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Chirurgia Cardiotoracica e Vascolare

Gestione e ottimizzazione dell’emostasi

Farmaci antifibrinolitici

Can topical application of tranexamic acid reduce blood loss in thoracic surgery? A prospective randomised double blind investigation. (apre una nuova finestra)

Dell'Amore A, Caroli G, Nizar A, Cassanelli N, Luciano G, Greco D, Dolci G, Bini A, Stella F.

Fonte‎: Heart Lung Circ 2012;21(11):706-10.

Indicizzato‎: PubMed 22842057

DOI‎: 10.1016/j.hlc.2012.06.016 (apre una nuova finestra)

Can local application of tranexamic acid reduce post-coronary bypass surgery blood loss? A randomized controlled trial. (apre una nuova finestra)

Fawzy H, Elmistekawy E, Bonneau D, Latter D, Errett L.

Fonte‎: J Cardiothorac Surg 2009;4:25.

Indicizzato‎: PubMed 19538741

DOI‎: 10.1186/1749-8090-4-25 (apre una nuova finestra)

Current status of pharmacologic therapies in patient blood management. (apre una nuova finestra)

Goodnough LT, Shander A.

Fonte‎: Anesth Analg 2013;116(1):15-34.

Indicizzato‎: PubMed 23223098

DOI‎: 10.1213/ANE.0b013e318273f4ae (apre una nuova finestra)

Putting the record straight on aprotinin as safe and effective: results from a mixed treatment meta-analysis of trials of aprotinin. (apre una nuova finestra)

Howell N, Senanayake E, Freemantle N, Pagano D.

Fonte‎: J Thorac Cardiovasc Surg 2013;145(1):234-40.

Indicizzato‎: PubMed 22889481

DOI‎: 10.1016/j.jtcvs.2012.07.018 (apre una nuova finestra)

The risk-benefit profile of aprotinin versus tranexamic acid in cardiac surgery. (apre una nuova finestra)

Karkouti K, Wijeysundera DN, Yau TM, McCluskey SA, Tait G, Beattie WS.

Fonte‎: Anesth Analg 2010;110(1):21-9.

Indicizzato‎: PubMed 19910626

DOI‎: 10.1213/ANE.0b013e3181c0ea6d (apre una nuova finestra)

Comparative evaluation of the effects of tranexamic acid and low-dose aprotinin on post-valvular heart surgery bleeding and allogenic transfusion. (apre una nuova finestra)

Mansouri M, Attary M, Bagheri K, Massoumi G, Ghavami B.

Fonte‎: Interact Cardiovasc Thorac Surg 2012;15(1):23-7.

Indicizzato‎: PubMed 22514257

DOI‎: 10.1093/icvts/ivs114 (apre una nuova finestra)

A randomized trial of tranexamic acid in combination with cell salvage plus a meta-analysis of randomized trials evaluating tranexamic acid in off-pump coronary artery bypass grafting. (apre una nuova finestra)

Murphy GJ, Mango E, Lucchetti V, Battaglia F, Catapano D, Rogers CA, Angelini GD.

Fonte‎: J Thorac Cardiovasc Surg 2006;132(3):475-80, 480.e1-8.

Indicizzato‎: PubMed 16935098

DOI‎: 10.1016/j.jtcvs.2006.01.064 (apre una nuova finestra)

Tranexamic acid in patients undergoing coronary-artery surgery. (apre una nuova finestra)

Myles PS, Smith JA, Forbes A, Silbert B, Jayarajah M, Painter T, Cooper DJ, Marasco S, McNeil J, Bussières JS, McGuinness S, Byrne K, Chan MT, Landoni G, Wallace S, ATACAS Investigators of the ANZCA Clinical Trials Network

Fonte‎: N Engl J Med 2017;376(2):136-48.

Indicizzato‎: PubMed 27774838

DOI‎: 10.1056/NEJMoa1606424 (apre una nuova finestra)

Aprotinin for patients exposed to clopidogrel before off-pump coronary bypass. (apre una nuova finestra)

Nurözler F, Kutlu T, Küçük G.

Fonte‎: Asian Cardiovasc Thorac Ann 2008;16(6):483-7.

Indicizzato‎: PubMed 18984759

DOI‎: 10.1177/021849230801600611 (apre una nuova finestra)

Protective effects of tranexamic acid on clopidogrel before coronary artery bypass grafting: a multicenter randomized trial. (apre una nuova finestra)

Shi J, Ji H, Ren F, Wang G, Xu M, Xue Y, Chen M, Qi J, Li L.

Fonte‎: JAMA Surg 2013;148(6):538-47.

Indicizzato‎: PubMed 23426385

DOI‎: 10.1001/jamasurg.2013.1560 (apre una nuova finestra)

Tranexamic acid reduces blood loss after off-pump coronary surgery: a prospective, randomized, double-blind, placebo-controlled study. (apre una nuova finestra)

Wang G, Xie G, Jiang T, Wang Y, Wang W, Ji H, Liu M, Chen L, Li L.

Fonte‎: Anesth Analg 2012;115(2):239-43.

Indicizzato‎: PubMed 21737704

DOI‎: 10.1213/ANE.0b013e3182264a11 (apre una nuova finestra)

Effects of aprotinin on short-term and long-term outcomes after coronary artery bypass grafting surgery. (apre una nuova finestra)

Wang X, Zheng Z, Ao H, Zhang S, Wang Y, Zhang H, Hu S.

Fonte‎: Ann Thorac Surg 2010;89(5):1489-95.

Indicizzato‎: PubMed 20417766

DOI‎: 10.1016/j.athoracsur.2010.02.006 (apre una nuova finestra)

Low postoperative dose of aprotinin reduces bleeding and is safe in patients receiving clopidogrel before coronary artery bypass surgery. A prospective randomized study. (apre una nuova finestra)

Øvrum E, Tangen G, Tølløfsrud S, Ringdal MA, Øystese R, Istad R.

Fonte‎: Interact Cardiovasc Thorac Surg 2010;10(4):545-8.

Indicizzato‎: PubMed 20067988

DOI‎: 10.1510/icvts.2009.226613 (apre una nuova finestra)

Fattore VII attivato ricombinante (rFVIIa)

Recombinant activated factor VII in cardiac surgery: experience from the Australian and New Zealand Haemostasis Registry. (apre una nuova finestra)

Dunkley S, Phillips L, McCall P, Brereton J, Lindeman R, Jankelowitz G, Cameron P.

Fonte‎: Ann Thorac Surg 2008;85(3):836-44.

Indicizzato‎: PubMed 18291152

DOI‎: 10.1016/j.athoracsur.2007.06.076 (apre una nuova finestra)

Repeat cardiac surgery in a Jehovah's Witness patient with thrombocytopenia. (apre una nuova finestra)

Elmistekawy E, Lapierre H, Bourke M, Dennie C, Labinaz M, Ruel M.

Fonte‎: Can J Cardiol 2011;27(6):869.e7-8.

Indicizzato‎: PubMed 21983113

DOI‎: 10.1016/j.cjca.2011.07.632 (apre una nuova finestra)

Safety and efficacy of recombinant activated factor VII: a randomized placebo-controlled trial in the setting of bleeding after cardiac surgery. (apre una nuova finestra)

Gill R, Herbertson M, Vuylsteke A, Olsen PS, von Heymann C, Mythen M, Sellke F, Booth F, Schmidt TA.

Fonte‎: Circulation 2009;120(1):21-7.

Indicizzato‎: PubMed 19546387

DOI‎: 10.1161/CIRCULATIONAHA.108.834275 (apre una nuova finestra)

Intraoperative use of recombinant activated factor VII during complex aortic surgery. (apre una nuova finestra)

Goksedef D, Panagopoulos G, Nassiri N, Levine RL, Hountis PG, Plestis KA.

Fonte‎: J Thorac Cardiovasc Surg 2012;143(5):1198-204.

Indicizzato‎: PubMed 22285329

DOI‎: 10.1016/j.jtcvs.2012.01.004 (apre una nuova finestra)

Off-label use of recombinant human factor VIIa. (apre una nuova finestra)

Goodnough LT, Levy JH.

Fonte‎: Ann Thorac Surg 2014;98(2):393-5.

Indicizzato‎: PubMed 25087781

DOI‎: 10.1016/j.athoracsur.2014.06.007 (apre una nuova finestra)

Off-label use of recombinant activated factor VII in intractable haemorrhage after cardiovascular surgery: an observational study of practices in 23 French cardiac centres (2005-7). (apre una nuova finestra)

Hacquard M, Durand M, Lecompte T, Boini S, Briançon S, Carteaux JP.

Fonte‎: Eur J Cardiothorac Surg 2011;40(6):1320-7.

Indicizzato‎: PubMed 21550261

DOI‎: 10.1016/j.ejcts.2011.03.032 (apre una nuova finestra)

Comprehensive Canadian review of the off-label use of recombinant activated factor VII in cardiac surgery. (apre una nuova finestra)

Karkouti K, Beattie WS, Arellano R, Aye T, Bussieres JS, Callum JL, Cheng D, Heinrich L, Kent B, Lee TW, MacAdams C, Mazer CD, Muirhead B, Rochon AG, Rubens FD, Sawchuk C, Wang S, Waters T, Wong BI, Yau TM.

Fonte‎: Circulation 2008;118(4):331-8.

Indicizzato‎: PubMed 18606914

DOI‎: 10.1161/CIRCULATIONAHA.108.764308 (apre una nuova finestra)

Role of recombinant factor VIIa in the treatment of intractable bleeding in vascular surgery. (apre una nuova finestra)

Končar IB, Davidović LB, Savić N, Sinđelić RB, Ilić N, Dragas M, Markovic M, Kostic D.

Fonte‎: J Vasc Surg 2011;53(4):1032-7.

Indicizzato‎: PubMed 21215579

DOI‎: 10.1016/j.jvs.2010.07.075 (apre una nuova finestra)

Recombinant factor VIIa treatment of severe bleeding in cardiac surgery patients: a retrospective analysis of dosing, efficacy, and safety outcomes. (apre una nuova finestra)

Masud F, Bostan F, Chi E, Pass SE, Samir H, Stuebing K, Liebl MG.

Fonte‎: J Cardiothorac Vasc Anesth 2009;23(1):28-33.

Indicizzato‎: PubMed 18948033

DOI‎: 10.1053/j.jvca.2008.08.003 (apre una nuova finestra)

Recombinant activated factor VII significantly reduces transfusion requirements in cardiothoracic surgery. (apre una nuova finestra)

Omar HR, Enten G, Karlnoski R, Ching YH, Mangar D, Camporesi EM.

Fonte‎: Drugs R D 2015;15(2):187-94.

Indicizzato‎: PubMed 25862216

DOI‎: 10.1007/s40268-015-0093-9 (apre una nuova finestra)

Hemostatic management of severe thrombocytopenia in a patient undergoing pulmonic valve replacement. (apre una nuova finestra)

Tanaka KA, Li P, McHugh SM, Subramaniam K.

Fonte‎: A A Case Rep 2015;5(1):3-5.

Indicizzato‎: PubMed 26125690

DOI‎: 10.1213/XAA.0000000000000166 (apre una nuova finestra)

Recombinant activated factor VII in cardiac surgery: a systematic review. (apre una nuova finestra)

Warren O, Mandal K, Hadjianastassiou V, Knowlton L, Panesar S, John K, Darzi A, Athanasiou T.

Fonte‎: Ann Thorac Surg 2007;83(2):707-14.

Indicizzato‎: PubMed 17258029

DOI‎: 10.1016/j.athoracsur.2006.10.033 (apre una nuova finestra)

Concentrati di fattori della coagulazione

Reduced use of allogeneic platelets through high-yield perioperative autologous plateletpheresis and reinfusion. (apre una nuova finestra)

Alberts M, Bandarenko N, Gaca J, Lockhart E, Milano C, Alexander S, Linder D, Lombard FW, Welsby IJ.

Fonte‎: Transfusion 2014;54(5):1348-57.

Indicizzato‎: PubMed 24898456

DOI‎: 10.1111/trf.12463 (apre una nuova finestra)

Use of prothrombin complex concentrate for excessive bleeding after cardiac surgery. (apre una nuova finestra)

Arnékian V, Camous J, Fattal S, Rézaiguia-Delclaux S, Nottin R, Stéphan F.

Fonte‎: Interact Cardiovasc Thorac Surg 2012;15(3):382-9.

Indicizzato‎: PubMed 22623627

DOI‎: 10.1093/icvts/ivs224 (apre una nuova finestra)

Reducing blood transfusion in aortic surgery: a novel approach. (apre una nuova finestra)

Birla R, Nawaytou O, Shaw M, Jackson A, Mills K, Kuduvalli M, Field M, Agarwal S

Fonte‎: Ann Thorac Surg 2019;108(5):1369-75.

Indicizzato‎: PubMed 31255616

DOI‎: 10.1016/j.athoracsur.2019.04.127 (apre una nuova finestra)

Prophylactic use of factor IX concentrate in a Jehovah's Witness patient. (apre una nuova finestra)

Bolliger D, Sreeram G, Duncan A, Molinaro RJ, Szlam F, Chen EP, Tanaka KA.

Fonte‎: Ann Thorac Surg 2009;88(5):1666-8.

Indicizzato‎: PubMed 19853132

DOI‎: 10.1016/j.athoracsur.2009.03.095 (apre una nuova finestra)

Safety and efficacy of prothrombin complex concentrate as first-line treatment in bleeding after cardiac surgery. (apre una nuova finestra)

Cappabianca G, Mariscalco G, Biancari F, Maselli D, Papesso F, Cottini M, Crosta S, Banescu S, Ahmed AB, Beghi C.

Fonte‎: Crit Care 2016;20:5.

Indicizzato‎: PubMed 26738468

DOI‎: 10.1186/s13054-015-1172-6 (apre una nuova finestra)

Comparison of 4-factor prothrombin complex concentrate with frozen plasma for management of hemorrhage during and after cardiac surgery: a randomized pilot trial. (apre una nuova finestra)

Karkouti K, Bartoszko J, Grewal D, Bingley C, Armali C, Carroll J, Hucke HP, Kron A, McCluskey SA, Rao V, Callum J

Fonte‎: JAMA Netw Open 2021;4(4):e213936.

Indicizzato‎: PubMed 33792729

DOI‎: 10.1001/jamanetworkopen.2021.3936 (apre una nuova finestra)

Prophylactic fibrinogen infusion reduces bleeding after coronary artery bypass surgery. A prospective randomised pilot study. (apre una nuova finestra)

Karlsson M, Ternström L, Hyllner M, Baghaei F, Flinck A, Skrtic S, Jeppsson A.

Fonte‎: Thromb Haemost 2009;102(1):137-44.

Indicizzato‎: PubMed 19572078

DOI‎: 10.1160/TH08-09-0587 (apre una nuova finestra)

Effects of fibrinogen concentrate as first-line therapy during major aortic replacement surgery: a randomized, placebo-controlled trial. (apre una nuova finestra)

Rahe-Meyer N, Solomon C, Hanke A, Schmidt DS, Knoerzer D, Hochleitner G, Sørensen B, Hagl C, Pichlmaier M.

Fonte‎: Anesthesiology 2013;118(1):40-50.

Indicizzato‎: PubMed 23249928

DOI‎: 10.1097/ALN.0b013e3182715d4d (apre una nuova finestra)

Randomized, double-blinded, placebo-controlled trial of fibrinogen concentrate supplementation after complex cardiac surgery. (apre una nuova finestra)

Ranucci M, Baryshnikova E, Crapelli GB, Rahe-Meyer N, Menicanti L, Frigiola A; Surgical Clinical Outcome REsearch (SCORE) Group.

Fonte‎: J Am Heart Assoc 2015;4(6):e002066.

Indicizzato‎: PubMed 26037084

DOI‎: 10.1161/JAHA.115.002066 (apre una nuova finestra)

Prothrombin complex concentrate in cardiac surgery: a systematic review and meta-analysis. (apre una nuova finestra)

Roman M, Biancari F, Ahmed AB, Agarwal S, Hadjinikolaou L, Al-Sarraf A, Tsang G, Oo AY, Field M, Santini F, Mariscalco G

Fonte‎: Ann Thorac Surg 2019;107(4):1275-83.

Indicizzato‎: PubMed 30458156

DOI‎: 10.1016/j.athoracsur.2018.10.013 (apre una nuova finestra)

Coagulopathy after cardiopulmonary bypass in Jehovah's Witness patients: management of two cases using fractionated components and factor VIIa. (apre una nuova finestra)

Sniecinski RM, Chen EP, Levy JH, Szlam F, Tanaka KA.

Fonte‎: Anesth Analg 2007;104(4):763-5.

Indicizzato‎: PubMed 17377078

DOI‎: 10.1213/01.ane.0000250913.45299.f3 (apre una nuova finestra)

Haemostatic therapy in coronary artery bypass graft patients with decreased platelet function: comparison of fibrinogen concentrate with allogeneic blood products. (apre una nuova finestra)

Solomon C, Schöchl H, Hanke A, Calatzis A, Hagl C, Tanaka K, Rahe-Meyer N.

Fonte‎: Scand J Clin Lab Invest 2012;72(2):121-8.

Indicizzato‎: PubMed 22233480

DOI‎: 10.3109/00365513.2011.643818 (apre una nuova finestra)


Effects of desmopressin on platelet function under conditions of hypothermia and acidosis: an in vitro study using multiple electrode aggregometry. (apre una nuova finestra)

Hanke AA, Dellweg C, Kienbaum P, Weber CF, Görlinger K, Rahe-Meyer N.

Fonte‎: Anaesthesia 2010;65(7):688-91.

Indicizzato‎: PubMed 20477783

DOI‎: 10.1111/j.1365-2044.2010.06367.x (apre una nuova finestra)

Platelet mapping and desmopressin reversal of platelet inhibition during emergency carotid endarterectomy. (apre una nuova finestra)

Ranucci M, Nano G, Pazzaglia A, Bianchi P, Casana R, Tealdi DG.

Fonte‎: J Cardiothorac Vasc Anesth 2007;21(6):851-4.

Indicizzato‎: PubMed 18068065

DOI‎: 10.1053/j.jvca.2007.05.009 (apre una nuova finestra)

Desmopressin for reducing postoperative blood loss and transfusion requirements following cardiac surgery in adults. (apre una nuova finestra)

Wademan BH, Galvin SD.

Fonte‎: Interact Cardiovasc Thorac Surg 2014;18(3):360-70.

Indicizzato‎: PubMed 24263581

DOI‎: 10.1093/icvts/ivt491 (apre una nuova finestra)

Farmaci emostatici topici

A comprehensive review of topical hemostatic agents: efficacy and recommendations for use. (apre una nuova finestra)

Achneck HE, Sileshi B, Jamiolkowski RM, Albala DM, Shapiro ML, Lawson JH.

Fonte‎: Ann Surg 2010;251(2):217-28.

Indicizzato‎: PubMed 20010084

DOI‎: 10.1097/SLA.0b013e3181c3bcca (apre una nuova finestra)

A review of topical hemostatic agents for use in cardiac surgery. (apre una nuova finestra)

Barnard J, Millner R.

Fonte‎: Ann Thorac Surg 2009;88(4):1377-83.

Indicizzato‎: PubMed 19766855

DOI‎: 10.1016/j.athoracsur.2009.02.092 (apre una nuova finestra)

Armentarium of topical hemostatic products in cardiovascular surgery: an update. (apre una nuova finestra)

Forcillo J, Perrault LP.

Fonte‎: Transfus Apher Sci 2014;50(1):26-31.

Indicizzato‎: PubMed 24412443

DOI‎: 10.1016/j.transci.2013.12.009 (apre una nuova finestra)

A novel reverse thermosensitive polymer to achieve temporary atraumatic vessel occlusion in infra-popliteal bypasses. (apre una nuova finestra)

Mani K, Campbell A, Fitzpatrick J, Modarai B, Carrell T, Rashid H, Zayed H.

Fonte‎: Eur J Vasc Endovasc Surg 2013;45(1):51-6.

Indicizzato‎: PubMed 23134676

DOI‎: 10.1016/j.ejvs.2012.10.008 (apre una nuova finestra)

Drug, devices, technologies, and techniques for blood management in minimally invasive and conventional cardiothoracic surgery: a consensus statement from the International Society for Minimally Invasive Cardiothoracic Surgery (ISMICS) 2011. (apre una nuova finestra)

Menkis AH, Martin J, Cheng DC, Fitzgerald DC, Freedman JJ, Gao C, Koster A, Mackenzie GS, Murphy GJ, Spiess B, Ad N.

Fonte‎: Innovations (Phila) 2012;7(4):229-41.

Indicizzato‎: PubMed 23123988

DOI‎: 10.1097/IMI.0b013e3182747699 (apre una nuova finestra)

Control of troublesome bleeding during repair of acute type A dissection with use of modified rapid deployment hemostat (MRDH). (apre una nuova finestra)

Salerno TA, Gaughan C, Suarez M, Panos AL.

Fonte‎: J Card Surg 2009;24(6):722-4.

Indicizzato‎: PubMed 20078720

DOI‎: 10.1111/j.1540-8191.2009.00915.x (apre una nuova finestra)

Topical haemostatic agents. (apre una nuova finestra)

Seyednejad H, Imani M, Jamieson T, Seifalian AM.

Fonte‎: Br J Surg 2008;95(10):1197-225.

Indicizzato‎: PubMed 18763249

DOI‎: 10.1002/bjs.6357 (apre una nuova finestra)

Test viscoelastici per individuare un sanguinamento dovuto a intervento chirurgico o coagulopatia

An audit of red cell and blood product use after the institution of thromboelastometry in a cardiac intensive care unit. (apre una nuova finestra)

Anderson L, Quasim I, Soutar R, Steven M, Macfie A, Korte W.

Fonte‎: Transfus Med 2006;16(1):31-9.

Indicizzato‎: PubMed 16480437

DOI‎: 10.1111/j.1365-3148.2006.00645.x (apre una nuova finestra)

Management of hemorrhage in cardiothoracic surgery. (apre una nuova finestra)

Görlinger K, Shore-Lesserson L, Dirkmann D, Hanke AA, Rahe-Meyer N, Tanaka KA.

Fonte‎: J Cardiothorac Vasc Anesth 2013;27(4 Suppl):S20-34.

Indicizzato‎: PubMed 23910533

DOI‎: 10.1053/j.jvca.2013.05.014 (apre una nuova finestra)

Point-of-care testing: a prospective, randomized clinical trial of efficacy in coagulopathic cardiac surgery patients. (apre una nuova finestra)

Weber CF, Görlinger K, Meininger D, Herrmann E, Bingold T, Moritz A, Cohn LH, Zacharowski K.

Fonte‎: Anesthesiology 2012;117(3):531-47.

Indicizzato‎: PubMed 22914710

DOI‎: 10.1097/ALN.0b013e318264c644 (apre una nuova finestra)