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Jehovah’s Witnesses


Sickle Cell Disease (Pediatrics)

Management of Vaso-Occlusive Crisis and Acute Chest Syndrome—Antibiotic and Respiratory Therapy

The use of incentive spirometry in pediatric patients with sickle cell disease to reduce the incidence of acute chest syndrome.

Ahmad FA, Macias CG, Allen JY.

Source‎: J Pediatr Hematol Oncol 2011;33(6):415-20.

Indexed‎: PubMed 21792036

DOI‎: 10.1097/MPH.0b013e31821ed4ce

Safety of purified poloxamer 188 in sickle cell disease: phase I study of a non-ionic surfactant in the management of acute chest syndrome.

Ballas SK, Files B, Luchtman-Jones L, Benjamin L, Swerdlow P, Hilliard L, Coates T, Abboud M, Wojtowicz-Praga S, Grindel JM.

Source‎: Hemoglobin 2004;28(2):85-102.

Indexed‎: PubMed 15182051

Beneficial effect of intravenous dexamethasone in children with mild to moderately severe acute chest syndrome complicating sickle cell disease.

Bernini JC, Rogers ZR, Sandler ES, Reisch JS, Quinn CT, Buchanan GR.

Source‎: Blood 1998;92(9):3082-9.

Indexed‎: PubMed 9787142

A short course of prednisone in the management of acute chest syndrome of sickle cell disease.

Kumar R, Qureshi S, Mohanty P, Rao SP, Miller ST.

Source‎: J Pediatr Hematol Oncol 2010;32(3):e91-4.

Indexed‎: PubMed 20216237

DOI‎: 10.1097/MPH.0b013e3181c29c52

A randomized, placebo-controlled trial of arginine therapy for the treatment of children with sickle cell disease hospitalized with vaso-occlusive pain episodes.

Morris CR, Kuypers FA, Lavrisha L, Ansari M, Sweeters N, Stewart M, Gildengorin G, Neumayr L, Vichinsky EP.

Source‎: Haematologica 2013;98(9):1375-82.

Indexed‎: PubMed 23645695

DOI‎: 10.3324/haematol.2013.086637

Preliminary assessment of inhaled nitric oxide for acute vaso-occlusive crisis in pediatric patients with sickle cell disease.

Weiner DL, Hibberd PL, Betit P, Cooper AB, Botelho CA, Brugnara C.

Source‎: JAMA 2003;289(9):1136-42.

Indexed‎: PubMed 12622584

Predictors of bacteremia in febrile children with sickle cell disease.

West DC, Andrada E, Azari R, Rangaswami AA, Kuppermann N.

Source‎: J Pediatr Hematol Oncol 2002;24(4):279-83.

Indexed‎: PubMed 11972096

The medical section of is designed as an informational resource primarily for use by clinicians and other health-care professionals. It provides neither medical advice nor treatment recommendations and does not substitute for an appropriately qualified health-care provider. The clinical literature cited is not published by Jehovah’s Witnesses, but it outlines transfusion-alternative strategies that might be considered. It is the responsibility of each qualified health-care provider to maintain awareness of new information, discuss options for care, and assist patients in making choices in accord with their medical condition, wishes, values, and beliefs. Not all listed strategies are appropriate or acceptable to all patients.

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