation in pediatric thrombocytopenic patient with primary sclerosing cholangitis.
Preoperative use of romiplostim in thrombocytopenic patients with chronic hepatitis C and liver cirrhosis.
Avatrombopag before procedures reduces need for platelet transfusion in patients with chronic liver disease and thrombocytopenia.
抗凝固療法の管理と中和
Emergency reversal of anticoagulation: from theory to real use of prothrombin complex concentrates. A retrospective Italian experience.
Perioperative management of antithrombotic therapy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines.
Pharmacological prophylaxis of bleeding in surgical patients treated with aspirin.
Four-factor prothrombin complex concentrate versus plasma for rapid vitamin K antagonist reversal in patients needing urgent surgical or invasive interventions: a phase 3b, open-label, non-inferiority, randomised trial.
How I treat warfarin-associated coagulopathy in patients with intracerebral hemorrhage.
Long-term safety and efficacy of a pasteurized nanofiltrated prothrombin complex concentrate (Beriplex P/N): a pharmacovigilance study.
Reversing the effects of antiplatelet agents in the setting of intracranial hemorrhage: a look at the literature.
Bleeding risk and reversal strategies for old and new anticoagulants and antiplatelet agents.
Emergency reversal of warfarin anticoagulation.
Effect of non-specific reversal agents on anticoagulant activity of dabigatran and rivaroxaban: a randomised crossover ex vivo study in healthy volunteers.
Recent advances in the development of specific antidotes for target-specific oral anticoagulants.
Idarucizumab for dabigatran reversal - full cohort analysis.
Reversal of clopidogrel-induced bleeding with rFVIIa in healthy subjects: a randomized, placebo-controlled, double-blind, exploratory study.
Oral anticoagulation in surgical procedures: risks and recommendations.
Recombinant factor VIIa (rFVIIa) and hemodialysis to manage massive dabigatran-associated postcardiac surgery bleeding.
止血の管理と最適化
Aortic dissection and hypothermic arrest in a Jehovah's Witness patient: a case for recombinant factor VIIa?
The treatment of bleeding is to stop the bleeding! Treatment of trauma-related hemorrhage.
Prophylactic use of factor IX concentrate in a Jehovah's Witness patient.
Bloodless orthotopic heart transplantation in a Jehovah's Witness.
Alternatives to allogeneic platelet transfusion.
Tranexamic acid in patients undergoing noncardiac surgery.
Fibrinogen replacement therapy: a critical review of the literature.
First-line therapy with coagulation factor concentrates combined with point-of-care coagulation testing is associated with decreased allogeneic blood transfusion in cardiovascular surgery: a retrospective, single-center cohort study.
Effects of desmopressin on platelet function under conditions of hypothermia and acidosis: an in vitro study using multiple electrode aggregometry.
Anti-fibrinolytic use for minimising perioperative allogeneic blood transfusion.
Putting the record straight on aprotinin as safe and effective: results from a mixed treatment meta-analysis of trials of aprotinin.
Comprehensive Canadian review of the off-label use of recombinant activated factor VII in cardiac surgery.
Prophylactic fibrinogen infusion reduces bleeding after coronary artery bypass surgery. A prospective randomised pilot study.
Effect of tranexamic acid on surgical bleeding: systematic review and cumulative meta-analysis.
Systematic review, meta-analysis and meta-regression of the effect of tranexamic acid on surgical blood loss.
Management of severe perioperative bleeding: Guidelines from the European Society of Anaesthesiology.
Fibrinogen as a therapeutic target for bleeding: a review of critical levels and replacement therapy.
Recombinant factor VIIa as last-resort treatment of desperate haemorrhage.
Effects of fibrinogen concentrate as first-line therapy during major aortic replacement surgery: a randomized, placebo-controlled trial.
Bleeding in a Jehovah's Witness patient undergoing a redo aortic valve replacement controlled with cryoprecipitate and a prothrombin complex concentrate.
Use of rotation thromboelastometry (ROTEM) to achieve successful treatment of polytrauma with fibrinogen concentrate and prothrombin complex concentrate.
Association of intravenous tranexamic acid with thromboembolic events and mortality: a systematic review, meta-analysis, and meta-regression.
Oral is as effective as intravenous tranexamic acid at reducing blood loss in thoracolumbar spinal fusions: a prospective randomized trial.
抗線溶薬
遺伝子組換え活性型血液凝固第Ⅶ因子製剤(rFVIIa)
濃縮凝固因子製剤
デスモプレシン
外科的出血か凝固異常による出血かを同定するための血液粘弾性試験
体温管理(低体温の回避)
Influence of body core temperature on blood loss and transfusion requirements during off-pump coronary artery bypass grafting: A comparison of 3 warming systems.
Effectiveness of strategies for the management and/or prevention of hypothermia within the adult perioperative environment.
The effects of mild perioperative hypothermia on blood loss and transfusion requirement.
Mild hypothermia increases blood loss and transfusion requirements during total hip arthroplasty.
A systematic review of intraoperative warming to prevent postoperative complications.
Intraoperative core temperature patterns, transfusion requirement, and hospital duration in patients warmed with forced air.
Aggressive warming reduces blood loss during hip arthroplasty.
Randomized clinical trial of perioperative systemic warming in major elective abdominal surgery.
注意深い輸液・体液管理
Perioperative fluid management strategies in major surgery: a stratified meta-analysis.
How good patient blood management leads to excellent outcomes in Jehovah's Witness patients undergoing cardiac surgery.
Restrictive strategy of intraoperative fluid maintenance during optimization of oxygen delivery decreases major complications after high-risk surgery.
Choice of fluid in acute illness: what should be given? An international consensus.
Strategies to reduce the use of blood products: a European perspective.
Impact of goal-directed perioperative fluid management in high-risk surgical procedures: a literature review.
Safety of modern starches used during surgery.
Management of intraoperative fluid balance and blood conservation techniques in adult cardiac surgery.
術中の自己血管理
Safety of intraoperative blood salvage during liver transplantation in patients with hepatocellular carcinoma: A systematic review and meta-analysis.
Cell salvage in obstetrics.
Does autologous blood transfusion during liver transplantation for hepatocellular carcinoma increase risk of recurrence?
Cell salvage as part of a blood conservation strategy in anaesthesia.
Phase II comparison study of intraoperative autotransfusion for major oncologic procedures.
Autologous blood transfusion during emergency trauma operations.
Cell salvage for minimising perioperative allogeneic blood transfusion.
Cerebral effect of acute normovolemic hemodilution during brain tumor resection.
Very low rate of patient-related adverse events associated with the use of intraoperative cell salvage.
Intra-operative cell salvage: a fresh look at the indications and contraindications.
Role of intraoperative red cell salvage and autologus transfusion in metastatic spine surgery: a pilot study and review of literature.
Greater volume of acute normovolemic hemodilution may aid in reducing blood transfusions after cardiac surgery.
Oncologic outcomes following radical prostatectomy with intraoperative cell salvage.
The use of acute hemodilution in parturients undergoing cesarean section.
Safety of the use of blood salvage and autotransfusion during liver transplantation for hepatocellular carcinoma.
A case of thoracic esophageal cancer undergone esophagectomy after induction chemotherapy in a Jehovah's Witness.
A prospective randomized trial of acute normovolemic hemodilution compared to standard intraoperative management in patients undergoing major hepatic resection.
Acute normovolemic hemodilution and nitroglycerin-induced hypotension: comparative effects on tissue oxygenation and allogeneic blood transfusion requirement in total hip arthroplasty.
Association of Anaesthetists guidelines: cell salvage for peri-operative blood conservation 2018.
Transfusion-free strategies in liver and pancreatic surgery: a predictive model of blood conservation for transfusion avoidance in mainstream populations.
Can there be a place for intraoperative salvaged blood in spine tumor surgery?
Use of intraoperative cell-salvage for autologous blood transfusions in metastatic spine tumour surgery: a systematic review.
Metastatic efficiency of tumour cells can be impaired by intraoperative cell salvage process: truth or conjecture?
A prospective randomized study comparing two techniques of perioperative blood conservation: isovolemic hemodilution and hypervolemic hemodilution.
Cardioprotective effects of acute normovolemic hemodilution in patients undergoing coronary artery bypass surgery.
The impact of intraoperative autologous blood transfusion during type III radical hysterectomy for early-stage cervical cancer.
Acute normovolemic hemodilution.
Acute normovolemic hemodilution, intraoperative cell salvage and PulseCO hemodynamic monitoring in a Jehovah's Witness with placenta percreta.
Intraoperative cell salvage during radical cystectomy does not affect long-term survival.
Acute normovolemic hemodilution is safe in neurosurgery.
Intraoperative cell salvage in radical prostatectomy does not appear to increase long-term biochemical recurrence, metastases, or mortality.
Impaired red blood cell deformability after transfusion of stored allogeneic blood but not autologous salvaged blood in cardiac surgery patients.
The effect of acute normovolemic hemodilution and acute hypervolemic hemodilution on coagulation and allogeneic transfusion.
Is cell salvage safe in liver resection? A pilot study.
Acute normovolemic hemodilution.
Perioperative management including dual cell salvage in a Jehovah's Witness patient undergoing major urological surgery.
Intra-operative cell salvage in South Africa: feasible, beneficial and economical.
Should intraoperative cell-salvaged blood be used in patients with suspected or known malignancy?
Blood salvage and cancer surgery: a meta-analysis of available studies.
Предоперацонная гиперволемическая гемодилюция 6% гидроксиэтил-крахмалом 130/0,4 (HES 130/0,4) как способ сокращения потребности в трансфузии донорской крови. [Preoperative hypervolemic hemodilution with 6% hydroxyethyl starch 130/0,4 (HES 130/ 0.4) solution as a way of reducing needs for donor blood transfusion.] [Russian, English abstract]
血液回収法
急性等容量性血液希釈
麻酔学的血液温存法
Greater peripheral blood flow but less bleeding with propofol versus sevoflurane during spine surgery: a possible physiologic model?
Controlled hypotension: a guide to drug choice.
Controlled hypotension for spinal surgery.
Magnesium sulphate as a technique of hypotensive anaesthesia.
Effect of induced hypotensive anaesthesia vs isovolaemic haemodilution on blood loss and transfusion requirements in orthognathic surgery: a prospective, single-blinded, randomized, controlled clinical study.
The safety of controlled hypotension for shoulder arthroscopy in the beach-chair position.
The effect of neuraxial blocks on surgical blood loss and blood transfusion requirements: a meta-analysis.
Influence of controlled hypotension versus normotension on amount of blood loss during breast reduction.
A comparison of neuraxial block versus general anesthesia for elective total hip replacement: a meta-analysis.
Comparison of outcomes of using spinal versus general anesthesia in total hip arthroplasty.
Hypotensive resuscitation strategy reduces transfusion requirements and severe postoperative coagulopathy in trauma patients with hemorrhagic shock: preliminary results of a randomized controlled trial.
Comparison of hypotensive epidural anaesthesia and spinal anaesthesia on blood loss and coagulation during and after total hip arthroplasty.
Induced hypotension with epidural/general anesthesia reduces transfusion in radical prostate surgery.
Laparoscopic and robotic partial nephrectomy with controlled hypotensive anesthesia to avoid hilar clamping: feasibility, safety and perioperative functional outcomes.
Anaesthesia for hip fracture surgery in adults.
Deliberate hypotension in orthopedic surgery reduces blood loss and transfusion requirements: a meta-analysis of randomized controlled trials.
Does neuraxial anesthesia reduce intraoperative blood loss? A meta-analysis.
Reduction of postoperative mortality and morbidity with epidural or spinal anaesthesia: results from overview of randomised trials.
Comparative perioperative outcomes associated with neuraxial versus general anesthesia for simultaneous bilateral total knee arthroplasty.
High Le Fort I and bilateral split sagittal osteotomy in Crouzon syndrome.
低血圧法
局所麻酔
医原性貧血を避けるための採血量の制限
Comparison of structured use of routine laboratory tests or near-patient assessment with clinical judgement in the management of bleeding after cardiac surgery.
Savoring every drop—vampire or mosquito?
First-line therapy with coagulation factor concentrates combined with point-of-care coagulation testing is associated with decreased allogeneic blood transfusion in cardiovascular surgery: a retrospective, single-center cohort study.
Diagnostic blood loss from phlebotomy and hospital-acquired anemia during acute myocardial infarction.
Surgical vampires and rising health care expenditure: reducing the cost of daily phlebotomy.
Point-of-care testing: a prospective, randomized clinical trial of efficacy in coagulopathic cardiac surgery patients.
術後貧血の管理
Recombinant human erythropoietin therapy in critically ill Jehovah's Witnesses.
Severe acute anemia after liver transplantation in an elderly Jehovah's Witness treated with high-dose erythropoietin and ferric carboxymaltose: a case report.
Recombinant human erythropoietin in severe anaemia: issues of dosing and duration.
Efficacy of recombinant human erythropoietin in the critically ill patient: a randomized, double-blind, placebo-controlled trial.
The role of erythropoietin therapy in the critically ill.
Recombinant human erythropoietin therapy in critically ill patients: a dose-response study [ISRCTN48523317].
Intravenous ferric carboxymaltose versus standard care in the management of postoperative anaemia: a prospective, open-label, randomised controlled trial.
Safety of off-label erythropoiesis stimulating agents in critically ill patients: a meta-analysis.
An international consensus statement on the management of postoperative anaemia after major surgical procedures.
How do we treat life-threatening anemia in a Jehovah's Witness patient?
Recombinant human erythropoietin use in a critically ill Jehovah's Witness after cardiac surgery.
Randomized, double-blinded, placebo-controlled trial of fibrinogen concentrate supplementation after complex cardiac surgery.
Life-threatening postoperative blood loss in a Jehovah's Witness, treated with high-dose erythropoietin.
Transfusion-free management of gastrointestinal bleeding: the experience of a Bloodless Institute.
Efficacy of recombinant human erythropoietin in critically ill patients admitted to a long-term acute care facility: a randomized, double-blind, placebo-controlled trial.
患者の貧血に対する許容力の最適化
The influence of volume management on outcome.
Hyperbaric oxygen reverses organ dysfunction in severe anemia.
Management of a Jehovah's Witness patient with sepsis and profuse bleeding after emergency coronary artery bypass graft surgery: rethinking the critical threshold of oxygen delivery.
Hyperoxic ventilation at the critical haematocrit.
Prophylactic hypothermia and neuromuscular blockade to limit myocardial oxygen demand in a critically anemic Jehovah's Witness after emergency surgery.
Pillar III—optimisation of anaemia tolerance.
Norepinephrine increases tolerance to acute anemia.
Transfusion-free management of gastrointestinal bleeding: the experience of a Bloodless Institute.
等容量性貧血の許容
Liberal or restrictive transfusion in high-risk patients after hip surgery.
Patient blood management: a patient-orientated approach to blood replacement with the goal of reducing anemia, blood loss and the need for blood transfusion in elective surgery.
Restrictive blood transfusion practices are associated with improved patient outcomes.
A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care.
Restrictive versus liberal transfusion strategy for red blood cell transfusion: systematic review of randomised trials with meta-analysis and trial sequential analysis.
Transfusion strategies for patients in pediatric intensive care units.
Anemia and perioperative red blood cell transfusion: a matter of tolerance.
Is a restrictive transfusion strategy safe for resuscitated and critically ill trauma patients?
Effect of a liberal versus restrictive transfusion strategy on mortality in patients with moderate to severe head injury.
Pillar III—optimisation of anaemia tolerance.
Trends in red blood cell transfusion and 30-day mortality among hospitalized patients.
Impact of more restrictive blood transfusion strategies on clinical outcomes: a meta-analysis and systematic review.
Mortality and morbidity in non-transfusable and transfusable patients: a systematic review and meta-analysis.
大量出血の有害作用
The beneficial effects of minimizing blood loss in pancreatoduodenectomy.
輸血のリスクと不確実性
Blood transfusion and cancer surgery outcomes: a continued reason for concern.
Surgical outcomes and transfusion of minimal amounts of blood in the operating room.
Adverse blood transfusion outcomes: establishing causation.
Morbidity and mortality risk associated with red blood cell and blood-component transfusion in isolated coronary artery bypass grafting.
Efficacy of red blood cell transfusion in the critically ill: a systematic review of the literature.
Survival rate changes with transfusion of blood products during liver transplantation.
Emerging infectious disease agents and their potential threat to transfusion safety.
Current perspectives in transfusion-transmitted infectious diseases: emerging and re-emerging infections.
臨床成績
Peri-operative blood transfusion increases length of hospital stay and number of postoperative complications in non-cardiac surgical patients.
Association between the use of blood components and the five-year mortality after liver transplant. [Associação entre Uso de Hemocomponentes e Mortalidade em Cinco Anos após Transplante Hepático.] [English, Portuguese]
How good patient blood management leads to excellent outcomes in Jehovah's Witness patients undergoing cardiac surgery.
Methods of bloodless care, clinical outcomes, and costs for adult patients who decline allogeneic transfusions.
Risk-adjusted clinical outcomes in patients enrolled in a bloodless program.
The important role for intravenous iron in perioperative patient blood management in major abdominal surgery: a randomized controlled trial.
Association between intraoperative blood transfusion and mortality and morbidity in patients undergoing noncardiac surgery.
Restrictive blood transfusion practices are associated with improved patient outcomes.
Intraoperative cardiac arrests in adults undergoing noncardiac surgery: incidence, risk factors, and survival outcome.
"Bloodless" neurosurgery among Jehovah's Witnesses: a comparison with matched concurrent controls.
Review article: Risks of anemia and related management strategies: can perioperative blood management improve patient safety?
Cardiac surgery in Jehovah's Witness patients: ten-year experience.
Total hip arthroplasty was found to be safe in Jehovah's Witness patients: a multi-centered matched study.
The impact of blood conservation on outcomes in cardiac surgery: is it safe and effective?
Outcome of patients who refuse transfusion after cardiac surgery: a natural experiment with severe blood conservation.
Randomized, double-blinded, placebo-controlled trial of fibrinogen concentrate supplementation after complex cardiac surgery.
Health care-associated infection after red blood cell transfusion: a systematic review and meta-analysis.
Trends in red blood cell transfusion and 30-day mortality among hospitalized patients.
Impact of more restrictive blood transfusion strategies on clinical outcomes: a meta-analysis and systematic review.
Clinical efficacy of implementing a patient blood management (PBM) protocol in joint replacement surgery: a retrospective cohort study in a national referral center.
Mortality and morbidity in non-transfusable and transfusable patients: a systematic review and meta-analysis.
Blood-management programs: a clinical and administrative model with program implementation strategies.
Implementation of a comprehensive patient blood management program for hospitalized patients at a large united states medical center.
From product to patient-transfusion and patient blood management.
Safety and efficacy of methods for reducing perioperative allogeneic transfusion: a critical review of the literature.
経済効果
Cost-effectiveness of cell salvage and alternative methods of minimising perioperative allogeneic blood transfusion: a systematic review and economic model.
Estimating the epidemiological and economic impact of implementing preoperative anaemia measures in the German healthcare system: the health economic footprint of patient blood management.
Greater than sevenfold return on investment for a comprehensive patient blood management program with equivalent or improved outcomes.
Risk-adjusted clinical outcomes in patients enrolled in a bloodless program.
Economic considerations on transfusion medicine and patient blood management.
Tranexamic acid reduces blood loss and financial cost in primary total hip and knee replacement surgery.
Blood product conservation is associated with improved outcomes and reduced costs after cardiac surgery.
From blood transfusion to patient blood management: a new paradigm for patient care and cost assessment of blood transfusion practice.
Safety, cost savings, simplicity back broader use of bloodless surgery.
Associations between preoperative anaemia and hospital costs following major abdominal surgery: cohort study.
Effects of intravenous iron combined with low-dose recombinant human erythropoietin on transfusion requirements in iron-deficient patients undergoing bilateral total knee replacement arthroplasty.
ONTraC: a 20-year history of a successfully coordinated provincewide patient blood management program: Lessons learned and goals achieved.
A prospective study investigating the cost effectiveness of intraoperative blood salvage during liver transplantation.
Effective reduction of blood product use in a community teaching hospital: when less is more.
Prospective monitoring of plasma and platelet transfusions in a large teaching hospital results in significant cost reduction.
Activity-based costs of blood transfusions in surgical patients at four hospitals.
Intra-operative cell salvage in South Africa: feasible, beneficial and economical.
Randomized trial comparing packed red cell blood transfusion with and without leukocyte depletion for gastrointestinal surgery.
Implementation of a comprehensive patient blood management program for hospitalized patients at a large united states medical center.
The volume of returned red blood cells in a large blood salvage program: where does it all go?
An economic analysis of costs associated with development of a cell salvage program.
集学的,職種横断的な,個別化されたアプローチ
Strategies to prevent blood loss and reduce transfusion in emergency general surgery, WSES-AAST consensus paper.
Care of the injured Jehovah's Witness patient: case report and review of the literature.
Trauma surgery.
Traumatically injured Jehovah's Witnesses: a sixteen-year experience of treatment and transfusion dilemmas at a level I trauma center.
Emergency subtotal colectomy in a Jehovah's Witness with massive lower gastrointestinal bleeding: challenges encountered and lessons learned.
Clinical strategies in the medical care of Jehovah's Witnesses.
Reducing blood loss in a burn care unit: a review of its key determinants.
Jehovah's Witnesses: unique problems in a unique trauma population.
病院前
Guidelines for prehospital fluid resuscitation in the injured patient.
Pre-hospital haemostatic dressings: a systematic review.
Prehospital intravenous fluid administration is associated with higher mortality in trauma patients: a National Trauma Data Bank analysis.
Does increased prehospital replacement volume lead to a poor clinical course and an increased mortality? A matched-pair analysis of 1896 patients of the Trauma Registry of the German Society for Trauma Surgery who were managed by an emergency doctor at the accident site.
Tourniquet use in the civilian prehospital setting.
Early prehospital tranexamic acid following injury is associated with a 30-day survival benefit: A secondary analysis of a randomized clinical trial.
Prehospital tranexamic acid is associated with a survival benefit without an increase in complications: results of two harmonized randomized clinical trials.
Scoop and run to the trauma center or stay and play at the local hospital: hospital transfer's effect on mortality.
Prehospital tranexamic acid for severe trauma.
Is advanced life support better than basic life support in prehospital care? A systematic review.
Prehospital interventions for penetrating trauma victims: a prospective comparison between Advanced Life Support and Basic Life Support.
Effect of low-dose supplementation of arginine vasopressin on need for blood product transfusions in patients with trauma and hemorrhagic shock: a randomized clinical trial.
A balanced approach to tourniquet use: lessons learned and relearned.
積極的な出血コントロール
ショックの治療管理
病院への迅速な搬送
抗凝固療法の管理と中和
Strategies to prevent blood loss and reduce transfusion in emergency general surgery, WSES-AAST consensus paper.
Four-factor prothrombin complex concentrate versus plasma for rapid vitamin K antagonist reversal in patients needing urgent surgical or invasive interventions: a phase 3b, open-label, non-inferiority, randomised trial.
Guidance on the emergent reversal of oral thrombin and factor Xa inhibitors.
Bleeding risk and reversal strategies for old and new anticoagulants and antiplatelet agents.
Emergency reversal of warfarin anticoagulation.
Management of anticoagulation agents in trauma patients.
Idarucizumab for dabigatran reversal - full cohort analysis.
Reversal of clopidogrel-induced bleeding with rFVIIa in healthy subjects: a randomized, placebo-controlled, double-blind, exploratory study.
Rapid warfarin reversal in the setting of intracranial hemorrhage: a comparison of plasma, recombinant activated factor VII, and prothrombin complex concentrate.
迅速な動脈塞栓術または機械的血管閉塞
Selective angiographic embolization of blunt splenic traumatic injuries in adults decreases failure rate of nonoperative management.
Traumatic injuries: radiological hemostatic intervention at admission.
Management options for gastric variceal hemorrhage.
医原性貧血を避けるための採血量の制限
Phlebotomy in the intensive care unit: strategies for blood conservation.
The increasing burden of phlebotomy in the development of anaemia and need for blood transfusion amongst trauma patients.
止血の管理と最適化
Efficacy of recombinant activated Factor VII in patients with massive uncontrolled bleeding: a retrospective observational analysis.
The treatment of bleeding is to stop the bleeding! Treatment of trauma-related hemorrhage.
Successful rotational thromboelastometry-guided treatment of traumatic haemorrhage, hyperfibrinolysis and coagulopathy.
Strategies to prevent blood loss and reduce transfusion in emergency general surgery, WSES-AAST consensus paper.
Effects of tranexamic acid on death, disability, vascular occlusive events and other morbidities in patients with acute traumatic brain injury (CRASH-3): a randomised, placebo-controlled trial.
Alternatives to allogeneic platelet transfusion.
Desmopressin is a transfusion sparing option to reverse platelet dysfunction in patients with severe traumatic brain injury.
Effect of treatment delay on the effectiveness and safety of antifibrinolytics in acute severe haemorrhage: a meta-analysis of individual patient-level data from 40 138 bleeding patients.
The exclusive use of coagulation factor concentrates enables reversal of coagulopathy and decreases transfusion rates in patients with major blunt trauma.
Antifibrinolytic drugs for acute traumatic injury.
Association of cryoprecipitate and tranexamic acid with improved survival following wartime injury: findings from the MATTERs II Study.
The importance of early treatment with tranexamic acid in bleeding trauma patients: an exploratory analysis of the CRASH-2 randomised controlled trial.
Use of rotation thromboelastometry (ROTEM) to achieve successful treatment of polytrauma with fibrinogen concentrate and prothrombin complex concentrate.
Topical tranexamic acid compared with anterior nasal packing for treatment of epistaxis in patients taking antiplatelet drugs: randomized controlled trial.
抗線溶薬
遺伝子組換え活性型血液凝固第Ⅶ因子製剤(rFVIIa)
濃縮凝固因子製剤
デスモプレシン
外科的出血か凝固異常による出血かを同定するための血液粘弾性試験
体温管理(低体温の回避)
Strategies to prevent blood loss and reduce transfusion in emergency general surgery, WSES-AAST consensus paper.
The effects of mild perioperative hypothermia on blood loss and transfusion requirement.
The effects of intraoperative hypothermia on surgical site infection: an analysis of 524 trauma laparotomies.
Randomized clinical trial of perioperative systemic warming in major elective abdominal surgery.
酸素供給の最適化
The influence of volume management on outcome.
Optimization of tissue oxygenation in critically ill Jehovah's Witness patients.
Severe blood loss anemia in a Jehovah's Witness treated with adjunctive hyperbaric oxygen therapy.
低血圧蘇生
Damage control resuscitation is associated with a reduction in resuscitation volumes and improvement in survival in 390 damage control laparotomy patients.
Hypotensive resuscitation during active hemorrhage: impact on in-hospital mortality.
Resuscitation with hydroxyethyl starch improves renal function and lactate clearance in penetrating trauma in a randomized controlled study: the FIRST trial (Fluids in Resuscitation of Severe Trauma).
Hypotensive resuscitation strategy reduces transfusion requirements and severe postoperative coagulopathy in trauma patients with hemorrhagic shock: preliminary results of a randomized controlled trial.
Zeugen Jehovas und Schwerverletzung mit drohender Hämorrhagie. Wie komplex ist die Behandlung? [Jehovah's Witnesses and severe injury with impending hemorrhaging: how complex is the treatment?] [German, English abstract]
ダメージコントロール
Strategies to prevent blood loss and reduce transfusion in emergency general surgery, WSES-AAST consensus paper.
Preperitonal pelvic packing for hemodynamically unstable pelvic fractures: a paradigm shift.
Damage control orthopaedics: lessons learned.
Safety and efficacy of the electrothermal bipolar vessel sealer in trauma.
Damage control surgery of the critical Jehovah's Witness patient - a narrative review.
Damage control surgery.
Pelvic packing or angiography: competitive or complementary?
Safety and efficacy of damage control external fixation versus early definitive stabilization for femoral shaft fractures in the multiple-injured patient.
血液回収法
Intraoperative blood salvage in penetrating abdominal trauma: a randomised, controlled trial.
Autologous blood transfusion during emergency trauma operations.
Strategies to prevent blood loss and reduce transfusion in emergency general surgery, WSES-AAST consensus paper.
Does autotransfusion from a contaminated trauma laparotomy field increase the risk of complications?
貧血の早期管理
Recombinant human erythropoietin therapy in critically ill Jehovah's Witnesses.
Recombinant human erythropoietin in severe anaemia: issues of dosing and duration.
Thalidomide for recurrent bleeding due to small-intestinal angiodysplasia.
Bloodless management of the anemic patient in the emergency department.
Improved survival of critically ill trauma patients treated with recombinant human erythropoietin.
Erythropoiesis in multiply injured patients.
Erythropoiesis-stimulating agent administration and survival after severe traumatic brain injury: a prospective study.
Zeugen Jehovas und Schwerverletzung mit drohender Hämorrhagie. Wie komplex ist die Behandlung? [Jehovah's Witnesses and severe injury with impending hemorrhaging: how complex is the treatment?] [German, English abstract]
等容量性貧血の許容
A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care.
Anemia and perioperative red blood cell transfusion: a matter of tolerance.
Is a restrictive transfusion strategy safe for resuscitated and critically ill trauma patients?
Effect of a liberal versus restrictive transfusion strategy on mortality in patients with moderate to severe head injury.
Restrictive versus liberal blood transfusion for gastrointestinal bleeding: a systematic review and meta-analysis of randomised controlled trials.
Transfusion strategies for acute upper gastrointestinal bleeding.
臨床成績
Association of blood transfusion with increased mortality in myocardial infarction: a meta-analysis and diversity-adjusted study sequential analysis.
Allogenic blood transfusion in the first 24 hours after trauma is associated with increased systemic inflammatory response syndrome (SIRS) and death.
Allogeneic blood transfusion increases the risk of postoperative bacterial infection: a meta-analysis.
Improved outcomes and reduced costs associated with a health-system-wide patient blood management program: a retrospective observational study in four major adult tertiary-care hospitals.
Anemia and perioperative red blood cell transfusion: a matter of tolerance.
Red blood cell transfusions worsen the outcomes even in critically ill patients undergoing a restrictive transfusion strategy.
The risk of death for Jehovah's Witnesses after major trauma.
Anemia and blood transfusion in critically ill patients.
経済効果
Impact of a patient blood management monitoring and feedback programme on allogeneic blood transfusions and related costs.
術前の患者の評価と輸血リスクの評価
Estimating the transfusion risk following total knee arthroplasty.
Ginkgo biloba: persistent bleeding after total hip arthroplasty caused by herbal self-medication.
Factors affecting transfusion requirement after hip fracture: can we reduce the need for blood?
Multicentre cohort study of red blood cell use for revision hip arthroplasty and factors associated with greater risk of allogeneic blood transfusion.
術前の計画と患者の状態の最適化
Should all patients be optimized to the same preoperative hemoglobin level to avoid transfusion in primary knee arthroplasty?
Practical recommendations for patient blood management and the reduction of perioperative transfusion in joint replacement surgery.
Preparing a Jehovah's Witness for major elective surgery.
Detection, evaluation, and management of preoperative anaemia in the elective orthopaedic surgical patient: NATA guidelines.
Causal analysis of World Health Organization's surgical safety checklist implementation quality and impact on care processes and patient outcomes: secondary analysis from a large stepped wedge cluster randomized controlled trial in Norway.
Blood management strategies for total knee arthroplasty.
Revision total hip arthroplasty in Jehovah's Witnesses at a public hospital: practical recommendations for a low-resource setting.
Primary and revision total hip replacement in patients who are Jehovah's Witnesses.
Preoperative correction of anemia to allow a 3000 ml blood loss without transfusion in a Jehovah's Witness presenting for explantation of an infected hip joint prosthesis: a case report.
Preparation of the patient for surgery.
集学的,職種横断的な,個別化されたアプローチ
Tranexamic acid reduces blood transfusion in total knee arthroplasty even when a blood conservation program is applied.
Should all patients be optimized to the same preoperative hemoglobin level to avoid transfusion in primary knee arthroplasty?
The effect of a preoperative erythropoietin protocol as part of a multifaceted blood management program in daily clinical practice (CME).
Blood conservation techniques in spinal deformity surgery: a retrospective review of patients refusing blood transfusion.
Effect of a patient blood management programme on preoperative anaemia, transfusion rate, and outcome after primary hip or knee arthroplasty: a quality improvement cycle.
Effect of tranexamic acid on reducing postoperative blood loss in combined hypotensive epidural anesthesia and general anesthesia for total hip replacement.
Blood transfusion after primary total knee arthroplasty can be significantly minimised through a multimodal blood-loss prevention approach.
Allogeneic blood transfusion reduction by risk-based protocol in total joint arthroplasty.
Clinical efficacy of implementing a patient blood management (PBM) protocol in joint replacement surgery: a retrospective cohort study in a national referral center.
Spinal deformity surgery in patients for whom blood transfusion is not an option: a single-center experience.
Hypotensive anesthesia combined with tranexamic acid reduces perioperative blood loss in simultaneous bilateral total hip arthroplasty: a retrospective cohort study.
術前貧血管理と赤血球数の最適化
Effect of erythropoietin on perioperative blood transfusions in primary total hip arthroplasty: a systematic review.
The use of preoperative erythropoiesis-stimulating agents (ESAs) in patients who underwent knee or hip arthroplasty: a meta-analysis of randomized clinical trials.
Impact of preoperative erythropoietin on allogeneic blood transfusions in surgical patients: results from a systematic review and meta-analysis.
A propensity-matched cohort study of intravenous iron versus red cell transfusions for preoperative iron-deficiency anemia.
The effect of a preoperative erythropoietin protocol as part of a multifaceted blood management program in daily clinical practice (CME).
Detection, evaluation, and management of preoperative anaemia in the elective orthopaedic surgical patient: NATA guidelines.
Treatment through a preoperative anemia clinic is associated with a reduction in perioperative red blood cell transfusion in patients undergoing orthopedic and gynecologic surgery.
The efficacy of pre-operative preparation with intravenous iron and/or erythropoietin in anaemic patients undergoing orthopaedic surgery: an observational study.
Efficacy and safety of erythropoietin and intravenous iron in perioperative blood management: a systematic review.
Very-short-term perioperative intravenous iron administration and postoperative outcome in major orthopedic surgery: a pooled analysis of observational data from 2547 patients.
Effects of intravenous iron combined with low-dose recombinant human erythropoietin on transfusion requirements in iron-deficient patients undergoing bilateral total knee replacement arthroplasty.
Penny-wise and pound-foolish: the challenges of preoperative anaemia management.
Clinical efficacy of implementing a patient blood management (PBM) protocol in joint replacement surgery: a retrospective cohort study in a national referral center.
血管造影による塞栓術または血管閉塞
Bloodless surgery by a regional intraarterial tourniquet during primary and revision THA.
Preoperative embolization significantly decreases intraoperative blood loss during palliative surgery for spinal metastasis.
Intravascular balloon to minimize blood loss during total hip replacement in a Jehovah's Witness.
Embolization of hypervascular bone metastases reduces intraoperative blood loss: a case-control study.
Use of aortic balloon occlusion to decrease blood loss during sacral tumor resection.
The role of preoperative transarterial embolization in spinal tumors. A large single-center experience.
外科的血液温存法
Intraoperative nonpharmacotherapeutic blood management strategies in total knee arthroplasty.
Postoperative blood loss prevention in total knee arthroplasty.
Bloodless surgery by a regional intraarterial tourniquet during primary and revision THA.
Efficacy and cost effectiveness of harmonic scalpel compared with electrocautery in posterior instrumentation of the spine.
Radiofrequency bipolar hemostatic sealer reduces blood loss, transfusion requirements, and cost for patients undergoing multilevel spinal fusion surgery: a case control study.
Blood management strategies in primary and revision total knee arthroplasty for Jehovah's Witness patients.
Revision total hip arthroplasty in Jehovah's Witnesses at a public hospital: practical recommendations for a low-resource setting.
Virtually bloodless posterior midline exposure of the lumbar spine using the "para-midline" fatty plane.
The effect of patient positioning on intraabdominal pressure and blood loss in spinal surgery.
低侵襲治療法
Single-incision anterior approach for total hip arthroplasty on an orthopaedic table.
Keyhole sliding hip screw fixation for stable intertrochanteric hip fractures: a novel technique.
Minimally invasive versus open posterior lumbar interbody fusion: a systematic review.
止血の管理と最適化
A comprehensive review of topical hemostatic agents: efficacy and recommendations for use.
Intraoperative pharmacotherapeutic blood management strategies in total knee arthroplasty.
Hemostatic techniques reduce hospital stay following multilevel posterior cervical spine surgery.
Tranexamic acid in patients undergoing noncardiac surgery.
Repeat-dose intravenous tranexamic acid further decreases blood loss in total knee arthroplasty.
The use of recombinant factor VIIa for severe intractable bleeding during spine surgery.
The efficacy of combined use of intraarticular and intravenous tranexamic acid on reducing blood loss and transfusion rate in total knee arthroplasty.
The efficacy of bone wax in reduction of perioperative blood loss in total hip arthroplasty via direct anterior approach: a prospective randomized clinical trial.
Use of a fibrin sealant within a blood-saving protocol in patients undergoing revision hip arthroplasty: effects on post-operative blood transfusion and healthcare-related cost analysis.
Efficacy and Safety of Antifibrinolytic Agents in Reducing Perioperative Blood Loss and Transfusion Requirements in Scoliosis Surgery: A Systematic Review and Meta-Analysis.
Oral is as effective as intravenous tranexamic acid at reducing blood loss in thoracolumbar spinal fusions: a prospective randomized trial.
抗線溶薬
遺伝子組換え活性型血液凝固第Ⅶ因子製剤(rFVIIa)
局所止血剤
体温管理(低体温の回避)
Thermal management and blood loss during hip arthroplasty.
Mild hypothermia increases blood loss and transfusion requirements during total hip arthroplasty.
Aggressive warming reduces blood loss during hip arthroplasty.
術中の自己血管理
Bloodless spinal surgery: a review of the normovolemic hemodilution technique.
Role of intraoperative red cell salvage and autologus transfusion in metastatic spine surgery: a pilot study and review of literature.
Reduction of blood loss with the use of a new combined intra-operative and post-operative autologous blood transfusion system compared with no drainage in primary total hip replacement.
Acute normovolemic hemodilution and nitroglycerin-induced hypotension: comparative effects on tissue oxygenation and allogeneic blood transfusion requirement in total hip arthroplasty.
Can there be a place for intraoperative salvaged blood in spine tumor surgery?
Use of intraoperative cell-salvage for autologous blood transfusions in metastatic spine tumour surgery: a systematic review.
The effect of acute normovolemic hemodilution and acute hypervolemic hemodilution on coagulation and allogeneic transfusion.
Blood management in total knee arthroplasty: a comparison of techniques.
Intraoperative cell salvage in revision hip arthroplasty.
Efficacy of intraoperative blood collection and reinfusion in revision total hip arthroplasty.
血液回収法
急性等容量性血液希釈
麻酔学的血液温存法
Greater peripheral blood flow but less bleeding with propofol versus sevoflurane during spine surgery: a possible physiologic model?
Controlled hypotension for spinal surgery.
The effect of neuraxial blocks on surgical blood loss and blood transfusion requirements: a meta-analysis.
Hypotensive epidural anesthesia in patients with aortic stenosis undergoing total hip replacement.
A comparison of neuraxial block versus general anesthesia for elective total hip replacement: a meta-analysis.
Comparison of outcomes of using spinal versus general anesthesia in total hip arthroplasty.
Comparison of hypotensive epidural anaesthesia and spinal anaesthesia on blood loss and coagulation during and after total hip arthroplasty.
Anaesthesia for hip fracture surgery in adults.
Deliberate hypotension in orthopedic surgery reduces blood loss and transfusion requirements: a meta-analysis of randomized controlled trials.
Comparative perioperative outcomes associated with neuraxial versus general anesthesia for simultaneous bilateral total knee arthroplasty.
Hypotensive anesthesia combined with tranexamic acid reduces perioperative blood loss in simultaneous bilateral total hip arthroplasty: a retrospective cohort study.
低血圧法
局所麻酔
術後血液回収
Reduction of blood loss with the use of a new combined intra-operative and post-operative autologous blood transfusion system compared with no drainage in primary total hip replacement.
医原性貧血を避けるための採血量の制限
Savoring every drop—vampire or mosquito?
Surgical vampires and rising health care expenditure: reducing the cost of daily phlebotomy.
等容量性貧血の許容
A restrictive hemoglobin transfusion threshold of less than 7 g/dL decreases blood utilization without compromising outcomes in patients with hip fractures.
Liberal or restrictive transfusion in high-risk patients after hip surgery.
Anemia versus transfusion: does blood conservation increase the risk of complications?
臨床成績
Allogeneic blood transfusions and postoperative infections after total hip or knee arthroplasty.
Restrictive blood transfusion practices are associated with improved patient outcomes.
Is total hip arthroplasty a successful and safe procedure in Jehovah's Witnesses? Mean five-year results.
Effect of a patient blood management programme on preoperative anaemia, transfusion rate, and outcome after primary hip or knee arthroplasty: a quality improvement cycle.
Improved outcomes and reduced costs associated with a health-system-wide patient blood management program: a retrospective observational study in four major adult tertiary-care hospitals.
Total hip arthroplasty was found to be safe in Jehovah's Witness patients: a multi-centered matched study.
Clinical efficacy of implementing a patient blood management (PBM) protocol in joint replacement surgery: a retrospective cohort study in a national referral center.
経済効果
Experience of a network of transfusion coordinators for blood conservation (Ontario Transfusion Coordinators [ONTraC]).
Tranexamic acid reduces blood loss and financial cost in primary total hip and knee replacement surgery.
Safety, cost savings, simplicity back broader use of bloodless surgery.
Effects of intravenous iron combined with low-dose recombinant human erythropoietin on transfusion requirements in iron-deficient patients undergoing bilateral total knee replacement arthroplasty.
Use of a fibrin sealant within a blood-saving protocol in patients undergoing revision hip arthroplasty: effects on post-operative blood transfusion and healthcare-related cost analysis.
Cost benefit analysis of topical tranexamic acid in primary total hip and knee arthroplasty.
術前の患者の評価と輸血リスクの評価
An update on drug interactions with the herbal medicine Ginkgo biloba.
Guidelines on the assessment of bleeding risk prior to surgery or invasive procedures. British Committee for Standards in Haematology.
Preoperative assessment of coagulation disorders.
Preparing a Jehovah's Witness for major elective surgery.
Prediction of transfusion requirements in surgical patients: a review.
In the clinic. Preoperative evaluation.
Preoperative anaemia and postoperative outcomes in non-cardiac surgery: a retrospective cohort study.
術前の計画と患者の状態の最適化
Optimizing postoperative outcomes with efficient preoperative assessment and management.
Safety and feasibility of urological procedures in Jehovah's Witness patients.
Preparation of the patient for surgery.
集学的,職種横断的な,個別化されたアプローチ
Preparing a Jehovah's Witness for major elective surgery.
Bloodless surgery in urologic oncology: a review of hematologic, anesthetic, and surgical considerations.
Estrategias para la prostatectomía retropúbica radical sin transfusión en testigos de Jehová. [Strategies for transfusion-free radical retropubic prostatectomy in Jehovah's Witnesses.] [Spanish, English abstract]
Bloodless medicine: clinical care without allogeneic blood transfusion.
Multidisciplinary management of a Jehovah's Witness patient for the removal of a renal cell carcinoma extending into the right atrium.
Patient blood management in Europe.
Laparoscopic nephron-sparing surgery in a Jehovah's Witness patient.
術前貧血管理と赤血球数の最適化
The role of intravenous iron in anemia management and transfusion avoidance.
A propensity-matched cohort study of intravenous iron versus red cell transfusions for preoperative iron-deficiency anemia.
The short-term use of erythropoetin-stimulating agents: impact on the biochemical recurrence of prostate cancer.
The preoperative use of erythropoietin stimulating proteins prior to radical prostatectomy is not associated with increased cardiovascular or thromboembolic morbidity or mortality.
Comparison of two different doses of preoperative recombinant erythropoietin in men undergoing radical retropubic prostatectomy.
Penny-wise and pound-foolish: the challenges of preoperative anaemia management.
外科的血液温存法
Reducing blood loss in open radical retropubic prostatectomy with prophylactic periprostatic sutures.
Bloodless surgery in urologic oncology: a review of hematologic, anesthetic, and surgical considerations.
Delayed intraoperative hydration limits blood loss during radical retropubic prostatectomy.
Holmium laser enucleation versus photoselective vaporization for prostatic adenoma greater than 60 ml: preliminary results of a prospective, randomized clinical trial.
Bipolar transurethral resection of the prostate causes less bleeding than the monopolar technique: a single-centre randomized trial of 202 patients.
Modification of retropubic adenomectomy: improved hemostasis and outcome.
Comparison of transfusion requirements between open and robotic-assisted laparoscopic radical prostatectomy.
Systematic review and meta-analysis of perioperative outcomes and complications after robot-assisted radical prostatectomy.
Induced hypotension with epidural/general anesthesia reduces transfusion in radical prostate surgery.
Laparoscopic and robotic partial nephrectomy with controlled hypotensive anesthesia to avoid hilar clamping: feasibility, safety and perioperative functional outcomes.
Robot-assisted extraperitoneal laparoscopic radical prostatectomy: experience in a high-volume laparoscopy reference centre.
Limited hydration may reduce intraoperative blood loss in retropubic radical prostatectomy.
A simple and reliable hemostatic technique during partial nephrectomy.
Simplified hemostatic technique during laparoscopic partial nephrectomy.
Laparoscopic nephron-sparing surgery in a Jehovah's Witness patient.
止血の管理と最適化
Intraoperative use of tranexamic acid to reduce transfusion rate in patients undergoing radical retropubic prostatectomy: double blind, randomised, placebo controlled trial.
Tranexamic acid in patients undergoing noncardiac surgery.
Anti-fibrinolytic use for minimising perioperative allogeneic blood transfusion.
Effect of tranexamic acid on surgical bleeding: systematic review and cumulative meta-analysis.
Tranexamic acid reduces blood loss during percutaneous nephrolithotomy: a prospective randomized controlled study.
Recombinant activated factor VIIa for the treatment of bleeding in major abdominal surgery including vascular and urological surgery: a review and meta-analysis of published data.
抗線溶薬
遺伝子組換え活性型血液凝固第Ⅶ因子製剤(rFVIIa)
体温管理(低体温の回避)
Effectiveness of strategies for the management and/or prevention of hypothermia within the adult perioperative environment.
The effects of mild perioperative hypothermia on blood loss and transfusion requirement.
A systematic review of intraoperative warming to prevent postoperative complications.
術中の自己血管理
Towards bloodless cystectomy: a 10-year experience of intra-operative cell salvage during radical cystectomy.
Cell salvage as part of a blood conservation strategy in anaesthesia.
Cell salvage for minimising perioperative allogeneic blood transfusion.
The potential for reintroduction of tumor cells during intraoperative blood salvage: reduction of risk with use of the RC-400 leukocyte depletion filter.
Intra-operative cell salvage: a fresh look at the indications and contraindications.
Oncologic outcomes following radical prostatectomy with intraoperative cell salvage.
Blood conservation strategies to minimize allogeneic blood use in urologic surgery.
Acute normovolemic hemodilution.
Intraoperative cell salvage during radical cystectomy does not affect long-term survival.
Intraoperative cell salvage in radical prostatectomy does not appear to increase long-term biochemical recurrence, metastases, or mortality.
Acute normovolemic hemodilution.
Perioperative management including dual cell salvage in a Jehovah's Witness patient undergoing major urological surgery.
Acute normovolemic hemodilution for radical prostatectomy: can it replace preoperative autologous blood transfusion?
Should intraoperative cell-salvaged blood be used in patients with suspected or known malignancy?
Intraoperative red blood cell salvage and autologous transfusion during open radical retropubic prostatectomy: a cost-benefit analysis.
Blood salvage and cancer surgery: a meta-analysis of available studies.
Предоперацонная гиперволемическая гемодилюция 6% гидроксиэтил-крахмалом 130/0,4 (HES 130/0,4) как способ сокращения потребности в трансфузии донорской крови. [Preoperative hypervolemic hemodilution with 6% hydroxyethyl starch 130/0,4 (HES 130/ 0.4) solution as a way of reducing needs for donor blood transfusion.] [Russian, English abstract]
血液回収法
急性等容量性血液希釈
麻酔学的血液温存法
Induced hypotension with epidural/general anesthesia reduces transfusion in radical prostate surgery.
Laparoscopic and robotic partial nephrectomy with controlled hypotensive anesthesia to avoid hilar clamping: feasibility, safety and perioperative functional outcomes.
低血圧法
医原性貧血を避けるための採血量の制限
Phlebotomy—a minimalist approach.
Reduction of blood loss from laboratory testing in hospitalized adult patients using small-volume (pediatric) tubes.
等容量性貧血の許容
Liberal or restrictive transfusion in high-risk patients after hip surgery.
A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care.
Transfusion strategies for patients in pediatric intensive care units.
Red blood cell transfusion in non-bleeding critically ill patients with moderate anemia: is there a benefit?
Red blood cell transfusion is associated with increased rebleeding in patients with nonvariceal upper gastrointestinal bleeding.
臨床成績
Association between perioperative blood transfusions and clinical outcomes in patients undergoing bladder cancer surgery: a systematic review and meta-analysis study.
Blood transfusion is associated with increased perioperative morbidity and adverse oncologic outcomes in bladder cancer patients receiving neoadjuvant chemotherapy and radical cystectomy.
Safety and feasibility of urological procedures in Jehovah's Witness patients.
出産前の評価,病院内の準備,臨床経験
Committee opinion no. 590: Preparing for clinical emergencies in obstetrics and gynecology.
Preparedness for postpartum hemorrhage: an obstetric hemorrhage equipment tray.
Women who decline blood during labour: Review of findings and lessons learnt from 52 years of Confidential Enquiries into maternal mortality in the United Kingdom (1962-2019).
Prenatal identification of invasive placentation using ultrasound: systematic review and meta-analysis.
Clinical validation of risk stratification criteria for peripartum hemorrhage.
Jehovah's Witnesses and those who refuse blood transfusion.
Optimizing outcomes through protocols, multidisciplinary drills, and simulation.
Guidelines for the management of vasa previa.
Preventing deaths due to haemorrhage.
Incidence, indications, and predictors of adverse outcomes of postpartum hysterectomies: 20-year experience in a tertiary care centre.
Frequency of inherited bleeding disorders in women with menorrhagia.
Managing the ten most common life-threatening scenarios associated with postpartum hemorrhage.
Evaluation of risk-assessment tools for severe postpartum hemorrhage in women undergoing cesarean delivery.
Active management of the third stage of labour: prevention and treatment of postpartum hemorrhage.
Response times for emergency cesarean delivery: use of simulation drills to assess and improve obstetric team performance.
Blood-conservation strategies in a blood-refusal parturient with placenta previa and placenta percreta.
Optimization of competency in obstetrical emergencies: a role for simulation training.
Bloodless management of postpartum hemorrhage and Jehovah's Witnesses.
Prise en charge de l'hémorragie post-partum sans transfusions sanguines chez les Témoins de Jéhovah. [Bloodless management of postpartum hemorrhage and Jehovah's Witnesses.] [English, French]
Predelivery maternal fibrinogen as a predictor of blood loss after vaginal delivery.
Better planning could have saved life of woman who refused transfusion, MD says.
Didactic and simulation nontechnical skills team training to improve perinatal patient outcomes in a community hospital.
Successful reduction of massive postpartum haemorrhage by use of guidelines and staff education.
Emergency postpartum hysterectomy for uncontrolled postpartum bleeding: a systematic review.
Surgical intervention in the management of postpartum hemorrhage.
Comprehensive maternal hemorrhage protocols reduce the use of blood products and improve patient safety.
Improving hospital systems for the care of women with major obstetric hemorrhage.
The treatment of obstetric haemorrhage in women who refuse blood transfusion.
Antenatal diagnosis of placenta accreta leads to reduced blood loss.
Risk factors for uterine atony/postpartum hemorrhage requiring treatment after vaginal delivery.
集学的,職種横断的な,計画的で個別化されたアプローチ
Evaluation and management of postpartum hemorrhage: consensus from an international expert panel.
ACOG Practice Bulletin: Clinical Management Guidelines for Obstetrician-Gynecologists Number 76, October 2006: postpartum hemorrhage.
Uses and misuse of blood transfusion in obstetrics in Lagos, Nigeria.
Case records of the Massachusetts General Hospital. Case 23-2011. A 40-year-old pregnant woman with placenta accreta who declined blood products.
Surgical management of severe obstetric hemorrhage: experience with an obstetric hemorrhage equipment tray.
Management of massive bleeding in a Jehovah's Witness obstetric patient: the overwhelming importance of a pre-established multidisciplinary protocol.
Massive obstetric hemorrhage in a Jehovah's Witness: intraoperative strategies and high-dose erythropoietin use.
Minimizing blood loss at cesarean-hysterectomy for placenta previa percreta.
Obstetric outcomes in Jehovah's Witnesses: case series over nine years in a London teaching hospital.
Prophylactic use of intravascular balloon catheters in women with placenta accreta, increta and percreta.
Abnormally invasive placenta--AIP. Awareness and pro-active management is necessary.
Jehovah's Witnesses and those who refuse blood transfusion.
Maternal morbidity in cases of placenta accreta managed by a multidisciplinary care team compared with standard obstetric care.
Optimizing outcomes through protocols, multidisciplinary drills, and simulation.
Randomized trial of early detection and treatment of postpartum hemorrhage.
Refusal of blood transfusion by Jehovah's Witness women: a survey of current management in obstetric and gynaecological practice in the UK.
Pregnancy, labour and delivery in a Jehovah's Witness with esophageal varices and thrombocytopenia. [English, French abstract]
Successful resuscitation following massive obstetric hemorrhage in a patient of the Jehovah's Witness faith: a case report.
Clinical practice guidelines prevention and management of primary postpartum haemorrhage.
Caring for pregnant women for whom transfusion is not an option. A national review to assist in patient care.
Minimizing surgical blood loss at cesarean hysterectomy for placenta previa with evidence of placenta increta or placenta percreta: the state of play in 2020.
Common errors and remedies in managing postpartum haemorrhage.
The theory and practice of bloodless surgery.
Patient blood management in obstetrics: management of anaemia and haematinic deficiencies in pregnancy and in the post-partum period: NATA consensus statement.
Bloodless management of postpartum hemorrhage and Jehovah's Witnesses.
Prise en charge de l'hémorragie post-partum sans transfusions sanguines chez les Témoins de Jéhovah. [Bloodless management of postpartum hemorrhage and Jehovah's Witnesses.] [English, French]
Better planning could have saved life of woman who refused transfusion, MD says.
Postpartum hemorrhage.
Role of prophylactic uterine artery balloon catheters in the management of women with suspected placenta accreta.
Patient blood management (PBM) in pregnancy and childbirth: literature review and expert opinion.
The role of interventional radiology in reducing haemorrhage and hysterectomy following caesarean section for morbidly adherent placenta.
Multidisciplinary management of invasive placenta previa.
貧血の管理
How I treat anemia in pregnancy: iron, cobalamin, and folate.
Intravenous versus oral iron for treatment of anemia in pregnancy: a randomized trial.
The role of intravenous iron in anemia management and transfusion avoidance.
Placental transfusion strategies in very preterm neonates: a systematic review and meta-analysis.
Diagnosis and treatment of iron-deficiency anaemia during pregnancy and postpartum.
Treatment of iron deficiency anemia in pregnancy and postpartum.
Delayed cord clamping versus early cord clamping in elective cesarean section: a randomized controlled trial.
Effect of delayed cord clamping on very preterm infants.
Intravenous iron treatment in pregnancy: comparison of high-dose ferric carboxymaltose vs. iron sucrose.
Umbilical cord milking reduces need for red cell transfusions and improves neonatal adaptation in preterm infants: meta-analysis.
Antenatal erythropoietin and intra-operative cell salvage in a Jehovah's Witness with placenta praevia.
Iron deficiency anemia in women: a practical guide to detection, diagnosis, and treatment.
Treatment of iron deficiency and iron deficiency anemia with intravenous ferric carboxymaltose in pregnancy.
Early versus delayed cord clamping in term and preterm births: a review.
Anaemia in pregnancy.
Treatment of iron deficiency anemia in pregnancy with intravenous versus oral iron: systematic review and meta-analysis.
Anaemia, prenatal iron use, and risk of adverse pregnancy outcomes: systematic review and meta-analysis.
Late vs early clamping of the umbilical cord in full-term neonates: systematic review and meta-analysis of controlled trials.
Delayed umbilical cord clamping in premature neonates.
Triplet pregnancy in a Jehovah's Witness: recombinant human erythropoietin and iron supplementation for minimising the risks of excessive blood loss.
Placental transfusion: a review.
A prospective randomized, controlled trial of intravenous versus oral iron for moderate iron deficiency anaemia of pregnancy.
Three-year follow-up of a randomised clinical trial of intravenous versus oral iron for anaemia in pregnancy.
Iron deficiency anaemia in pregnancy and postpartum: pathophysiology and effect of oral versus intravenous iron therapy.
Intravenous iron sucrose versus oral iron in treatment of iron deficiency anemia in pregnancy: a randomized clinical trial.
Selective use of recombinant human erythropoietin in pregnant patients with severe anemia or nonresponsive to iron sucrose alone.
Evaluation of anemia.
Recombinant erythropoietin for the treatment of iron deficiency anemia in pregnancy: a systematic review.
Recombinant human erythropoietin in a triplet pregnancy: a case report.
Anemia in Pregnancy: ACOG Practice Bulletin, Number 233.
The effects of umbilical cord milking in extremely preterm infants: a randomized controlled trial.
Committee Opinion No. 684: Delayed umbilical cord clamping after birth.
Effect of timing of umbilical cord clamping of term infants on maternal and neonatal outcomes.
Patient blood management in obstetrics: management of anaemia and haematinic deficiencies in pregnancy and in the post-partum period: NATA consensus statement.
Comparison of the maternal and neonatal outcomes of pregnant women whose anemia was not corrected before delivery and pregnant women who were treated with intravenous iron in the third trimester.
UK guidelines on the management of iron deficiency in pregnancy.
Daily oral iron supplementation during pregnancy.
Intermittent oral iron supplementation during pregnancy.
Effect of timing of umbilical cord clamping and other strategies to influence placental transfusion at preterm birth on maternal and infant outcomes.
Milking compared with delayed cord clamping to increase placental transfusion in preterm neonates: a randomized controlled trial.
Timing of umbilical cord clamping after birth for optimizing placental transfusion.
Efficacy and safety of adjuvant recombinant human erythropoietin and ferrous sulfate as treatment for iron deficiency anemia during the third trimester of pregnancy.
Effectiveness of intravenous iron sucrose in management of iron-deficient anemia of pregnancy at rural hospital set up.
Contemporary uses of erythropoietin in pregnancy: a literature review.
Iron absorption from oral iron supplements given on consecutive versus alternate days and as single morning doses versus twice-daily split dosing in iron-depleted women: two open-label, randomised controlled trials.
Current concepts in preoperative anemia management in obstetrics.
妊娠初期
妊娠第3期
遅延臍帯クランプによる新生児の貧血予防
血小板減少症の治療管理
Successful treatment of severe thrombocytopenia with romiplostim in a pregnant patient with systemic lupus erythematosus.
Rescue therapy with romiplostim for refractory primary immune thrombocytopenia during pregnancy.
Eltrombopag to treat thrombocytopenia during last month of pregnancy in a woman with MYH9-related disease: a case report.
Use of thrombopoietin receptor agonists for immune thrombocytopenia in pregnancy: results from a multicenter study.
A case of refractory immune thrombocytopenia in pregnancy managed with elthrombopag.
Safety and efficacy of eltrombopag for treatment of chronic immune thrombocytopenia: results of the long-term, open-label EXTEND study.
早産の抑制または分娩遅延
Cerclage for short cervix on ultrasonography in women with singleton gestations and previous preterm birth: a meta-analysis.
Prophylactic administration of progesterone by vaginal suppository to reduce the incidence of spontaneous preterm birth in women at increased risk: a randomized placebo-controlled double-blind study.
Tocolytic therapy for preterm delivery: systematic review and network meta-analysis.
Progestogens for preterm birth prevention: a systematic review and meta-analysis.
早産のリスクがある妊婦の胎児肺成熟の促進
Antenatal betamethasone for women at risk for late preterm delivery.
Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth.
Antenatal corticosteroid therapy before 24 weeks of gestation: a systematic review and meta-analysis.
Repeat doses of prenatal corticosteroids for women at risk of preterm birth for improving neonatal health outcomes.
Different corticosteroids and regimens for accelerating fetal lung maturation for babies at risk of preterm birth.
予防的周術期血管閉塞術
Prophylactic use of intravascular balloon catheters in women with placenta accreta, increta and percreta.
Nonremoval of an abnormally invasive placenta at cesarean section with postoperative uterine artery embolization.
Conservative management of invasive placenta using combined prophylactic internal iliac artery balloon occlusion and immediate postoperative uterine artery embolization.
The management and outcomes of placenta accreta, increta, and percreta in the UK: a population-based descriptive study.
Prophylactic balloon occlusion of the common iliac arteries for the management of suspected placenta accreta/percreta: conclusions from a short case series.
Prophylactic use of resuscitative endovascular balloon occlusion of the aorta in women with abnormal placentation: a systematic review, meta-analysis, and case series.
Role of prophylactic uterine artery balloon catheters in the management of women with suspected placenta accreta.
術中の自己血管理
Cell salvage in obstetrics.
Cell salvage as part of a blood conservation strategy in anaesthesia.
The economic benefits of cell salvage in obstetric haemorrhage.
Intraoperative autologous blood transfusion.
Blood conservation techniques in obstetrics: a UK perspective.
Cell salvage in obstetrics: an evaluation of the ability of cell salvage combined with leucocyte depletion filtration to remove amniotic fluid from operative blood loss at caesarean section.
Very low rate of patient-related adverse events associated with the use of intraoperative cell salvage.
The use of cell salvage in women undergoing cesarean hysterectomy for abnormal placentation.
Normovolemic hemodilution before cesarean hysterectomy for placenta percreta.
The use of acute hemodilution in parturients undergoing cesarean section.
Use of cell salvage at the time of cesarean delivery: a meta-analysis of randomized controlled trials.
Cell salvage for obstetric patients who decline blood transfusion: a national survey.
Introduction of cell salvage to a large obstetric unit: the first six months.
The introduction of intra-operative cell salvage in obstetric clinical practice: a review of the available evidence.
Blood-conservation strategies in a blood-refusal parturient with placenta previa and placenta percreta.
Red blood cell salvage during obstetric hemorrhage.
The impact of intraoperative autologous blood transfusion during type III radical hysterectomy for early-stage cervical cancer.
Intraoperative red cell salvage during obstetric surgery in 50 Japanese women.
Acute normovolemic hemodilution, intraoperative cell salvage and PulseCO hemodynamic monitoring in a Jehovah's Witness with placenta percreta.
Blood salvage during caesarean section.
Intraoperative cell salvaged blood as part of a blood conservation strategy in Caesarean section: is fetal red cell contamination important?
The safety of intraoperative autologous blood collection and autotransfusion during cesarean section.
Contamination of salvaged maternal blood by amniotic fluid and fetal red cells during elective Caesarean section.
Obstetric intra-operative cell salvage: a review of an established cell salvage service with 1170 re-infused cases.
Blood cell salvage during cesarean delivery.
Is cell salvaged vaginal blood loss suitable for re-infusion?
Peripartum use of cell salvage: a university practice audit and literature review.
Amniotic fluid removal during cell salvage in the cesarean section patient.
血液回収法
急性等容量性血液希釈
分娩第3期における積極的管理
Active versus expectant management for women in the third stage of labour.
Controlled cord traction for the third stage of labour.
A comparison of active management and expectant management of the third stage of labour: a Swedish randomised controlled trial.
Active management of the third stage of labour: prevention and treatment of postpartum hemorrhage.
Prevention and Management of Postpartum Haemorrhage: Green-top Guideline No. 52.
The effects of a peripartum strategy to prevent and treat primary postpartum haemorrhage at health facilities in Niger: a longitudinal, 72-month study.
子宮収縮薬
Randomized controlled trial comparing carbetocin, misoprostol, and oxytocin for the prevention of postpartum hemorrhage following an elective cesarean delivery.
Uterotonic agents for preventing postpartum haemorrhage: a network meta-analysis.
Preventing postpartum hemorrhage after cesarean delivery: A network meta-analysis of available pharmacologic agents.
A randomised controlled trial comparing oxytocin and oxytocin + ergometrine for prevention of postpartum haemorrhage at caesarean section.
Prophylactic use of ergot alkaloids in the third stage of labour.
Treatment for primary postpartum haemorrhage.
Comparison of two oxytocin regimens to prevent uterine atony at cesarean delivery: a randomized controlled trial.
Prospective randomized trial of oxytocin administration for active management of the third stage of labor.
A randomized clinical trial of preoperative versus postoperative misoprostol in elective cesarean delivery.
Dose and duration of oxytocin to prevent postpartum hemorrhage: a review.
Prostaglandin E2 analogue sulprostone for treatment of atonic postpartum hemorrhage.
The effects of a peripartum strategy to prevent and treat primary postpartum haemorrhage at health facilities in Niger: a longitudinal, 72-month study.
Intravenous sulprostone infusion in the treatment of retained placenta.
Carbetocin for preventing postpartum haemorrhage.
Prostaglandins for preventing postpartum haemorrhage.
Prophylactic oxytocin for the third stage of labour to prevent postpartum haemorrhage.
分娩後異常出血の外科的制御
Stepwise uterine devascularization: a novel technique for management of uncontrolled postpartum hemorrhage with preservation of the uterus.
Surgical management of placenta accreta: a cohort series and suggested approach.
Minimizing blood loss at cesarean-hysterectomy for placenta previa percreta.
The combination of intrauterine balloon tamponade and the B-Lynch procedure for the treatment of severe postpartum hemorrhage.
Uterine compression sutures for the management of severe postpartum hemorrhage.
Minimizing surgical blood loss at cesarean hysterectomy for placenta previa with evidence of placenta increta or placenta percreta: the state of play in 2020.
Uterine compression sutures, an update: review of efficacy, safety and complications of B-Lynch suture and other uterine compression techniques for postpartum haemorrhage.
Important surgical measures and techniques at cesarean hysterectomy for placenta previa accreta.
Hayman uterine compression stitch for arresting atonic postpartum hemorrhage: 5 years experience.
The uterine sandwich for persistent uterine atony: combining the B-Lynch compression suture and an intrauterine Bakri balloon.
Uterine artery ligation in the control of postcesarean hemorrhage.
Initial interventions to combat hemorrhage during cesarean section and internal iliac artery ligation.
Postpartum hemorrhage.
Uterine tamponade using condom catheter balloon in the management of non-traumatic postpartum hemorrhage.
B-Lynch suture for massive persistent postpartum hemorrhage following stepwise uterine devascularization.
The surgical approach to postpartum haemorrhage.
Emergency surgery for PPH in women declining blood transfusion or when allogeneic blood is not available.
The treatment of obstetric haemorrhage in women who refuse blood transfusion.
Application of uterine compression suture in association with intrauterine balloon tamponade ('uterine sandwich') for postpartum hemorrhage.
一時的処置
Two-provider technique for bimanual uterine compression to control postpartum hemorrhage.
Initial experience with a dual-balloon catheter for the management of postpartum hemorrhage.
Systematic review of conservative management of postpartum hemorrhage: what to do when medical treatment fails.
Management of postpartum hemorrhage by uterine balloon tamponade: prospective evaluation of effectiveness.
Balloon tamponade in the management of postpartum haemorrhage: a review.
Using the uterine-specific Bakri balloon in the management of postpartum hemorrhage: case series and conceptual/practical guidelines.
Use of Bakri balloon tamponade in the treatment of postpartum hemorrhage: a series of 50 cases from a tertiary teaching hospital.
Uterine packing with chitosan-covered tamponade to treat postpartum hemorrhage.
Balloon tamponade for the management of postpartum uterine hemorrhage.
Aortic compression in massive postpartum haemorrhage—an old but lifesaving technique.
Conservative approach in heavy postpartum hemorrhage associated with coagulopathy.
Non-pneumatic anti-shock garment for improving maternal survival following severe postpartum haemorrhage: a systematic review.
The effects of a peripartum strategy to prevent and treat primary postpartum haemorrhage at health facilities in Niger: a longitudinal, 72-month study.
Uterine balloon tamponade for the treatment of postpartum hemorrhage: a systematic review and meta-analysis.
Positive effects of the non-pneumatic anti-shock garment on delays in accessing care for postpartum and postabortion hemorrhage in Egypt and Nigeria.
Successful use of BT-Cath(®) balloon tamponade in the management of postpartum haemorrhage due to placenta previa.
Success factors for Bakri™ balloon usage secondary to uterine atony: a retrospective, multicentre study.
Use of Bakri balloon in post-partum haemorrhage: a series of 15 cases.
Balloon tamponade for postpartum vaginal lacerations in a woman refusing blood transfusion.
止血の管理と最適化
Effectiveness of tranexamic acid on blood loss in patients undergoing elective cesarean section: randomized clinical trial.
Role of thromboelastography versus coagulation screen as a safety predictor in pre-eclampsia/eclampsia patients undergoing lower-segment caesarean section in regional anaesthesia.
The efficacy of fibrinogen concentrate compared with cryoprecipitate in major obstetric haemorrhage--an observational study.
Use of recombinant activated factor VII in primary postpartum hemorrhage: the Northern European registry 2000-2004.
Assessment of coagulation in the obstetric population using ROTEM® thromboelastometry.
The use of fibrinogen concentrate to correct hypofibrinogenaemia rapidly during obstetric haemorrhage.
Association between fibrinogen level and severity of postpartum haemorrhage: secondary analysis of a prospective trial.
Obstetric hemorrhage and coagulation: an update. Thromboelastography, thromboelastometry, and conventional coagulation tests in the diagnosis and prediction of postpartum hemorrhage.
Tisseel for management of traumatic postpartum haemorrhage.
The use of recombinant activated FVII in postpartum hemorrhage.
Effect of treatment delay on the effectiveness and safety of antifibrinolytics in acute severe haemorrhage: a meta-analysis of individual patient-level data from 40 138 bleeding patients.
Can intravenous injection of tranexamic acid be used in routine practice with active management of the third stage of labor in vaginal delivery? A randomized controlled study.
Efficacy of intravenous tranexamic acid in reducing blood loss after elective cesarean section: a prospective, randomized, double-blind, placebo-controlled study.
Uterine packing with chitosan-covered tamponade to treat postpartum hemorrhage.
Recombinant human factor VIIa prevents hysterectomy in severe postpartum hemorrhage: single center study.
Postpartum hemorrhage: when uterotonics and sutures fail.
Major obstetric haemorrhage: monitoring with thromboelastography, laboratory analyses or both?
Recombinant activated factor VII (rFVIIa/NovoSeven®) in the management of severe postpartum haemorrhage: initial report of a multicentre case series in Japan.
Recombinant human FVIIa for reducing the need for invasive second-line therapies in severe refractory postpartum hemorrhage: a multicenter, randomized, open controlled trial.
Fibrinogen as a therapeutic target for bleeding: a review of critical levels and replacement therapy.
Recombinant factor VIIa after amniotic fluid embolism and disseminated intravascular coagulopathy.
Coagulopathy and placental abruption: changing management with ROTEM-guided fibrinogen concentrate therapy.
Use of FloSeal haemostatic gel in massive obstetric haemorrhage: a case report.
Successful treatment of severe intra-abdominal bleeding associated with disseminated intravascular coagulation using recombinant activated factor VII.
Successful management by recombinant activated factor VII in a case of disseminated intravascular coagulopathy caused by obstetric hemorrhage.
Recombinant factor VIIa as last-resort treatment of desperate haemorrhage.
Factor VIIa in puerperal hemorrhage with disseminated intravascular coagulation.
Recombinant activated factor VII in obstetric hemorrhage: experiences from the Australian and New Zealand Haemostasis Registry.
Recombinant factor VIIa to successfully manage disseminated intravascular coagulation from amniotic fluid embolism.
Topical application of recombinant activated factor VII during cesarean delivery for placenta previa.
Effect of early tranexamic acid administration on mortality, hysterectomy, and other morbidities in women with post-partum haemorrhage (WOMAN): an international, randomised, double-blind, placebo-controlled trial.
Association between fibrinogen levels and severity of postpartum hemorrhage in singleton vaginal deliveries at a Japanese perinatal center.
Tranexamic acid for preventing postpartum blood loss after cesarean delivery: a systematic review and meta-analysis of randomized controlled trials.
Haemostatic monitoring during postpartum haemorrhage and implications for management.
Randomized controlled trial of tranexamic acid among parturients at increased risk for postpartum hemorrhage undergoing cesarean delivery.
Role of recombinant factor VIIa in the clinical management of severe postpartum hemorrhage: consensus among European experts.
A systematic review: the use of desmopressin for treatment and prophylaxis of bleeding disorders in pregnancy.
Fibrin sealant for management of complicated obstetric lacerations.
抗線溶薬
遺伝子組換え活性型血液凝固第Ⅶ因子製剤(rFVIIa)
濃縮凝固因子製剤
デスモプレシン
局所止血剤
外科的出血か凝固異常による出血かを同定するための血液粘弾性試験
分娩後異常出血に対する注意深い監視
Complications of the third stage of labour.
Peripartum hysterectomy.
Randomized trial of early detection and treatment of postpartum hemorrhage.
Sonographic evaluation for intra-abdominal hemorrhage after cesarean delivery.
Ultrasonographic visualization of bleeding sites can help control postpartum hemorrhage using intrauterine balloon tamponade.
National Partnership for Maternal Safety: consensus bundle on obstetric hemorrhage.
Patient blood management in obstetrics: prevention and treatment of postpartum haemorrhage. A NATA consensus statement.
持続的な出血に対する早期子宮摘出
Evaluation and management of postpartum hemorrhage: consensus from an international expert panel.
Abdominal packing for intractable obstetrical and gynecologic hemorrhage.
Peripartum hysterectomy.
Planned vs emergent cesarean hysterectomy.
Lessons learned from the outcome of bloodless emergency laparotomies on Jehovah's Witness women presenting in the extremis with ruptured uterus.
An effective pressure pack for severe pelvic hemorrhage.
Emergency peripartum hysterectomy.
Emergency peripartum hysterectomy in a tertiary obstetric center: 8-year evaluation.
Pelvic umbrella pack for refractory obstetric hemorrhage secondary to posterior uterine rupture.
Caring for pregnant women for whom transfusion is not an option. A national review to assist in patient care.
Peripartum hysterectomy in the UK: management and outcomes of the associated haemorrhage.
Blood-conservation strategies in a blood-refusal parturient with placenta previa and placenta percreta.
Bloodless management of postpartum hemorrhage and Jehovah's Witnesses.
Prise en charge de l'hémorragie post-partum sans transfusions sanguines chez les Témoins de Jéhovah. [Bloodless management of postpartum hemorrhage and Jehovah's Witnesses.] [English, French]
A 27-year review of obstetric hysterectomy.
Emergency postpartum hysterectomy for uncontrolled postpartum bleeding: a systematic review.
Peripartum hysterectomy for primary postpartum haemorrhage: incidence and maternal morbidity.
医原性貧血を避けるための採血量の制限
Savoring every drop—vampire or mosquito?
The practical utility of routine postpartum hemoglobin assessment.
産後貧血の管理
Efficacy of intravenous iron for treating postpartum anemia in low-resource African countries: a pilot study in Malawi.
Massive obstetric hemorrhage in a Jehovah's Witness: intraoperative strategies and high-dose erythropoietin use.
Intravenous versus oral iron therapy for postpartum anaemia.
Effectiveness of recombinant erythropoietin and iron sucrose vs. iron therapy only, in patients with postpartum anaemia and blunted erythropoiesis.
Anémies sévères du post-partum immédiat. Pratique clinique et intérêt du fer par voie intraveineuse. [Acute postpartum anaemia. Clinical practice and interest of intravenous iron.] [French, English abstract]
Treatment for women with postpartum iron deficiency anaemia.
Iron deficiency anemia in women: a practical guide to detection, diagnosis, and treatment.
Intravenous iron sucrose versus oral iron ferrous sulfate for antenatal and postpartum iron deficiency anemia: a randomized trial.
To the rescue: the role of intravenous iron in the management of severe anaemia in the peri-partum setting.
Effect of administering recombinant erythropoietin to women with postpartum anemia: a meta-analysis.
Iron sucrose with and without recombinant erythropoietin for the treatment of severe postpartum anemia: a prospective, randomized, open-label study.
Recombinant human erythropoietin treatment of postpartum anemia. Preliminary results.
Patient blood management in obstetrics: management of anaemia and haematinic deficiencies in pregnancy and in the post-partum period: NATA consensus statement.
Life-threatening postoperative blood loss in a Jehovah's Witness, treated with high-dose erythropoietin.
Ferric carboxymaltose injection in the treatment of postpartum iron deficiency anemia: a randomized controlled clinical trial.
Comparative study of efficacy and safety of ferric carboxymaltose versus iron sucrose in post-partum anaemia.
Oral vs intravenous iron therapy for postpartum anemia: a systematic review and meta-analysis.
Intravenous ferric carboxymaltose compared with oral iron in the treatment of postpartum anemia: a randomized controlled trial.
Efficacy and safety of intravenous ferric carboxymaltose compared with oral iron for the treatment of iron deficiency anaemia in women after childbirth in Tanzania: a parallel-group, open-label, randomised controlled phase 3 trial.
A 12-week randomised study comparing intravenous iron sucrose versus oral ferrous sulphate for treatment of postpartum anemia.
患者の貧血に対する許容力の最適化
Severe blood loss anemia in a Jehovah's Witness treated with adjunctive hyperbaric oxygen therapy.
Successful resuscitation following massive obstetric hemorrhage in a patient of the Jehovah's Witness faith: a case report.
Hyperbaric oxygen therapy in the management of severe acute anaemia in a Jehovah's Witness.
Pillar III—optimisation of anaemia tolerance.
Cardiac output and fluid replacement in a Jehovah's Witness with severe postpartum hemorrhage.
Optimization of oxygen delivery in a Jehovah's Witness with severe anaemia after postpartum haemorrhage.
Use of hyperbaric oxygen therapy and PEGylated carboxyhemoglobin bovine in a Jehovah's Witness with life-threatening anemia following postpartum hemorrhage.
等容量性貧血の許容
Transfusion practices in postpartum hemorrhage: a population-based study.
A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care.
Restrictive transfusion strategy does not affect clinical prognosis in patients with ectopic pregnancy.
Avoiding unnecessary blood transfusions in women with profound anaemia.
Anemia and perioperative red blood cell transfusion: a matter of tolerance.
What factors contribute to hospital variation in obstetric transfusion rates?
Cardiac output and fluid replacement in a Jehovah's Witness with severe postpartum hemorrhage.
Transfusion policy after severe postpartum haemorrhage: a randomised non-inferiority trial.
周産期母子の合併症予防のための補助療法
Committee Opinion No. 712: Intrapartum management of intraamniotic infection.
VTE, thrombophilia, antithrombotic therapy, and pregnancy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines.
Limited course of antibiotic treatment for chorioamnionitis.
Intrapartum antibiotics and risk factors for early onset sepsis.
Daily compared with 8-hour gentamicin for the treatment of intrapartum chorioamnionitis: a randomized controlled trial.
Management of neonates with suspected or proven early-onset bacterial sepsis.
Thromboprophylaxis after cesarean delivery: a decision analysis.
No. 233--Antibiotic therapy in preterm premature rupture of the membranes.
医療資源の限られる状況
Emergency peripartum hysterectomy in a tertiary hospital in southern Nigeria.
The use of the condom-catheter for the treatment of postpartum haemorrhage - the Sokoto experience.
Efficacy of intravenous iron for treating postpartum anemia in low-resource African countries: a pilot study in Malawi.
Emergency peripartum hysterectomy in a low resource setting: a 5-year analysis.
Treatment of post-partum haemorrhage with sublingual misoprostol versus oxytocin in women receiving prophylactic oxytocin: a double-blind, randomised, non-inferiority trial.
Temporary treatment of severe postpartum hemorrhage.
Rectally administered misoprostol versus intravenous oxytocin infusion during cesarean delivery to reduce intraoperative and postoperative blood loss.
A randomized trial of sublingual misoprostol to augment routine third-stage management among women at risk of postpartum hemorrhage.
Sublingual misoprostol as an adjunct to oxytocin during cesarean delivery in women at risk of postpartum hemorrhage.
Lessons learned from the outcome of bloodless emergency laparotomies on Jehovah's Witness women presenting in the extremis with ruptured uterus.
Oxytocin via Uniject (a prefilled single-use injection) versus oral misoprostol for prevention of postpartum haemorrhage at the community level: a cluster-randomised controlled trial.
Per-protocol effect of earlier non-pneumatic anti-shock garment application for obstetric hemorrhage.
Experience in the use of non-pneumatic anti-shock garment (NASG) in the management of postpartum haemorrhage with hypovolemic shock in the Fundación Valle Del Lili, Cali, Colombia.
Iron supplementation in iron-replete and nonanemic pregnant women in Tanzania: a randomized clinical trial.
Multiple-micronutrient supplementation for women during pregnancy.
Misoprostol to prevent and treat postpartum haemorrhage: a systematic review and meta-analysis of maternal deaths and dose-related effects.
A simple alternative to parenteral oxytocics for the third stage of labor.
Prevention and treatment of postpartum hemorrhage in low-resource settings.
Obstetric hemorrhage and shock management: using the low technology Non-pneumatic Anti-Shock Garment in Nigerian and Egyptian tertiary care facilities.
A comparative study of the non-pneumatic anti-shock garment for the treatment of obstetric hemorrhage in Egypt.
Non-pneumatic anti-shock garments: clinical trials and results.
Iron sucrose versus oral iron therapy in pregnancy anemia.
Obstetric hysterectomy: fifteen years' experience in a Nigerian tertiary centre.
Non-pneumatic anti-shock garment for improving maternal survival following severe postpartum haemorrhage: a systematic review.
A randomized clinical trial of preoperative versus postoperative misoprostol in elective cesarean delivery.
Umbilical vein injection of misoprostol versus normal saline for the treatment of retained placenta: intrapartum placebo-controlled trial.
Ferric carboxymaltose: a revolution in the treatment of postpartum anemia in Indian women.
Emergency peripartum hysterectomy.
Effectiveness of intravenous iron sucrose in management of iron-deficient anemia of pregnancy at rural hospital set up.
Uterine balloon tamponade for the treatment of postpartum haemorrhage in resource-poor settings: a systematic review.
Management of postpartum hemorrhage in low resource settings.
Blood salvage device for use during ruptured ectopic pregnancy in low-resource countries.
Treatment of post-partum haemorrhage with sublingual misoprostol versus oxytocin in women not exposed to oxytocin during labour: a double-blind, randomised, non-inferiority trial.
臨床成績
Obstetric outcomes in Jehovah's Witnesses: case series over nine years in a London teaching hospital.
Major gynecologic and obstetric surgery in Jehovah's Witnesses.
Health care-associated infection after red blood cell transfusion: a systematic review and meta-analysis.
Obstetric outcomes and acceptance of alternative therapies to blood transfusion by Jehovah's Witnesses in Japan: a single-center study.
経済効果
Cost savings of red cell salvage during cesarean delivery.
The economic benefits of cell salvage in obstetric haemorrhage.
Cost-effectiveness of the non-pneumatic anti-shock garment (NASG): evidence from a cluster randomized controlled trial in Zambia and Zimbabwe.
Impact of a patient blood management monitoring and feedback programme on allogeneic blood transfusions and related costs.
Cost-effectiveness of red blood cell transfusion vs. non-intervention in women with acute anaemia after postpartum haemorrhage.
Cost-effectiveness of two interventions for the prevention of postpartum hemorrhage in Senegal.
術前の患者の評価と輸血リスクの評価
Preoperative assessment of risk factors.
術前の計画と患者の状態の最適化
Management of Jehovah's Witnesses in otolaryngology, head and neck surgery.
Preparing a Jehovah's Witness for major elective surgery.
Avoiding blood transfusion in surgical patients (including Jehovah's Witnesses).
Control of bleeding in endoscopic skull base surgery: current concepts to improve hemostasis.
Perioperative and intraoperative maneuvers to optimize surgical outcomes in skull base surgery.
Perioperative approach in the surgical management of carotid body tumors.
集学的,職種横断的な,個別化されたアプローチ
Ivory osteoma of the craniofacial skeleton.
Head and neck surgery in the Jehovah's Witness patient.
Blood loss mitigation and replacement in facial surgery: a review.
The ex utero intrapartum treatment procedure for congenital ranula in a Jehovah's Witness.
Case report: The management of advanced oral cancer in a Jehovah's Witness using the Ultracision Harmonic Scalpel.
Jehovah's Witness head and neck free flap reconstruction patient outcomes.
Perioperative management of pediatric patients undergoing juvenile angiofibroma resection. A case series and educational review highlighting patient blood management.
Hemostasis in otologic and neurotologic surgery.
Microvascular free-tissue transfer for head and neck reconstruction in Jehovah's Witness patients.
Maintenance of normal hematocrit in high-risk thyroid surgery without allogeneic blood transfusion: a case report.
Management of Jehovah's Witness patients undergoing major head and neck surgery.
ENT surgery, blood and Jehovah's Witnesses.
術前貧血管理と赤血球数の最適化
The role of intravenous iron in anemia management and transfusion avoidance.
The effect of preoperative recombinant erythropoietin on postoperative hematocrit level after orthognathic surgery.
Penny-wise and pound-foolish: the challenges of preoperative anaemia management.
血管造影による塞栓術または血管閉塞
Transarterial embolization for control of bleeding in patients with head and neck cancer.
Arterial embolization in the management of posterior epistaxis.
Devascularization of head and neck paragangliomas by direct percutaneous embolization.
Pre-operative embolisation of the thyroid artery in a patient with a large papillary carcinoma of the thyroid.
Perioperative approach in the surgical management of carotid body tumors.
外科的血液温存法
Hemostasis in laryngeal surgery.
Argon beam coagulation for post-tonsillectomy hemostasis.
Multiple analyses of factors related to intraoperative blood loss and the role of reverse Trendelenburg position in endoscopic sinus surgery.
Case report: The management of advanced oral cancer in a Jehovah's Witness using the Ultracision Harmonic Scalpel.
Hemostasis in tonsillectomy.
Haemostasis in head and neck surgical procedures: Valsalva manoeuvre versus Trendelenburg tilt.
Comparison of three techniques in adult tonsillectomy.
The effect of patient positioning on amount of intraoperative bleeding in rhinoplasty: a randomized controlled trial.
Hemostasis in endoscopic sinus surgery.
Perioperative and intraoperative maneuvers to optimize surgical outcomes in skull base surgery.
Ultrasonic glossectomy—simple and bloodless.
止血の管理と最適化
Topical application of tranexamic acid after adenoidectomy: a double-blind, prospective, randomized, controlled study.
The effect of intravenous tranexamic acid on blood loss and surgical field quality during endoscopic sinus surgery: a placebo-controlled clinical trial.
Effect of microporous polysaccharide hemospheres (MPH) on bleeding after endoscopic sinus surgery: randomized controlled study.
The effect of nasal application of cocaine/adrenaline on blood loss in Le Fort I osteotomies.
Use of Floseal®, a human gelatine-thrombin matrix sealant, in surgery: a systematic review.
The efficacy of preoperative oral tranexamic acid on intraoperative bleeding during rhinoplasty.
Desmopressin as a hemostatic agent to provide a dry intraoperative field in rhinoplasty.
Surgical removal of intra- and extraoral cavernous lymphangiomas using intraoperative-assisted intralesional fibrin glue injections.
Efficacy of tranexamic acid on operative bleeding in endoscopic sinus surgery: a meta-analysis and systematic review.
Effectiveness of chitosan-based packing in 35 patients with recalcitrant epistaxis in the context of coagulopathy.
Effect of gauze placement soaked with adrenaline at suprabullar recess on hemostasis during endoscopic sinus surgery: a randomized controlled trial.
Effect of desmopressin administration on intraoperative blood loss and quality of the surgical field during functional endoscopic sinus surgery: a randomized, clinical trial.
The role of antifibrinolytics in reducing blood loss during craniofacial or orthognathic surgical procedures: a meta-analysis.
抗線溶薬
デスモプレシン
他の薬剤
局所止血剤
術中の自己血管理
Are cell salvage and autologous blood transfusion safe in endonasal surgery?
Effects of standardized acute normovolemic hemodilution on intraoperative allogeneic blood transfusion in patients undergoing major maxillofacial surgery.
A case of thoracic esophageal cancer undergone esophagectomy after induction chemotherapy in a Jehovah's Witness.
Intraoperative red cell salvage in head and neck surgery.
Acute perioperative normovolaemic haemodilution in major maxillofacial surgery.
Blood-sparing techniques in head and neck surgery.
Should intraoperative cell-salvaged blood be used in patients with suspected or known malignancy?
Blood salvage and cancer surgery: a meta-analysis of available studies.
血液回収法
急性等容量性血液希釈
麻酔学的血液温存法
Comparison of surgical conditions during propofol or sevoflurane anaesthesia for endoscopic sinus surgery.
Anesthetic techniques in endoscopic sinus and skull base surgery.
Magnesium sulphate as a technique of hypotensive anaesthesia.
Effect of induced hypotensive anaesthesia vs isovolaemic haemodilution on blood loss and transfusion requirements in orthognathic surgery: a prospective, single-blinded, randomized, controlled clinical study.
The efficacy of hypotensive agents on intraoperative bleeding and recovery following general anesthesia for nasal surgery: a network meta-analysis.
Anesthetic considerations for orthognathic surgery with evaluation of difficult intubation and technique for hypotensive anesthesia.
Is it safe to decrease hemodynamic parameters to achieve bloodless surgical field during transnasal endoscopic procedures? Our experience in fifteen patients.
低血圧法
輸血のリスクと不確実性
Anemia during sequential induction chemotherapy and chemoradiation for head and neck cancer: the impact of blood transfusion on treatment outcome.
Transfusion as a predictor of recurrence and survival in head and neck cancer surgery patients.
Does transfusion improve the outcome for HNSCC patients treated with radiotherapy?—results from the randomized DAHANCA 5 and 7 trials.
Transfusion of allogenic leukocyte-depleted packed red blood cells is associated with postoperative morbidity in patients undergoing oral and oropharyngeal cancer surgery.
術前の患者の評価と輸血リスクの評価
Identifying patients at risk of intraoperative and postoperative transfusion in isolated CABG: toward selective conservation strategies.
Perioperative care of a Jehovah's Witness with a leaking abdominal aortic aneurysm.
Blood loss and transfusion rates associated with transcatheter aortic valve replacement: recommendations for patients who refuse blood transfusion.
Association between bleeding events and in-hospital mortality after percutaneous coronary intervention.
Preoperative hemostasis and its association with bleeding and blood component transfusion requirements in cardiopulmonary bypass surgery.
2012 update to the Society of Thoracic Surgeons Guideline on use of antiplatelet drugs in patients having cardiac and noncardiac operations.
Relation of the HAS-BLED bleeding risk score to major bleeding, cardiovascular events, and mortality in anticoagulated patients with atrial fibrillation.
Preoperative anemia is an independent predictor of postoperative mortality and adverse cardiac events in elderly patients undergoing elective vascular operations.
Predictors of bleeding and time dependence of association of bleeding with mortality: insights from the Trial to Assess Improvement in Therapeutic Outcomes by Optimizing Platelet Inhibition With Prasugrel--Thrombolysis in Myocardial Infarction 38 (TRITON-TIMI 38).
Cardiac surgery in Jehovah's Witness patients: ten-year experience.
A multivariable model for predicting the need for blood transfusion in patients undergoing first-time elective coronary bypass graft surgery.
Interrelationship of preoperative anemia, intraoperative anemia, and red blood cell transfusion as potentially modifiable risk factors for acute kidney injury in cardiac surgery: a historical multicentre cohort study.
The influence of baseline hemoglobin concentration on tolerance of anemia in cardiac surgery.
Transfusion Risk and Clinical Knowledge (TRACK) score and cardiac surgery in patients refusing transfusion.
Combined clopidogrel and aspirin treatment up to surgery increases the risk of postoperative myocardial infarction, blood loss and reoperation for bleeding in patients undergoing coronary artery bypass grafting.
Predictors of transfusion requirements for cardiac surgical procedures at a blood conservation center.
Identification des facteurs prédictifs de transfusion sanguine homologue en chirurgie cardiaque à partir d'une étude observationnelle. [Identification of risk factors for allogenic transfusion in cardiac surgery from an observational study.] [French]
Aortic valve replacement through a minimally invasive approach: preoperative planning, surgical technique, and outcome.
Major bleeding, transfusions, and anemia: the deadly triad of cardiac surgery.
Predicting transfusions in cardiac surgery: the easier, the better: the Transfusion Risk and Clinical Knowledge score.
Impact of preoperative anemia on outcome in adult cardiac surgery: a propensity-matched analysis.
Preparation of the patient for surgery.
Risk factors for red cell transfusion in adults undergoing coronary artery bypass surgery: a systematic review.
Factors predicting loss and gain of red cell volume in cardiac surgery patients.
The effect of pre-operative aspirin on bleeding, transfusion, myocardial infarction, and mortality in coronary artery bypass surgery: a systematic review of randomized and observational studies.
A surgeon's guide to herbal supplements.
Risk factors for red blood cell transfusion after coronary artery bypass graft surgery.
Blood conservation strategies can be applied safely to high-risk complex aortic surgery.
Management of blood transfusion in aortic valve surgery: impact of a blood conservation strategy.
術前の計画と患者の状態の最適化
Hybrid approach to pulmonary valve replacement with melody prosthesis following pulmonary banding.
Changes in haemoglobin levels during hospital course and long-term outcome after acute myocardial infarction.
Preoperative assessment and management to prevent complications during high-risk vascular surgery.
Preparing a Jehovah's Witness for major elective surgery.
Effect on outcomes and exercise performance of anemia in patients with aortic stenosis who underwent transcatheter aortic valve replacement.
The operating surgeon is an independent predictor of chest tube drainage following cardiac surgery.
Preoperative hemostasis and its association with bleeding and blood component transfusion requirements in cardiopulmonary bypass surgery.
Avoiding blood transfusion in surgical patients (including Jehovah's Witnesses).
Effect of timing of chronic preoperative aspirin discontinuation on morbidity and mortality in patients having combined coronary artery bypass grafting and valve surgery.
The theory and practice of bloodless surgery.
Strategies and outcomes of cardiac surgery in Jehovah's Witnesses.
Prevalence, factors associated with, and prognostic effects of preoperative anemia on short- and long-term mortality in patients undergoing transcatheter aortic valve implantation.
The association of perioperative transfusion with 30-day morbidity and mortality in patients undergoing major vascular surgery.
Aortic valve replacement in a Jehovah's Witness: a case of multi-disciplinary clinical management for bloodless surgery.
An updated bleeding model to predict the risk of post-procedure bleeding among patients undergoing percutaneous coronary intervention: a report using an expanded bleeding definition from the National Cardiovascular Data Registry CathPCI Registry.
Heart transplant in Jehovah's Witness patients: a case-control study.
Preparation of the patient for surgery.
Optimizing transfusion in vascular surgery: is bloodless surgery an option?
Preoperative hematocrit as a predictor of perioperative morbidities following nonemergent coronary artery bypass surgery.
Cardiovascular surgery in Jehovah's Witness patients: the role of preoperative optimization.
STS/SCA/AmSECT/SABM update to the clinical practice guidelines on patient blood management.
Impact of haemoglobin concentration on cardiovascular outcome after vascular surgery: a retrospective observational cohort study.
Preoperative optimization of the vascular surgery patient.
集学的,職種横断的な,個別化されたアプローチ
Blood conservation strategies in cardiac surgery: more is better.
Blood loss and transfusion rates associated with transcatheter aortic valve replacement: recommendations for patients who refuse blood transfusion.
Blood transfusion reduction in cardiac surgery: multidisciplinary approach at a community hospital.
Perioperative management of four anaemic female Jehovah's Witnesses undergoing urgent complex cardiac surgery.
Bilateral sequential lung transplantation in Jehovah's Witnesses.
Aortic valve replacement in a dialysis-dependent Jehovah's Witness: successful use of a minicircuit, microplegia, and multimodality blood conservation technique.
Blood conservation strategies reduce the need for transfusions in ascending and aortic arch surgery.
Conservation of blood during cardiovascular surgery.
Bloodless orthotopic heart transplantation in a Jehovah's Witness.
Repair of type A dissection in a Jehovah's Witness with prior cardiac operation.
Hemodilution and surgical hemostasis contribute significantly to transfusion requirements in patients undergoing coronary artery bypass.
Double-valve surgery in Shprintzen-Goldberg syndrome.
Repeat cardiac surgery in a Jehovah's Witness patient with thrombocytopenia.
Should Jehovah's Witness patients be listed for heart transplantation?
Cardiopulmonary bypass in Jehovah's Witnesses.
Successful ascending aorta and hemiarch replacement and aortic valve resuspension via redo median sternotomy using hypothermic circulatory arrest in a practicing Jehovah's Witnesses patient.
2011 ACCF/AHA Guideline for Coronary Artery Bypass Graft Surgery: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines.
Jehovah's Witnesses requiring complex urgent cardiothoracic surgery.
Successful allograft root re-replacement for prosthetic valve endocarditis with improvement of renal function in a Jehovah's Witness patient.
Anesthesia management of a Jehovah's Witness patient with pheochromocytoma undergoing off pump coronary artery bypass graft surgery—a case report.
Treatment of anemia in patients with heart disease: a systematic review.
Total aortic arch replacement for the treatment of Kommerell's diverticulum in a Jehovah's Witness.
An evolution in blood management: past, present, and future.
Blood conservation—a team sport.
Blood conservation strategies in Jehovah's Witness patients undergoing complex aortic surgery: a report of three cases.
Aortic arch replacement and elephant trunk procedure: an interdisciplinary approach to surgical reconstruction, perfusion strategies and blood management.
Multidisciplinary management of a Jehovah's Witness patient for the removal of a renal cell carcinoma extending into the right atrium.
Update on blood conservation for cardiac surgery.
Anesthetic management for ascending aorta replacement in a patient who refused autologous transfusion for religious reasons.
Successful surgical repair of acute type A aortic dissection without the use of blood products.
Aortic valve replacement in a Jehovah's Witness: a case of multi-disciplinary clinical management for bloodless surgery.
Bloodless third complex heart operation in a Jehovah's Witness patient with extremely low preoperative haemoglobin level.
Aortic valve replacement and repair of left ventricular pseudoaneurysm in a Jehovah's Witness.
Thoraco-abdominal aneurysm repair in a Jehovah's Witness: maximising blood conservation.
Programmatic blood conservation in cardiac surgery.
Multi-modality blood conservation strategy in open-heart surgery: an audit.
Successful use of ECMO in a Jehovah's Witness after complicated re-heart transplant.
Therapeutic options to minimize allogeneic blood transfusions and their adverse effects in cardiac surgery: a systematic review. [Opções terapêuticas para minimizar transfusões de sangue alogênico e seus efeitos adversos em cirurgia cardíaca: revisão sistemática.] [English, Portuguese]
Bloodless aortic valve and ascending aorta replacement surgery requiring circulatory arrest: two case studies.
2011 update to the Society of Thoracic Surgeons and the Society of Cardiovascular Anesthesiologists blood conservation clinical practice guidelines.
Effects of a targeted blood management programme on allogeneic blood transfusion in abdominal aortic aneurysm surgery.
A structured blood conservation programme reduces transfusions and costs in cardiac surgery.
Effects of a multimodality blood conservation schema toward improvement of intraoperative hemoglobin levels and off-pump transfusions in coronary artery bypass graft surgery.
A standardized multidisciplinary approach reduces the use of allogeneic blood products in patients undergoing cardiac surgery.
Ten-year patterns in blood product utilization during cardiothoracic surgery with cardiopulmonary bypass in a tertiary hospital.
Coronary artery bypass grafting in a dialysis-dependent Jehovah's Witness.
Implementation of a comprehensive blood conservation program can reduce blood use in a community cardiac surgery program.
Blood conservation strategies can be applied safely to high-risk complex aortic surgery.
Management of blood transfusion in aortic valve surgery: impact of a blood conservation strategy.
Rupture of chronic type B aortic dissection in a Jehovah's Witness: successful surgical repair without blood transfusion.
The perfusionist's role in a collaborative multidisciplinary approach to blood transfusion reduction in cardiac surgery.
術前貧血管理と赤血球数の最適化
Ferric carboxymaltose in patients with heart failure and iron deficiency.
Successful repair of a giant abdominal aortoiliac aneurysm in a Jehovah's Witness.
Blood loss and transfusion rates associated with transcatheter aortic valve replacement: recommendations for patients who refuse blood transfusion.
Impact of preoperative erythropoietin on allogeneic blood transfusions in surgical patients: results from a systematic review and meta-analysis.
A propensity-matched cohort study of intravenous iron versus red cell transfusions for preoperative iron-deficiency anemia.
Epoetin dosing for blood conservation in Jehovah's Witness patients undergoing cardiac surgery—a systematic review.
Effects of preoperative intravenous erythropoietin plus iron on outcome in anemic patients after cardiac valve replacement.
Intravenous ferric carboxymaltose in iron-deficient chronic heart failure patients with and without anaemia: a subanalysis of the FAIR-HF trial.
Current status of pharmacologic therapies in patient blood management.
Intraoperative anemia and single red blood cell transfusion during cardiac surgery: an assessment of postoperative outcome including patients refusing blood transfusion.
The influence of baseline hemoglobin concentration on tolerance of anemia in cardiac surgery.
Practice advisory on the implementation of preoperative anemia management: the Society of Cardiovascular Anesthesiologists and the Society for the Advancement of Patient Blood Management.
Randomised open-label trial comparing intravenous iron and an erythropoiesis-stimulating agent versus oral iron to treat preoperative anaemia in cardiac surgery (INITIATE trial).
Efficacy and safety of erythropoietin and intravenous iron in perioperative blood management: a systematic review.
The least of 3 evils: exposure to red blood cell transfusion, anemia, or both?
Jehovah's Witnesses and cardiac surgery: a single institution's experience.
Determining optimal treatment to correct preoperative anemia and reduce perioperative allogeneic blood transfusions in cardiac surgery: a retrospective cohort study.
Randomized, double-blind, placebo-controlled trial of effects of enteral iron supplementation on anemia and risk of infection during surgical critical illness.
Efficacy of quadruple treatment on different types of pre-operative anaemia: secondary analysis of a randomised controlled trial.
Penny-wise and pound-foolish: the challenges of preoperative anaemia management.
Preoperative erythropoietin and blood conservation management for thoracoabdominal aneurysm repair in a Jehovah's Witness.
Intravenous iron in heart failure: beyond targeting anemia.
Cardiovascular surgery in Jehovah's Witness patients: the role of preoperative optimization.
Intravenous iron without erythropoietin for the treatment of iron deficiency anemia in patients with moderate to severe congestive heart failure and chronic kidney insufficiency.
Preoperative very short-term, high-dose erythropoietin administration diminishes blood transfusion rate in off-pump coronary artery bypass: a randomized blind controlled study.
A single dose of erythropoietin reduces perioperative transfusions in cardiac surgery: results of a prospective single-blind randomized controlled trial.
Blood conservation strategies can be applied safely to high-risk complex aortic surgery.
Effect of single recombinant human erythropoietin injection on transfusion requirements in preoperatively anemic patients undergoing valvular heart surgery.
抗凝固療法の管理と中和
Prothrombin complex concentrates versus fresh frozen plasma for warfarin reversal. A systematic review and meta-analysis.
Pharmacological prophylaxis of bleeding in surgical patients treated with aspirin.
Reversal of warfarin: case-based practice recommendations.
Stopping antiplatelet medication before coronary artery bypass graft surgery: is there an optimal timing to minimize bleeding?
Is a fully heparin-bonded cardiopulmonary bypass circuit superior to a standard cardiopulmonary bypass circuit?
Heparin-bonded circuits versus nonheparin-bonded circuits: an evaluation of their effect on clinical outcomes.
Heparin-coated extracorporeal circulation in combination with low dose systemic heparinization reduces early postoperative blood loss in cardiac surgery.
Idarucizumab for dabigatran reversal.
Idarucizumab for dabigatran reversal - full cohort analysis.
Platelet mapping and desmopressin reversal of platelet inhibition during emergency carotid endarterectomy.
Efficacy and safety of a 4-factor prothrombin complex concentrate in patients on vitamin K antagonists presenting with major bleeding: a randomized, plasma-controlled, phase IIIb study.
Protective effects of tranexamic acid on clopidogrel before coronary artery bypass grafting: a multicenter randomized trial.
Andexanet alfa for the reversal of Factor Xa inhibitor activity.
Recombinant factor VIIa (rFVIIa) and hemodialysis to manage massive dabigatran-associated postcardiac surgery bleeding.
Heparinized cardiopulmonary bypass circuits and low systemic anticoagulation: an analysis of nearly 6000 patients undergoing coronary artery bypass grafting.
診断目的以外の失血の抑制
Bleeding complications in patients with acute coronary syndrome undergoing early invasive management can be reduced with radial access, smaller sheath sizes, and timely sheath removal.
Bleeding avoidance strategies. Consensus and controversy.
Influence of arterial access site selection on outcomes in primary percutaneous coronary intervention: are the results of randomized trials achievable in clinical practice?
血管造影による塞栓術または血管閉塞
Resection of intralobar pulmonary sequestration after coil embolization of aberrant arteries: report of a case.
A multidisciplinary approach to carotid paragangliomas.
Impact of preoperative embolization on outcomes of carotid body tumor resections.
Intraoperative embolization with poloxamer 407 during surgical resection of a carotid body tumor.
外科的血液温存法
Reduced re-exploration and blood product transfusion after the introduction of the Papworth haemostasis checklist.
Repair of an ascending aortic aneurysm using reduction aortoplasty in a Jehovah's Witness.
A randomised controlled trial of the use of a tourniquet to reduce blood loss during transtibial amputation for peripheral arterial disease.
Conservation of blood during cardiovascular surgery.
Planned versus unplanned reexplorations for bleeding: a comparison of morbidity and mortality.
The operating surgeon is an independent predictor of chest tube drainage following cardiac surgery.
Reoperation in a Jehovah's Witness 22 years after aortic allograft reconstruction of the right ventricular outflow tract.
Repair of a large main pulmonary artery aneurysm in a 71-year-old Jehovah's Witness patient.
Successful allograft root re-replacement for prosthetic valve endocarditis with improvement of renal function in a Jehovah's Witness patient.
Staged repair for a chronic dissecting thoracic aortic aneurysm with no transfusion in a Jehovah's Witness patient.
Reexploration for bleeding after coronary artery bypass surgery: risk factors, outcomes, and the effect of time delay.
Process improvement in cardiac surgery: development and implementation of a reoperation for bleeding checklist.
Successful surgical treatment of a ruptured abdominal aortic aneurysm without homologous blood transfusion in a Jehovah's Witness: report of a case.
Unusual modification of the cabrol shunt for control of hemorrhage in acute type A aortic dissection.
Bloodless surgery of acute type A aortic dissection in a Jehovah's Witness patient.
Using the Boazul cuff to reduce blood loss in varicose vein surgery.
Hybrid operation for combined aortic arch aneurysm and aortic root dilation in a Jehovah's Witness patient.
Novel wrapping technique with insertion of fat tissue for hemostasis in aortic surgery.
CASE 12-2016 Ascending aorta dissection in a Jehovah's Witness patient on warfarin.
Controlled hypotension and minimal inflation pressure: a new approach for pneumatic tourniquet application in upper limb surgery.
Staged hybrid approach for an acute-on-chronic aortic dissection with rupture in a Jehovah's Witness patient: case report.
Use of a pneumatic tourniquet improves outcome following trans-tibial amputation.
Minimally invasive hybrid treatment of acute type I aortic dissection: a single-stage technique without circulatory arrest.
低侵襲治療法
Hybrid approach to pulmonary valve replacement with melody prosthesis following pulmonary banding.
Off-pump myocardial revascularizaton in a Jehovah's Witness patient with pheochromocytoma.
Blood loss and transfusion rates associated with transcatheter aortic valve replacement: recommendations for patients who refuse blood transfusion.
Endovascular treatment of multiple anomalous splenic artery aneurysms in a Jehovah's Witness.
Transcatheter aortic valve implantation in Jehovah's Witness patients with symptomatic severe aortic valve stenosis.
Percutaneous embolization of lung sequestration using a novel occluding device.
Outcomes of coronary artery bypass graft surgery versus drug-eluting stents in older adults.
Resection of left ventricular rhabdomyosarcoma.
Bleeding complications after surgical aortic valve replacement compared with transcatheter aortic valve replacement: insights from the PARTNER I Trial (Placement of Aortic Transcatheter Valve).
Beating heart minimally invasive mitral valve surgery in patients with patent coronary bypass grafts. [English, French abstract]
Minimally invasive approach provides at least equivalent results for surgical correction of mitral regurgitation: a propensity-matched comparison.
Heart-failing Jehovah's Witness patient successfully treated by minimally invasive LVAD implantation without any blood transfusions.
Thoracoscopic treatment of pulmonary sequestration.
Long-term comparison of endovascular and open repair of abdominal aortic aneurysm.
Endovascular repair of ascending aortic dissection: a novel treatment option for patients judged unfit for direct surgical repair.
Complete replacement of open repair for ruptured abdominal aortic aneurysms by endovascular aneurysm repair: a two-center 14-year experience.
One thousand minimally invasive mitral valve operations: early outcomes, late outcomes, and echocardiographic follow-up.
Drug, devices, technologies, and techniques for blood management in minimally invasive and conventional cardiothoracic surgery: a consensus statement from the International Society for Minimally Invasive Cardiothoracic Surgery (ISMICS) 2011.
Minimally invasive mitral valve surgery: a systematic review and meta-analysis.
Minimally invasive mitral valve surgery through right thoracotomy in patients with patent coronary artery bypass grafts.
Hybrid minimally invasive extraction of atrial clot avoids redo sternotomy in Jehovah's Witness.
Aortic valve replacement through a minimally invasive approach: preoperative planning, surgical technique, and outcome.
Endovascular repair of aortic arch false aneurysm with branched endograft.
Endovascular treatment of a superior mesenteric artery embolism in a high-risk Jehovah's Witness.
Impact of timing and surgical approach on outcomes after mitral valve regurgitation operations.
Mitral valve surgery: right lateral minithoracotomy or sternotomy? A systematic review and meta-analysis.
Minimal access aortic valve replacement using a minimal extracorporeal circulatory system.
止血の管理と最適化
Topical application of antifibrinolytic drugs for on-pump cardiac surgery: a systematic review and meta-analysis. [L'application topique de médicaments anti-fibrinolytiques pour la chirurgie cardiaque avec circulation extra-corporelle : analyse méthodique et méta-analyse.] [English, French abstract]
A comprehensive review of topical hemostatic agents: efficacy and recommendations for use.
Reduced use of allogeneic platelets through high-yield perioperative autologous plateletpheresis and reinfusion.
An audit of red cell and blood product use after the institution of thromboelastometry in a cardiac intensive care unit.
Use of prothrombin complex concentrate for excessive bleeding after cardiac surgery.
Aortic dissection and hypothermic arrest in a Jehovah's Witness patient: a case for recombinant factor VIIa?
A review of topical hemostatic agents for use in cardiac surgery.
Use of recombinant activated factor VII for refractory after lung transplant bleeding as an effective strategy to restrict blood transfusion and associated complications.
Reducing blood transfusion in aortic surgery: a novel approach.
Prophylactic use of factor IX concentrate in a Jehovah's Witness patient.
Safety and efficacy of prothrombin complex concentrate as first-line treatment in bleeding after cardiac surgery.
Bloodless orthotopic heart transplantation in a Jehovah's Witness.
State of the art - how I manage coagulopathy in cardiac surgery patients.
Can topical application of tranexamic acid reduce blood loss in thoracic surgery? A prospective randomised double blind investigation.
Recombinant activated factor VII in cardiac surgery: experience from the Australian and New Zealand Haemostasis Registry.
Repeat cardiac surgery in a Jehovah's Witness patient with thrombocytopenia.
Can local application of tranexamic acid reduce post-coronary bypass surgery blood loss? A randomized controlled trial.
Off-label use of recombinant activated factor VII for cardiac surgical bleeding.
Armentarium of topical hemostatic products in cardiovascular surgery: an update.
Safety and efficacy of recombinant activated factor VII: a randomized placebo-controlled trial in the setting of bleeding after cardiac surgery.
Intraoperative use of recombinant activated factor VII during complex aortic surgery.
Off-label use of recombinant human factor VIIa.
Current status of pharmacologic therapies in patient blood management.
First-line therapy with coagulation factor concentrates combined with point-of-care coagulation testing is associated with decreased allogeneic blood transfusion in cardiovascular surgery: a retrospective, single-center cohort study.
Management of hemorrhage in cardiothoracic surgery.
The effect of epsilon-aminocaproic acid and aprotinin on fibrinolysis and blood loss in patients undergoing primary, isolated coronary artery bypass surgery: a randomized, double-blind, placebo-controlled, noninferiority trial.
Off-label use of recombinant activated factor VII in intractable haemorrhage after cardiovascular surgery: an observational study of practices in 23 French cardiac centres (2005-7).
Effects of desmopressin on platelet function under conditions of hypothermia and acidosis: an in vitro study using multiple electrode aggregometry.
Putting the record straight on aprotinin as safe and effective: results from a mixed treatment meta-analysis of trials of aprotinin.
Comparison of 4-factor prothrombin complex concentrate with frozen plasma for management of hemorrhage during and after cardiac surgery: a randomized pilot trial.
Comprehensive Canadian review of the off-label use of recombinant activated factor VII in cardiac surgery.
The risk-benefit profile of aprotinin versus tranexamic acid in cardiac surgery.
Prophylactic fibrinogen infusion reduces bleeding after coronary artery bypass surgery. A prospective randomised pilot study.
Role of recombinant factor VIIa in the treatment of intractable bleeding in vascular surgery.
Use of activated recombinant factor VII in severe bleeding—evidence for efficacy and safety in trauma, postpartum hemorrhage, cardiac surgery, and gastrointestinal bleeding.
Recombinant activated factor VII for postoperative hemorrhage following repair of acute type A aortic dissection.
A novel reverse thermosensitive polymer to achieve temporary atraumatic vessel occlusion in infra-popliteal bypasses.
Comparative evaluation of the effects of tranexamic acid and low-dose aprotinin on post-valvular heart surgery bleeding and allogenic transfusion.
Recombinant factor VIIa treatment of severe bleeding in cardiac surgery patients: a retrospective analysis of dosing, efficacy, and safety outcomes.
Drug, devices, technologies, and techniques for blood management in minimally invasive and conventional cardiothoracic surgery: a consensus statement from the International Society for Minimally Invasive Cardiothoracic Surgery (ISMICS) 2011.
A randomized trial of tranexamic acid in combination with cell salvage plus a meta-analysis of randomized trials evaluating tranexamic acid in off-pump coronary artery bypass grafting.
Tranexamic acid in patients undergoing coronary-artery surgery.
Aprotinin for patients exposed to clopidogrel before off-pump coronary bypass.
Recombinant activated factor VII significantly reduces transfusion requirements in cardiothoracic surgery.
Fibrinogen concentrate reduces intraoperative bleeding when used as first-line hemostatic therapy during major aortic replacement surgery: results from a randomized, placebo-controlled trial.
Effects of fibrinogen concentrate as first-line therapy during major aortic replacement surgery: a randomized, placebo-controlled trial.
Randomized, double-blinded, placebo-controlled trial of fibrinogen concentrate supplementation after complex cardiac surgery.
Fibrinogen supplementation after cardiac surgery: insights from the zero-plasma trial (ZEPLAST).
Platelet mapping and desmopressin reversal of platelet inhibition during emergency carotid endarterectomy.
Bleeding in a Jehovah's Witness patient undergoing a redo aortic valve replacement controlled with cryoprecipitate and a prothrombin complex concentrate.
Prothrombin complex concentrate in cardiac surgery: a systematic review and meta-analysis.
Control of troublesome bleeding during repair of acute type A dissection with use of modified rapid deployment hemostat (MRDH).
Topical haemostatic agents.
Protective effects of tranexamic acid on clopidogrel before coronary artery bypass grafting: a multicenter randomized trial.
Effect of high- vs low-dose tranexamic acid infusion on need for red blood cell transfusion and adverse events in patients undergoing cardiac surgery: The OPTIMAL randomized clinical trial.
Coagulopathy after cardiopulmonary bypass in Jehovah's Witness patients: management of two cases using fractionated components and factor VIIa.
Haemostatic therapy in coronary artery bypass graft patients with decreased platelet function: comparison of fibrinogen concentrate with allogeneic blood products.
Hemostatic management of severe thrombocytopenia in a patient undergoing pulmonic valve replacement.
Treatment of excessive bleeding in Jehovah's Witness patients after cardiac surgery with recombinant factor VIIa (Novoseven®).
Desmopressin for reducing postoperative blood loss and transfusion requirements following cardiac surgery in adults.
Tranexamic acid reduces blood loss after off-pump coronary surgery: a prospective, randomized, double-blind, placebo-controlled study.
Effects of aprotinin on short-term and long-term outcomes after coronary artery bypass grafting surgery.
Recombinant activated factor VII in cardiac surgery: a systematic review.
A point-of-care assessment of the effects of desmopressin on impaired platelet function using multiple electrode whole-blood aggregometry in patients after cardiac surgery.
Point-of-care testing: a prospective, randomized clinical trial of efficacy in coagulopathic cardiac surgery patients.
Low postoperative dose of aprotinin reduces bleeding and is safe in patients receiving clopidogrel before coronary artery bypass surgery. A prospective randomized study.
抗線溶薬
遺伝子組換え活性型血液凝固第Ⅶ因子製剤(rFVIIa)
濃縮凝固因子製剤
デスモプレシン
局所止血剤
外科的出血か凝固異常による出血かを同定するための血液粘弾性試験
体温管理(低体温の回避)
Perioperative maintenance of normothermia reduces the incidence of morbid cardiac events. A randomized clinical trial.
Influence of body core temperature on blood loss and transfusion requirements during off-pump coronary artery bypass grafting: A comparison of 3 warming systems.
The effects of mild perioperative hypothermia on blood loss and transfusion requirement.
注意深い輸液・体液管理
Influence of intraoperative fluid volume on cardiopulmonary bypass hematocrit and blood transfusions in coronary artery bypass surgery.
How good patient blood management leads to excellent outcomes in Jehovah's Witness patients undergoing cardiac surgery.
Strategies to reduce the use of blood products: a European perspective.
Highly positive intraoperative fluid balance during cardiac surgery is associated with adverse outcome.
Effects of a multimodality blood conservation schema toward improvement of intraoperative hemoglobin levels and off-pump transfusions in coronary artery bypass graft surgery.
Management of intraoperative fluid balance and blood conservation techniques in adult cardiac surgery.
Intra-operative intravenous fluid restriction reduces perioperative red blood cell transfusion in elective cardiac surgery, especially in transfusion-prone patients: a prospective, randomized controlled trial.
術中の自己血管理
Reduced use of allogeneic platelets through high-yield perioperative autologous plateletpheresis and reinfusion.
Efficacy and cost-effectiveness of cell saver usage in the repair of thoracic aortic aneurysms and dissections.
Use of minimal extracorporeal circulation improves outcome after heart surgery; a systematic review and meta-analysis of randomized controlled trials.
Minimal extracorporeal circulation reduces the incidence of postoperative major adverse events after elective coronary artery bypass grafting in high-risk patients. A single-institutional prospective randomized study.
Acute normovolemic hemodilution reduces allogeneic red blood cell transfusion in cardiac surgery: a systematic review and meta-analysis of randomized trials.
Evaluation of coagulation factors and platelet function from an off-line modified ultrafiltration technique for post-cardiopulmonary bypass circuit blood recovery.
A new PRECiSe (priming reduced extracorporeal circulation setup) minimizes the need for blood transfusions: first clinical results in coronary artery bypass grafting.
Meta-analysis of randomised trials comparing the effectiveness of miniaturised versus conventional cardiopulmonary bypass in adult cardiac surgery.
Ultrafiltration reduces blood transfusions following cardiac surgery: a meta-analysis.
Prescriptive patient extracorporeal circuit and oxygenator sizing reduces hemodilution and allogeneic blood product transfusion during adult cardiac surgery.
Cell salvage for minimising perioperative allogeneic blood transfusion.
Aortic valve replacement in a dialysis-dependent Jehovah's Witness: successful use of a minicircuit, microplegia, and multimodality blood conservation technique.
Efficacy of intraoperative cell salvage in decreasing perioperative blood transfusion rates in first-time cardiac surgery patients: a retrospective study.
Decreased transfusion requirements with use of acute normovolemic hemodilution in open aortic aneurysm repair.
Minimized perfusion circuits: an alternative in the surgical treatment of Jehovah's Witnesses.
Significant reduction in blood loss in patients undergoing minimal extracorporeal circulation.
Greater volume of acute normovolemic hemodilution may aid in reducing blood transfusions after cardiac surgery.
Is microplegia really superior to standard blood cardioplegia? The results from a meta-analysis.
Novel ultrafiltration technique for blood conservation in cardiac operations.
Impact of minimized extracorporeal circulation on outcome in patients with preoperative anemia undergoing coronary artery bypass surgery.
Does washing swabs increase the efficiency of red cell recovery by cell salvage in aortic surgery?
Transfusion requirements and outcomes in patients undergoing abdominal aortic surgery using intra-operative cell salvage.
Impact of intraoperative high-volume autologous blood collection on allogeneic transfusion during and after cardiac surgery: a propensity score matched analysis.
Retrograde autologous priming in cardiac surgery: results from a systematic review and meta-analysis.
Total cavopulmonary connection in a 35-month-old Jehovah's Witness child.
Retrograde autologous priming of the cardiopulmonary bypass circuit reduces blood transfusion in small adults: a prospective, randomized trial.
Reinfusion of blood within aneurysm sac: a simple method of intraoperative blood conservation in elective abdominal aortic surgery.
Overcoming challenges: the use of minimal extracorporeal circulation in Jehovah's Witnesses undergoing cardiac surgery.
Miniaturized versus conventional cardiopulmonary bypass in high-risk patients undergoing coronary artery bypass surgery.
Transfusion-free anesthetic management for open heart surgery in a neonate—a case report.
Cardioprotective effects of acute normovolemic hemodilution in patients undergoing coronary artery bypass surgery.
Beneficial effects of using a minimal extracorporeal circulation system during coronary artery bypass grafting.
Perfusion approaches to blood conservation.
Large volume acute normovolemic hemodilution in patients undergoing cardiac surgery with intermediate-high risk of transfusion: a randomized controlled trial.
Hemodilution in high-risk cardiac surgery: Laboratory values, physiological parameters, and outcomes.
Use of the Hemobag® for modified ultrafiltration in a Jehovah's Witness patient undergoing cardiac surgery.
An analysis of the influence of intra-operative blood salvage and autologous transfusion on reducing the need for allogeneic transfusion in elective infrarenal abdominal aortic aneurysm repair.
Minimized extracorporeal circulation system in coronary artery bypass surgery: a 10-year single-center experience with 2243 patients.
Coronary artery bypass grafting with a minimized cardiopulmonary bypass circuit: a prospective, randomized trial.
Impaired red blood cell deformability after transfusion of stored allogeneic blood but not autologous salvaged blood in cardiac surgery patients.
Retrograde autologous priming reduces transfusion requirements in coronary artery bypass surgery.
The role of cell salvage autotransfusion in abdominal aortic aneurysm surgery.
Effects of a targeted blood management programme on allogeneic blood transfusion in abdominal aortic aneurysm surgery.
Acute normovolemic hemodilution and intraoperative cell salvage in aortic surgery.
Retrograde autologous priming as a safe and easy method to reduce hemodilution and transfusion requirements during cardiac surgery.
Minimised closed circuit coronary artery bypass grafting in the elderly is associated with lower levels of organ-specific biomarkers: a prospective randomised study.
The effect of retrograde autologous priming volume on haemodilution and transfusion requirements during cardiac surgery.
Intraoperative cell salvage is associated with reduced postoperative blood loss and transfusion requirements in cardiac surgery: a cohort study.
The efficacy of an intraoperative cell saver during cardiac surgery: a meta-analysis of randomized trials.
Reduction of allogeneic red blood cell usage during cardiac surgery by an integrated intra- and postoperative blood salvage strategy: results of a randomized comparison.
The effect of acute normovolaemic haemodilution on blood transfusion requirements in abdominal aortic aneurysm repair.
Autologous versus allogeneic transfusion in aortic surgery: a multicenter randomized clinical trial.
Miniaturized cardiopulmonary bypass improves short-term outcome in cardiac surgery: a meta-analysis of randomized controlled studies.
血液回収法
急性等容量性血液希釈
逆行性自己血充填(RAP)
限外濾過
小型人工心肺(灌流)回路
術後血液回収
Reinfusion of mediastinal blood after heart surgery.
Safety and efficacy of perioperative cell salvage and autotransfusion after coronary artery bypass grafting: a randomized trial.
Reduction of allogeneic red blood cell usage during cardiac surgery by an integrated intra- and postoperative blood salvage strategy: results of a randomized comparison.
医原性貧血を避けるための採血量の制限
Comparison of structured use of routine laboratory tests or near-patient assessment with clinical judgement in the management of bleeding after cardiac surgery.
First-line therapy with coagulation factor concentrates combined with point-of-care coagulation testing is associated with decreased allogeneic blood transfusion in cardiovascular surgery: a retrospective, single-center cohort study.
Hospital-acquired anemia: prevalence, outcomes, and healthcare implications.
Contemporary bloodletting in cardiac surgical care.
Predictors and impact of bleeding complications in percutaneous coronary intervention, acute coronary syndromes, and ST-segment elevation myocardial infarction.
Hospital-acquired anemia and in-hospital mortality in patients with acute myocardial infarction.
Diagnostic blood loss from phlebotomy and hospital-acquired anemia during acute myocardial infarction.
Surgical vampires and rising health care expenditure: reducing the cost of daily phlebotomy.
Do blood tests cause anemia in hospitalized patients? The effect of diagnostic phlebotomy on hemoglobin and hematocrit levels.
Point-of-care testing: a prospective, randomized clinical trial of efficacy in coagulopathic cardiac surgery patients.
術後貧血の管理
Successful repair of a giant abdominal aortoiliac aneurysm in a Jehovah's Witness.
Transfusion-free treatment strategies for acute anemia in critical care.
How do we treat life-threatening anemia in a Jehovah's Witness patient?
Recombinant human erythropoietin use in a critically ill Jehovah's Witness after cardiac surgery.
Successful rescue therapy for severe acute anemia: managing the critically ill Jehovah's Witness.
Intravenous iron following cardiac surgery does not increase the infection rate.
患者の貧血に対する許容力の最適化
Management of a Jehovah's Witness patient with sepsis and profuse bleeding after emergency coronary artery bypass graft surgery: rethinking the critical threshold of oxygen delivery.
Prophylactic hypothermia and neuromuscular blockade to limit myocardial oxygen demand in a critically anemic Jehovah's Witness after emergency surgery.
Care of the injured Jehovah's Witness patient: case report and review of the literature.
Pillar III—optimisation of anaemia tolerance.
等容量性貧血の許容
Lowering the hemoglobin threshold for transfusion in coronary artery bypass procedures: effect on patient outcome.
A prospective, randomized trial limiting perioperative red blood cell transfusions in vascular patients.
Conservative versus liberal red cell transfusion in acute myocardial infarction (the CRIT Randomized Pilot Study).
Restrictive blood transfusion practices are associated with improved patient outcomes.
Is a low transfusion threshold safe in critically ill patients with cardiovascular diseases?
Blood transfusion and 30-day mortality in patients with coronary artery disease and anemia following noncardiac surgery.
Impact of transfusion policy on acute coronary syndrome after major vascular reconstruction.
Restrictive or liberal red-cell transfusion for cardiac surgery.
Postoperative anemia and exercise tolerance after cardiac operations in patients without transfusion: what hemoglobin level is acceptable?
Restrictive versus liberal transfusion strategy for red blood cell transfusion in critically ill patients and in patients with acute coronary syndrome: a systematic review, meta-analysis and trial sequential analysis.
Trends in red blood cell transfusion and 30-day mortality among hospitalized patients.
Impact of more restrictive blood transfusion strategies on clinical outcomes: a meta-analysis and systematic review.
Perioperative anemia and transfusions and late mortality in coronary artery bypass patients.
Is it the patient or the physician who cannot tolerate anemia? A prospective analysis in 1854 non-transfused coronary artery surgery patients.
Does anemia impact hospital readmissions after coronary artery bypass surgery?
Safe application of a restrictive transfusion protocol in moderate-risk patients undergoing cardiac operations.
Blood conservation in cardiac surgery: let's get restrictive.
Management of blood transfusion in aortic valve surgery: impact of a blood conservation strategy.
医療資源の限られる状況
The development of cardiac surgery in West Africa--the case of Ghana.
Giving tranexamic acid to reduce surgical bleeding in sub-Saharan Africa: an economic evaluation.
Comparison of results of autologous versus homologous blood transfusion in open-heart surgery.
大量出血の有害作用
Association between bleeding events and in-hospital mortality after percutaneous coronary intervention.
Increased chest tube drainage is independently associated with adverse outcome after cardiac surgery.
Bleeding avoidance strategies. Consensus and controversy.
The association of blood transfusion with mortality after cardiac surgery: cause or confounding? (CME).
Bleeding, blood transfusion, and increased mortality after percutaneous coronary intervention: implications for contemporary practice.
Adverse impact of bleeding on prognosis in patients with acute coronary syndromes.
Tolerance of intraoperative hemoglobin decrease during cardiac surgery.
Incidence and impact of a single-unit red blood cell transfusion: analysis of The Society of Thoracic Surgeons Database 2010-2019.
The independent association of massive blood loss with mortality in cardiac surgery.
The influence of baseline hemoglobin concentration on tolerance of anemia in cardiac surgery.
Reexploration for bleeding after coronary artery bypass surgery: risk factors, outcomes, and the effect of time delay.
Association between bleeding and mortality among women and men with high-risk acute coronary syndromes: insights from the Early versus Delayed, Provisional Eptifibatide in Acute Coronary Syndromes (EARLY ACS) trial.
Blood transfusion after percutaneous coronary intervention and risk of subsequent adverse outcomes: a systematic review and meta-analysis.
Impact of bleeding on mortality after percutaneous coronary intervention results from a patient-level pooled analysis of the REPLACE-2 (Randomized Evaluation of PCI Linking Angiomax to Reduced Clinical Events), ACUITY (Acute Catheterization and Urgent Intervention Triage Strategy), and HORIZONS-AMI (Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction) trials.
Impact of intraoperative blood loss on long-term survival after lung cancer resection.
Periprocedural bleeding and 1-year outcome after percutaneous coronary interventions: appropriateness of including bleeding as a component of a quadruple end point.
Major bleeding, transfusions, and anemia: the deadly triad of cardiac surgery.
Financial and clinical outcomes associated with surgical bleeding complications.
Elective surgery without transfusion: influence of preoperative hemoglobin level and blood loss on mortality.
Impact of major bleeding and blood transfusions after cardiac surgery: analysis from the Acute Catheterization and Urgent Intervention Triage strategY (ACUITY) trial.
Adverse impact of bleeding and transfusion on the outcome post-transcatheter aortic valve implantation: insights from the Pooled-RotterdAm-Milano-Toulouse In Collaboration Plus (PRAGMATIC Plus) initiative.
Prognostic significance of bleeding location and severity among patients with acute coronary syndromes.
Morbidity of bleeding after cardiac surgery: is it blood transfusion, reoperation for bleeding, or both?
Perioperative blood transfusion is associated with worse clinical outcomes in resected lung cancer.
Operative blood loss, blood transfusion, and 30-day mortality in older patients after major noncardiac surgery.
輸血のリスクと不確実性
Variation in transfusion practices and the effect on outcomes after noncardiac surgery.
Blood transfusion and the risk of atrial fibrillation after cardiac surgery.
Impact of blood product transfusion on short and long-term survival after cardiac surgery: more evidence.
Postoperative complications associated with transfusion of platelets and plasma in cardiac surgery.
Characterizing the epidemiology of perioperative transfusion-associated circulatory overload.
Conservative versus liberal red cell transfusion in acute myocardial infarction (the CRIT Randomized Pilot Study).
The independent effects of anemia and transfusion on mortality after coronary artery bypass.
Is transfusion associated with graft occlusion after cardiac operations?
The relationship between intraoperative blood transfusion and postoperative systemic inflammatory response syndrome.
Risks of packed red blood cell transfusion in patients undergoing cardiac surgery.
Association between intraoperative blood transfusion and mortality and morbidity in patients undergoing noncardiac surgery.
Blood transfusion and infection after cardiac surgery.
Intraoperative use of packed red blood cell transfusion and mortality in patients undergoing abdominal or thoracoabdominal aortic aneurysm surgery.
Blood transfusions are associated with urinary biomarkers of kidney injury in cardiac surgery.
Blood transfusions in cardiac surgery: indications, risks, and conservation strategies.
Perioperative red blood cell transfusion is associated with adverse cardiovascular outcomes in heart valve surgery.
Persistent effect of red cell transfusion on health-related quality of life after cardiac surgery.
Morbidity and mortality risk associated with red blood cell and blood-component transfusion in isolated coronary artery bypass grafting.
Transfusion in coronary artery bypass grafting is associated with reduced long-term survival.
Red cell transfusion is associated with an increased risk for postoperative atrial fibrillation.
Effect of peri-operative red blood cell transfusion on 30-day and 1-year mortality following coronary artery bypass surgery.
Blood transfusion after percutaneous coronary intervention and risk of subsequent adverse outcomes: a systematic review and meta-analysis.
The least of 3 evils: exposure to red blood cell transfusion, anemia, or both?
Efficacy of red blood cell transfusion in the critically ill: a systematic review of the literature.
Red blood cell transfusion is a determinant of neurological complications after cardiac surgery.
Prognostic impact of blood transfusion after primary angioplasty for acute myocardial infarction: analysis from the CADILLAC (Controlled Abciximab and Device Investigation to Lower Late Angioplasty Complications) Trial.
Blood transfusion is associated with increased morbidity and mortality after lower extremity revascularization.
The association of perioperative transfusion with 30-day morbidity and mortality in patients undergoing major vascular surgery.
Transfusion of 1 and 2 units of red blood cells is associated with increased morbidity and mortality.
Relationship of blood transfusion and clinical outcomes in patients with acute coronary syndromes.
Allogeneic blood transfusions explain increased mortality in women after coronary artery bypass graft surgery.
Health care-associated infection after red blood cell transfusion: a systematic review and meta-analysis.
Intraoperative blood transfusion of one or two units of packed red blood cells is associated with a fivefold risk of stroke in patients undergoing elective carotid endarterectomy.
Impaired red blood cell deformability after transfusion of stored allogeneic blood but not autologous salvaged blood in cardiac surgery patients.
Impact on early and late mortality after blood transfusion in coronary artery bypass graft surgery.
Perioperative anemia and transfusions and late mortality in coronary artery bypass patients.
Blood transfusion in cardiac surgery does increase the risk of 5-year mortality: results from a contemporary series of 1714 propensity-matched patients.
Balancing the benefits and risks of blood transfusions in patients undergoing cardiac surgery: a propensity-matched analysis.
Patterns and outcomes of red blood cell transfusion in patients undergoing percutaneous coronary intervention.
Impact of blood transfusion on short- and long-term mortality in patients with ST-segment elevation myocardial infarction.
Impact of red blood cell transfusion on platelet aggregation and inflammatory response in anemic coronary and noncoronary patients: the TRANSFUSION-2 study (impact of transfusion of red blood cell on platelet activation and aggregation studied with flow cytometry use and light transmission aggregometry).
Platelet transfusions during coronary artery bypass graft surgery are associated with serious adverse outcomes.
The association of perioperative red blood cell transfusions and decreased long-term survival after cardiac surgery.
Blood transfusion for lower extremity bypass is associated with increased wound infection and graft thrombosis.
Transfusion of red blood cells: the impact on short-term and long-term survival after coronary artery bypass grafting, a ten-year follow-up.
Survival and length of stay following blood transfusion in octogenarians following cardiac surgery.
The role of patient's profile and allogeneic blood transfusion in development of post-cardiac surgery infections: a retrospective study.
Transfusion of older stored blood and risk of death: a meta-analysis.
Perioperative blood transfusion is associated with worse clinical outcomes in resected lung cancer.
The deleterious effect of red blood cell storage on microvascular response to transfusion.
Harms associated with single unit perioperative transfusion: retrospective population based analysis.
Perioperative transfusion and long-term mortality after cardiac surgery: a meta-analysis.
Intraoperative platelet transfusion is associated with increased postoperative sternal wound infections among type A aortic dissection patients after total arch replacement.
Dose-dependent effects of intraoperative low volume red blood cell transfusions on postoperative outcomes in cardiac surgery patients.
臨床成績
Impact of red blood cell transfusion on clinical outcomes in patients with acute myocardial infarction.
Comparison of outcome in Jehovah's Witness patients in cardiac surgery: an Australian experience.
Perioperative red blood cell transfusion and outcome in stable patients after elective major vascular surgery.
Liberal or restrictive transfusion in high-risk patients after hip surgery.
Association between bleeding events and in-hospital mortality after percutaneous coronary intervention.
How good patient blood management leads to excellent outcomes in Jehovah's Witness patients undergoing cardiac surgery.
Effect of blood transfusion on long-term survival after cardiac operation.
Decreased erythrocyte deformability after transfusion and the effects of erythrocyte storage duration.
Risk-adjusted clinical outcomes in patients enrolled in a bloodless program.
Blood transfusion in cardiac surgery is a risk factor for increased hospital length of stay in adult patients.
Optimizing safety and success: the advantages of bloodless cardiac surgery. A systematic review and meta-analysis of outcomes in Jehovah's Witnesses.
Restrictive blood transfusion practices are associated with improved patient outcomes.
Patient blood management in cardiac surgery results in fewer transfusions and better outcome.
Costs and outcomes after cardiac surgery in patients refusing transfusion compared with those who do not: a case-matched study.
Blood transfusion and 30-day mortality in patients with coronary artery disease and anemia following noncardiac surgery.
Blood transfusion and infection after cardiac surgery.
Incidence and impact of a single-unit red blood cell transfusion: analysis of The Society of Thoracic Surgeons Database 2010-2019.
Transfusion of blood during cardiac surgery is associated with higher long-term mortality in low-risk patients.
Cardiac surgery in Jehovah's Witness patients: ten-year experience.
Results of open heart surgery in Jehovah's Witnesses patients.
Perioperative red blood cell transfusion is associated with adverse cardiovascular outcomes in heart valve surgery.
Blood product conservation is associated with improved outcomes and reduced costs after cardiac surgery.
Transfusion of blood components and postoperative infection in patients undergoing cardiac surgery.
Red blood cell transfusions impact pneumonia rates after coronary artery bypass grafting.
The effect of universal leukoreduction on postoperative infections and length of hospital stay in elective orthopedic and cardiac surgery.
Efficacy of red blood cell transfusion in the critically ill: a systematic review of the literature.
Outcomes from cardiac surgery in Jehovah's Witness patients: experience over twenty-one years.
Short term outcomes after cardiac surgery in a Jehovah's Witness population: an institutional experience.
Strategies and outcomes of cardiac surgery in Jehovah's Witnesses.
The impact of blood conservation on outcomes in cardiac surgery: is it safe and effective?
Forum for debate: safety of allogeneic blood transfusion alternatives in the surgical/critically ill patient. [Foro de debate: seguridad de las alternativas a la transfusión alogénica en el paciente quirúrgico y/o crítico.] [English, Spanish]
Increased mortality, postoperative morbidity, and cost after red blood cell transfusion in patients having cardiac surgery.
The association of perioperative transfusion with 30-day morbidity and mortality in patients undergoing major vascular surgery.
Relationships among haemoglobin level, packed red cell transfusion and clinical outcomes in patients after cardiac surgery.
Transfusion rate as a quality metric: is blood conservation a learnable skill?
Transfusion of 1 and 2 units of red blood cells is associated with increased morbidity and mortality.
Bloodless lung transplantation in Jehovah's Witnesses: impact on perioperative parameters and outcome compared with a matched control group.
Outcome of patients who refuse transfusion after cardiac surgery: a natural experiment with severe blood conservation.
Mid-term clinical outcomes in cardiac surgery of Jehovah's Witnesses.
Impact of a blood conservation program on 30-day morbidity and mortality: a cohort study.
Major bleeding, transfusions, and anemia: the deadly triad of cardiac surgery.
Cirugía cardiaca sin sangre en testigos de Jehová: resultados frente a grupo control. Bloodless cardiac surgery in Jehovah's Witnesses: outcomes compared with a control group. [Spanish, English]
Health care-associated infection after red blood cell transfusion: a systematic review and meta-analysis.
Impact of more restrictive blood transfusion strategies on clinical outcomes: a meta-analysis and systematic review.
Heart transplant in Jehovah's Witness patients: a case-control study.
Perioperative anemia and transfusions and late mortality in coronary artery bypass patients.
The safety and efficacy of "bloodless" cardiac surgery.
Comparisons of cardiac surgery outcomes in Jehovah's versus non-Jehovah's Witnesses.
Outcomes in cardiac surgery in 500 consecutive Jehovah's Witness patients: 21 year experience.
Outcome of Jehovah's Witnesses after adult cardiac surgery: systematic review and meta-analysis of comparative studies.
Transfusion strategies for acute upper gastrointestinal bleeding.
Perioperative blood transfusion is associated with worse clinical outcomes in resected lung cancer.
Bloodless cardiac surgery is associated with decreased morbidity and mortality.
Anemia, hemorrhage, and transfusion in percutaneous coronary intervention, acute coronary syndromes, and ST-segment elevation myocardial infarction.
Perioperative transfusion and long-term mortality after cardiac surgery: a meta-analysis.
Management of blood transfusion in aortic valve surgery: impact of a blood conservation strategy.
経済効果
Efficacy and cost-effectiveness of cell saver usage in the repair of thoracic aortic aneurysms and dissections.
Costs of excessive postoperative hemorrhage in cardiac surgery.
Risk-adjusted clinical outcomes in patients enrolled in a bloodless program.
Experience of a network of transfusion coordinators for blood conservation (Ontario Transfusion Coordinators [ONTraC]).
Clinical and economic outcomes associated with blood transfusions among elderly Americans following coronary artery bypass graft surgery requiring cardiopulmonary bypass.
Restrictive blood transfusion practices are associated with improved patient outcomes.
Blood conservation in cardiac surgery: the Virginia Commonwealth University (VCU) experience.
Patient blood management in cardiac surgery results in fewer transfusions and better outcome.
Costs and outcomes after cardiac surgery in patients refusing transfusion compared with those who do not: a case-matched study.
Comprehensive multimodality blood conservation: 100 consecutive CABG operations without transfusion.
Impact of a patient blood management monitoring and feedback programme on allogeneic blood transfusions and related costs.
Blood product conservation is associated with improved outcomes and reduced costs after cardiac surgery.
Safety, cost savings, simplicity back broader use of bloodless surgery.
Increased mortality, postoperative morbidity, and cost after red blood cell transfusion in patients having cardiac surgery.
Safety, efficacy, and cost of intraoperative cell salvage and autotransfusion after off-pump coronary artery bypass surgery: A randomized trial.
A cost-minimization analysis of the angio-seal vascular closure device following percutaneous coronary intervention.
Cost-effectiveness of transcatheter aortic valve replacement compared with surgical aortic valve replacement in high-risk patients with severe aortic stenosis: results of the PARTNER (Placement of Aortic Transcatheter Valves) trial (Cohort A).
Activity-based costs of blood transfusions in surgical patients at four hospitals.
Impact of bleeding-related complications and/or blood product transfusions on hospital costs in inpatient surgical patients.
A structured blood conservation programme reduces transfusions and costs in cardiac surgery.
A single dose of erythropoietin reduces perioperative transfusions in cardiac surgery: results of a prospective single-blind randomized controlled trial.
集学的,職種横断的な,個別化されたアプローチ
Hydroxyethylstarch as a replacement fluid in therapeutic plasma exchange for lupus nephritis in a Jehovah's Witness.
Successful management of a Jehovah's Witness with thrombotic thrombocytopenic purpura unwilling to be treated with therapeutic plasma exchange.
Bovine hemoglobin: a nontraditional approach to the management of acute anemia in a Jehovah's Witness patient with autoimmune hemolytic anemia.
The treatment of acute lymphoblastic leukemia in Jehovah's Witnesses and patients who cannot accept blood products.
The use of recombinant factor VIIa in a Jehovah's Witness with auto-immune thrombocytopenia and post-splenectomy haemorrhage.
Thrombotic thrombocytopenic purpura treated with vincristine in a Jehovah's Witness.
貧血の管理
Clinical data for intravenous iron - debunking the hype around hypersensitivity.
Expert consensus guidelines: intravenous iron uses, formulations, administration, and management of reactions.
自己免疫性溶血性貧血
Erythropoietin may improve anemia in patients with autoimmune hemolytic anemia associated with reticulocytopenia.
The changing spectrum of drug-induced immune hemolytic anemia.
Low-dose rituximab in adult patients with idiopathic autoimmune hemolytic anemia: clinical efficacy and biologic studies.
Autoimmune hemolytic anemia.
Low-dose rituximab and alemtuzumab combination therapy for patients with steroid-refractory autoimmune cytopenias.
A case of late-onset systemic lupus erythematosus with severe anemia.
High-dose cyclophosphamide for refractory autoimmune hemolytic anemia.
Anti-CD20 monoclonal antibody for the treatment of severe, immune-mediated, pure red cell aplasia and hemolytic anemia.
Rituximab for the treatment of refractory autoimmune hemolytic anemia in children.
鉄欠乏性貧血
Risks for anaphylaxis with intravenous iron formulations: a retrospective cohort study.
Canadian expert consensus: management of hypersensitivity reactions to intravenous iron in adults.
Intravenous iron in patients undergoing maintenance hemodialysis.
再生不良性貧血
Eltrombopag added to immunosuppression in severe aplastic anemia.
Eltrombopag added to standard immunosuppression for aplastic anemia.
好中球減少症の治療管理
Successful management of a Jehovah's Witness with thrombotic thrombocytopenic purpura unwilling to be treated with therapeutic plasma exchange.
Thrombopoietin-receptor agonists in haematological disorders: the Danish experience.
Use of intravenous gamma globulin for the treatment of autoimmune neutropenia of childhood and autoimmune hemolytic anemia.
Successful treatment of autoimmune neutropenia with recombinant human granulocyte-colony stimulating factor (R-metHuG-CSF).
The use of rhG-CSF in chronic autoimmune neutropenia: reversal of autoimmune phenomena, a case history.
B-cell depletion for autoimmune thrombocytopenia and autoimmune hemolytic anemia in pediatric systemic lupus erythematosus.
Successful treatment of refractory immune thrombocytopenia with anti-CD20 antibody in a patient with systemic lupus erythematosus.
Danazol in the treatment of systemic lupus erythematosus: a qualitative systematic review.
Thrombotic thrombocytopenic purpura treated with vincristine in a Jehovah's Witness.
血小板減少症の治療管理
Effect of avatrombopag in the management of severe and refractory chemotherapy-induced thrombocytopenia (CIT) in patients with solid tumors.
Long-term follow-up for up to 5 years on the risk of leukaemic progression in thrombocytopenic patients with lower-risk myelodysplastic syndromes treated with romiplostim or placebo in a randomised double-blind trial.
特発性血小板減少性紫斑病(免疫性血小板減少症・ITP)
Adults with immune thrombocytopenia who switched to avatrombopag following prior treatment with eltrombopag or romiplostim: a multicentre US study.
Efficacy of high-dose methylprednisolone as a first-line therapy in adult patients with idiopathic thrombocytopenic purpura.
Systematic review: efficacy and safety of rituximab for adults with idiopathic thrombocytopenic purpura.
Perioperative oral eltrombopag versus intravenous immunoglobulin in patients with immune thrombocytopenia: a non-inferiority, multicentre, randomised trial.
A prospective, randomized trial of high-dose intravenous immune globulin G therapy, oral prednisone therapy, and no therapy in childhood acute immune thrombocytopenic purpura.
High-dose dexamethasone as a first- and second-line treatment of idiopathic thrombocytopenic purpura in adults.
Guidelines for the investigation and management of idiopathic thrombocytopenic purpura in adults, children and in pregnancy.
IVMP+IVIG raises platelet counts faster than IVIG alone: results of a randomized, blinded trial in childhood ITP.
Initial treatment of immune thrombocytopenic purpura with high-dose dexamethasone.
How I treat immune thrombocytopenia: the choice between splenectomy or a medical therapy as a second-line treatment.
Use of eltrombopag for secondary immune thrombocytopenia in clinical practice.
Splenectomy for adult patients with idiopathic thrombocytopenic purpura: a systematic review to assess long-term platelet count responses, prediction of response, and surgical complications.
Romiplostim or standard of care in patients with immune thrombocytopenia.
Therapy with high-dose dexamethasone (HD-DXM) in previously untreated patients affected by idiopathic thrombocytopenic purpura: a GIMEMA experience.
The American Society of Hematology 2011 evidence-based practice guideline for immune thrombocytopenia.
American Society of Hematology 2019 guidelines for immune thrombocytopenia.
International consensus report on the investigation and management of primary immune thrombocytopenia.
Intravenous anti-D treatment of immune thrombocytopenic purpura: experience in 272 patients.
血栓性血小板減少性紫斑病(TTP)
Successful management of a Jehovah's Witness with thrombotic thrombocytopenic purpura unwilling to be treated with therapeutic plasma exchange.
Assessment and monitoring of patients with immune-mediated thrombotic thrombocytopenic purpura (iTTP): strategies to improve outcomes.
Therapeutic modalities in thrombotic thrombocytopenic purpura management among Jehovah's Witness patients: a review of reported cases.
Thrombotic thrombocytopenic purpura treated with vincristine in a Jehovah's Witness.
止血の管理と最適化
Recombinant factor VIIa for refractive haemorrhage in autoimmune idiopathic thrombocytopenic purpura.
Effective hemostasis with rFVIIa treatment in two patients with severe thrombocytopenia and life-threatening hemorrhage.
Life-threatening retro-pharyngeal bleed in a case of systemic lupus erythematosus--an uncommon but important evil of a common disease.
Experiences with recombinant FVIIa in the emergency treatment of patients with autoimmune thrombocytopenia: a review of the literature.
The use of recombinant factor VIIa in a Jehovah's Witness with auto-immune thrombocytopenia and post-splenectomy haemorrhage.
遺伝子組換え活性型血液凝固第Ⅶ因子製剤(rFVIIa)
代替的な置換液を使用する血漿交換療法
Starch and albumin mixture as replacement fluid in therapeutic plasma exchange is safe and effective.
Hydroxyethylstarch as a replacement fluid in therapeutic plasma exchange for lupus nephritis in a Jehovah's Witness.
Treatment of thrombotic thrombocytopenic purpura with the cryosupernatant fraction of plasma: a case report and review of the literature.
Pentastarch as partial replacement fluid for therapeutic plasma exchange: effect on plasma proteins, adverse events during treatment, and serum ionized calcium.
Immunoadsorption in Guillain-Barré syndrome and myasthenia gravis.
Replacement fluids in plasmapheresis: cross-over comparative study.
Tryptophan-immobilized column-based immunoadsorption as the choice method for plasmapheresis in Guillain-Barré syndrome.
Pentastarch instead of albumin as replacement fluid for therapeutic plasma exchange. The Canadian Apheresis Group.
医原性貧血を避けるための採血量の制限
Phlebotomy—a minimalist approach.
The use of a blood conservation device to reduce red blood cell transfusion requirements: a before and after study.
Reduction of blood loss from laboratory testing in hospitalized adult patients using small-volume (pediatric) tubes.
Reducing adult phlebotomy blood loss with the use of pediatric-sized blood collection tubes.
等容量性貧血の許容
A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care.
Feasibility of a restrictive red-cell transfusion policy for patients treated with intensive chemotherapy for acute myeloid leukaemia.
Transfusion strategies for patients in pediatric intensive care units.
Red blood cell transfusion in non-bleeding critically ill patients with moderate anemia: is there a benefit?
A restrictive platelet transfusion policy allowing long-term support of outpatients with severe aplastic anemia.
Anemia and blood transfusion in critically ill patients.
臨床成績
Long-term follow-up for up to 5 years on the risk of leukaemic progression in thrombocytopenic patients with lower-risk myelodysplastic syndromes treated with romiplostim or placebo in a randomised double-blind trial.
Prospective study of erythropoietin use on quality of life and cost effectiveness in acute myeloid leukemia and allogeneic hematopoietic stem cell transplantation patients.
経済効果
Impact of a patient blood management monitoring and feedback programme on allogeneic blood transfusions and related costs.
Cost-effectiveness of eltrombopag vs intravenous immunoglobulin for the perioperative management of immune thrombocytopenia.
経済的評価
The cost of blood transfusion in Western Europe as estimated from six studies.
Multimodal patient blood management program based on a three-pillar strategy: a systematic review and meta-analysis.
Cost estimate of platelet transfusion in the United States for patients with chronic liver disease and associated thrombocytopenia undergoing elective procedures.
Blood management: a primer for clinicians.
Peri-operative blood transfusion increases length of hospital stay and number of postoperative complications in non-cardiac surgical patients.
Health and economic outcomes associated with uncontrolled surgical bleeding: a retrospective analysis of the premier perspectives database.
Estimating the epidemiological and economic impact of implementing preoperative anaemia measures in the German healthcare system: the health economic footprint of patient blood management.
Implementation of a patient blood management program based on a low-income country-adapted clinical decision support system.
Greater than sevenfold return on investment for a comprehensive patient blood management program with equivalent or improved outcomes.
Methods of bloodless care, clinical outcomes, and costs for adult patients who decline allogeneic transfusions.
Implementing a health system-wide patient blood management program with a clinical community approach.
Risk-adjusted clinical outcomes in patients enrolled in a bloodless program.
The ONTraC Ontario program in blood conservation.
Restrictive blood transfusion practices are associated with improved patient outcomes.
The contemporary economics of transfusions.
Improving red cell transfusion in the elective surgical setting: an improvement collaborative with evaluation.
Economic considerations on transfusion medicine and patient blood management.
Activity-based cost of platelet transfusions in medical and surgical inpatients at a US hospital.
The cost of one unit blood transfusion components and cost-effectiveness analysis results of transfusion improvement program.
Transfusing wisely: clinical decision support improves blood transfusion practices.
Impact of a patient blood management monitoring and feedback programme on allogeneic blood transfusions and related costs.
A model-based cost-effectiveness analysis of Patient Blood Management.
Improved outcomes and reduced costs associated with a health-system-wide patient blood management program: a retrospective observational study in four major adult tertiary-care hospitals.
Clinical, economical and safety impact of ferric carboxymaltose use in Patient Blood Management programme in Portuguese National Health Service hospitals.
Risks, benefits, alternatives and indications of allogenic blood transfusions.
Adequacy of physician documentation and correlation with assessment of transfusion appropriateness: a follow-up study in the setting of prospective audits and patient blood management.
The costs of producing a unit of blood in Zimbabwe.
Evaluation of a multilevel laboratory stewardship intervention targeted to cardiac and thoracic surgical services at an academic medical center.
A contemporary analysis of phlebotomy and iatrogenic anemia development throughout hospitalization in critically ill adults.
The cost of blood: a study of the total cost of red blood cell transfusion in patients with β-thalassemia using time-driven activity-based costing.
Associations between preoperative anaemia and hospital costs following major abdominal surgery: cohort study.
Frequency and outcomes of blood products transfusion across procedures and clinical conditions warranting inpatient care: an analysis of the 2004 healthcare cost and utilization project nationwide inpatient sample database.
ONTraC: A 20-year history of a successfully coordinated provincewide Patient Blood Management Program: lessons learned and goals achieved.
Effective reduction of blood product use in a community teaching hospital: when less is more.
Health care-associated infection after red blood cell transfusion: a systematic review and meta-analysis.
Perioperative inappropriate red blood cell transfusions significantly increase total costs in elective surgical patients, representing an important economic burden for hospitals.
Activity-based costs of blood transfusions in surgical patients at four hospitals.
Activity-based costs of plasma transfusions in medical and surgical inpatients at a US hospital.
Financial and clinical outcomes associated with surgical bleeding complications.
Accurate costs of blood transfusion: a microcosting of administering blood products in the United Kingdom National Health Service.
Impact of bleeding-related complications and/or blood product transfusions on hospital costs in inpatient surgical patients.
Cost-effectiveness and budget impact of comprehensive anemia management, the first pillar of patient blood management, on the Turkish healthcare system.
Costs to hospitals of acquiring and processing blood in the US: a survey of hospital-based blood banks and transfusion services.
Increased hospital costs associated with red blood cell transfusion.
Associations of a preoperative anemia and suboptimal iron stores screening and management clinic in colorectal surgery with hospital cost, reimbursement, and length of stay: a net cost analysis.
Implementation of a comprehensive patient blood management program for hospitalized patients at a large united states medical center.
血液回収法
The use of blood cell salvage in acetabular fracture internal fixation surgery.
The economic benefits of cell salvage in obstetric haemorrhage.
Cost-effectiveness of cell salvage and alternative methods of minimising perioperative allogeneic blood transfusion: a systematic review and economic model.
Clinical utility of autologous salvaged blood: a review.
Impact of a patient blood management program and an outpatient anemia management protocol on red cell transfusions in oncology inpatients and outpatients.
Intraoperative cell salvage versus allogeneic transfusion during abdominal aortic surgery: clinical and financial outcomes.
Safety, cost savings, simplicity back broader use of bloodless surgery.
Clinical efficacy and cost effectiveness of intraoperative cell salvage in pelvic trauma surgery.
A prospective study investigating the cost effectiveness of intraoperative blood salvage during liver transplantation.
Intra-operative cell salvage in South Africa: feasible, beneficial and economical.
Intraoperative red blood cell salvage and autologous transfusion during open radical retropubic prostatectomy: a cost-benefit analysis.
Cost benefits of intraoperative cell salvage in radical cystectomy.
The volume of returned red blood cells in a large blood salvage program: where does it all go?
An economic analysis of costs associated with development of a cell salvage program.
胸部心臓血管外科
The impact of a multidisciplinary blood conservation protocol on patient outcomes and cost after cardiac surgery.
Costs of bleeds relating to acute coronary syndrome therapies.
Preoperative anemia management program reduces blood transfusion in elective cardiac surgical patients, improving outcomes and decreasing hospital length of stay.
Recombinant factor VIIa (NovoSeven RT) use in high risk cardiac surgery.
Experience of a network of transfusion coordinators for blood conservation (Ontario Transfusion Coordinators [ONTraC]).
Clinical effects of reverting from leukoreduced to nonleukoreduced blood in cardiac surgery.
Clinical and economic outcomes associated with blood transfusions among elderly Americans following coronary artery bypass graft surgery requiring cardiopulmonary bypass.
Treatment of refractory bleeding after cardiac operations with low-dose recombinant activated factor VII (NovoSeven®): a propensity score analysis.
The clinical and economic burden of significant bleeding during lung resection surgery: a retrospective matched cohort analysis of real-world data.
How do we develop and implement a preoperative anemia clinic designed to improve perioperative outcomes and reduce cost?
Comprehensive multimodality blood conservation: 100 consecutive CABG operations without transfusion.
Positive impact of retrograde autologous priming in adult patients undergoing cardiac surgery: a randomized clinical trial.
Cost effectiveness of implementing ESC guidelines for treatment of iron deficiency in heart failure in the Nordic countries.
Economic evaluation of national patient blood management clinical guidelines in cardiac surgery.
Blood product conservation is associated with improved outcomes and reduced costs after cardiac surgery.
Intraoperative cell salvage versus allogeneic transfusion during abdominal aortic surgery: clinical and financial outcomes.
Evaluation of a multilevel laboratory stewardship intervention targeted to cardiac and thoracic surgical services at an academic medical center.
Increased mortality, postoperative morbidity, and cost after red blood cell transfusion in patients having cardiac surgery.
Safety, efficacy, and cost of intraoperative cell salvage and autotransfusion after off-pump coronary artery bypass surgery: A randomized trial.
Bleeding after cardiac surgery is associated with an increase in the total cost of the hospital stay.
Protocol guided bleeding management improves cardiac surgery patient outcomes.
Association between bleeding, blood transfusion, and costs among patients with non-ST-segment elevation acute coronary syndromes.
Mortality, length of stay, and cost implications of procedural bleeding after percutaneous interventions using large-bore catheters.
Blood transfusion is associated with increased resource utilisation, morbidity and mortality in cardiac surgery.
Hospital economic impact from hemostatic matrix usage in cardiac surgery.
A structured blood conservation programme reduces transfusions and costs in cardiac surgery.
Administration of recombinant activated factor VII in the intensive care unit after complex cardiovascular surgery: clinical and economic outcomes.
Safety, efficacy, and cost-effectiveness of intraoperative blood salvage in OPCABG with different amount of bleeding: a single-center, retrospective study.
Management of blood transfusion in aortic valve surgery: impact of a blood conservation strategy.
Cost of bleeding in trauma and complex cardiac surgery.
集中治療
Tumescent technique for burn wound debridement: a cost effective method of reducing transfusion requirements.
Cost-effectiveness of recombinant human erythropoietin for reducing red blood cells transfusions in critically ill patients.
A contemporary analysis of phlebotomy and iatrogenic anemia development throughout hospitalization in critically ill adults.
Anemia, bleeding, and blood transfusion in the intensive care unit: causes, risks, costs, and new strategies.
Non-essential blood tests in the intensive care unit: a prospective observational study. [Tests sanguins non essentiels á l’unité de soins intensifs : une étude observationnelle prospective.]
The best strategy for red blood cell transfusion in severe burn patients, restrictive or liberal: a randomized controlled trial.
Effect of a restrictive transfusion strategy on transfusion-attributable severe acute complications and costs in the US ICUs: a model simulation.
血液内科
Early intravenous iron administration in the Emergency Department reduces red blood cell unit transfusion, hospitalisation, re-transfusion, length of stay and costs.
Hemoglobin level at initiation of darbepoetin alfa: impact on need for transfusion and associated costs in chemotherapy-induced anemia treatment in Europe.
Restrictive blood transfusion practices are associated with improved patient outcomes.
Modeling the cost-effectiveness of prothrombin complex concentrate compared with fresh frozen plasma in emergency warfarin reversal in the United Kingdom.
Recombinant activated factor VII use in critically ill infants with active hemorrhage.
Cost-effectiveness of eltrombopag vs intravenous immunoglobulin for the perioperative management of immune thrombocytopenia.
Blood use in patients receiving intensive chemotherapy for acute leukemia or hematopoietic stem cell transplantation: the impact of a health system-wide patient blood management program.
Impact of a conservative red blood cell transfusion strategy in children undergoing hematopoietic stem cell transplantation.
The cost of blood: a study of the total cost of red blood cell transfusion in patients with β-thalassemia using time-driven activity-based costing.
Implementation of a patient blood management monitoring and feedback program significantly reduces transfusions and costs.
Prospective study of erythropoietin use on quality of life and cost effectiveness in acute myeloid leukemia and allogeneic hematopoietic stem cell transplantation patients.
Budget impact analysis on erythropoiesis-stimulating agents use for the management of chemotherapy-induced anaemia in Greece.
Outcomes of erythropoiesis-stimulating agents in cancer patients with chemotherapy-induced anemia.
Comparative net cost impact of the utilization of romiplostim and intravenous immunoglobulin for the treatment of patients with immune thrombocytopenia in Québec, Canada.
Blood transfusion versus hydroxyurea in beta-thalassemia in Iran: a cost-effectiveness study.
The burden of blood transfusion: a utilization and economic analysis--a pilot study in patients with chemotherapy-induced anemia (CIA).
Prospective monitoring of plasma and platelet transfusions in a large teaching hospital results in significant cost reduction.
Cost-effectiveness of hydroxyurea in reducing the frequency of pain episodes and hospitalization in pediatric sickle cell disease.
Increased hospital costs associated with red blood cell transfusion.
オンコロジー
Should intravenous iron be the standard of care in oncology?
The cost-effectiveness of treatment with erythropoietin compared to red blood cell transfusions for patients with chemotherapy induced anaemia: a Markov model.
Cost of outpatient blood transfusion in cancer patients.
Implementation of a patient blood management monitoring and feedback program significantly reduces transfusions and costs.
整形外科
Topical (intra-articular) tranexamic acid reduces blood loss and transfusion rates following total hip replacement: a randomized controlled trial (TRANX-H).
Topical (intra-articular) tranexamic acid reduces blood loss and transfusion rates following total knee replacement: a randomized controlled trial (TRANX-K).
Multimodal patient blood management program based on a three-pillar strategy: a systematic review and meta-analysis.
Effect of epsilon aminocaproic acid on red-cell transfusion requirements in major spinal surgery.
The combined use of oral and topical tranexamic acid is a safe, efficient and low-cost method in reducing blood loss and transfusion rates in total knee arthroplasty.
An evaluation of the use of topical tranexamic acid in total knee arthroplasty.
Hemostatic techniques reduce hospital stay following multilevel posterior cervical spine surgery.
Comparing ε-aminocaproic acid and tranexamic acid in reducing postoperative transfusions in total knee arthroplasty.
Process improvement project using tranexamic acid is cost-effective in reducing blood loss and transfusions after total hip and total knee arthroplasty.
Comparing cost, efficacy, and safety of intravenous and topical tranexamic acid in total hip and knee arthroplasty.
Clinical and cost effectiveness-related aspects of retransfusion in total hip and knee arthroplasty.
The safety, efficacy, and cost-effectiveness of intraoperative cell salvage in metastatic spine tumor surgery.
Effect of tranexamic acid on transfusion rates following total joint arthroplasty: a cost and comparative effectiveness analysis.
Saving blood and reducing costs: updating blood transfusion practice in lower limb arthroplasty.
Methods of bloodless care, clinical outcomes, and costs for adult patients who decline allogeneic transfusions.
Radiofrequency bipolar hemostatic sealer reduces blood loss, transfusion requirements, and cost for patients undergoing multilevel spinal fusion surgery: a case control study.
Tranexamic acid decreases blood loss after total shoulder arthroplasty.
Restrictive versus liberal red blood cell transfusion strategy after hip surgery: a decision model analysis of healthcare costs.
Economic impact of tranexamic acid in healthy patients undergoing primary total hip and knee arthroplasty.
Cell saver for adult spinal deformity surgery reduces cost.
Tranexamic acid in patients with cancer undergoing endoprosthetic reconstruction: a cost analysis.
Topically applied epsilon-aminocaproic acid reduces blood loss and length of hospital stay after total knee arthroplasty.
Does tranexamic acid reduce blood transfusion cost for primary total hip arthroplasty? A case-control study.
Tranexamic acid reduces blood loss and financial cost in primary total hip and knee replacement surgery.
Using tranexamic acid for an additional 24 hours postoperatively in hip and knee arthroplasty saves money: a cost analysis from the TRAC-24 randomized control trial.
Effect of a patient blood management programme on preoperative anaemia, transfusion rate, and outcome after primary hip or knee arthroplasty: a quality improvement cycle.
Improved outcomes and reduced costs associated with a health-system-wide patient blood management program: a retrospective observational study in four major adult tertiary-care hospitals.
Transfusion strategy for primary knee and hip arthroplasty: impact of an algorithm to lower transfusion rates and hospital costs.
A safe, simple and cost-effective protocol for blood transfusion in primary total knee replacement.
Are allogeneic transfusions decreasing in total knee arthroplasty patients? National Inpatient Sample 2009-2013.
Transfusion cost savings with tranexamic acid in primary total knee arthroplasty from 2009 to 2012.
The cost of post-operative shed blood salvage after total knee arthroplasty: an analysis of 1,093 consecutive procedures.
Cost of post-operative intravenous iron therapy in total lower limb arthroplasty: a retrospective, matched cohort study.
Effects of intravenous iron combined with low-dose recombinant human erythropoietin on transfusion requirements in iron-deficient patients undergoing bilateral total knee replacement arthroplasty.
Comparative risk of transfusion and incremental total hospitalization cost for primary unilateral, bilateral, and revision total knee arthroplasty procedures.
The efficacy, safety, and cost-effectives of combined administration of intravenous and local tranexamic acid in the management of patients undergoing primary total hip arthroplasty: a prospective, blinded and randomized clinical study.
Blood loss control with two doses of tranexamic acid in a multimodal protocol for total knee arthroplasty.
ONTraC: A 20-year history of a successfully coordinated provincewide Patient Blood Management Program: lessons learned and goals achieved.
Cost analysis of tranexamic acid in anemic total joint arthroplasty patients.
Intravenous administration of tranexamic acid effectively reduces blood loss in primary total knee arthroplasty in a 610-patient consecutive case series.
Tranexamic acid use and postoperative outcomes in patients undergoing total hip or knee arthroplasty in the United States: retrospective analysis of effectiveness and safety.
One intraoperative dose of tranexamic acid for patients having primary hip or knee arthroplasty.
Pharmacologic hemostatic agents in total joint arthroplasty--a cost-effectiveness analysis.
Efficacy and cost-effectiveness of cell saving blood autotransfusion in adult lumbar fusion.
Improved patient blood management and cost saving in hip replacement surgery through the implementation of pre-operative Sucrosomial® iron supplementation: a quality improvement assessment study.
Use of a fibrin sealant within a blood-saving protocol in patients undergoing revision hip arthroplasty: effects on post-operative blood transfusion and healthcare-related cost analysis.
Use of tranexamic acid is a cost effective method in preventing blood loss during and after total knee replacement.
Increased hospital costs associated with red blood cell transfusion.
Cost benefit analysis of topical tranexamic acid in primary total hip and knee arthroplasty.
Clinical and budget impact of treating preoperative anemia in major orthopedic surgery--a retrospective observational study.
Blood loss and cost-effectiveness of oral vs intravenous tranexamic acid in primary total hip arthroplasty: a randomized clinical trial.
Incidence and costs of bleeding-related complications in French hospitals following surgery for various diagnoses.
The effectiveness of reinfusion after total knee replacement. A prospective randomised controlled study.
Efficacy and safety of tranexamic acid in total hip replacement: a PRISMA-compliant meta-analysis of 25 randomized controlled trials.
泌尿器科
Preoperative recombinant human erythropoietin injection versus preoperative autologous blood donation in patients undergoing radical retropubic prostatectomy.
The ONTraC Ontario program in blood conservation.
Presurgical hyper-volaemic haemodilution for saving blood transfusion?
Restrictive transfusion in radical cystectomy is safe.
Blood loss associated with radical cystectomy: a prospective, randomized study comparing Impact LigaSure vs. stapling device.
Intraoperative red blood cell salvage and autologous transfusion during open radical retropubic prostatectomy: a cost-benefit analysis.
Cost benefits of intraoperative cell salvage in radical cystectomy.
外傷
The use of blood cell salvage in acetabular fracture internal fixation surgery.
Intraoperative blood salvage in penetrating abdominal trauma: a randomised, controlled trial.
Cost-effectiveness analysis of administering tranexamic acid to bleeding trauma patients using evidence from the CRASH-2 trial.
Tranexamic acid and reduction of blood transfusion in lower limb trauma surgery: a randomized controlled study.
Implementation of a patient blood management monitoring and feedback program significantly reduces transfusions and costs.
Clinical efficacy and cost effectiveness of intraoperative cell salvage in pelvic trauma surgery.
Use of tranexamic acid in trauma patients: an analysis of cost-effectiveness for use in Brazil.
A fast-track anaemia clinic in the Emergency Department: cost-analysis of intravenous iron administration for treating iron-deficiency anaemia.
The CRASH-2 trial: a randomised controlled trial and economic evaluation of the effects of tranexamic acid on death, vascular occlusive events and transfusion requirement in bleeding trauma patients.
Intra-operative cell salvage in South Africa: feasible, beneficial and economical.
Reversal of coagulopathy in critically ill patients with traumatic brain injury: recombinant factor VIIa is more cost-effective than plasma.
Cost of bleeding in trauma and complex cardiac surgery.
口腔顎顔面外科
Acute perioperative normovolaemic haemodilution in major maxillofacial surgery.
一般外科
Cost-effectiveness of cell salvage and alternative methods of minimising perioperative allogeneic blood transfusion: a systematic review and economic model.
Cost-effectiveness of the non-pneumatic anti-shock garment (NASG): evidence from a cluster randomized controlled trial in Zambia and Zimbabwe.
Estimating the epidemiological and economic impact of implementing preoperative anaemia measures in the German healthcare system: the health economic footprint of patient blood management.
Implementation of a patient blood management program based on a low-income country-adapted clinical decision support system.
Potential economic impact of using a restrictive transfusion trigger among patients undergoing major abdominal surgery.
Methods of bloodless care, clinical outcomes, and costs for adult patients who decline allogeneic transfusions.
Clinical utility of autologous salvaged blood: a review.
Pediatric red blood cell transfusions increase resource use.
Giving tranexamic acid to reduce surgical bleeding in sub-Saharan Africa: an economic evaluation.
Effects of standardized acute normovolemic hemodilution on intraoperative allogeneic blood transfusion in patients undergoing major maxillofacial surgery.
Transfusion free surgery: single institution experience of 27 consecutive liver transplants in Jehovah's Witnesses.
A decision model and cost analysis of intra-operative cell salvage during hepatic resection.
Implementation of a patient blood management monitoring and feedback program significantly reduces transfusions and costs.
Health economics of patient blood management: a cost-benefit analysis based on a meta-analysis.
Use of a saline-coupled bipolar sealer open liver resection for hepatic malignancy: medical resource use and costs.
Cost-effectiveness analysis of plasma versus recombinant factor VIIa for placing intracranial pressure monitors in pretransplant patients with acute liver failure.
A prospective study investigating the cost effectiveness of intraoperative blood salvage during liver transplantation.
Bloodless donor hepatectomy in living donor liver transplantation: counterclockwise liver rotation and early hanging maneuver.
Perioperative inappropriate red blood cell transfusions significantly increase total costs in elective surgical patients, representing an important economic burden for hospitals.
Timing of factor VIIa in liver transplantation impacts cost and clinical outcomes.
The beneficial effects of minimizing blood loss in pancreatoduodenectomy.
Rotational thromboelastometry or conventional coagulation tests in liver transplantation: comparing blood loss, transfusions, and cost.
Intra-operative cell salvage in South Africa: feasible, beneficial and economical.
Standardization and streamlining of a pancreas surgery practice improves outcomes and resource utilization: a single institution's 20-year experience.
Economic analysis of an intraoperative cell salvage service.
Randomized trial comparing packed red cell blood transfusion with and without leukocyte depletion for gastrointestinal surgery.
Increased hospital costs associated with red blood cell transfusion.
Associations of a preoperative anemia and suboptimal iron stores screening and management clinic in colorectal surgery with hospital cost, reimbursement, and length of stay: a net cost analysis.
Screening and treating pre-operative anaemia and suboptimal iron stores in elective colorectal surgery: a cost effectiveness analysis.
Perioperative parenteral tranexamic acid in liver tumor resection: a prospective randomized trial toward a "blood transfusion"-free hepatectomy.
Secure, low-cost technique for laparoscopic hepatic resection using the crush-clamp method with a bipolar sealer.
産科
Methods of bloodless care, clinical outcomes, and costs for adult patients who decline allogeneic transfusions.
Tranexamic acid for treatment of women with post-partum haemorrhage in Nigeria and Pakistan: a cost-effectiveness analysis of data from the WOMAN trial.
Cost-effectiveness analysis of intraoperative cell salvage for obstetric hemorrhage.
Intra-operative cell salvage in South Africa: feasible, beneficial and economical.
Obstetric intra-operative cell salvage: a review of an established cell salvage service with 1170 re-infused cases.
新生児科
Recombinant activated factor VII use in critically ill infants with active hemorrhage.
A comparison of costs associated with endoscope-assisted craniectomy versus open cranial vault repair for infants with sagittal synostosis.
集学的,職種横断的な,計画的で個別化されたアプローチ
Stress ulcer prophylaxis during invasive mechanical ventilation.
Optimizing outcomes in the Jehovah's Witness following trauma: special management concerns for a unique population.
Extremely severe anaemia in a critically ill patient who declined a blood transfusion.
Management strategies for perioperative anaemia in the severely burn-injured Jehovah's Witness patients who decline a blood transfusion: a systematic review with illustrative case reports.
Transfusion-free treatment strategies for acute anemia in critical care.
Clinical strategies in the medical care of Jehovah's Witnesses.
血小板減少症の治療管理
Alternatives to allogeneic platelet transfusion.
Romiplostim for the emergency management of severe immune thrombocytopenia with intracerebral hemorrhage.
Correction of subclinical coagulation disorders before percutaneous dilatational tracheotomy.
抗凝固療法の管理と中和
Reversal of antithrombotic agents.
Hemodialysis for the treatment of dabigatran-associated bleeding: a case report and systematic review.
Full study report of andexanet alfa for bleeding associated with factor Xa inhibitors.
Andexanet alfa for acute major bleeding associated with factor Xa inhibitors.
Reversal of rivaroxaban and dabigatran by prothrombin complex concentrate: a randomized, placebo-controlled, crossover study in healthy subjects.
Four-factor prothrombin complex concentrate versus plasma for rapid vitamin K antagonist reversal in patients needing urgent surgical or invasive interventions: a phase 3b, open-label, non-inferiority, randomised trial.
Anticoagulant and antiplatelet medications encountered in emergency surgery patients: a review of reversal strategies.
Guidance on the emergent reversal of oral thrombin and factor Xa inhibitors.
Bleeding risk and reversal strategies for old and new anticoagulants and antiplatelet agents.
Emergency reversal of warfarin anticoagulation.
Effect of non-specific reversal agents on anticoagulant activity of dabigatran and rivaroxaban: a randomised crossover ex vivo study in healthy volunteers.
Prothrombin complex concentrate (Beriplex P/N) for emergency anticoagulation reversal: a prospective multinational clinical trial.
Management of direct factor Xa inhibitor-related major bleeding with prothrombin complex concentrate: a meta-analysis.
Idarucizumab for dabigatran reversal.
Idarucizumab for dabigatran reversal - full cohort analysis.
Desmopressin antagonizes the in vitro platelet dysfunction induced by GPIIb/IIIa inhibitors and aspirin.
Role of agents for reversing the effects of target-specific oral anticoagulants.
Reversal of clopidogrel-induced bleeding with rFVIIa in healthy subjects: a randomized, placebo-controlled, double-blind, exploratory study.
2017 ACC expert consensus decision pathway on management of bleeding in patients on oral anticoagulants: a report of the American College of Cardiology Task Force on Expert Consensus Decision Pathways.
Rapid warfarin reversal in the setting of intracranial hemorrhage: a comparison of plasma, recombinant activated factor VII, and prothrombin complex concentrate.
Reversal of warfarin-induced hemorrhage in the emergency department.
医原性貧血を避けるための採血量の制限
The increasing burden of phlebotomy in the development of anaemia and need for blood transfusion amongst trauma patients.
Anemia, transfusion, and phlebotomy practices in critically ill patients with prolonged ICU length of stay: a cohort study.
Savoring every drop—vampire or mosquito?
Highly conservative phlebotomy in adult intensive care--a prospective randomized controlled trial.
Prehospital intravenous fluid administration is associated with higher mortality in trauma patients: a National Trauma Data Bank analysis.
Blood loss from laboratory testing, anemia, and red blood cell transfusion in the intensive care unit: a retrospective study.
Hospital-acquired anemia: prevalence, outcomes, and healthcare implications.
Twenty-five million liters of blood into the sewer.
Anemia, bleeding, and blood transfusion in the intensive care unit: causes, risks, costs, and new strategies.
The use of a blood conservation device to reduce red blood cell transfusion requirements: a before and after study.
'ICU vampirism' - time for judicious blood draws in critically ill patients.
A simple "blood-saving bundle" reduces diagnostic blood loss and the transfusion rate in mechanically ventilated patients.
Reduction of blood loss from laboratory testing in hospitalized adult patients using small-volume (pediatric) tubes.
Effects of price information on test ordering in an intensive care unit.
A narrative review on hospital-acquired anemia: keeping blood where it belongs.
Drug-induced anemia and other red cell disorders: a guide in the age of polypharmacy.
Iatrogenic anemia (can it be prevented?).
Blood conservation strategies to reduce the need for red blood cell transfusion in critically ill patients.
止血の管理と最適化
Coagulopathy caused by vitamin K deficiency in critically ill, hospitalized patients.
Salvage use of activated recombinant factor VII in the management of refractory bleeding following cardiac surgery.
The treatment of bleeding is to stop the bleeding! Treatment of trauma-related hemorrhage.
Effects of tranexamic acid on death, disability, vascular occlusive events and other morbidities in patients with acute traumatic brain injury (CRASH-3): a randomised, placebo-controlled trial.
Desmopressin reduces transfusion needs after surgery: a meta-analysis of randomized clinical trials.
Vitamin K deficiency and D-dimer levels in the intensive care unit: a prospective cohort study.
Alternatives to allogeneic platelet transfusion.
The use of fibrin sealant in burn operations.
The early use of fibrinogen, prothrombin complex concentrate, and recombinant-activated factor VIIa in massive bleeding.
Tranexamic acid: less bleeding and less thrombosis?
A Jehovah's Witness with complex abdominal trauma and coagulopathy: use of factor VII and a review of the literature.
Results of the control trial: efficacy and safety of recombinant activated factor VII in the management of refractory traumatic hemorrhage.
Use of recombinant activated factor VII in patients without hemophilia: a meta-analysis of randomized control trials.
Rescue treatment with recombinant factor VIIa is effective in patients with life-threatening bleedings secondary to major wound excision: a report of four cases.
Use of recombinant activated factor VII in Jehovah's Witness patients with critical bleeding.
Plasma fibrinogen level on admission to the intensive care unit is a powerful predictor of postoperative bleeding after cardiac surgery with cardiopulmonary bypass.
Combination of recombinant factor VIIa and fibrinogen corrects clot formation in primary immune thrombocytopenia at very low platelet counts.
Use of fibrin sealant in thermal injury.
Recombinant factor VIIa in trauma patients with the 'triad of death.'
Effects of intravenous tranexamic acid on bleeding during burn surgery: a double-blinded randomized clinical trial.
Tranexamic acid for reducing mortality in emergency and urgent surgery.
The importance of early treatment with tranexamic acid in bleeding trauma patients: an exploratory analysis of the CRASH-2 randomised controlled trial.
Antifibrinolytic drugs for acute traumatic injury.
Perioperative treatment algorithm for bleeding burn patients reduces allogeneic blood product requirements.
Low-dose recombinant factor VIIa for trauma patients with coagulopathy.
Desmopressin in treatment of haematological disorders and in prevention of surgical bleeding.
Treatment of excessive bleeding in Jehovah's Witness patients after cardiac surgery with recombinant factor VIIa (Novoseven®).
Use of tranexamic acid to reduce bleeding in burns surgery.
Tranexamic acid reduced blood transfusions in acute burn surgery: a retrospective case-controlled trial.
Strategies to reduce the use of blood products: a European perspective.
Transfusion in trauma: why and how should we change our current practice?
Viscoelastic point-of-care testing to assist with the diagnosis, management and monitoring of haemostasis: a systematic review and cost-effectiveness analysis.
抗線溶薬
遺伝子組換え活性型血液凝固第Ⅶ因子製剤(rFVIIa)
濃縮凝固因子製剤
デスモプレシン
他の薬剤
局所止血剤
外科的出血か凝固異常による出血かを同定するための血液粘弾性試験
体温管理(低体温の回避)
Coagulation management in multiple trauma: a systematic review.
Should normothermia be restored and maintained during resuscitation after trauma and hemorrhage?
Body temperature alterations in the critically ill.
The effects of mild perioperative hypothermia on blood loss and transfusion requirement.
Hypothermic coagulopathy in trauma: effect of varying levels of hypothermia on enzyme speed, platelet function, and fibrinolytic activity.
薬剤性の貧血や血小板減少の予防
Mechanisms and etiologies of thrombocytopenia in the intensive care unit: impact of extensive investigations.
Drugs affecting coagulation.
Approach to the diagnosis and management of drug-induced immune thrombocytopenia.
Drug-induced immune thrombocytopenia.
Thrombocytopenia in the intensive care unit patient.
Variability of findings in drug-induced immune haemolytic anaemia: experience over 20 years in a single centre.
Anemia, bleeding, and blood transfusion in the intensive care unit: causes, risks, costs, and new strategies.
Drug-induced thrombocytopenia in critically ill patients.
Recurrent acute thrombocytopenia in the hospitalized patient: sepsis, DIC, HIT, or antibiotic-induced thrombocytopenia.
Drugs that affect platelet function.
Drug-induced anemia and other red cell disorders: a guide in the age of polypharmacy.
Vancomycin-induced immune thrombocytopenia.
Evaluation and management of drug-induced thrombocytopenia in the acutely ill patient.
酸素供給の最適化と酸素消費の最小限化
The influence of volume management on outcome.
Cardiac output monitoring.
Optimization of tissue oxygenation in critically ill Jehovah's Witness patients.
Severe blood loss anemia in a Jehovah's Witness treated with adjunctive hyperbaric oxygen therapy.
Resuscitation with hydroxyethyl starch improves renal function and lactate clearance in penetrating trauma in a randomized controlled study: the FIRST trial (Fluids in Resuscitation of Severe Trauma).
Care of the injured Jehovah's Witness patient: case report and review of the literature.
Techniques for assessment of intravascular volume in critically ill patients.
Colloids versus crystalloids for fluid resuscitation in critically ill patients.
Cardiac output and fluid replacement in a Jehovah's Witness with severe postpartum hemorrhage.
Clinical strategies in the medical care of Jehovah's Witnesses.
Crystalloids versus colloids during acute normovolemic anemia: the quest continues…
A systematic review of the application of hyperbaric oxygen in the treatment of severe anemia: an evidence-based approach.
Extreme anemia in an injured Jehovah's Witness: a test of our understanding of the physiology of severe anemia and the threshold for blood transfusion.
The use of barbiturate coma as salvage therapy in a postoperative Jehovah's Witness patient with life-threatening anemia.
Hyperbaric oxygen in the critically ill.
ダメージコントロール
Damage control resuscitation is associated with a reduction in resuscitation volumes and improvement in survival in 390 damage control laparotomy patients.
Hypotensive resuscitation during active hemorrhage: impact on in-hospital mortality.
Haemorrhage control in severely injured patients.
Permissive Hypotension beim schweren Trauma. [Permissive hypotension in severe trauma.] [German]
Damage control orthopedics: current evidence.
Hypotensive resuscitation strategy reduces transfusion requirements and severe postoperative coagulopathy in trauma patients with hemorrhagic shock: preliminary results of a randomized controlled trial.
Traumatically injured Jehovah's Witnesses: a sixteen-year experience of treatment and transfusion dilemmas at a level I trauma center.
Damage control surgery.
Jehovah's Witnesses: unique problems in a unique trauma population.
血液回収法
Autotransfusion from haemothorax after penetrating chest trauma: a simple, life-saving procedure.
Intraoperative blood salvage in penetrating abdominal trauma: a randomised, controlled trial.
Autologous blood transfusion during emergency trauma operations.
Red blood cell salvage analysis from clotted blood.
The utility of an autologous blood salvage system in emergency thoracotomy for a hemothorax after chest trauma.
Guidelines for Blood Recovery and Reinfusion in Surgery and Trauma.
貧血の管理
Pharmacokinetics and pharmacodynamics of six epoetin alfa dosing regimens in anemic critically ill patients without acute blood loss.
Recombinant human erythropoietin therapy in critically ill Jehovah's Witnesses.
Reducing postburn injury anemia in a Jehovah's Witness patient.
A US multicenter, retrospective, observational study of erythropoiesis-stimulating agent utilization in anemic, critically ill patients admitted to the intensive care unit.
Severe acute anemia after liver transplantation in an elderly Jehovah's Witness treated with high-dose erythropoietin and ferric carboxymaltose: a case report.
Recombinant human erythropoietin in severe anaemia: issues of dosing and duration.
Efficacy of recombinant human erythropoietin in the critically ill patient: a randomized, double-blind, placebo-controlled trial.
Erythropoietin for critically ill trauma patients: a missed opportunity?
Postoperative management of severe acute anemia in a Jehovah's Witness.
Restrictive transfusion in geriatric trauma patients.
High-dose recombinant human erythropoietin stimulates reticulocyte production in patients with multiple organ dysfunction syndrome.
Recombinant human erythropoietin therapy in critically ill patients: a dose-response study [ISRCTN48523317].
Management of a Jehovah's Witness patient with sepsis and profuse bleeding after emergency coronary artery bypass graft surgery: rethinking the critical threshold of oxygen delivery.
Management strategies for perioperative anaemia in the severely burn-injured Jehovah's Witness patients who decline a blood transfusion: a systematic review with illustrative case reports.
Long-term ECMO treatment in Jehovah's Witness patient without transfusions.
Outcomes with the use of recombinant human erythropoietin in critically ill burn patients.
Safety of off-label erythropoiesis stimulating agents in critically ill patients: a meta-analysis.
Transfusion-free treatment strategies for acute anemia in critical care.
Improved survival of critically ill trauma patients treated with recombinant human erythropoietin.
Reticulocyte counts and their relation to hemoglobin levels in trauma patients.
Randomized, double-blind, placebo-controlled trial of effects of enteral iron supplementation on anemia and risk of infection during surgical critical illness.
How do we treat life-threatening anemia in a Jehovah's Witness patient?
Recombinant human erythropoietin use in a critically ill Jehovah's Witness after cardiac surgery.
Successful rescue therapy for severe acute anemia: managing the critically ill Jehovah's Witness.
Erythropoietin response is blunted in critically ill patients.
Life-threatening postoperative blood loss in a Jehovah's Witness, treated with high-dose erythropoietin.
Management of anemia in patients who decline blood transfusion.
Erythropoiesis-stimulating agent administration and survival after severe traumatic brain injury: a prospective study.
Intravenous iron following cardiac surgery does not increase the infection rate.
Erythropoietin improves long-term neurological outcome in acute ischemic stroke patients: a randomized, prospective, placebo-controlled clinical trial.
Pharmacotherapy for reducing RBC transfusion for patients in the ICU: a systematic review and network meta-analysis.
患者の貧血に対する許容力の最適化
Severe acute anemia after liver transplantation in an elderly Jehovah's Witness treated with high-dose erythropoietin and ferric carboxymaltose: a case report.
High oxygen partial pressure decreases anemia-induced heart rate increase equivalent to transfusion.
Extremely severe anaemia in a critically ill patient who declined a blood transfusion.
Management of a Jehovah's Witness patient with sepsis and profuse bleeding after emergency coronary artery bypass graft surgery: rethinking the critical threshold of oxygen delivery.
Successful resuscitation following massive obstetric hemorrhage in a patient of the Jehovah's Witness faith: a case report.
Prophylactic hypothermia and neuromuscular blockade to limit myocardial oxygen demand in a critically anemic Jehovah's Witness after emergency surgery.
Anemia tolerance during normo-, hypo-, and hypervolemia.
Care of the injured Jehovah's Witness patient: case report and review of the literature.
Management of severe blood loss after tumor resection in a Jehovah's Witness. [Abstract in English, French, German]
When blood is not an option: factors affecting survival after the use of a hemoglobin-based oxygen carrier in 54 patients with life-threatening anemia.
Pillar III—optimisation of anaemia tolerance.
等容量性貧血の許容
Blood transfusion for upper gastrointestinal bleeding: is less more again?
Liberal or restrictive transfusion in high-risk patients after hip surgery.
Conservative versus liberal red cell transfusion in acute myocardial infarction (the CRIT Randomized Pilot Study).
Hemoglobin levels and transfusions in neurocritically ill patients: a systematic review of comparative studies.
Anemia prevalence and incidence and red blood cell transfusion practices in aneurysmal subarachnoid hemorrhage: results of a multicenter cohort study.
Restrictive blood transfusion practices are associated with improved patient outcomes.
Perioperative anämietoleranz. Mechanismen, einflussfaktoren, grenzen. [Tolerance to perioperative anemia. Mechanisms, influencing factors and limits.] [German, English]
A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care.
Lower versus higher hemoglobin threshold for transfusion in septic shock.
Management of a Jehovah's Witness patient with sepsis and profuse bleeding after emergency coronary artery bypass graft surgery: rethinking the critical threshold of oxygen delivery.
Red blood cell transfusion in non-bleeding critically ill patients with moderate anemia: is there a benefit?
Discharge hemoglobin and outcome in patients with acute nonvariceal upper gastrointestinal bleeding.
Restrictive or liberal red-cell transfusion for cardiac surgery.
Is a restrictive transfusion strategy safe for resuscitated and critically ill trauma patients?
Effect of a liberal versus restrictive transfusion strategy on mortality in patients with moderate to severe head injury.
Red blood cell transfusion is associated with increased rebleeding in patients with nonvariceal upper gastrointestinal bleeding.
Restrictive versus liberal transfusion strategy for red blood cell transfusion in critically ill patients and in patients with acute coronary syndrome: a systematic review, meta-analysis and trial sequential analysis.
Effect of erythropoietin and transfusion threshold on neurological recovery after traumatic brain injury: a randomized clinical trial.
Successful use of ECMO in a Jehovah's Witness after complicated re-heart transplant.
Impact of more restrictive blood transfusion strategies on clinical outcomes: a meta-analysis and systematic review.
Permissive anämie. [Permissive anemia.] [German]
Outcomes of protocol-driven care of critically ill severely anemic patients for whom blood transfusion is not an option.
An update on mortality and morbidity in patients with very low postoperative hemoglobin levels who decline blood transfusion (CME).
Associations of nadir haemoglobin level and red blood cell transfusion with mortality and length of stay in surgical specialties: a retrospective cohort study.
Transfusion strategies for acute upper gastrointestinal bleeding.
Restrictive versus liberal transfusion strategies for older mechanically ventilated critically ill patients: a randomized pilot trial.
The deleterious effect of red blood cell storage on microvascular response to transfusion.
Human cardiovascular and metabolic response to acute, severe isovolemic anemia.
The effect of red blood cell transfusion on cerebral oxygenation and metabolism after severe traumatic brain injury.
大量出血の有害作用
Association between bleeding events and in-hospital mortality after percutaneous coronary intervention.
Increased chest tube drainage is independently associated with adverse outcome after cardiac surgery.
Health and economic outcomes associated with uncontrolled surgical bleeding: a retrospective analysis of the premier perspectives database.
Bleeding, blood transfusion, and increased mortality after percutaneous coronary intervention: implications for contemporary practice.
Adverse impact of bleeding on prognosis in patients with acute coronary syndromes.
Financial and clinical outcomes associated with surgical bleeding complications.
Impact of bleeding-related complications and/or blood product transfusions on hospital costs in inpatient surgical patients.
輸血のリスクと不確実性
Association among blood transfusion, sepsis, and decreased long-term survival after colon cancer resection.
Impact of blood product transfusion on short and long-term survival after cardiac surgery: more evidence.
Conservative versus liberal red cell transfusion in acute myocardial infarction (the CRIT Randomized Pilot Study).
The CRIT study: anemia and blood transfusion in the critically ill--current clinical practice in the United States.
Surgical outcomes and transfusion of minimal amounts of blood in the operating room.
Incidence of transfusion reactions: a multicenter study utilizing systematic active surveillance and expert adjudication.
Efficacy of red blood cell transfusion in the critically ill: a systematic review of the literature.
Impact of red blood cells transfusion on ICU-acquired bloodstream infections: a case-control study.
Anemia versus transfusion: does blood conservation increase the risk of complications?
Risks associated with red blood cell transfusion in the trauma population, a meta-analysis.
Anemia, allogenic blood transfusion, and immunomodulation in the critically ill.
Effect of erythropoietin and transfusion threshold on neurological recovery after traumatic brain injury: a randomized clinical trial.
Health care-associated infection after red blood cell transfusion: a systematic review and meta-analysis.
Contemporary risk factors and outcomes of transfusion-associated circulatory overload.
Red blood cell transfusions and nosocomial infections in critically ill patients.
Transfusion of older stored blood and risk of death: a meta-analysis.
The deleterious effect of red blood cell storage on microvascular response to transfusion.
Posttransfusion increase of hematocrit per se does not improve circulatory oxygen delivery due to increased blood viscosity.
臨床成績
Blood transfusion for upper gastrointestinal bleeding: is less more again?
Multimodal patient blood management program based on a three-pillar strategy: a systematic review and meta-analysis.
The CRIT study: anemia and blood transfusion in the critically ill--current clinical practice in the United States.
The impact of packed red blood cell transfusion on clinical outcomes in patients with septic shock treated with early goal directed therapy.
Restrictive blood transfusion practices are associated with improved patient outcomes.
Safe and successful restriction of transfusion in burn patients.
Efficacy of red blood cell transfusion in the critically ill: a systematic review of the literature.
Health care-associated infection after red blood cell transfusion: a systematic review and meta-analysis.
Impact of more restrictive blood transfusion strategies on clinical outcomes: a meta-analysis and systematic review.
Why an alternative to blood transfusion?
Red blood cell transfusions worsen the outcomes even in critically ill patients undergoing a restrictive transfusion strategy.
Red blood cell transfusions and nosocomial infections in critically ill patients.
The risk of death for Jehovah's Witnesses after major trauma.
経済効果
Restrictive blood transfusion practices are associated with improved patient outcomes.
Improved outcomes and reduced costs associated with a health-system-wide patient blood management program: a retrospective observational study in four major adult tertiary-care hospitals.
Cost-effectiveness of recombinant human erythropoietin for reducing red blood cells transfusions in critically ill patients.
Implementation of a patient blood management monitoring and feedback program significantly reduces transfusions and costs.
Trauma-induced coagulopathy: impact of the early coagulation support protocol on blood product consumption, mortality and costs.
The CRASH-2 trial: a randomised controlled trial and economic evaluation of the effects of tranexamic acid on death, vascular occlusive events and transfusion requirement in bleeding trauma patients.
Reversal of coagulopathy in critically ill patients with traumatic brain injury: recombinant factor VIIa is more cost-effective than plasma.
Effect of a restrictive transfusion strategy on transfusion-attributable severe acute complications and costs in the US ICUs: a model simulation.
集学的,職種横断的な,個別化されたアプローチ
Leucemia aguda en los Testigos de Jehová. [Acute leukemia in Jehovah's Witnesses.] [Spanish]
Long-term prognosis of childhood acute promyelocytic leukaemia with arsenic trioxide administration in induction and consolidation chemotherapy phases: a single-centre experience.
Low-dose cytosine arabinoside as an alternative treatment for acute leukemia in Jehovah's Witnesses.
Major surgery in an osteosarcoma patient refusing blood transfusion: case report.
Conventional compared with individualized chemotherapy for childhood acute lymphoblastic leukemia.
Childhood cancer and the Jehovah's Witness faith.
Acute leukemia in Jehovah's Witnesses: a challenge for hematologists.
Myeloablative therapy and bone marrow transplantation in Jehovah's Witnesses with malignancies: single center experience.
Bloodless (transfusion-free) hematopoietic stem cell transplants: the Mexican experience.
Oncological management of pediatric cancer patients belonging to Jehovahs Witnesses: a two-institutional experience report.
Tratamiento de la leucemia aguda linfoblástica con poliquimioterapia sin hemoderivados en niños Testigos de Jehová. [Treatment of acute lymphoblastic leukemia using combination chemotherapy without blood-derived products in Jehovah's Witness children.
貧血の管理
Once weekly recombinant human erythropoietin treatment for cancer-induced anemia in children with acute lymphoblastic leukemia receiving maintenance chemotherapy: a randomized case-controlled study.
Intravenous iron for critically ill children. Comparison of three dose regimens.
Epoetin alpha decreases the number of erythrocyte transfusions in patients with acute lymphoblastic leukemia, lymphoblastic lymphoma, and Burkitt leukemia/lymphoma: results of a randomized clinical trial.
Recombinant human erythropoietin beta therapy: an effective strategy to reduce transfusion requirement in children receiving anticancer treatment.
Intravenous iron sucrose for children with iron deficiency failing to respond to oral iron therapy.
Recombinant human erythropoietin beta: the effect of weekly dosing on anemia, quality of life, and long-term outcomes in pediatric cancer patients.
Epoetin alfa in patients with advanced-stage Hodgkin's lymphoma: results of the randomized placebo-controlled GHSG HD15EPO trial.
Treatment patterns and outcomes in management of solid cancer patients suffering from anemia in Penang hospital.
Randomized, double-blind, placebo-controlled trial of every-3-week darbepoetin alfa 300 micrograms for treatment of chemotherapy-induced anemia.
Hemoglobin response and improvements in quality of life in anemic children with cancer receiving myelosuppressive chemotherapy.
The efficacy of recombinant human erythropoietin in treatment chemotherapy induced anemia in children diagnosed with a solid cancer.
Intravenous iron sucrose for children with iron deficiency anemia.
Advances in Pediatric Intravenous Iron Therapy.
2007 Standards, Options, and Recommendations: use of erythropoiesis-stimulating agents (ESA: epoetin alfa, epoetin beta, and darbepoetin) for the management of anemia in children with cancer.
The role of iron in the management of chemotherapy-induced anemia in cancer patients receiving erythropoiesis-stimulating agents.
Prospective study of erythropoietin use on quality of life and cost effectiveness in acute myeloid leukemia and allogeneic hematopoietic stem cell transplantation patients.
Erythropoietic growth factors for children with cancer: a systematic review of the literature.
Randomized trial of intravenous iron supplementation in patients with chemotherapy-related anemia without iron deficiency treated with darbepoetin alpha.
Intravenous low molecular weight iron dextran in children with iron deficiency anemia unresponsive to oral iron.
Double-blind, placebo-controlled study of quality of life, hematologic end points, and safety of weekly epoetin alfa in children with cancer receiving myelosuppressive chemotherapy.
The role of recombinant erythropoietin in childhood cancer.
Efficacy and safety of iorEPOCIM for chemotherapy- or radiotherapy-induced anemia in pediatric cancer patients.
A single institutional experience: is epoetin alpha effective in anemic children with cancer?
Single dose darbepoetin alfa is useful in reducing red cell transfusions in leukemic children receiving chemotherapy.
Early epoetin alfa treatment in children with solid tumors.
赤血球造血刺激因子製剤
鉄静注
血小板減少症の治療管理
Eltrombopag for secondary failure of platelet recovery post-allogeneic hematopoietic stem cell transplant in children.
The role of interleukin-11 to prevent chemotherapy-induced thrombocytopenia in patients with solid tumors, lymphoma, acute myeloid leukemia and bone marrow failure syndromes.
Recombinant human interleukin 11 and bacterial infection in patients with haematological malignant disease undergoing chemotherapy: a double-blind placebo-controlled randomised trial.
Romiplostim for immune thrombocytopenia in neuroblastoma patients receiving chemotherapy.
Romiplostim for therapy-related thrombocytopenia in pediatric malignancies.
Eltrombopag for delayed platelet recovery and secondary thrombocytopenia following allogeneic stem cell transplantation in children.
Romiplostim for secondary thrombocytopenia following allogeneic stem cell transplantation in children.
Recombinant human erythropoietin reduces the need for erythrocyte and platelet transfusions in pediatric patients with sarcoma: a randomized, double-blind, placebo-controlled trial.
Chemotherapy induced thrombocytopenia in pediatric oncology.
Oncological management of pediatric cancer patients belonging to Jehovahs Witnesses: a two-institutional experience report.
Low-dose interleukin-11 in patients with bone marrow failure: update of the M. D. Anderson Cancer Center experience.
Safety and cost effectiveness of a 10 x 10(9)/L trigger for prophylactic platelet transfusions compared with the traditional 20 x 10(9)/L trigger: a prospective comparative trial in 105 patients with acute myeloid leukemia.
止血の管理と最適化
Pediatric off-label use of recombinant factor VIIa.
Epsilon aminocaproic acid prevents bleeding in severely thrombocytopenic patients with hematological malignancies.
The use of DDAVP in children with bleeding disorders.
Recombinant activated factor VII usage in life threatening hemorrhage: a pediatric experience.
Control of bleeding caused by thrombocytopenia associated with hematologic malignancy: an audit of the clinical use of recombinant activated Factor VII.
Low dose bolus aminocaproic acid: an alternative to platelet transfusion in thrombocytopenia?
Safety and efficacy of recombinant factor VIIa by pediatric age cohort: reassessment of compassionate use and trial data supporting US label.
Use of recombinant factor VIIa prior to lumbar puncture in pediatric patients with acute leukemia.
The use of antifibrinolytics in pediatric patients with hypoproliferative thrombocytopenia.
A comprehensive review of rFVIIa use in a tertiary care pediatric center.
Preliminary experience with epsilon aminocaproic acid for treatment of intractable upper tract hematuria in children with hematological disorders.
Treatment of refractory thrombocytopenic bleeding with 1-desamino-8-D-arginine vasopressin (desmopressin).
Recombinant activated factor VII for severe gastrointestinal bleeding after chemotherapy in an infant with acute megakaryoblastic leukemia.
Off-label use of recombinant factor VIIa in pediatric patients.
The use of Tachosil as hemostatic sealant in nephron sparing surgery for Wilms tumor: preliminary observations.
Dosing, efficacy, and safety of recombinant factor VIIa (rFVIIa) in pediatric versus adult patients: the experience of the Hemostasis and Thrombosis Research Society (HTRS) registry (2004-2008).
Successful treatment of severe gastrointestinal bleeding after chemotherapy in acute myeloblastic leukemia with recombinant activated factor VII: report on one case and review of other uses in acute leukemias.
A controlled trial of tranexamic acid therapy for the reduction of bleeding during treatment of acute myeloid leukemia.
Successful treatment of acute lymphoblastic leukemia with l-asparaginase-induced intracranial hemorrhage to activated recombinant factor VIIa in a child.
Single-center experience: use of recombinant factor VIIa for acute life-threatening bleeding in children without congenital hemorrhagic disorder.
抗線溶薬
遺伝子組換え活性型血液凝固第Ⅶ因子製剤(rFVIIa)
デスモプレシン
局所止血剤
好中球減少症の治療管理
Granulocyte colony-stimulating factor ameliorates toxicity of intensification chemotherapy for acute lymphoblastic leukemia.
Guideline for the management of fever and neutropenia in children with cancer and/or undergoing hematopoietic stem-cell transplantation.
Use of recombinant human granulocyte colony-stimulating factor to increase chemotherapy dose-intensity: a randomized trial in very high-risk childhood acute lymphoblastic leukemia.
Human granulocyte colony-stimulating factor after induction chemotherapy in children with acute lymphoblastic leukemia.
個別化または変法化学療法(用量もしくは時期の調整)
Conventional compared with individualized chemotherapy for childhood acute lymphoblastic leukemia.
Childhood cancer and the Jehovah's Witness faith.
Reduction from seven to five cycles of intensive induction chemotherapy in children with high-risk neuroblastoma.
Assessment of arsenic trioxide and all-trans retinoic acid for the treatment of pediatric acute promyelocytic leukemia: a report from the Children's Oncology Group AAML1331 Trial.
Clinical outcomes of hypomethylating agents and venetoclax in newly diagnosed unfit and relapsed/refractory paediatric, adolescent and young adult acute myeloid leukaemia patients.
Long-term efficacy of low-dose all-trans retinoic acid plus minimal chemotherapy induction followed by the addition of intravenous arsenic trioxide post-remission therapy in newly diagnosed acute promyelocytic leukaemia.
Acute leukemia in Jehovah's Witnesses: a challenge for hematologists.
Autologous and allogeneic stem cell transplant in Jehovah's Witnesses: a single-center experience on 22 patients.
Myeloablative therapy and bone marrow transplantation in Jehovah's Witnesses with malignancies: single center experience.
Bloodless (transfusion-free) hematopoietic stem cell transplants: the Mexican experience.
Possibilities for tailored and targeted therapy in paediatric acute myeloid leukaemia.
Tratamiento de la leucemia aguda linfoblástica con poliquimioterapia sin hemoderivados en niños Testigos de Jehová. [Treatment of acute lymphoblastic leukemia using combination chemotherapy without blood-derived products in Jehovah's Witness children.
免疫療法
Blinatumomab versus chemotherapy for advanced acute lymphoblastic leukemia.
Chimeric antigen receptor T cells for sustained remissions in leukemia.
Tisagenlecleucel in children and young adults with B-cell lymphoblastic leukemia.
Gemtuzumab ozogamicin can reduce minimal residual disease in patients with childhood acute myeloid leukemia.
Gemtuzumab ozogamicin reduces relapse risk in FLT3/ITD acute myeloid leukemia: a report from the Children's Oncology Group.
医原性貧血を避けるための採血量の制限
Controlling phlebotomy volume diminishes PICU transfusion: implementation processes and impact.
Blood loss from laboratory diagnostic tests in children.
Identifying factors to minimize phlebotomy-induced blood loss in the pediatric intensive care unit.
中等度の等容量性貧血の許容
Computerized physician order entry with decision support decreases blood transfusions in children.
Extreme anemia (Hb 33 g/L) in a 13-year-old girl: is the transfusion always mandatory?
The frequency of bleeding complications in patients with haematological malignancy following the introduction of a stringent prophylactic platelet transfusion policy.
Effect of restrictive versus liberal red cell transfusion strategies on haemostasis: systematic review and meta-analysis.
Safety of lumbar puncture for children with acute lymphoblastic leukemia and thrombocytopenia.
Transfusion strategies for patients in pediatric intensive care units.
Impact of a conservative red blood cell transfusion strategy in children undergoing hematopoietic stem cell transplantation.
輸血のリスクと不確実性
The contribution of multiple packed red blood cell transfusions toward cardiac and liver dysfunction in pediatric patients with acute myeloid leukemia.
Indications for and adverse effects of red-cell transfusion.
Blood product transfusions and clinical outcomes in pediatric patients with acute lung injury.
Severe thrombocytopenia in a child secondary to passive platelet antibody transfer from a plasma transfusion.
Clinical outcomes associated with RBC transfusions in critically ill children: a 1-year prospective study.
Platelet transfusions in pediatric intensive care.
Serious hazards of transfusion in children (SHOT).
Is the number of blood products transfused associated with lower survival in children with acute lymphoblastic leukemia?
The risk of transfusion-transmitted infections in sub-Saharan Africa.
Association between length of storage of red blood cell units and outcome of critically ill children: a prospective observational study.
Transfusion-associated Chagas disease (American trypanosomiasis) in Mexico: implications for transfusion medicine in the United States.
Transfusion reactions in pediatric compared with adult patients: a look at rate, reaction type, and associated products.
Transfusion in critically ill children: indications, risks, and challenges.
Widespread use of fresh frozen plasma in US children's hospitals despite limited evidence demonstrating a beneficial effect.
Transfusion related acute lung injury in a child with leukemia.
Adverse outcomes of blood transfusion in children: analysis of UK reports to the serious hazards of transfusion scheme 1996-2005.
Emerging infectious disease agents and their potential threat to transfusion safety.
Current perspectives in transfusion-transmitted infectious diseases: emerging and re-emerging infections.
Analysis of pediatric adverse reactions to transfusions.
臨床成績
Childhood cancer and the Jehovah's Witness faith.
Gemtuzumab ozogamicin in children and adolescents with de novo acute myeloid leukemia improves event-free survival by reducing relapse risk: results from the randomized phase III Children's Oncology Group trial AAML0531.
Red blood cell transfusion and outcome in cancer.
Bloodless cancer treatment results of patients who do not want blood transfusion: single center experience of 77 cases.
術前の患者の評価と輸血リスクの評価
Pediatric responsibilities for preoperative evaluation.
The pediatrician's role in the evaluation and preparation of pediatric patients undergoing anesthesia.
The use of rFVIIa in non-haemophilia bleeding conditions in paediatrics. A systematic review.
Intraoperative blood loss in pediatric liver transplantation: analysis of preoperative risk factors.
術前の計画と患者の状態の最適化
The efficacy of pre-operative erythropoietin therapy.
The pediatrician's role in the evaluation and preparation of pediatric patients undergoing anesthesia.
The use of rFVIIa in non-haemophilia bleeding conditions in paediatrics. A systematic review.
Épargne sanguine en chirurgie pédiatrique : situations à risque, stratégie d'épargne et limites. [Blood salvage in paediatric surgery: situations at risk of haemorrhage, salvage strategies and their limits.] [French]
How to limit allogenic blood transfusion in children.
集学的,職種横断的な,個別化されたアプローチ
The care of a child with multiple trauma and severe anemia who was a Jehovah's Witness.
Perioperative bleeding management in pediatric patients.
Blood transfusion risks and alternative strategies in pediatric patients.
Major hepatectomy in children: approaching blood transfusion-free.
Extensive lower limb injuries in a child complicated by complex pain management and profound anemia.
Blood conservation strategies in pediatric anesthesia.
Blood conservation in pediatric anesthesia.
Blood conservation in the perioperative setting.
How to limit allogenic blood transfusion in children.
術前貧血管理と赤血球数の最適化
The efficacy of pre-operative erythropoietin therapy.
Erythropoietin increases reticulocyte counts and maintains hematocrit in neonates requiring surgery.
Intravenous iron for critically ill children. Comparison of three dose regimens.
Intraoperative tranexamic acid reduces blood transfusion in children undergoing craniosynostosis surgery: a randomized double-blind study.
The care of a child with multiple trauma and severe anemia who was a Jehovah's Witness.
The use of recombinant erythropoietin in the reduction of blood transfusion rates in craniosynostosis repair in infants and children.
Hydroxycarbamide and erythropoietin in the preoperative management of children with sickle cell anaemia undergoing moderate risk surgery.
Blood transfusion risks and alternative strategies in pediatric patients.
Is a prophylactic treatment by erythropoietin relevant to reduce red blood cell transfusion in the pediatric intensive care unit?
Advances in Pediatric Intravenous Iron Therapy.
Extensive lower limb injuries in a child complicated by complex pain management and profound anemia.
Perioperative intravenous fluid therapy in children: guidelines from the Association of the Scientific Medical Societies in Germany.
血小板減少症の治療管理
First successful use of eltrombopag before surgery in a child with MYH9-related thrombocytopenia.
Romiplostim for therapy-related thrombocytopenia in pediatric malignancies.
Romiplostim treatment allows for platelet transfusion-free liver transplantation in pediatric thrombocytopenic patient with primary sclerosing cholangitis.
外科的血液温存法
Major hepatectomy in children: approaching blood transfusion-free.
止血の管理と最適化
Pediatric off-label use of recombinant factor VIIa.
Use of tranexamic acid as a rescue measure to achieve hemostasis after massive blood loss in a pediatric neurosurgical patient.
A randomized control trial to verify the efficacy of pre-operative intravenous tranexamic acid in the control of tonsillectomy bleeding.
Perioperative bleeding management in pediatric patients.
Management of dilutional coagulopathy during pediatric major surgery.
Blood transfusion risks and alternative strategies in pediatric patients.
The use of rFVIIa in non-haemophilia bleeding conditions in paediatrics. A systematic review.
Association of intravenous tranexamic acid with thromboembolic events and mortality: a systematic review, meta-analysis, and meta-regression.
抗線溶薬
遺伝子組換え活性型血液凝固第Ⅶ因子製剤(rFVIIa)
外科的出血か凝固異常による出血かを同定するための血液粘弾性試験
注意深い輸液・体液管理
Perioperative intravenous fluid therapy in children: guidelines from the Association of the Scientific Medical Societies in Germany.
術中の自己血管理
Major childhood tumor resection using normovolemic hemodilution anesthesia and hetastarch.
Perioperative blood salvage during surgical correction of craniosynostosis in infants.
Reducing allogenic blood transfusions during pediatric cranial vault surgical procedures: a prospective analysis of blood recycling.
The advantages of hemodilution anesthesia for major liver resection in children.
Hemodilution anesthesia: a valuable aid to major cancer surgery in children.
Systemic haemodynamics and oxygenation during haemodilution in children.
Blood conservation strategies in pediatric anesthesia.
Blood conservation in pediatric anesthesia.
How to limit allogenic blood transfusion in children.
血液回収法
急性等容量性血液希釈
麻酔学的血液温存法
Management of severe anemia without transfusion in a pediatric Jehovah's Witness patient.
Regional anaesthesia in paediatric surgery: results of 2200 children.
The effects of peritonsillar infiltration on the reduction of intraoperative blood loss and post-tonsillectomy pain in children.
Early experiences of vasodilators and hypotensive anesthesia in children.
Caudal epidural anesthesia reduces blood loss during hypospadias repair.
Blood transfusion risks and alternative strategies in pediatric patients.
Controlled hypotension in children: a critical review of available agents.
低血圧法
局所麻酔
他の技法
医原性貧血を避けるための採血量の制限
Anemia, blood loss, and blood transfusions in North American children in the intensive care unit.
Perioperative bleeding management in pediatric patients.
Accuracy and precision of hemoglobin point-of-care testing during major pediatric surgery.
Identifying factors to minimize phlebotomy-induced blood loss in the pediatric intensive care unit.
術後貧血の管理
Management of severe anemia without transfusion in a pediatric Jehovah's Witness patient.
患者の貧血に対する許容力の最適化
Management of severe anemia without transfusion in a pediatric Jehovah's Witness patient.
Perioperative bleeding management in pediatric patients.
中等度の等容量性貧血の許容
Minimizing blood transfusions in the surgical correction of craniosynostosis: a 10-year single-center experience.
Transfusion strategies for patients in pediatric intensive care units.
Major hepatectomy in children: approaching blood transfusion-free.
The impact of restrictive transfusion practices on hemodynamically stable critically ill children without heart disease: a secondary analysis of the age of blood in children in the PICU trial.
Perioperative intravenous fluid therapy in children: guidelines from the Association of the Scientific Medical Societies in Germany.
医療資源の限られる状況
The efficacy of pre-operative erythropoietin therapy.
Regional anaesthesia in paediatric surgery: results of 2200 children.
輸血のリスクと不確実性
Anemia, blood loss, and blood transfusions in North American children in the intensive care unit.
Clinical outcomes associated with RBC transfusions in critically ill children: a 1-year prospective study.
Association between length of storage of transfused red blood cells and multiple organ dysfunction syndrome in pediatric intensive care patients.
Relationship between transfusion volume and outcomes in children undergoing noncardiac surgery.
Serious hazards of transfusion in children (SHOT).
RBC transfusions in children requiring intensive care admission after traumatic injury.
Blood transfusion risks and alternative strategies in pediatric patients.
Incidence of acute transfusion reactions to platelets in hospitalized pediatric patients based on the US hemovigilance reporting system.
Adverse outcomes of blood transfusion in children: analysis of UK reports to the serious hazards of transfusion scheme 1996-2005.
臨床成績
Anemia, blood loss, and blood transfusions in North American children in the intensive care unit.
Risk-adjusted clinical outcomes in patients enrolled in a bloodless program.
Relationship between transfusion volume and outcomes in children undergoing noncardiac surgery.
Management of dilutional coagulopathy during pediatric major surgery.
Clinical outcomes, blood utilization, and ethical considerations for pediatric patients in a bloodless medicine and surgery program.
Early death and late morbidity after blood transfusion of injured children: a pilot study.
The impact of restrictive transfusion practices on hemodynamically stable critically ill children without heart disease: a secondary analysis of the age of blood in children in the PICU trial.
経済効果
Risk-adjusted clinical outcomes in patients enrolled in a bloodless program.
Pediatric red blood cell transfusions increase resource use.
The impact of restrictive transfusion practices on hemodynamically stable critically ill children without heart disease: a secondary analysis of the age of blood in children in the PICU trial.
術前の患者の評価と輸血リスクの評価
Predictive factors for homologous transfusion during paediatric scoliosis surgery.
Pediatric responsibilities for preoperative evaluation.
The pediatrician's role in the evaluation and preparation of pediatric patients undergoing anesthesia.
Minimizing perioperative blood loss and transfusions in children. [Réduire les pertes sanguines et les besoins transfusionnels en chirurgie pédiatrique.] [English, French abstract]
Utility of a paediatric bleeding questionnaire as a screening tool for von Willebrand disease in apparently healthy children.
Intraoperative blood loss in pediatric liver transplantation: analysis of preoperative risk factors.
Multivariate model for predicting postoperative blood loss in children undergoing cardiac surgery: a preliminary study.
Risks and predictors of blood transfusion in pediatric patients undergoing open heart operations.
Factors influencing blood loss and allogeneic blood transfusion practice in craniosynostosis surgery.
術前の計画と患者の状態の最適化
Major surgery in an osteosarcoma patient refusing blood transfusion: case report.
Minimizing perioperative blood loss and transfusions in children. [Réduire les pertes sanguines et les besoins transfusionnels en chirurgie pédiatrique.] [English, French abstract]
Blood transfusion risks and alternative strategies in pediatric patients.
Blood-conservation techniques in craniofacial surgery.
Épargne sanguine en chirurgie pédiatrique : situations à risque, stratégie d'épargne et limites. [Blood salvage in paediatric surgery: situations at risk of haemorrhage, salvage strategies and their limits.] [French]
Liver resection using saline-linked radiofrequency technology in an infant with congenital hepatoblastoma.
Systematic review of interventions for minimizing perioperative blood transfusion for surgery for craniosynostosis.
How to limit allogenic blood transfusion in children.
集学的,職種横断的な,個別化されたアプローチ
Correction of congenital heart defects in Jehovah's Witness children.
The care of a child with multiple trauma and severe anemia who was a Jehovah's Witness.
Total cavopulmonary connection in a 35-month-old Jehovah's Witness child.
Transfusion-free cardiac surgery with cardiopulmonary bypass in a 2.2-kg neonate.
Transfusion-free complex cardiac surgery with cardiopulmonary bypass in a 3.55-kg Jehovah's Witness neonate.
Transfusion-free complex cardiac surgery: with use of deep hypothermic circulatory arrest in a preterm 2.96-kg Jehovah's witness neonate.
Acute normovolemic hemodilution combined with hypotensive anesthesia and other techniques to avoid homologous transfusion in spinal fusion surgery.
Endoscopy-assisted early correction of single-suture metopic craniosynostosis: a 19-year experience.
Blood conservation techniques in spinal deformity surgery: a retrospective review of patients refusing blood transfusion.
Blood conservation operations in pediatric cardiac patients: a paradigm shift of blood use.
Transfusion-free anesthetic management for open heart surgery in a neonate—a case report.
Major hepatectomy in children: approaching blood transfusion-free.
Perioperative management of pediatric patients undergoing juvenile angiofibroma resection. A case series and educational review highlighting patient blood management.
The theory and practice of bloodless surgery.
Cardiac surgery without blood products in a Jehovah's Witness child with factor VII deficiency.
Implementation of a patient blood management program in pediatric scoliosis surgery. [Implementación de un programa de alternativas a la transfusión sanguínea en cirugía de escoliosis en pediatría.] [English, Spanish]
Bloodless pediatric cardiopulmonary bypass for a 3.2-kg patient whose parents are of Jehovah's Witness faith.
Transfusion-free calvarial vault reconstruction using multimodal blood conservation strategies in two pediatric Jehovah's Witness patients with craniosynostosis.
Extensive lower limb injuries in a child complicated by complex pain management and profound anemia.
Heart retransplantation in children without the use of blood product. [Retransplante cardíaco em criança sem o uso de hemoderivados.] [English, Portuguese abstract]
Strategic and operational aspects of a transfusion-free neonatal arterial switch operation.
Blood conservation strategies in pediatric anesthesia.
Blood conservation in pediatric anesthesia.
Blood conservation in the perioperative setting.
Systematic review of interventions for minimizing perioperative blood transfusion for surgery for craniosynostosis.
How to limit allogenic blood transfusion in children.
Transfusion-free cranial vault remodeling: a novel, multifaceted approach.
術前貧血管理と赤血球数の最適化
Erythropoietin increases reticulocyte counts and maintains hematocrit in neonates requiring surgery.
Intravenous iron for critically ill children. Comparison of three dose regimens.
Intravenous iron sucrose for children with iron deficiency failing to respond to oral iron therapy.
Intraoperative tranexamic acid reduces blood transfusion in children undergoing craniosynostosis surgery: a randomized double-blind study.
The care of a child with multiple trauma and severe anemia who was a Jehovah's Witness.
The use of recombinant erythropoietin in the reduction of blood transfusion rates in craniosynostosis repair in infants and children.
Hydroxycarbamide and erythropoietin in the preoperative management of children with sickle cell anaemia undergoing moderate risk surgery.
Increased hematocrit and decreased transfusion requirements in children given erythropoietin before undergoing craniofacial surgery.
Successful blood conservation during craniosynostotic correction with dual therapy using Procrit and cell saver.
Is a prophylactic treatment by erythropoietin relevant to reduce red blood cell transfusion in the pediatric intensive care unit?
Advances in Pediatric Intravenous Iron Therapy.
2007 Standards, Options, and Recommendations: use of erythropoiesis-stimulating agents (ESA: epoetin alfa, epoetin beta, and darbepoetin) for the management of anemia in children with cancer.
Erythropoietin therapy and acute preoperative normovolaemic haemodilution in infants undergoing craniosynostosis surgery.
Safety of preoperative erythropoietin in surgical calvarial remodeling: an 8-year retrospective review and analysis.
Use of erythropoietin for bloodless surgery in a Jehovah's Witness infant.
Cardiac surgery without blood products in a Jehovah's Witness child with factor VII deficiency.
Extensive lower limb injuries in a child complicated by complex pain management and profound anemia.
Chirurgie hemorragique chez deux enfants de temoins de Jehovah refusant l'autotransfusion programmee : place de l'erythropoietine. [Hemorrhagic surgery in two Jehovah's Witness children refusing programmed autotransfusion: a place for erythropoietin.] [French, English abstract]
Erythropoietin in pediatric cardiac surgery: clinical efficacy and effective dose.
Quantifying risk of transfusion in children undergoing spine surgery.
血小板減少症の治療管理
First successful use of eltrombopag before surgery in a child with MYH9-related thrombocytopenia.
Romiplostim for therapy-related thrombocytopenia in pediatric malignancies.
Romiplostim treatment allows for platelet transfusion-free liver transplantation in pediatric thrombocytopenic patient with primary sclerosing cholangitis.
止血の管理と最適化
Emergent pediatric anticoagulation reversal using a 4-factor prothrombin complex concentrate.
Utility of Sonoclot analysis and tranexamic acid in tetralogy of Fallot patients undergoing intracardiac repair.
Pediatric off-label use of recombinant factor VIIa.
A systematic review of the use of antifibrinolytic agents in pediatric surgery and implications for craniofacial use.
Use of tranexamic acid as a rescue measure to achieve hemostasis after massive blood loss in a pediatric neurosurgical patient.
Recombinant activated factor VII usage in life threatening hemorrhage: a pediatric experience.
Aprotinin, transfusions, and kidney injury in neonates and infants undergoing cardiac surgery.
Recombinant activated factor VII (rFVIIa) treatment in infants with hemorrhage.
A Jehovah's Witness child with hemophilia B and factor IX inhibitors undergoing scoliosis surgery. [Chirurgie de la scoliose chez un enfant Témoin de Jéhovah souffrant d’hémophilie B et présentant des inhibiteurs du facteur IX.] [English, French abstract]
Perioperative monitoring of thromboelastograph on blood protection and recovery for severely cyanotic patients undergoing complex cardiac surgery.
Efficacy and safety of prophylactic large dose of tranexamic acid in spine surgery: a prospective, randomized, double-blind, placebo-controlled study.
The efficacy of antifibrinolytic drugs in children undergoing noncardiac surgery: a systematic review of the literature.
Plasma fibrinogen concentration is correlated with postoperative blood loss in children undergoing cardiac surgery. A retrospective review.
The effect of Amicar on perioperative blood loss in idiopathic scoliosis: the results of a prospective, randomized double-blind study.
Hemostatic effects of fibrinogen concentrate compared with cryoprecipitate in children after cardiac surgery: a randomized pilot trial.
A randomized control trial to verify the efficacy of pre-operative intravenous tranexamic acid in the control of tonsillectomy bleeding.
Perioperative bleeding management in pediatric patients.
Efficacy of tranexamic acid in pediatric craniosynostosis surgery: a double-blind, placebo-controlled trial.
Tranexamic acid is efficacious at decreasing the rate of blood loss in adolescent scoliosis surgery: a randomized placebo-controlled trial.
Differential effects of aprotinin and tranexamic acid on outcomes and cytokine profiles in neonates undergoing cardiac surgery.
Review of the off-label use of recombinant activated factor VII in pediatric cardiac surgery patients.
Management of dilutional coagulopathy during pediatric major surgery.
Higher fibrinogen concentrations for reduction of transfusion requirements during major paediatric surgery: a prospective randomised controlled trial.
Anesthetic management for transfusion-free Rastelli's procedure in a pediatric Jehovah's Witness patient.
The safety and efficacy of antifibrinolytic therapy in neonatal cardiac surgery.
Anesthetic management in a pediatric patient with Noonan syndrome, mastocytosis, and von Willebrand disease: a case report.
Tranexamic acid versus ɛ-aminocaproic acid: efficacy and safety in paediatric cardiac surgery.
The use of rFVIIa in non-haemophilia bleeding conditions in paediatrics. A systematic review.
Thromboelastometry-guided intraoperative haemostatic management reduces bleeding and red cell transfusion after paediatric cardiac surgery.
Antifibrinolytic agents reduce blood loss during pediatric vertebral column resection procedures.
Four-factor prothrombin complex concentrates in paediatric patients—a retrospective case series.
Comparative analysis of antifibrinolytic medications in pediatric heart surgery.
Cardiac surgery without blood products in a Jehovah's Witness child with factor VII deficiency.
Activated coagulation time vs. intrinsically activated modified rotational thromboelastometry in assessment of hemostatic disturbances and blood loss after protamine administration in elective cardiac surgery: analysis from the clinical trial (NCT01281397).
Use of tranexamic acid in infants undergoing choroid plexus papilloma surgery: a report of two cases.
Use of recombinant activated factor VII for controlling refractory postoperative bleeding in children undergoing cardiac surgery with cardiopulmonary bypass.
The effect of aprotinin, tranexamic acid, and aminocaproic acid on blood loss and use of blood products in major pediatric surgery: a meta-analysis.
Recombinant activated factor VII for hemorrhage after pediatric cardiac surgery.
The role of Amicar in same-day anterior and posterior spinal fusion for idiopathic scoliosis.
Comparison of three dose regimens of aprotinin in infants undergoing the arterial switch operation.
Pharmacokinetics of tranexamic acid in neonates, infants, and children undergoing cardiac surgery with cardiopulmonary bypass.
Does the intraoperative tranexamic acid decrease operative blood loss during posterior spinal fusion for treatment of adolescent idiopathic scoliosis?
Single-center experience: use of recombinant factor VIIa for acute life-threatening bleeding in children without congenital hemorrhagic disorder.
Off-label use of rFVIIa in children with excessive bleeding: a consecutive study of 153 off-label uses in 139 children.
抗線溶薬
遺伝子組換え活性型血液凝固第Ⅶ因子製剤(rFVIIa)
濃縮凝固因子製剤
デスモプレシン
外科的出血か凝固異常による出血かを同定するための血液粘弾性試験
体温管理(低体温の回避)
Consequences of inadvertent perioperative hypothermia.
Effect of temperature on thromboelastography and implications for clinical use in newborns undergoing therapeutic hypothermia.
Comparison of resistive heating and forced-air warming to prevent inadvertent perioperative hypothermia.
Effect of hypothermia on the coagulation cascade.
注意深い輸液・体液管理
Bloodless surgery in a pediatric Jehovah's Witness.
Association of postoperative furosemide use with a reduced blood transfusion rate in sagittal craniosynostosis surgery.
Transfusion-free complex cardiac surgery: with use of deep hypothermic circulatory arrest in a preterm 2.96-kg Jehovah's witness neonate.
Fluid overload is associated with higher mortality and morbidity in pediatric patients undergoing cardiac surgery.
Pediatric Cardiac Intensive Care Society 2014 Consensus Statement: pharmacotherapies in cardiac critical care fluid management.
Intraoperative fluid management in children—a comparison of three fluid regimens.
The effect of cardiopulmonary bypass prime volume on the need for blood transfusion after pediatric cardiac surgery.
Perioperative intravenous fluid therapy in children: guidelines from the Association of the Scientific Medical Societies in Germany.
術中の自己血管理
Major childhood tumor resection using normovolemic hemodilution anesthesia and hetastarch.
Efficacy of intraoperative cell salvage systems in pediatric idiopathic scoliosis patients undergoing posterior spinal fusion with segmental spinal instrumentation.
Transfusion of cell saver salvaged blood in neonates and infants undergoing open heart surgery significantly reduces RBC and coagulant product transfusions and donor exposures: results of a prospective, randomized, clinical trial.
Hemodilution as a method to reduce transfusion requirements in adolescent spine fusion surgery.
Perioperative blood salvage during surgical correction of craniosynostosis in infants.
Hemodiluição normovolêmica aguda em crianças submetidas a artrodese de coluna vertebral pela via posterior. [Acute normovolemic hemodilution in children submitted to posterior spinal fusion.] [Portuguese, English]
Major surgery in an osteosarcoma patient refusing blood transfusion: case report.
Perfusionist strategies for blood conservation in pediatric cardiac surgery.
Impact of intraoperative normovolemic hemodilution on transfusion requirements for 68 patients undergoing lumbar laminectomies with instrumented posterolateral fusion.
Bloodless spinal surgery: a review of the normovolemic hemodilution technique.
Reducing allogenic blood transfusions during pediatric cranial vault surgical procedures: a prospective analysis of blood recycling.
Open cardiac surgery in the first hours of life using autologous umbilical cord blood.
Acute normovolemic hemodilution combined with hypotensive anesthesia and other techniques to avoid homologous transfusion in spinal fusion surgery.
Blood conservation techniques in spinal deformity surgery: a retrospective review of patients refusing blood transfusion.
Successful blood conservation during craniosynostotic correction with dual therapy using Procrit and cell saver.
Transfusion-free anesthetic management for open heart surgery in a neonate—a case report.
Erythropoietin therapy and acute preoperative normovolaemic haemodilution in infants undergoing craniosynostosis surgery.
Implementation of a patient blood management program in pediatric scoliosis surgery. [Implementación de un programa de alternativas a la transfusión sanguínea en cirugía de escoliosis en pediatría.] [English, Spanish]
Bloodless pediatric cardiopulmonary bypass for a 3.2-kg patient whose parents are of Jehovah's Witness faith.
Economic evaluation of cell salvage in pediatric surgery.
The advantages of hemodilution anesthesia for major liver resection in children.
Hemodilution anesthesia: a valuable aid to major cancer surgery in children.
Detection of rare blood group, Bombay (Oh) phenotype patients and management by acute normovolemic hemodilution.
Systemic haemodynamics and oxygenation during haemodilution in children.
Blood conservation strategies in pediatric anesthesia.
血液回収法
急性等容量性血液希釈
麻酔学的血液温存法
Effects of prone and jackknife positioning on lumbar disc herniation surgery.
Management of severe anemia without transfusion in a pediatric Jehovah's Witness patient.
The effects of peritonsillar infiltration on the reduction of intraoperative blood loss and post-tonsillectomy pain in children.
Early experiences of vasodilators and hypotensive anesthesia in children.
Controlled hypotension: a guide to drug choice.
Evaluation of sodium nitroprusside for controlled hypotension in children during surgery.
Magnesium sulphate as a technique of hypotensive anaesthesia.
Spinal instrumentation for Duchenne's muscular dystrophy: experience of hypotensive anaesthesia to minimise blood loss.
Caudal epidural anesthesia reduces blood loss during hypospadias repair.
Clonidine facilitates controlled hypotension in adolescent children.
Acute normovolemic hemodilution combined with hypotensive anesthesia and other techniques to avoid homologous transfusion in spinal fusion surgery.
Blood conservation techniques in spinal deformity surgery: a retrospective review of patients refusing blood transfusion.
Anesthetic management of the hybrid stage 1 procedure for hypoplastic left heart syndrome (HLHS).
Deliberate hypotension in orthopedic surgery reduces blood loss and transfusion requirements: a meta-analysis of randomized controlled trials.
Zur lokalen Infiltration von Epinephrin und Bupivacain vor Tonsillektomie. [Local infiltration of epinephrine and bupivacaine before tonsillectomy]. [German, English abstract]
Clevidipine for controlled hypotension during spinal surgery in adolescents.
Controlled hypotension in children: a critical review of available agents.
低血圧法
局所麻酔
他の技法
医原性貧血を避けるための採血量の制限
Reducing blood testing in pediatric patients after heart surgery: a quality improvement project.
Prevention of iatrogenic anemia in critical and neonatal care.
Use of erythropoietin for bloodless surgery in a Jehovah's Witness infant.
Accuracy and precision of hemoglobin point-of-care testing during major pediatric surgery.
Blood loss from laboratory diagnostic tests in children.
Identifying factors to minimize phlebotomy-induced blood loss in the pediatric intensive care unit.
Blood conservation in neonatal and pediatric populations.
術後貧血の管理
Management of severe anemia without transfusion in a pediatric Jehovah's Witness patient.
Intérêt du fer intraveineux dans les anémies induites par l'hémodilution en chirurgie cardiaque pédiatrique. [Post-haemodilution anaemia in paediatric cardiac surgery: benefit of intravenous iron therapy.] [French, English abstract]
Erythropoietin in pediatric cardiac surgery: clinical efficacy and effective dose.
患者の貧血に対する許容力の最適化
Management of severe anemia without transfusion in a pediatric Jehovah's Witness patient.
Fluid overload is associated with impaired oxygenation and morbidity in critically ill children.
Effects of intravascular volume therapy using hydroxyethyl starch (130/0.4) on post-operative bleeding and transfusion requirements in children undergoing cardiac surgery: a randomized clinical trial.
Perioperative bleeding management in pediatric patients.
Pillar III—optimisation of anaemia tolerance.
Therapeutic options to minimize allogeneic blood transfusions and their adverse effects in cardiac surgery: a systematic review. [Opções terapêuticas para minimizar transfusões de sangue alogênico e seus efeitos adversos em cirurgia cardíaca: revisão sistemática.] [English, Portuguese]
中等度の等容量性貧血の許容
Extreme anemia (Hb 33 g/L) in a 13-year-old girl: is the transfusion always mandatory?
Minimizing blood transfusions in the surgical correction of craniosynostosis: a 10-year single-center experience.
Outcomes using a conservative versus liberal red blood cell transfusion strategy in infants requiring cardiac operation.
Patient blood management: a patient-orientated approach to blood replacement with the goal of reducing anemia, blood loss and the need for blood transfusion in elective surgery.
The premature infants in need of transfusion (PINT) study: A randomized, controlled trial of a restrictive (low) versus liberal (high) transfusion threshold for extremely low birth weight infants.
Transfusion strategies for patients in pediatric intensive care units.
The impact of restrictive transfusion practices on hemodynamically stable critically ill children without heart disease: a secondary analysis of the age of blood in children in the PICU trial.
Effect of transfusion guidelines on postoperative transfusion in children undergoing craniofacial reconstruction surgery.
Neurodevelopmental outcome of extremely low birth weight infants randomly assigned to restrictive or liberal hemoglobin thresholds for blood transfusion.
医療資源の限られる状況
The efficacy of pre-operative erythropoietin therapy.
Regional anaesthesia in paediatric surgery: results of 2200 children.
大量出血の有害作用
Association of blood products administration during cardiopulmonary bypass and excessive post-operative bleeding in pediatric cardiac surgery.
Excessive postoperative bleeding and outcomes in neonates undergoing cardiopulmonary bypass.
Early postoperative bleeding is independently associated with increased surgical mortality in infants after cardiopulmonary bypass.
輸血のリスクと不確実性
Association of blood products administration during cardiopulmonary bypass and excessive post-operative bleeding in pediatric cardiac surgery.
Anemia, blood loss, and blood transfusions in North American children in the intensive care unit.
Aprotinin, transfusions, and kidney injury in neonates and infants undergoing cardiac surgery.
Blood product transfusions and clinical outcomes in pediatric patients with acute lung injury.
Clinical outcomes associated with RBC transfusions in critically ill children: a 1-year prospective study.
Nitric oxide scavenging by red blood cell microparticles and cell-free hemoglobin as a mechanism for the red cell storage lesion.
Association between length of storage of transfused red blood cells and multiple organ dysfunction syndrome in pediatric intensive care patients.
Relationship between transfusion volume and outcomes in children undergoing noncardiac surgery.
Benefits and risks of red blood cell transfusion in pediatric patients undergoing cardiac surgery.
Serious hazards of transfusion in children (SHOT).
RBC transfusions in children requiring intensive care admission after traumatic injury.
Increased red blood cell transfusions are associated with worsening outcomes in pediatric heart transplant patients.
Adverse blood transfusion outcomes: establishing causation.
Association between length of storage of red blood cell units and outcome of critically ill children: a prospective observational study.
Blood transfusion risks and alternative strategies in pediatric patients.
Incidence of acute transfusion reactions to platelets in hospitalized pediatric patients based on the US hemovigilance reporting system.
Transfusion and risk of infection in Canada: update 2012. [Les transfusions et le risque d'infection au Canada : mise à jour pour 2012.] [English, French]
Efficacy of red blood cell transfusion in the critically ill: a systematic review of the literature.
Duration of red blood cell storage and outcomes in pediatric cardiac surgery: an association found for pump prime blood.
Adverse outcomes of blood transfusion in children: analysis of UK reports to the serious hazards of transfusion scheme 1996-2005.
Emerging infectious disease agents and their potential threat to transfusion safety.
Current perspectives in transfusion-transmitted infectious diseases: emerging and re-emerging infections.
Risks and predictors of blood transfusion in pediatric patients undergoing open heart operations.
臨床成績
Relationship between transfusion volume and outcomes in children undergoing noncardiac surgery.
Increased red blood cell transfusions are associated with worsening outcomes in pediatric heart transplant patients.
Clinical outcomes, blood utilization, and ethical considerations for pediatric patients in a bloodless medicine and surgery program.
Early death and late morbidity after blood transfusion of injured children: a pilot study.
The impact of restrictive transfusion practices on hemodynamically stable critically ill children without heart disease: a secondary analysis of the age of blood in children in the PICU trial.
経済効果
Pediatric red blood cell transfusions increase resource use.
Economic evaluation of cell salvage in pediatric surgery.
The impact of restrictive transfusion practices on hemodynamically stable critically ill children without heart disease: a secondary analysis of the age of blood in children in the PICU trial.
術前の患者の評価と輸血リスクの評価
Predictive factors for homologous transfusion during paediatric scoliosis surgery.
術前の計画と患者の状態の最適化
Major surgery in an osteosarcoma patient refusing blood transfusion: case report.
集学的,職種横断的な,個別化されたアプローチ
Posterior spine fusion in a Jehovah's Witness patient with severe rigid idiopathic scoliosis - a case report.
Major surgery in an osteosarcoma patient refusing blood transfusion: case report.
Acute normovolemic hemodilution combined with hypotensive anesthesia and other techniques to avoid homologous transfusion in spinal fusion surgery.
Blood conservation techniques in spinal deformity surgery: a retrospective review of patients refusing blood transfusion.
Implementation of a patient blood management program in pediatric scoliosis surgery. [Implementación de un programa de alternativas a la transfusión sanguínea en cirugía de escoliosis en pediatría.] [English, Spanish]
術前貧血管理と赤血球数の最適化
Quantifying risk of transfusion in children undergoing spine surgery.
止血の管理と最適化
A systematic review of the use of antifibrinolytic agents in pediatric surgery and implications for craniofacial use.
A Jehovah's Witness child with hemophilia B and factor IX inhibitors undergoing scoliosis surgery. [Chirurgie de la scoliose chez un enfant Témoin de Jéhovah souffrant d’hémophilie B et présentant des inhibiteurs du facteur IX.] [English, French abstract]
Efficacy and safety of prophylactic large dose of tranexamic acid in spine surgery: a prospective, randomized, double-blind, placebo-controlled study.
The efficacy of antifibrinolytic drugs in children undergoing noncardiac surgery: a systematic review of the literature.
The effect of Amicar on perioperative blood loss in idiopathic scoliosis: the results of a prospective, randomized double-blind study.
Tranexamic acid is efficacious at decreasing the rate of blood loss in adolescent scoliosis surgery: a randomized placebo-controlled trial.
Higher fibrinogen concentrations for reduction of transfusion requirements during major paediatric surgery: a prospective randomised controlled trial.
Antifibrinolytic agents reduce blood loss during pediatric vertebral column resection procedures.
The effect of aprotinin, tranexamic acid, and aminocaproic acid on blood loss and use of blood products in major pediatric surgery: a meta-analysis.
The role of Amicar in same-day anterior and posterior spinal fusion for idiopathic scoliosis.
Does the intraoperative tranexamic acid decrease operative blood loss during posterior spinal fusion for treatment of adolescent idiopathic scoliosis?
抗線溶薬
遺伝子組換え活性型血液凝固第Ⅶ因子製剤(rFVIIa)
濃縮凝固因子製剤
外科的出血か凝固異常による出血かを同定するための血液粘弾性試験
術中の自己血管理
Efficacy of intraoperative cell salvage systems in pediatric idiopathic scoliosis patients undergoing posterior spinal fusion with segmental spinal instrumentation.
Hemodilution as a method to reduce transfusion requirements in adolescent spine fusion surgery.
Major surgery in an osteosarcoma patient refusing blood transfusion: case report.
Bloodless spinal surgery: a review of the normovolemic hemodilution technique.
Acute normovolemic hemodilution combined with hypotensive anesthesia and other techniques to avoid homologous transfusion in spinal fusion surgery.
Blood conservation techniques in spinal deformity surgery: a retrospective review of patients refusing blood transfusion.
Is cell salvage cost-effective in posterior arthrodesis for adolescent idiopathic scoliosis in the public health system?
Implementation of a patient blood management program in pediatric scoliosis surgery. [Implementación de un programa de alternativas a la transfusión sanguínea en cirugía de escoliosis en pediatría.] [English, Spanish]
Economic evaluation of cell salvage in pediatric surgery.
Detection of rare blood group, Bombay (Oh) phenotype patients and management by acute normovolemic hemodilution.
Indications and outcomes of cell saver in adolescent scoliosis correction surgery: a systematic review.
Intraoperative cell salvage in revision hip arthroplasty.
血液回収法
急性等容量性血液希釈
麻酔学的血液温存法
Evaluation of sodium nitroprusside for controlled hypotension in children during surgery.
Spinal instrumentation for Duchenne's muscular dystrophy: experience of hypotensive anaesthesia to minimise blood loss.
Acute normovolemic hemodilution combined with hypotensive anesthesia and other techniques to avoid homologous transfusion in spinal fusion surgery.
Blood conservation techniques in spinal deformity surgery: a retrospective review of patients refusing blood transfusion.
Clevidipine for controlled hypotension during spinal surgery in adolescents.
低血圧法
経済効果
Is cell salvage cost-effective in posterior arthrodesis for adolescent idiopathic scoliosis in the public health system?
Economic evaluation of cell salvage in pediatric surgery.
輸血回避のための出生前治療計画
Risk of early-onset neonatal infection with maternal infection or colonization: a global systematic review and meta-analysis.
Intrapartum antibiotics and risk factors for early onset sepsis.
Potential drug-drug interactions in infant, child, and adolescent patients in children's hospitals.
Risk factors of transfusion in anemia of very low birth weight infants.
Erythropoiesis and the approach to anemia in premature infants.
Development of a strategic process using checklists to facilitate team preparation and improve communication during neonatal resuscitation.
集学的,職種横断的な,個別化されたアプローチ
Iron supplementation for preterm infants receiving restrictive red blood cell transfusions: reassessment of practice safety.
Nonpharmacological, blood conservation techniques for preventing neonatal anemia—effective and promising strategies for reducing transfusion.
A practical guide to reducing/eliminating red blood cell transfusions in the neonatal intensive care unit.
Effect of intravenous iron supplementation on erythropoiesis in erythropoietin-treated premature infants.
Effect of timing of umbilical cord clamping and other strategies to influence placental transfusion at preterm birth on maternal and infant outcomes.
未熟児貧血の治療管理
Efficacy and safety of umbilical cord milking at birth: a systematic review and meta-analysis.
Effects of umbilical cord milking on the need for packed red blood cell transfusions and early neonatal hemodynamic adaptation in preterm infants born ≤1500 g: a prospective, randomized, controlled trial.
Effect of delayed versus early umbilical cord clamping on neonatal outcomes and iron status at 4 months: a randomised controlled trial.
Iron supplementation for preterm infants receiving restrictive red blood cell transfusions: reassessment of practice safety.
Vitamin E levels during early iron supplementation in preterm infants.
Early versus delayed umbilical cord clamping in infants with congenital heart disease: a pilot, randomized, controlled trial.
Placental transfusion strategies in very preterm neonates: a systematic review and meta-analysis.
Implementing a program to improve compliance with neonatal intensive care unit transfusion guidelines was accompanied by a reduction in transfusion rate: a pre-post analysis within a multihospital health care system.
Using umbilical cord blood for the initial blood tests of VLBW neonates results in higher hemoglobin and fewer RBC transfusions.
Cord blood sampling for neonatal admission laboratory testing-an evidence-based blood conservation strategy.
Effect of umbilical cord blood sampling versus admission blood sampling on requirement of blood transfusion in extremely preterm infants: a randomized controlled trial.
Restrictive versus liberal red blood cell transfusion strategies for preterm infants: a systematic review of randomized controlled trials.
Red cell transfusion thresholds for preterm infants: finally some answers.
Erythropoietin concentrations and neurodevelopmental outcome in preterm infants.
Restrictive guideline reduces platelet count thresholds for transfusions in very low birth weight preterm infants.
Higher cumulative doses of erythropoietin and developmental outcomes in preterm infants.
Iron supplementation enhances response to high doses of recombinant human erythropoietin in preterm infants.
Umbilical cord blood as a replacement source for admission complete blood count in premature infants.
Effect of blood transfusions on the outcome of very low body weight preterm infants under two different transfusion criteria.
Effect of delayed cord clamping on very preterm infants.
Early erythropoietin administration does not increase the risk of retinopathy in preterm infants.
Unique risks of red blood cell transfusions in very-low-birth-weight neonates: associations between early transfusion and intraventricular hemorrhage and between late transfusion and necrotizing enterocolitis.
Whole-blood viscosity in the neonate: effects of gestational age, hematocrit, mean corpuscular volume and umbilical cord milking.
Postponing or eliminating red blood cell transfusions of very low birth weight neonates by obtaining all baseline laboratory blood tests from otherwise discarded fetal blood in the placenta.
Efficacy of recombinant erythropoietin for the late treatment of anemia of prematurity in a level IV neonatal intensive care unit: a retrospective single-center cohort study.
How to administrate erythropoietin, intravenous or subcutaneous?
Umbilical cord milking reduces need for red cell transfusions and improves neonatal adaptation in preterm infants: meta-analysis.
Association of haematocrit and red blood cell transfusion with outcomes in infants with shunt-dependent pulmonary blood flow and univentricular physiology.
Umbilical cord milking in term infants delivered by cesarean section: a randomized controlled trial.
An approach to using recombinant erythropoietin for neuroprotection in very preterm infants.
Safety of early high-dose recombinant erythropoietin for neuroprotection in very preterm infants.
Effects of liberal vs restrictive transfusion thresholds on survival and neurocognitive outcomes in extremely low-birth-weight infants: the ETTNO randomized clinical trial.
Early versus delayed cord clamping in term and preterm births: a review.
A randomized, controlled trial of the effects of adding vitamin B12 and folate to erythropoietin for the treatment of anemia of prematurity.
Effects of a combined therapy of erythropoietin, iron, folate, and vitamin B12 on the transfusion requirements of extremely low birth weight infants.
Resource implications of adopting a restrictive neonatal blood transfusion policy.
Umbilical cord milking reduces the need for red cell transfusions and improves neonatal adaptation in infants born at less than 29 weeks' gestation: a randomised controlled trial.
Late vs early clamping of the umbilical cord in full-term neonates: systematic review and meta-analysis of controlled trials.
Restrictive versus liberal red blood cell transfusion thresholds in very low birth weight infants: a systematic review and meta-analysis.
Association of umbilical cord management strategies with outcomes of preterm infants: a systematic review and network meta-analysis.
Clamp late and maintain perfusion (CLAMP) policy: delayed cord clamping in preterm infants.
Early versus late enteral prophylactic iron supplementation in preterm very low birth weight infants: a randomised controlled trial.
A phase I/II trial of high-dose erythropoietin in extremely low birth weight infants: pharmacokinetics and safety.
Effect of high-dose erythropoietin on blood transfusions in extremely low gestational age neonates: post hoc analysis of a randomized clinical trial.
Delayed umbilical cord clamping in premature neonates.
Neonatal resuscitation with an intact cord: a randomized clinical trial.
Umbilical cord milking versus delayed cord clamping in preterm infants.
Adverse effects of red blood cell transfusions in neonates: a systematic review and meta-analysis.
Higher or lower hemoglobin transfusion thresholds for preterm infants.
The premature infants in need of transfusion (PINT) study: A randomized, controlled trial of a restrictive (low) versus liberal (high) transfusion threshold for extremely low birth weight infants.
Transfusion strategies for patients in pediatric intensive care units.
Association between early administration of high-dose erythropoietin in preterm infants and brain MRI abnormality at term-equivalent age.
L'érythropoïétine humaine recombinante chez le nouveau-né : recommandations pour la pratique clinique de la Société française de néonatologie. [Recombinant human erythropoietin in neonates: guidelines for clinical practice from the French Society of Neonatology.] [French]
The effects of umbilical cord milking in extremely preterm infants: a randomized controlled trial.
Committee Opinion No. 684: Delayed umbilical cord clamping after birth.
Outcomes of extremely low birth weight infants given early high-dose erythropoietin.
Neurocognitive profiles of preterm infants randomly assigned to lower or higher hematocrit thresholds for transfusion.
Effect of timing of umbilical cord clamping of term infants on maternal and neonatal outcomes.
Seven-month developmental outcomes of very low birth weight infants enrolled in a randomized controlled trial of delayed versus immediate cord clamping.
Enteral iron supplementation in preterm and low birth weight infants.
The use of erythropoietin-stimulating agents versus supportive care in newborns with hereditary spherocytosis: a single centre's experience.
Effects of delayed cord clamping in very-low-birth-weight infants.
A practical guide to reducing/eliminating red blood cell transfusions in the neonatal intensive care unit.
A randomized, masked, placebo-controlled study of darbepoetin alfa in preterm infants.
Cognitive outcomes of preterm infants randomized to darbepoetin, erythropoietin, or placebo.
A randomized, masked study of weekly erythropoietin dosing in preterm infants.
Intravenous iron administration together with parenteral nutrition to very preterm Jehovah's Witness twins.
Effect of timing of umbilical cord clamping and other strategies to influence placental transfusion at preterm birth on maternal and infant outcomes.
Milking compared with delayed cord clamping to increase placental transfusion in preterm neonates: a randomized controlled trial.
Decrease in incidence of bronchopulmonary dysplasia with erythropoietin administration in preterm infants: a retrospective study.
Pharmacodynamically optimized erythropoietin treatment combined with phlebotomy reduction predicted to eliminate blood transfusions in selected preterm infants.
Use of recombinant human erythropoietin and risk of severe retinopathy in extremely low-birth-weight infants.
The effect of recombinant human erythropoietin on the development of retinopathy of prematurity.
Umbilical cord milking stabilizes cerebral oxygenation and perfusion in infants born before 29 weeks of gestation.
Early erythropoietin influences both transfusion and ventilation need in very low birth weight infants.
Delayed cord clamping in preterm infants delivered at 34-36 weeks' gestation: a randomised controlled trial.
Effect of gravity on volume of placental transfusion: a multicentre, randomised, non-inferiority trial.
Effects of transfusions in extremely low birth weight infants: a retrospective study.
Delayed umbilical cord clamping for reducing anaemia in low birthweight infants: implications for developing countries.
Erythropoietin prevents necrotizing enterocolitis in very preterm infants: a randomized controlled trial.
Red blood cell transfusion in newborn infants. [Les transfusions de culot globulaire aux nouveau-nés.] [English, French]
Neurodevelopmental outcome of extremely low birth weight infants randomly assigned to restrictive or liberal hemoglobin thresholds for blood transfusion.
Erythropoietin and retinopathy of prematurity: a meta-analysis.
Effect of short-term recombinant human erythropoietin therapy in the prevention of anemia of prematurity in very low birth weight neonates.
遅延臍帯クランプ
血液検査のための残余臍帯血の使用
赤血球造血刺激因子製剤
低出生体重児の貧血の許容
医原性貧血を避けるための採血量の制限
Using umbilical cord blood for the initial blood tests of VLBW neonates results in higher hemoglobin and fewer RBC transfusions.
Effect of minimization of early blood sampling losses among extremely premature neonates: a randomized clinical trial.
Respective effects of phlebotomy losses and erythropoietin treatment on the need for blood transfusion in very premature infants.
Umbilical cord blood as a replacement source for admission complete blood count in premature infants.
Postponing or eliminating red blood cell transfusions of very low birth weight neonates by obtaining all baseline laboratory blood tests from otherwise discarded fetal blood in the placenta.
Iatrogenic blood loss in extreme preterm infants due to frequent laboratory tests and procedures.
Risk factors of transfusion in anemia of very low birth weight infants.
Minimizing blood loss and the need for transfusions in very premature infants. Limiter les pertes de sang et le recours aux transfusions chez les grands prématurés. [English, French]
Phlebotomy overdraw in the neonatal intensive care nursery.
Reduction in red blood cell transfusions using a bedside analyzer in extremely low birth weight infants.
Impact of blood sampling in very preterm infants.
Implementation of a multi-parameter point-of-care-blood test analyzer reduces central laboratory testing and need for blood transfusions in very low birth weight infants.
Transcutaneous bilirubinometry reduces the need for blood sampling in neonates with visible jaundice.
Reliability of transcutaneous bilirubin devices in preterm infants: a systematic review.
A management guideline to reduce the frequency of blood transfusion in very-low-birth-weight infants.
Spectroscopic noninvasive measurement of hemoglobin compared with capillary and venous values in neonates.
Pharmacodynamically optimized erythropoietin treatment combined with phlebotomy reduction predicted to eliminate blood transfusions in selected preterm infants.
A mathematical modeling approach to quantify the role of phlebotomy losses and need for transfusions in neonatal anemia.
Identifying factors to minimize phlebotomy-induced blood loss in the pediatric intensive care unit.
Transcutaneous bilirubinometry in jaundiced neonates: a randomized controlled trial.
Reduction in red blood cell transfusions among preterm infants: results of a randomized trial with an in-line blood gas and chemistry monitor.
Blood conservation in neonatal and pediatric populations.
高ビリルビン血症の治療管理
Randomised controlled trial of single phototherapy with reflecting curtains versus double phototherapy in term newborns with hyperbilirubinaemia.
High-dose intravenous immunoglobulin therapy in neonatal immune haemolytic jaundice.
Effect of white plastic cover around the phototherapy unit on hyperbilirubinemia in full term neonates.
Clinical trial of tin mesoporphyrin to prevent neonatal hyperbilirubinemia.
Phototherapy to prevent severe neonatal hyperbilirubinemia in the newborn infant 35 or more weeks of gestation.
Phenobarbitone for prevention and treatment of unconjugated hyperbilirubinemia in preterm neonates: a systematic review and meta-analysis.
High-dose intravenous immunoglobulin therapy for rhesus haemolytic disease.
High-intensity phototherapy for the treatment of severe nonhaemolytic neonatal hyperbilirubinemia.
Efficacy of phototherapy for neonatal jaundice is increased by the use of low-cost white reflecting curtains.
Single dose of 50 mg/kg clofibrate in jaundice of healthy term neonates: randomised clinical trial of efficacy and safety.
Clofibrate in combination with phototherapy for unconjugated neonatal hyperbilirubinaemia.
Systematic review of intravenous immunoglobulin in haemolytic disease of the newborn.
Intravenous immune globulin in neonatal ABO isoimmunization: factors associated with clinical efficacy.
Effect of ursodeoxycholic acid on indirect hyperbilirubinemia in neonates treated with phototherapy.
Intravenous immune globulin reduces the need for exchange transfusions in Rhesus and ABO incompatibility.
Sn-mesoporphyrin interdiction of severe hyperbilirubinemia in Jehovah's Witness newborns as an alternative to exchange transfusion.
A method for interdicting the development of severe jaundice in newborns by inhibiting the production of bilirubin.
Light-emitting diode phototherapy for unconjugated hyperbilirubinaemia in neonates.
Hyperbilirubinemia in the newborn infant > or =35 weeks' gestation: an update with clarifications.
A randomized controlled trial of fluid supplementation in term neonates with severe hyperbilirubinemia.
Intravenous immunoglobulin G (IVIG) therapy for significant hyperbilirubinemia in ABO hemolytic disease of the newborn.
Treatment of clofibrate in jaundiced low birth weight neonates. [English, Turkish abstract]
Efficacy of phototherapy devices and outcomes among extremely low birth weight infants: multi-center observational study.
Prophylactic phototherapy for preventing jaundice in preterm or low birth weight infants.
Tin-mesoporphyrin in the treatment of severe hyperbilirubinemia in a very-low-birth-weight infant.
The effect of clofibrate with phototherapy in late pre-term newborns with non-hemolytic jaundice.
A randomized trial of phototherapy with filtered sunlight in African neonates.
Dose-response relationship of phototherapy for hyperbilirubinemia.
Clofibrate for unconjugated hyperbilirubinemia in neonates: a systematic review.
Interscapular site for transcutaneous bilirubin measurement in preterm infants: a better and safer screening site.
Efficacy of clofibrate on severe neonatal jaundice associated with glucose-6-phosphate dehydrogenase deficiency (a randomized clinical trial).
光線療法
免疫グロブリン静注療法
すずメソポルフィリン
他の薬剤
血小板減少症の治療管理
Vitamin K in neonates: how to administer, when and to whom.
Severe thrombocytopenia in the NICU.
Do platelet transfusions in the NICU adversely affect survival? Analysis of 1600 thrombocytopenic neonates in a multihospital healthcare system.
Thrombocytopenia related neonatal outcome in preterms.
Changes in thrombopoiesis and platelet reactivity in extremely low birth weight infants undergoing erythropoietin therapy for treatment of anaemia of prematurity.
Vitamin K in neonates: facts and myths.
Comment on: use of thrombopoietin receptor agonist (romiplostim) in neonatal autoimmune thrombocytopenia due to maternal immune thrombocytopenia.
Prophylactic vitamin K for vitamin K deficiency bleeding in neonates.
Vitamin K, an update for the paediatrician.
出産後
止血の管理と最適化
Recombinant activated factor VII (rFVIIa) treatment in infants with hemorrhage.
The use of recombinant activated factor VII in the treatment of massive pulmonary hemorrhage in a preterm infant.
The use of recombinant activated factor VII to control bleeding in a preterm infant undergoing exploratory laparotomy.
Recombinant activated factor VIIa (rFVIIa) treatment in very-low-birth-weight (VLBW) premature infants with acute pulmonary hemorrhage: a single-center, retrospective study.
Recombinant activated factor VIIa treatment for refractory hemorrhage in infants.
Use of recombinant factor VIIa in infants with severe coagulopathy.
Predicting response to rFVIIa in neonates with intractable bleeding or severe coagulation disturbances.
Successful use of recombinant activated FVII and aminocaproic acid in four neonates with life-threatening hemorrhage.
Use of recombinant factor VIIa for uncontrolled bleeding in neonates after cardiopulmonary bypass.
The use of recombinant factor VIIa for severe intractable bleeding during spine surgery.
Is the use of rFVIIa safe and effective in bleeding neonates? A retrospective series of 8 cases.
Treatment of severe pulmonary hemorrhage with activated recombinant factor VII (rFVIIa) in very low birth weight infants.
Thrombotic events in neonates receiving recombinant factor VIIa or fresh frozen plasma.
遺伝子組換え活性型血液凝固第Ⅶ因子製剤(rFVIIa)
薬剤性の貧血や血小板減少の予防
Patent ductus arteriosus, low platelets, cyclooxygenase inhibitors, and intraventricular hemorrhage in very low birth weight preterm infants.
Natalizumab use during the third trimester of pregnancy.
Hemolytic anemia and methemoglobinemia in a preterm baby as a complication of antenatal intraamnial injection of toluidine blue.
Drug-induced thrombocytopenia in children.
細菌性敗血症
Bacteremia, central catheters, and neonates: when to pull the line.
Recommendations for neonatal surfactant therapy.
Reducing central line-associated bloodstream infections in North Carolina NICUs.
Nonsterile glove use in addition to hand hygiene to prevent late-onset infection in preterm infants: randomized clinical trial.
The World Health Organization Guidelines on Hand Hygiene in Health Care and their consensus recommendations.
Strategies for prevention of health care-associated infections in the NICU.
Management of neonates with suspected or proven early-onset bacterial sepsis.
One dose per day compared to multiple doses per day of gentamicin for treatment of suspected or proven sepsis in neonates.
Risk factors and outcomes for multidrug-resistant Gram-negative bacteremia in the NICU.
予防
治療管理
術前貧血管理と赤血球数の最適化
Iron supplementation for preterm infants receiving restrictive red blood cell transfusions: reassessment of practice safety.
Erythropoietin increases reticulocyte counts and maintains hematocrit in neonates requiring surgery.
Iron supplementation enhances response to high doses of recombinant human erythropoietin in preterm infants.
Nonpharmacological, blood conservation techniques for preventing neonatal anemia—effective and promising strategies for reducing transfusion.
Effects of a combined therapy of erythropoietin, iron, folate, and vitamin B12 on the transfusion requirements of extremely low birth weight infants.
Early versus late enteral prophylactic iron supplementation in preterm very low birth weight infants: a randomised controlled trial.
Enteral iron supplementation in preterm and low birth weight infants.
Use of erythropoietin for bloodless surgery in a Jehovah's Witness infant.
Effect of intravenous iron supplementation on erythropoiesis in erythropoietin-treated premature infants.
Erythropoietin in pediatric cardiac surgery: clinical efficacy and effective dose.
中等度の等容量性貧血の許容
Implementing a program to improve compliance with neonatal intensive care unit transfusion guidelines was accompanied by a reduction in transfusion rate: a pre-post analysis within a multihospital health care system.
Restrictive versus liberal red blood cell transfusion strategies for preterm infants: a systematic review of randomized controlled trials.
Restrictive guideline reduces platelet count thresholds for transfusions in very low birth weight preterm infants.
Effect of blood transfusions on the outcome of very low body weight preterm infants under two different transfusion criteria.
Unique risks of red blood cell transfusions in very-low-birth-weight neonates: associations between early transfusion and intraventricular hemorrhage and between late transfusion and necrotizing enterocolitis.
Association of haematocrit and red blood cell transfusion with outcomes in infants with shunt-dependent pulmonary blood flow and univentricular physiology.
Impact of perioperative blood transfusion on postoperative outcomes in neonates.
Resource implications of adopting a restrictive neonatal blood transfusion policy.
Restrictive versus liberal red blood cell transfusion thresholds in very low birth weight infants: a systematic review and meta-analysis.
Adverse effects of red blood cell transfusions in neonates: a systematic review and meta-analysis.
The premature infants in need of transfusion (PINT) study: A randomized, controlled trial of a restrictive (low) versus liberal (high) transfusion threshold for extremely low birth weight infants.
Transfusion strategies for patients in pediatric intensive care units.
Neurocognitive profiles of preterm infants randomly assigned to lower or higher hematocrit thresholds for transfusion.
Effects of transfusions in extremely low birth weight infants: a retrospective study.
Red blood cell transfusion in newborn infants. [Les transfusions de culot globulaire aux nouveau-nés.] [English, French]
Neurodevelopmental outcome of extremely low birth weight infants randomly assigned to restrictive or liberal hemoglobin thresholds for blood transfusion.
血小板減少の許容
Implementing a program to improve compliance with neonatal intensive care unit transfusion guidelines was accompanied by a reduction in transfusion rate: a pre-post analysis within a multihospital health care system.
Severe thrombocytopenia in the NICU.
Do platelet transfusions in the NICU adversely affect survival? Analysis of 1600 thrombocytopenic neonates in a multihospital healthcare system.
Lowering platelet-count threshold for transfusion in preterm neonates decreases the number of transfusions without increasing severe hemorrhage events.
Restrictive guideline reduces platelet count thresholds for transfusions in very low birth weight preterm infants.
Randomized trial of platelet-transfusion thresholds in neonates.
Restrictive versus liberal red blood cell transfusion thresholds in very low birth weight infants: a systematic review and meta-analysis.
Two-year outcomes following a randomised platelet transfusion trial in preterm infants.
Severe thrombocytopenia and patterns of bleeding in neonates: results from a prospective observational study and implications for use of platelet transfusions.
Thrombocytopaenia and intraventricular haemorrhage in very premature infants: a tale of two cities.
医療資源の限られる状況
Effect of white plastic cover around the phototherapy unit on hyperbilirubinemia in full term neonates.
Twenty-year follow-up of kangaroo mother care versus traditional care.
Efficacy of phototherapy for neonatal jaundice is increased by the use of low-cost white reflecting curtains.
Phenobarbital and phototherapy combination enhances decline of total serum bilirubin and may decrease the need for blood exchange transfusion in newborns with isoimmune hemolytic disease.
A randomized trial of phototherapy with filtered sunlight in African neonates.
Safety and efficacy of filtered sunlight in treatment of jaundice in African neonates.
Efficacy of clofibrate on severe neonatal jaundice associated with glucose-6-phosphate dehydrogenase deficiency (a randomized clinical trial).
輸血のリスクと不確実性
Among very-low-birth-weight neonates is red blood cell transfusion an independent risk factor for subsequently developing a severe intraventricular hemorrhage?
Red blood cell transfusion of preterm neonates with a Grade 1 intraventricular hemorrhage is associated with extension to a Grade 3 or 4 hemorrhage.
Do platelet transfusions in the NICU adversely affect survival? Analysis of 1600 thrombocytopenic neonates in a multihospital healthcare system.
Transfusion-related acute gut injury: necrotizing enterocolitis in very low birth weight neonates after packed red blood cell transfusion.
The incidence and risk factors of severe retinopathy of prematurity in extremely low birth weight infants in Turkey.
Association, among very-low-birthweight neonates, between red blood cell transfusions in the week after birth and severe intraventricular hemorrhage.
Association of neonatal red blood cell transfusion with increase in serum bilirubin.
Blood product transfusions and clinical outcomes in pediatric patients with acute lung injury.
Instituting a program to reduce the erythrocyte transfusion rate was accompanied by reductions in the incidence of bronchopulmonary dysplasia, retinopathy of prematurity and necrotizing enterocolitis.
Preoperative blood transfusions and morbidity in neonates undergoing surgery.
Relationship between perioperative blood transfusion and surgical site infections in the newborn population: an ACS-NSQIP-Pediatrics analysis.
Impact of perioperative blood transfusion on postoperative outcomes in neonates.
Red blood cell transfusion in critically ill children: a narrative review.
A cluster of transfusion-associated babesiosis in extremely low birthweight premature infants.
The relationship between brain structure and cognition in transfused preterm children at school age.
Neurocognitive profiles of preterm infants randomly assigned to lower or higher hematocrit thresholds for transfusion.
Transfusion associated necrotizing enterocolitis: a meta-analysis of observational data.
Long-term outcome of brain structure in premature infants: effects of liberal vs restricted red blood cell transfusions.
Increased odds of necrotizing enterocolitis after transfusion of red blood cells in premature infants.
Post transfusion lung injury in the neonatal population.
Red blood cell transfusions are independently associated with intra-hospital mortality in very low birth weight preterm infants.
Emerging infectious disease agents and their potential threat to transfusion safety.
Current perspectives in transfusion-transmitted infectious diseases: emerging and re-emerging infections.
Thrombocytopaenia and intraventricular haemorrhage in very premature infants: a tale of two cities.
Transfusions and neurodevelopmental outcomes in extremely low gestation neonates enrolled in the PENUT Trial: a randomized clinical trial.
Packed red blood cell transfusion is an independent risk factor for necrotizing enterocolitis in premature infants.
Red blood cell transfusion and clinical outcomes in extremely low birth weight preterm infants.
Association between red blood cell transfusion and bronchopulmonary dysplasia in preterm infants.
術前の患者の評価と輸血リスクの評価
Herbal remedies affecting coagulation: a review.
Plasma fibrinogen concentration is correlated with postoperative blood loss in children undergoing cardiac surgery. A retrospective review.
Pediatric responsibilities for preoperative evaluation.
The pediatrician's role in the evaluation and preparation of pediatric patients undergoing anesthesia.
Predictive factors for red blood cell transfusion in children undergoing noncomplex cardiac surgery.
Multivariate model for predicting postoperative blood loss in children undergoing cardiac surgery: a preliminary study.
Risks and predictors of blood transfusion in pediatric patients undergoing open heart operations.
Factors associated with blood loss and blood product transfusions: a multivariate analysis in children after open-heart surgery.
術前の計画と患者の状態の最適化
Early versus delayed umbilical cord clamping in infants with congenital heart disease: a pilot, randomized, controlled trial.
The operating surgeon is an independent predictor of chest tube drainage following cardiac surgery.
The pediatrician's role in the evaluation and preparation of pediatric patients undergoing anesthesia.
Quality measures for congenital and pediatric cardiac surgery.
The theory and practice of bloodless surgery.
Pillar III—optimisation of anaemia tolerance.
The Ross operation in a Jehovah's Witness: a paradigm for heart surgery in children without transfusion.
集学的,職種横断的な,個別化されたアプローチ
Perfusionist strategies for blood conservation in pediatric cardiac surgery.
Bloodless cardiac surgery and the pediatric patient: a case study.
Perioperative blood conservation strategies in pediatric patients undergoing open-heart surgery: impact of non-autologous blood transfusion and surface-coated extracorporeal circuits.
Transfusion-free cardiac surgery with cardiopulmonary bypass in a 2.2-kg neonate.
Transfusion-free complex cardiac surgery: with use of deep hypothermic circulatory arrest in a preterm 2.96-kg Jehovah's witness neonate.
Anesthetic management for transfusion-free Rastelli's procedure in a pediatric Jehovah's Witness patient.
Blood conservation operations in pediatric cardiac patients: a paradigm shift of blood use.
Perioperative management of a child with hypoplastic left heart syndrome of the Jehovah's Witness faith presenting for hybrid comprehensive stage II procedure.
Transfusion-free anesthetic management for open heart surgery in a neonate—a case report.
The Ross operation in a Jehovah's Witness: a paradigm for heart surgery in children without transfusion.
A single-center strategy to minimize blood transfusion in neonates and children undergoing cardiac surgery.
Comprehensive blood conservation program in a new congenital cardiac surgical program allows bloodless surgery for the Jehovah Witness and a reduction for all patients.
Cardiac surgery without blood products in a Jehovah's Witness child with factor VII deficiency.
Bloodless pediatric cardiopulmonary bypass for a 3.2-kg patient whose parents are of Jehovah's Witness faith.
Effects of a comprehensive blood-sparing approach using body weight-adjusted miniaturized cardiopulmonary bypass circuits on transfusion requirements in pediatric cardiac surgery.
Heart retransplantation in children without the use of blood product. [Retransplante cardíaco em criança sem o uso de hemoderivados.] [English, Portuguese abstract]
Strategic and operational aspects of a transfusion-free neonatal arterial switch operation.
2011 update to the Society of Thoracic Surgeons and the Society of Cardiovascular Anesthesiologists blood conservation clinical practice guidelines.
Bloodless repair of aortic arch with dual aortic cannulation in a Jehovah's Witness patient.
Bloodless repair of isolated pulmonary artery in a neonate.
術前貧血管理と赤血球数の最適化
Erythropoietin increases reticulocyte counts and maintains hematocrit in neonates requiring surgery.
Bloodless cardiac surgery and the pediatric patient: a case study.
Minimizing perioperative blood loss and transfusions in children. [Réduire les pertes sanguines et les besoins transfusionnels en chirurgie pédiatrique.] [English, French abstract]
Transfusion-free cardiac surgery with cardiopulmonary bypass in a 2.2-kg neonate.
Intérêt du fer intraveineux dans les anémies induites par l'hémodilution en chirurgie cardiaque pédiatrique. [Post-haemodilution anaemia in paediatric cardiac surgery: benefit of intravenous iron therapy.] [French, English abstract]
The efficacy of preoperative administration of a single dose of recombinant human erythropoietin in pediatric cardiac surgery.
Use of erythropoietin for bloodless surgery in a Jehovah's Witness infant.
Cardiac surgery without blood products in a Jehovah's Witness child with factor VII deficiency.
Chirurgie hemorragique chez deux enfants de temoins de Jehovah refusant l'autotransfusion programmee : place de l'erythropoietine. [Hemorrhagic surgery in two Jehovah's Witness children refusing programmed autotransfusion: a place for erythropoietin.] [French, English abstract]
Erythropoietin in pediatric cardiac surgery: clinical efficacy and effective dose.
抗凝固療法の管理と中和
Emergent pediatric anticoagulation reversal using a 4-factor prothrombin complex concentrate.
Four-factor prothrombin complex concentrates in paediatric patients—a retrospective case series.
血管造影による塞栓術または血管閉塞
Neonatal pulmonary sequestration: clinical experience with transumbilical arterial embolization.
Coil embolization of pulmonary sequestration in two infants: a safe alternative to surgery.
外科的血液温存法
Conservation of blood during cardiovascular surgery.
Cardiac operation for congenital heart disease in children of Jehovah's Witnesses.
Process improvement in cardiac surgery: development and implementation of a reoperation for bleeding checklist.
Completion of the three-stage Fontan pathway without cardiopulmonary bypass.
Cardiac surgery without blood products in a Jehovah's Witness child with factor VII deficiency.
Extracardiac Fontan operation without cardiopulmonary bypass.
低侵襲治療法
Video-assisted thoracoscopic surgery for pulmonary sequestration in children.
Hybrid approach for hypoplastic left heart syndrome: intermediate results after the learning curve.
Thoracoscopic resection of intra- and extralobar pulmonary sequestration in the first 3 months of life.
Right ventricular outflow tract stent as a bridge to surgery in a premature infant with tetralogy of Fallot.
Neonatal pulmonary sequestration: clinical experience with transumbilical arterial embolization.
Anesthetic management of the hybrid stage 1 procedure for hypoplastic left heart syndrome (HLHS).
Experience in minimally invasive Nuss operation for 406 children with pectus excavatum.
Extracardiac Fontan operation without cardiopulmonary bypass.
Thoracoscopic versus open resection for congenital cystic adenomatoid malformations of the lung.
止血の管理と最適化
A comprehensive review of topical hemostatic agents: efficacy and recommendations for use.
Recombinant factor seven therapy for postoperative bleeding in neonatal and pediatric cardiac surgery.
Utility of Sonoclot analysis and tranexamic acid in tetralogy of Fallot patients undergoing intracardiac repair.
Pediatric off-label use of recombinant factor VIIa.
Avoiding transfusions in children undergoing cardiac surgery: a meta-analysis of randomized trials of aprotinin.
A systematic review of the use of antifibrinolytic agents in pediatric surgery and implications for craniofacial use.
Aprotinin, transfusions, and kidney injury in neonates and infants undergoing cardiac surgery.
Factor VII for excessive bleeding following congenital heart disease surgery.
Comparison of epsilon aminocaproic acid and tranexamic acid in pediatric cardiac surgery.
Efficacy of aprotinin, epsilon aminocaproic acid, or combination in cyanotic heart disease.
The Bayer 022 compassionate-use pediatric study.
Perioperative monitoring of thromboelastograph on blood protection and recovery for severely cyanotic patients undergoing complex cardiac surgery.
Plasma fibrinogen concentration is correlated with postoperative blood loss in children undergoing cardiac surgery. A retrospective review.
Efficacy and safety of fibrinogen concentrate in surgical patients: a meta-analysis of randomized controlled trials.
Hemostatic effects of fibrinogen concentrate compared with cryoprecipitate in children after cardiac surgery: a randomized pilot trial.
Differential effects of aprotinin and tranexamic acid on outcomes and cytokine profiles in neonates undergoing cardiac surgery.
Minimizing perioperative blood loss and transfusions in children. [Réduire les pertes sanguines et les besoins transfusionnels en chirurgie pédiatrique.] [English, French abstract]
Use of recombinant factor VIIa for uncontrolled bleeding in neonates after cardiopulmonary bypass.
Review of the off-label use of recombinant activated factor VII in pediatric cardiac surgery patients.
Intraoperative tranexamic acid in pediatric bloodless cardiac surgery.
The safety and efficacy of antifibrinolytic therapy in neonatal cardiac surgery.
Epsilon aminocaproic acid reduces blood transfusion and improves the coagulation test after pediatric open-heart surgery: a meta-analysis of 5 clinical trials.
Anesthetic management in a pediatric patient with Noonan syndrome, mastocytosis, and von Willebrand disease: a case report.
Tranexamic acid versus ɛ-aminocaproic acid: efficacy and safety in paediatric cardiac surgery.
Replacement of aprotinin by ε-aminocaproic acid in infants undergoing cardiac surgery: consequences for blood loss and outcome.
Hematologic and economic impact of aprotinin in reoperative pediatric cardiac operations.
Efficacy of tranexamic acid as compared to aprotinin in open heart surgery in children.
Thromboelastometry-guided intraoperative haemostatic management reduces bleeding and red cell transfusion after paediatric cardiac surgery.
Four-factor prothrombin complex concentrates in paediatric patients—a retrospective case series.
Is recombinant activated factor VII effective in the treatment of excessive bleeding after paediatric cardiac surgery?
Resternotomy in pediatric cardiac surgery: CoSeal initial experience.
Comparative analysis of antifibrinolytic medications in pediatric heart surgery.
Cardiac surgery without blood products in a Jehovah's Witness child with factor VII deficiency.
Use of recombinant activated factor VII for controlling refractory postoperative bleeding in children undergoing cardiac surgery with cardiopulmonary bypass.
The efficacy of tranexamic acid versus placebo in decreasing blood loss in pediatric patients undergoing repeat cardiac surgery.
Effective tranexamic acid concentration for 95% inhibition of tissue-type plasminogen activator induced hyperfibrinolysis in children with congenital heart disease: A prospective, controlled, in-vitro study.
Comparison of different doses of ε-aminocaproic acid in children for tetralogy of Fallot surgery: clinical efficacy and safety.
Increased recombinant activated factor VII use and need for surgical reexploration following a switch from aprotinin to epsilon-aminocaproic acid in infant cardiac surgery.
Recombinant activated factor VII for hemorrhage after pediatric cardiac surgery.
Recombinant factor VIIa to treat bleeding after cardiac surgery in an infant.
Recombinant factor VIIa to control excessive bleeding following surgery for congenital heart disease in pediatric patients.
Comparison of three dose regimens of aprotinin in infants undergoing the arterial switch operation.
Recombinant activated factor VII in cardiac surgery: a systematic review.
Defining the role of recombinant activated factor VII in pediatric cardiac surgery: where should we go from here?
Pharmacokinetics of tranexamic acid in neonates, infants, and children undergoing cardiac surgery with cardiopulmonary bypass.
Efficacy and safety of aprotinin in neonatal congenital heart operations.
Decreasing the need for transfusion: infant cardiac surgery using hemodilution and recombinant factor VIIa.
Single-center experience: use of recombinant factor VIIa for acute life-threatening bleeding in children without congenital hemorrhagic disorder.
The effect of preoperative tranexamic acid on blood loss after cardiac operations in children.
抗線溶薬
遺伝子組換え活性型血液凝固第Ⅶ因子製剤(rFVIIa)
濃縮凝固因子製剤
デスモプレシン
局所止血剤
外科的出血か凝固異常による出血かを同定するための血液粘弾性試験
体温管理(低体温の回避)
Randomized comparison between mild and moderate hypothermic cardiopulmonary bypass for neonatal arterial switch operation.
Effect of temperature on thromboelastography and implications for clinical use in newborns undergoing therapeutic hypothermia.
注意深い輸液・体液管理
Bloodless surgery in a pediatric Jehovah's Witness.
Perfusionist strategies for blood conservation in pediatric cardiac surgery.
Transfusion-free complex cardiac surgery: with use of deep hypothermic circulatory arrest in a preterm 2.96-kg Jehovah's witness neonate.
Fluid overload is associated with higher mortality and morbidity in pediatric patients undergoing cardiac surgery.
Pediatric Cardiac Intensive Care Society 2014 Consensus Statement: pharmacotherapies in cardiac critical care fluid management.
The effect of cardiopulmonary bypass prime volume on the need for blood transfusion after pediatric cardiac surgery.
Prolonged warm ischemia for transfusion-free arterial switch and ventricular septal defect surgery in a 4.5-Kg baby.
術中の自己血管理
Bloodless surgery in a pediatric Jehovah's Witness.
Open heart surgery for small children without homologous blood transfusion by using remote pump head system.
Safe minimization of cardiopulmonary bypass circuit volume for complex cardiac surgery in a 3.7 kg neonate.
Bloodless repair for a 3.6 kilogram transposition of the great arteries with Jehovah's Witness faith.
Five-year experience with mini-volume priming in infants ≤5 kg: safety of significantly smaller transfusion volumes.
Arterial switch operation in the first hours of life using autologous umbilical cord blood.
Transfusion of cell saver salvaged blood in neonates and infants undergoing open heart surgery significantly reduces RBC and coagulant product transfusions and donor exposures: results of a prospective, randomized, clinical trial.
Perfusionist strategies for blood conservation in pediatric cardiac surgery.
Open cardiac surgery in the first hours of life using autologous umbilical cord blood.
Clinical applications of retrograde autologous priming in cardiopulmonary bypass in pediatric cardiac surgery.
Bloodless cardiac surgery and the pediatric patient: a case study.
Small, smaller, smallest. Steps towards bloodless neonatal and infant cardiopulmonary bypass.
Clinical outcome and blood transfusion after infant cardiac surgery with a routine use of conventional ultrafiltration.
Intraoperative cell salvage in infants undergoing elective cardiac surgery: a prospective trial.
Specific requirements for bloodless cardiopulmonary bypass in neonates and infants; a review.
Perioperative blood conservation strategies in pediatric patients undergoing open-heart surgery: impact of non-autologous blood transfusion and surface-coated extracorporeal circuits.
Cardiac operation for congenital heart disease in children of Jehovah's Witnesses.
Effects of circuit miniaturization in reducing inflammatory response to infant cardiopulmonary bypass by elimination of allogeneic blood products.
Effects of autologous platelet concentrate reinfusion after open heart surgery in patients with congenital heart disease.
Quality improvement methodologies increase autologous blood product administration.
Total cavopulmonary connection in a 35-month-old Jehovah's Witness child.
Transfusion-free cardiac surgery with cardiopulmonary bypass in a 2.2-kg neonate.
Transfusion-free complex cardiac surgery with cardiopulmonary bypass in a 3.55-kg Jehovah's Witness neonate.
Transfusion-free cardiac reoperation in an 11-kg Jehovah's Witness child by use of a minimized cardiopulmonary bypass circuit.
Transfusion-free complex cardiac surgery: with use of deep hypothermic circulatory arrest in a preterm 2.96-kg Jehovah's witness neonate.
Anesthetic management for transfusion-free Rastelli's procedure in a pediatric Jehovah's Witness patient.
Safety of bloodless open-heart surgery on cardiopulmonary bypass in selected children: a single center experience with minimal invasive extracorporeal circulation.
Effects of mini-volume priming during cardiopulmonary bypass on clinical outcomes in low-bodyweight neonates: less transfusion and postoperative extracorporeal membrane oxygenation support.
Single center experience with a low volume priming cardiopulmonary bypass circuit for preventing blood transfusion in infants and small children.
Normovolemic hemodilution using hydroxyethyl starch 130/0.4 (Voluven) in a Jehovah's Witness child requiring cardiopulmonary bypass for ventricular septal defect repair.
Transfusion-free anesthetic management for open heart surgery in a neonate—a case report.
Cell saver blood transfusions may be associated with a decrease in inflammation and improved outcome measures in pediatric cardiac surgery patients.
Pediatric cardiac surgery without homologous blood transfusion, using a miniaturized bypass system in infants with lower body weight.
Asanguineous cardiopulmonary bypass in infants: impact on postoperative mortality and morbidity.
Perfusion techniques toward bloodless pediatric open heart surgery.
Cardiac surgery without blood products in a Jehovah's Witness child with factor VII deficiency.
Bloodless pediatric cardiopulmonary bypass for a 3.2-kg patient whose parents are of Jehovah's Witness faith.
Effects of a comprehensive blood-sparing approach using body weight-adjusted miniaturized cardiopulmonary bypass circuits on transfusion requirements in pediatric cardiac surgery.
Minimizing intraoperative hemodilution by use of a very low priming volume cardiopulmonary bypass in neonates with transposition of the great arteries.
The effect of cardiopulmonary bypass prime volume on the need for blood transfusion after pediatric cardiac surgery.
Prolonged warm ischemia for transfusion-free arterial switch and ventricular septal defect surgery in a 4.5-Kg baby.
Heart retransplantation in children without the use of blood product. [Retransplante cardíaco em criança sem o uso de hemoderivados.] [English, Portuguese abstract]
Strategic and operational aspects of a transfusion-free neonatal arterial switch operation.
Revisiting acute normovolemic hemodilution and blood transfusion during pediatric cardiac surgery: a prospective observational study.
Detection of rare blood group, Bombay (Oh) phenotype patients and management by acute normovolemic hemodilution.
Implementation of a multidisciplinary bleeding and transfusion protocol significantly decreases perioperative blood product utilization and improves some bleeding outcomes.
The effect of modified ultrafiltration duration on pulmonary functions and hemodynamics in newborns and infants following arterial switch operation.
Bloodless repair of isolated pulmonary artery in a neonate.
Decreasing the need for transfusion: infant cardiac surgery using hemodilution and recombinant factor VIIa.
Effects of circuit residual volume salvage reinfusion on the postoperative clinical outcome for pediatric patients undergoing cardiac surgery.
小型人工心肺(灌流)回路
血液回収法
急性等容量性血液希釈
逆行性自己血充填(RAP)
限外濾過
医原性貧血を避けるための採血量の制限
Reducing blood testing in pediatric patients after heart surgery: a quality improvement project.
Blood loss from laboratory diagnostic tests in children.
Identifying factors to minimize phlebotomy-induced blood loss in the pediatric intensive care unit.
術後貧血の管理
Management of severe anemia without transfusion in a pediatric Jehovah's Witness patient.
Intravenous iron for critically ill children. Comparison of three dose regimens.
Intérêt du fer intraveineux dans les anémies induites par l'hémodilution en chirurgie cardiaque pédiatrique. [Post-haemodilution anaemia in paediatric cardiac surgery: benefit of intravenous iron therapy.] [French, English abstract]
Use of erythropoietin for bloodless surgery in a Jehovah's Witness infant.
Erythropoietin in pediatric cardiac surgery: clinical efficacy and effective dose.
Open heart surgery without homologous blood transfusion and subsequent use of recombinant erythropoietin to treat postoperative anemia.
患者の貧血に対する許容力の最適化
Fluid overload is associated with impaired oxygenation and morbidity in critically ill children.
Effects of intravascular volume therapy using hydroxyethyl starch (130/0.4) on post-operative bleeding and transfusion requirements in children undergoing cardiac surgery: a randomized clinical trial.
Perioperative bleeding management in pediatric patients.
Pediatric Cardiac Intensive Care Society 2014 Consensus Statement: pharmacotherapies in cardiac critical care fluid management.
Pillar III—optimisation of anaemia tolerance.
Therapeutic options to minimize allogeneic blood transfusions and their adverse effects in cardiac surgery: a systematic review. [Opções terapêuticas para minimizar transfusões de sangue alogênico e seus efeitos adversos em cirurgia cardíaca: revisão sistemática.] [English, Portuguese]
中等度の等容量性貧血の許容
Children with single-ventricle physiology do not benefit from higher hemoglobin levels post cavopulmonary connection: results of a prospective, randomized, controlled trial of a restrictive versus liberal red-cell transfusion strategy.
Outcomes using a conservative versus liberal red blood cell transfusion strategy in infants requiring cardiac operation.
Association of haematocrit and red blood cell transfusion with outcomes in infants with shunt-dependent pulmonary blood flow and univentricular physiology.
Safety and effects of two red blood cell transfusion strategies in pediatric cardiac surgery patients: a randomized controlled trial.
Oxygen consumption and cardiovascular function in children during profound intraoperative normovolemic hemodilution.
Blood conservation operations in pediatric cardiac patients: a paradigm shift of blood use.
Transfusion strategies for patients in pediatric intensive care units.
Randomized trial of hematocrit 25% versus 35% during hypothermic cardiopulmonary bypass in infant heart surgery.
Transfusion in critically ill children: an ongoing dilemma.
Comparison of two red-cell transfusion strategies after pediatric cardiac surgery: a subgroup analysis.
医療資源の限られる状況
Cardiopulmonary bypass in Jehovah's Witnesses.
Direct cannulation in minimally invasive cardiac surgery with limited resources.
大量出血の有害作用
Association of blood products administration during cardiopulmonary bypass and excessive post-operative bleeding in pediatric cardiac surgery.
Excessive postoperative bleeding and outcomes in neonates undergoing cardiopulmonary bypass.
Predictors of long intensive care unit stay following cardiac surgery in children.
Major bleeding, transfusions, and anemia: the deadly triad of cardiac surgery.
Early postoperative bleeding is independently associated with increased surgical mortality in infants after cardiopulmonary bypass.
輸血のリスクと不確実性
Aprotinin, transfusions, and kidney injury in neonates and infants undergoing cardiac surgery.
Longer RBC storage duration is associated with increased postoperative infections in pediatric cardiac surgery.
Blood product transfusions and clinical outcomes in pediatric patients with acute lung injury.
Risk factors for surgical site infection after cardiac surgery in children.
Association between length of storage of transfused red blood cells and multiple organ dysfunction syndrome in pediatric intensive care patients.
Benefits and risks of red blood cell transfusion in pediatric patients undergoing cardiac surgery.
Serious hazards of transfusion in children (SHOT).
Increased red blood cell transfusions are associated with worsening outcomes in pediatric heart transplant patients.
Association of complications with blood transfusions in pediatric cardiac surgery patients.
Transfusion of leukocyte-depleted RBCs is independently associated with increased morbidity after pediatric cardiac surgery.
Red blood cell transfusion in critically ill children is independently associated with increased mortality.
Blood transfusion risks and alternative strategies in pediatric patients.
Incidence of acute transfusion reactions to platelets in hospitalized pediatric patients based on the US hemovigilance reporting system.
Transfusion and risk of infection in Canada: update 2012. [Les transfusions et le risque d'infection au Canada : mise à jour pour 2012.] [English, French]
Transfusion reactions in pediatric compared with adult patients: a look at rate, reaction type, and associated products.
Duration of red blood cell storage and outcomes in pediatric cardiac surgery: an association found for pump prime blood.
Blood transfusion during versus after cardiopulmonary bypass is associated with postoperative morbidity in neonates undergoing cardiac surgery.
Adverse outcomes of blood transfusion in children: analysis of UK reports to the serious hazards of transfusion scheme 1996-2005.
Emerging infectious disease agents and their potential threat to transfusion safety.
Current perspectives in transfusion-transmitted infectious diseases: emerging and re-emerging infections.
Risks and predictors of blood transfusion in pediatric patients undergoing open heart operations.
Critically ill children: to transfuse or not to transfuse packed red blood cells, that is the question.
臨床成績
Correction of congenital heart defects in Jehovah's Witness children.
Association of hemoglobin and transfusion with outcome after operations for hypoplastic left heart.
Association of complications with blood transfusions in pediatric cardiac surgery patients.
Safety of bloodless open-heart surgery on cardiopulmonary bypass in selected children: a single center experience with minimal invasive extracorporeal circulation.
Blood transfusion is associated with prolonged duration of mechanical ventilation in infants undergoing reparative cardiac surgery.
ファロー四徴症に対する自己血手術 [A total correction for tetralogy of Fallot without the use of homologous blood.] [Japanese]
Clinical outcomes, blood utilization, and ethical considerations for pediatric patients in a bloodless medicine and surgery program.
Cell saver blood transfusions may be associated with a decrease in inflammation and improved outcome measures in pediatric cardiac surgery patients.
Asanguineous cardiopulmonary bypass in infants: impact on postoperative mortality and morbidity.
Early death and late morbidity after blood transfusion of injured children: a pilot study.
Blood transfusion determines postoperative morbidity in pediatric cardiac surgery applying a comprehensive blood-sparing approach.
Blood transfusion after pediatric cardiac surgery is associated with prolonged hospital stay.
The indication for perioperative red blood cell transfusions is a predictive risk factor for severe postoperative morbidity and mortality in children undergoing cardiac surgery.
経済効果
Safety and effects of two red blood cell transfusion strategies in pediatric cardiac surgery patients: a randomized controlled trial.
Pediatric red blood cell transfusions increase resource use.
Hematologic and economic impact of aprotinin in reoperative pediatric cardiac operations.
Comparative analysis of antifibrinolytic medications in pediatric heart surgery.
Economic evaluation of cell salvage in pediatric surgery.
貧血への適応
Adaptation to anemia in hemoglobin E-ß thalassemia.
Studies in haemoglobin E beta-thalassaemia.
Haemoglobin E beta thalassaemia in Sri Lanka.
胎児ヘモグロビン合成の薬理学的誘導
Optimizing the dose of hydroxyurea therapy for patients with β-thalassemia intermedia (Hb E-β-thalassemia): a single center study from eastern India.
Treatment of beta-thalassemia patients with recombinant human erythropoietin: effect on transfusion requirements and soluble adhesion molecules.
Efficacy of erythropoietin on dialysis in patients with beta thalassemia minor.
Hydroxyurea in thalassemia intermedia--a promising therapy.
Effect of hydroxyurea on the transfusion requirements in patients with severe HbE-beta-thalassaemia: a genotypic and phenotypic study.
Echocardiographic finding in beta-thalassemia intermedia and major: absence of pulmonary hypertension following hydroxyurea treatment in beta-thalassemia intermedia.
Effect of combination therapy of hydroxyurea with l-carnitine and magnesium chloride on hematologic parameters and cardiac function of patients with beta-thalassemia intermedia.
Reduction of the clinical severity of sickle cell/beta-thalassemia with hydroxyurea: the experience of a single center in Greece.
Fetal globin stimulant therapies in the beta-hemoglobinopathies: principles and current potential.
The role of recombinant human erythropoietin in the treatment of thalassemia.
Single and combination drug therapy for fetal hemoglobin augmentation in hemoglobin E-beta 0-thalassemia: Considerations for treatment.
Darbepoetin alfa for the treatment of anaemia in alpha- or beta- thalassaemia intermedia syndromes.
The emerging role of fetal hemoglobin induction in non-transfusion-dependent thalassemia.
ヒドロキシ尿素(ヒドロキシカルバミド)療法
遺伝子組み換えエリスロポエチン(単独または他の製剤と併用)
産科
Variable efficacy of recombinant human erythropoietin in anemic pregnant women with different forms of heterozygous hemoglobinopathy.
Erythropoietin use in a pregnant Jehovah's Witness with anemia and beta-thalassemia: a case report.
Preliminary results with administration of recombinant human erythropoietin in sickle cell/beta-thalassemia patients during pregnancy.
Induction of fetal hemoglobin synthesis with recombinant human erythropoietin in anemic patients with heterozygous beta-thalassemia during pregnancy.
Effective treatment of beta-thalassemia intermedia during pregnancy with rHuEpo. A case report.
一般外科
Epidural anesthesia for laparoscopic cholecystectomy in a patient with sickle cell anemia, beta thalassemia, and Crohn's disease—a case report.
Intraoperative blood salvage during cesarean delivery in a patient with beta thalassemia intermedia.
支持療法
Treatment with bosentan in a patient with thalassemia intermedia and pulmonary arterial hypertension.
Prevalance of iron deficiency in thalassemia minor: a study from tertiary hospital.
Therapeutic roles of curcumin: lessons learned from clinical trials.
Iron out for nontransfused thalassemia.
Iron overload in β-thalassemia intermedia: an emerging concern.
Vitamin E supplement improves erythrocyte membrane fluidity of thalassemia: an ESR spin labeling study.
Deferasirox demonstrates a dose-dependent reduction in liver iron concentration and consistent efficacy across subgroups of non-transfusion-dependent thalassemia patients.
鉄キレート療法
栄養補助食品や他の支持療法
貧血への適応
Adaptation to anemia in hemoglobin E-ß thalassemia.
Age-related changes in adaptation to severe anemia in childhood in developing countries.
Studies in haemoglobin E beta-thalassaemia.
Haemoglobin E beta thalassaemia in Sri Lanka.
胎児ヘモグロビン合成の薬理学的誘導
Fetal hemoglobin inducers from the natural world: a novel approach for identification of drugs for the treatment of {beta}-thalassemia and sickle-cell anemia.
Optimizing the dose of hydroxyurea therapy for patients with β-thalassemia intermedia (Hb E-β-thalassemia): a single center study from eastern India.
Treatment of beta-thalassemia patients with recombinant human erythropoietin: effect on transfusion requirements and soluble adhesion molecules.
Hydroxyurea in thalassemia intermedia--a promising therapy.
Therapeutic superiority and safety of combined hydroxyurea with recombinant human erythropoietin over hydroxyurea in young β-thalassemia intermedia patients.
A randomized phase I/II trial of HQK-1001, an oral fetal globin gene inducer, in β-thalassaemia intermedia and HbE/β-thalassaemia.
Effect of hydroxyurea on the transfusion requirements in patients with severe HbE-beta-thalassaemia: a genotypic and phenotypic study.
Echocardiographic finding in beta-thalassemia intermedia and major: absence of pulmonary hypertension following hydroxyurea treatment in beta-thalassemia intermedia.
Hematologic and clinical responses of thalassemia intermedia patients to hydroxyurea during 6 years of therapy in Iran.
Effect of combination therapy of hydroxyurea with l-carnitine and magnesium chloride on hematologic parameters and cardiac function of patients with beta-thalassemia intermedia.
The effect of hydroxyurea on the coagulation system in sickle cell anemia and beta-thalassemia intermedia patients: a preliminary study.
Fetal globin stimulant therapies in the beta-hemoglobinopathies: principles and current potential.
Sustained increase in haemoglobin and RBC following long-term administration of recombinant human erythropoietin to patients with homozygous beta-thalassaemia.
Single and combination drug therapy for fetal hemoglobin augmentation in hemoglobin E-beta 0-thalassemia: Considerations for treatment.
Darbepoetin alfa for the treatment of anaemia in alpha- or beta- thalassaemia intermedia syndromes.
Butyric acid: what is the future for this old substance?
The emerging role of fetal hemoglobin induction in non-transfusion-dependent thalassemia.
ヒドロキシ尿素(ヒドロキシカルバミド)療法
遺伝子組み換えエリスロポエチン(単独または他の製剤と併用)
他の薬剤
一般外科
Bloodless surgery in a patient with thalassemia minor. Usefulness of erythropoietin, preoperative blood donation and intraoperative blood salvage.
支持療法
Prevalance of iron deficiency in thalassemia minor: a study from tertiary hospital.
Therapeutic roles of curcumin: lessons learned from clinical trials.
Iron out for nontransfused thalassemia.
Iron overload in β-thalassemia intermedia: an emerging concern.
Determining and surveying the role of carnitine and folic acid to decrease fatigue in β-thalassemia minor subjects.
Deferasirox for the treatment of iron overload in non-transfusion-dependent thalassemia.
鉄キレート療法
栄養補助食品や他の支持療法
胎児ヘモグロビン合成の薬理学的誘導
Efficacy of hydroxyurea in providing transfusion independence in β-thalassemia.
Hydroxyurea treatment in β-thalassemia patients: to respond or not to respond?
Preliminary results with administration of recombinant human erythropoietin in sickle cell/beta-thalassemia patients during pregnancy.
Decreased transfusion needs associated with hydroxyurea therapy in Algerian patients with thalassemia major or intermedia.
Induction of fetal hemoglobin synthesis with recombinant human erythropoietin in anemic patients with heterozygous beta-thalassemia during pregnancy.
Treatment of beta-thalassemia patients with recombinant human erythropoietin: effect on transfusion requirements and soluble adhesion molecules.
Hydroxyurea increases hemoglobin F levels and improves the effectiveness of erythropoiesis in beta-thalassemia/hemoglobin E disease.
Hydroxyurea can reduce or eliminate transfusion requirements in children with major and intermediate thalassemia.
Hydroxyurea as a first-line treatment of extramedullary hematopoiesis in patients with beta thalassemia: Four case reports.
Genotype-phenotype relationship of patients with β-thalassemia taking hydroxyurea: a 13-year experience in Iran.
Report on Patients with Non Transfusion-Dependent β-Thalassemia Major Being Treated with Hydroxyurea Attending the Thalassemia Research Center, Sari, Mazandaran Province, Islamic Republic of Iran in 2013.
Recombinant human erythropoietin therapy in a transfusion-dependent β-thalassemia major patient.
Clinical experience with fetal hemoglobin induction therapy in patients with β-thalassemia.
Fetal globin induction--can it cure beta thalassemia?
A randomised double-blind placebo-controlled clinical trial of oral hydroxyurea for transfusion-dependent β-thalassaemia.
Response to hydroxyurea treatment in Iranian transfusion-dependent beta-thalassemia patients.
Hydroxyurea therapy in 49 patients with major beta-thalassemia.
ヒドロキシ尿素(ヒドロキシカルバミド)療法
遺伝子組み換えエリスロポエチン(単独または他の製剤と併用)
非侵襲的出生前診断
Noninvasive prenatal diagnosis of monogenic diseases by targeted massively parallel sequencing of maternal plasma: application to β-thalassemia.
Non-invasive prenatal diagnosis of beta-thalassemia and sickle-cell disease using pyrophosphorolysis-activated polymerization and melting curve analysis.
支持療法
Experience with laparoscopic splenectomy.
Beta-thalassemia.
Partial radiofrequency ablation of the spleen in thalassemia.
Wheat grass juice reduces transfusion requirement in patients with thalassemia major: a pilot study.
The effect of folic acid supplementation in beta-thalassemia major: a randomized placebo-controlled clinical trial.
脾摘出術
栄養補助食品や他の支持療法
輸血のリスクと不確実性
Seropositivity of hepatitis C, hepatitis B and HIV in chronically transfused β-thalassaemia major patients.
Clinical outcome of frequent exposure to Torque Teno virus (TTV) through blood transfusion in thalassemia patients with or without hepatitis C virus (HCV) infection.
Prevalence of alloimmunisation in patients with beta thalassaemia major.
Marseillevirus prevalence in multitransfused patients suggests blood transmission.
Thalassemia Major in Adults: Short Stature, Hyperpigmentation, Inadequate Chelation, and Transfusion-Transmitted Infections are Key Features.
胎児ヘモグロビン合成の薬理学的誘導
Efficacy of hydroxyurea in providing transfusion independence in β-thalassemia.
Gγ-Xmn I polymorphism: a significant determinant of β-thalassemia treatment without blood transfusion.
Efficacy of hydroxyurea (HU) in reduction of pack red cell (PRC) transfusion requirement among children having beta-thalassemia major: Karachi HU trial (KHUT).
Hydroxyurea can eliminate transfusion requirements in children with severe beta-thalassemia.
Decreased transfusion needs associated with hydroxyurea therapy in Algerian patients with thalassemia major or intermedia.
Hydroxyurea can reduce or eliminate transfusion requirements in children with major and intermediate thalassemia.
Genotype-phenotype relationship of patients with β-thalassemia taking hydroxyurea: a 13-year experience in Iran.
Use of hydroxyurea and recombinant erythropoietin in management of homozygous ß⁰ thalassemia.
Termination of transfusion dependence in beta-thalassemia: two-year experience with recombinant human erythropoietin.
Fetal globin gene inducers: novel agents and new potential.
Fetal globin stimulant therapies in the beta-hemoglobinopathies: principles and current potential.
A randomised double-blind placebo-controlled clinical trial of oral hydroxyurea for transfusion-dependent β-thalassaemia.
Response to hydroxyurea treatment in Iranian transfusion-dependent beta-thalassemia patients.
Hydroxyurea therapy in 49 patients with major beta-thalassemia.
ヒドロキシ尿素(ヒドロキシカルバミド)療法
遺伝子組み換えエリスロポエチン(単独または他の製剤と併用)
他の薬剤
支持療法
Effect of antioxidant therapy on hepatic fibrosis and liver iron concentrations in β-thalassemia major patients.
Experience with laparoscopic splenectomy.
Treatment of vitamin D deficiency in transfusion-dependent thalassemia.
Beta-thalassemia.
Partial radiofrequency ablation of the spleen in thalassemia.
Wheat grass juice reduces transfusion requirement in patients with thalassemia major: a pilot study.
The effect of folic acid supplementation in beta-thalassemia major: a randomized placebo-controlled clinical trial.
Effect of wheat grass tablets on the frequency of blood transfusions in Thalassemia Major.
Laparoscopic splenectomy in patients under the age of eighteen. Experience in 18 cases.
脾摘出術
栄養補助食品や他の支持療法
輸血のリスクと不確実性
Seropositivity of hepatitis C, hepatitis B and HIV in chronically transfused β-thalassaemia major patients.
Blood transfusion and lung function in children with thalassemia major.
Pulmonary dysfunction in transfusion-dependent patients with thalassemia major.
Clinical outcome of frequent exposure to Torque Teno virus (TTV) through blood transfusion in thalassemia patients with or without hepatitis C virus (HCV) infection.
A prospective study for prevalence and/or development of transfusion-transmitted infections in multiply transfused thalassemia major patients.
Major causes of hospital admission in Beta thalassemia major patients in southern iran.
Prevalence of alloimmunisation in patients with beta thalassaemia major.
Post-transfusion hypertension, convulsion and intracranial haemorrhage in β-thalassemia major.
Marseillevirus prevalence in multitransfused patients suggests blood transmission.
Blood transfusion transmitted infections in multiple blood transfused patients of Beta thalassaemia.
クリーゼの回避
Prophylactic antibiotics for preventing pneumococcal infection in children with sickle cell disease.
Systematic review: hydroxyurea for the treatment of adults with sickle cell disease.
Sickle cell disease.
Cost-effectiveness of hydroxyurea in sickle cell anemia. Investigators of the Multicenter Study of Hydroxyurea in Sickle Cell Anemia.
A phase 3 trial of l-glutamine in sickle cell disease.
Malaria chemoprophylaxis in sickle cell disease.
Hydroxyurea for the treatment of sickle cell anemia.
Clinical effectiveness of decitabine in severe sickle cell disease.
The effect of prolonged administration of hydroxyurea on morbidity and mortality in adult patients with sickle cell syndromes: results of a 17-year, single-center trial (LaSHS).
胎児ヘモグロビンの薬理学的誘導
感染などの合併症の予防
血管閉塞性クリーゼおよび急性胸部症候群の治療管理
What is the best pharmacologic treatment for sickle cell disease pain crises?
Safety of purified poloxamer 188 in sickle cell disease: phase I study of a non-ionic surfactant in the management of acute chest syndrome.
Update on pain management in sickle cell disease.
Incentive spirometry to prevent acute pulmonary complications in sickle cell diseases.
Continuous inhaled nitric oxide therapy in a case of sickle cell disease with multiorgan involvement.
Management of sickle cell disease.
Low flow nocturnal oxygen therapy does not suppress haemoglobin levels or increase painful crises in sickle cell disease.
Fluid replacement therapy for acute episodes of pain in people with sickle cell disease.
Reduction of painful vaso-occlusive crisis of sickle cell anaemia by tinzaparin in a double-blind randomized trial.
Guidelines for the management of the acute painful crisis in sickle cell disease.
Hyperbaric oxygen therapy for vaso-occlusive crises in nine patients with sickle-cell disease.
Adult emergency department patients with sickle cell pain crisis: results from a quality improvement learning collaborative model to improve analgesic management.
Causes and outcomes of the acute chest syndrome in sickle cell disease. National Acute Chest Syndrome Study Group.
疼痛管理
補液療法(体液管理)
酸素投与
抗菌薬・呼吸療法
急性脾臓血球貯留クリーゼの治療管理
Laparoscopic splenectomy for hematological disorders. Our experience in adult and pediatric patients.
Extreme acute anemia in an adult sickle cell disease patient: look at the spleen.
Concomitant intraoperative splenic artery embolization and laparoscopic splenectomy versus laparoscopic splenectomy: comparison of treatment outcome.
Comparative treatment and literature review for laparoscopic splenectomy alone versus preoperative splenic artery embolization splenectomy.
貧血の管理
Preliminary results with administration of recombinant human erythropoietin in sickle cell/beta-thalassemia patients during pregnancy.
On the use of hydroxyurea/erythropoietin combination therapy for sickle cell disease.
Combination erythropoietin-hydroxyurea therapy in sickle cell disease: experience from the National Institutes of Health and a literature review.
Use of erythropoietin in a pregnant Jehovah's Witness with sickle-cell disease.
The use of barbiturate coma as salvage therapy in a postoperative Jehovah's Witness patient with life-threatening anemia.
外科患者の管理
Acute normovolemic hemodilution in sickle cell patient—a case report.
Blood transfusion in patients with sickle cell disease requiring laparoscopic cholecystectomy.
Erythropoietin therapy for sickle cell anemia in Jehovah's Witnesses.
Minor elective surgical procedures using general anesthesia in children with sickle cell anemia without pre-operative blood transfusion.
Hydroxycarbamide and erythropoietin in the preoperative management of children with sickle cell anaemia undergoing moderate risk surgery.
Impact of hydroxyurea on perioperative management and outcomes in children with sickle cell anemia.
A nontransfusional perioperative management regimen for patients with sickle cell disease undergoing laparoscopic cholecystectomy.
Tourniquet use during total knee replacement in a Jehovah's Witness with sickle cell trait: a case report.
輸血のリスクと不確実性
Primary hemorrhagic stroke in children with sickle cell disease is associated with recent transfusion and use of corticosteroids.
Delayed hemolytic transfusion reaction/hyperhemolysis syndrome in children with sickle cell disease.
Prevalence of human immunodeficiency virus transmission among transfused children with sickle cell anemia in Enugu Nigeria.
クリーゼの回避
Pharmacotherapy in sickle cell disease—state of the art and future prospects.
Long-term hydroxyurea therapy for infants with sickle cell anemia: the HUSOFT extension study.
Prophylactic antibiotics for preventing pneumococcal infection in children with sickle cell disease.
Hydroxyurea dose escalation for sickle cell anemia in sub-Saharan Africa.
The effect of hydroxcarbamide therapy on survival of children with sickle cell disease.
Sickle cell disease.
Evidence review of hydroxyurea for the prevention of sickle cell complications in low-income countries.
A phase 3 trial of l-glutamine in sickle cell disease.
Hydroxyurea treatment is associated with lower malaria incidence in children with sickle cell anemia in sub-Saharan Africa.
Malaria chemoprophylaxis in sickle cell disease.
Hydroxyurea for sickle cell disease: a systematic review for efficacy and toxicity in children.
Impact of hydroxyurea on clinical events in the BABY HUG trial.
Hydroxyurea for children with sickle cell anemia in sub-Saharan Africa.
Effect of hydroxyurea on growth in children with sickle cell anemia: results of the HUG-KIDS Study.
Hydroxyurea is associated with lower costs of care of young children with sickle cell anemia.
Hydroxycarbamide in very young children with sickle-cell anaemia: a multicentre, randomised, controlled trial (BABY HUG).
Hydroxycarbamide versus chronic transfusion for maintenance of transcranial doppler flow velocities in children with sickle cell anaemia-TCD With Transfusions Changing to Hydroxyurea (TWiTCH): a multicentre, open-label, phase 3, non-inferiority trial.
How I use hydroxyurea to treat young patients with sickle cell anemia.
Sustained long-term hematologic efficacy of hydroxyurea at maximum tolerated dose in children with sickle cell disease.
胎児ヘモグロビンの薬理学的誘導
感染などの合併症の予防
血管閉塞性クリーゼおよび急性胸部症候群の治療管理
The use of incentive spirometry in pediatric patients with sickle cell disease to reduce the incidence of acute chest syndrome.
What is the best pharmacologic treatment for sickle cell disease pain crises?
Safety of purified poloxamer 188 in sickle cell disease: phase I study of a non-ionic surfactant in the management of acute chest syndrome.
Beneficial effect of intravenous dexamethasone in children with mild to moderately severe acute chest syndrome complicating sickle cell disease.
Multi-modal intervention and prospective implementation of standardized sickle cell pain admission orders reduces 30-day readmission rate.
A short course of prednisone in the management of acute chest syndrome of sickle cell disease.
A randomized, placebo-controlled trial of arginine therapy for the treatment of children with sickle cell disease hospitalized with vaso-occlusive pain episodes.
Fluid replacement therapy for acute episodes of pain in people with sickle cell disease.
Reduction of painful vaso-occlusive crisis of sickle cell anaemia by tinzaparin in a double-blind randomized trial.
Guidelines for the management of the acute painful crisis in sickle cell disease.
Preliminary assessment of inhaled nitric oxide for acute vaso-occlusive crisis in pediatric patients with sickle cell disease.
Predictors of bacteremia in febrile children with sickle cell disease.
疼痛管理
補液療法(体液管理)
酸素投与
抗菌薬・呼吸療法
急性脾臓血球貯留クリーゼの治療管理
Acute splenic sequestration crisis in sickle cell disease: cohort study of 190 paediatric patients.
Splenic artery embolization before laparoscopic splenectomy in children.
貧血の管理
Hydroxyurea with dose escalation for primary stroke risk reduction in children with sickle cell anaemia in Tanzania (SPHERE): an open-label, phase 2 trial.
Preliminary results with administration of recombinant human erythropoietin in sickle cell/beta-thalassemia patients during pregnancy.
On the use of hydroxyurea/erythropoietin combination therapy for sickle cell disease.
Combination erythropoietin-hydroxyurea therapy in sickle cell disease: experience from the National Institutes of Health and a literature review.
Use of erythropoietin in a pregnant Jehovah's Witness with sickle-cell disease.
The use of barbiturate coma as salvage therapy in a postoperative Jehovah's Witness patient with life-threatening anemia.
外科患者の管理
Acute normovolemic hemodilution in sickle cell patient—a case report.
Blood transfusion in patients with sickle cell disease requiring laparoscopic cholecystectomy.
Erythropoietin therapy for sickle cell anemia in Jehovah's Witnesses.
Minor elective surgical procedures using general anesthesia in children with sickle cell anemia without pre-operative blood transfusion.
Hydroxycarbamide and erythropoietin in the preoperative management of children with sickle cell anaemia undergoing moderate risk surgery.
Impact of hydroxyurea on perioperative management and outcomes in children with sickle cell anemia.