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Terapia intensiva

Gestione e ottimizzazione dell’emostasi

Farmaci antifibrinolitici

Alternatives to allogeneic platelet transfusion. (apre una nuova finestra)

Desborough MJ, Smethurst PA, Estcourt LJ, Stanworth SJ.

Fonte‎: Br J Haematol 2016;175(3):381-92.

Indicizzato‎: PubMed 27650431

DOI‎: 10.1111/bjh.14338

https://www.ncbi.nlm.nih.gov/pubmed/27650431 (apre una nuova finestra)

Tranexamic acid: less bleeding and less thrombosis? (apre una nuova finestra)

Godier A, Roberts I, Hunt BJ.

Fonte‎: Crit Care 2012;16(3):135.

Indicizzato‎: PubMed 22748073

DOI‎: 10.1186/cc11374

https://www.ncbi.nlm.nih.gov/pubmed/22748073 (apre una nuova finestra)

Tranexamic acid for reducing mortality in emergency and urgent surgery. (apre una nuova finestra)

Perel P, Ker K, Morales Uribe CH, Roberts I

Fonte‎: Cochrane Database Syst Rev 2013;(1):CD010245.

Indicizzato‎: PubMed 23440847

DOI‎: 10.1002/14651858.CD010245.pub2

https://www.ncbi.nlm.nih.gov/pubmed/23440847 (apre una nuova finestra)

The importance of early treatment with tranexamic acid in bleeding trauma patients: an exploratory analysis of the CRASH-2 randomised controlled trial. (apre una nuova finestra)

Roberts I, Shakur H, Afolabi A, Brohi K, Coats T, Dewan Y, Gando S, Guyatt G, Hunt BJ, Morales C, Perel P, Prieto-Merino D, Woolley T; CRASH-2 collaborators.

Fonte‎: Lancet 2011;377(9771):1096-101, 1101.e1-2.

Indicizzato‎: PubMed 21439633

DOI‎: 10.1016/S0140-6736(11)60278-X

https://www.ncbi.nlm.nih.gov/pubmed/21439633 (apre una nuova finestra)

Antifibrinolytic drugs for acute traumatic injury. (apre una nuova finestra)

Roberts I, Shakur H, Ker K, Coats T; CRASH‐2 Trial collaborators.

Fonte‎: Cochrane Database Syst Rev 2011;(1):CD004896.

Indicizzato‎: PubMed 21249666

DOI‎: 10.1002/14651858.CD004896.pub3

https://www.ncbi.nlm.nih.gov/pubmed/21249666 (apre una nuova finestra)

Use of tranexamic acid to reduce bleeding in burns surgery. (apre una nuova finestra)

Tang YM, Chapman TW, Brooks P

Fonte‎: J Plast Reconstr Aesthet Surg 2012;65(5):684-6.

Indicizzato‎: PubMed 21983540

DOI‎: 10.1016/j.bjps.2011.09.028

https://www.ncbi.nlm.nih.gov/pubmed/21983540 (apre una nuova finestra)

Fattore VII attivato ricombinante (rFVIIa)

The treatment of bleeding is to stop the bleeding! Treatment of trauma-related hemorrhage. (apre una nuova finestra)

Boffard KD, Choong PI, Kluger Y, Riou B, Rizoli SB, Rossaint R, Warren B; NovoSeven Trauma Study Group.

Fonte‎: Transfusion 2009;49 Suppl 5:240S-7S.

Indicizzato‎: PubMed 19954486

DOI‎: 10.1111/j.1537-2995.2008.01987.x

https://www.ncbi.nlm.nih.gov/pubmed/19954486 (apre una nuova finestra)

Results of the control trial: efficacy and safety of recombinant activated factor VII in the management of refractory traumatic hemorrhage. (apre una nuova finestra)

Hauser CJ, Boffard K, Dutton R, Bernard GR, Croce MA, Holcomb JB, Leppaniemi A, Parr M, Vincent JL, Tortella BJ, Dimsits J, Bouillon B; CONTROL Study Group.

Fonte‎: J Trauma 2010;69(3):489-500.

Indicizzato‎: PubMed 20838118

DOI‎: 10.1097/TA.0b013e3181edf36e

https://www.ncbi.nlm.nih.gov/pubmed/20838118 (apre una nuova finestra)

Use of recombinant activated factor VII in Jehovah's Witness patients with critical bleeding. (apre una nuova finestra)

Kandane-Rathnayake RK, Isbister JP, Zatta AJ, Aoki NJ, Cameron P, Phillips LE; Australian and New Zealand Haemostasis Registry Steering Committee

Fonte‎: ANZ J Surg 2013;83(3):155-60.

Indicizzato‎: PubMed 23035873

DOI‎: 10.1111/j.1445-2197.2012.06285.x

https://www.ncbi.nlm.nih.gov/pubmed/23035873 (apre una nuova finestra)

Recombinant factor VIIa in trauma patients with the 'triad of death.' (apre una nuova finestra)

Mitra B, Cameron PA, Parr MJ, Phillips L.

Fonte‎: Injury 2012;43(9):1409-14.

Indicizzato‎: PubMed 21345431

DOI‎: 10.1016/j.injury.2011.01.033

https://www.ncbi.nlm.nih.gov/pubmed/21345431 (apre una nuova finestra)

Low-dose recombinant factor VIIa for trauma patients with coagulopathy. (apre una nuova finestra)

Stein DM, Dutton RP, Hess JR, Scalea TM.

Fonte‎: Injury 2008;39(9):1054-61.

Indicizzato‎: PubMed 18656871

DOI‎: 10.1016/j.injury.2008.03.032

https://www.ncbi.nlm.nih.gov/pubmed/18656871 (apre una nuova finestra)

Concentrati di fattori della coagulazione

Alternatives to allogeneic platelet transfusion. (apre una nuova finestra)

Desborough MJ, Smethurst PA, Estcourt LJ, Stanworth SJ.

Fonte‎: Br J Haematol 2016;175(3):381-92.

Indicizzato‎: PubMed 27650431

DOI‎: 10.1111/bjh.14338

https://www.ncbi.nlm.nih.gov/pubmed/27650431 (apre una nuova finestra)

Plasma fibrinogen level on admission to the intensive care unit is a powerful predictor of postoperative bleeding after cardiac surgery with cardiopulmonary bypass. (apre una nuova finestra)

Kindo M, Hoang Minh T, Gerelli S, Perrier S, Meyer N, Schaeffer M, Bentz J, Announe T, Mommerot A, Collange O, Pottecher J, Cristinar M, Thiranos JC, Gros H, Mertes PM, Billaud P, Mazzucotelli JP

Fonte‎: Thromb Res 2014;134(2):360-8.

Indicizzato‎: PubMed 24857189

DOI‎: 10.1016/j.thromres.2014.05.008

https://www.ncbi.nlm.nih.gov/pubmed/24857189 (apre una nuova finestra)

Strategies to reduce the use of blood products: a European perspective. (apre una nuova finestra)

Theusinger OM, Felix C, Spahn DR.

Fonte‎: Curr Opin Anaesthesiol 2012;25(1):59-65.

Indicizzato‎: PubMed 22113184

DOI‎: 10.1097/ACO.0b013e32834dec98

https://www.ncbi.nlm.nih.gov/pubmed/22113184 (apre una nuova finestra)

Desmopressina

Desmopressin reduces transfusion needs after surgery: a meta-analysis of randomized clinical trials. (apre una nuova finestra)

Crescenzi G, Landoni G, Biondi-Zoccai G, Pappalardo F, Nuzzi M, Bignami E, Fochi O, Maj G, Calabrò MG, Ranucci M, Zangrillo A

Fonte‎: Anesthesiology 2008;109(6):1063-76.

Indicizzato‎: PubMed 19034103

DOI‎: 10.1097/ALN.0b013e31818db18b

https://www.ncbi.nlm.nih.gov/pubmed/19034103 (apre una nuova finestra)

Alternatives to allogeneic platelet transfusion. (apre una nuova finestra)

Desborough MJ, Smethurst PA, Estcourt LJ, Stanworth SJ.

Fonte‎: Br J Haematol 2016;175(3):381-92.

Indicizzato‎: PubMed 27650431

DOI‎: 10.1111/bjh.14338

https://www.ncbi.nlm.nih.gov/pubmed/27650431 (apre una nuova finestra)

Desmopressin in treatment of haematological disorders and in prevention of surgical bleeding. (apre una nuova finestra)

Svensson PJ, Bergqvist PB, Juul KV, Berntorp E

Fonte‎: Blood Rev 2014;28(3):95-102.

Indicizzato‎: PubMed 24703870

DOI‎: 10.1016/j.blre.2014.03.001

https://www.ncbi.nlm.nih.gov/pubmed/24703870 (apre una nuova finestra)

Altri farmaci

Vitamin K deficiency and D-dimer levels in the intensive care unit: a prospective cohort study. (apre una nuova finestra)

Crowther MA, McDonald E, Johnston M, Cook D

Fonte‎: Blood Coagul Fibrinolysis 2002;13(1):49-52.

Indicizzato‎: PubMed 11994567

DOI‎: 10.1097/00001721-200201000-00007

https://www.ncbi.nlm.nih.gov/pubmed/11994567 (apre una nuova finestra)

Farmaci emostatici topici

The use of fibrin sealant in burn operations. (apre una nuova finestra)

Foster K

Fonte‎: Surgery 2007;142(4 Suppl):S50-4.

Indicizzato‎: PubMed 18019939

DOI‎: 10.1016/j.surg.2007.06.026

https://www.ncbi.nlm.nih.gov/pubmed/18019939 (apre una nuova finestra)

Use of fibrin sealant in thermal injury. (apre una nuova finestra)

McGill V, Kowal-Vern A, Lee M, Greenhalgh D, Gomperts E, Bray G, Gamelli R

Fonte‎: J Burn Care Rehabil 1997;18(5):429-34.

Indicizzato‎: PubMed 9313125

DOI‎: 10.1097/00004630-199709000-00011

https://www.ncbi.nlm.nih.gov/pubmed/9313125 (apre una nuova finestra)

Test viscoelastici per individuare un sanguinamento dovuto a intervento chirurgico o coagulopatia

Perioperative treatment algorithm for bleeding burn patients reduces allogeneic blood product requirements. (apre una nuova finestra)

Schaden E, Kimberger O, Kraincuk P, Baron DM, Metnitz PG, Kozek-Langenecker S

Fonte‎: Br J Anaesth 2012;109(3):376-81.

Indicizzato‎: PubMed 22719014

DOI‎: 10.1093/bja/aes186

https://www.ncbi.nlm.nih.gov/pubmed/22719014 (apre una nuova finestra)

Transfusion in trauma: why and how should we change our current practice? (apre una nuova finestra)

Theusinger OM, Spahn DR, Ganter MT.

Fonte‎: Curr Opin Anaesthesiol 2009;22(2):305-12.

Indicizzato‎: PubMed 19390257

DOI‎: 10.1097/ACO.0b013e3283212c7c

https://www.ncbi.nlm.nih.gov/pubmed/19390257 (apre una nuova finestra)

Viscoelastic point-of-care testing to assist with the diagnosis, management and monitoring of haemostasis: a systematic review and cost-effectiveness analysis. (apre una nuova finestra)

Whiting P, Al M, Westwood M, Ramos IC, Ryder S, Armstrong N, Misso K, Ross J, Severens J, Kleijnen J

Fonte‎: Health Technol Assess 2015;19(58):1-228.

Indicizzato‎: PubMed 26215747

DOI‎: 10.3310/hta19580

https://www.ncbi.nlm.nih.gov/pubmed/26215747 (apre una nuova finestra)