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Jehovah’s Witnesses

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Medicine and Surgery

Management and Optimization of Hemostasis

Correction of congenital heart defects in Jehovah's Witness children.

Alexi-Meskishvili V, Stiller B, Koster A, Böttcher W, Hübler M, Photiadis J, Lange PE, Hetzer R.

Source‎: Thorac Cardiovasc Surg 2004;52(3):141-6.

Indexed‎: PubMed 15192773

http://www.ncbi.nlm.nih.gov/pubmed/15192773

Use of tranexamic acid as a rescue measure to achieve hemostasis after massive blood loss in a pediatric neurosurgical patient.

Bharath K, Bhagat H, Mohindra S.

Source‎: J Neurosurg Anesthesiol 2011;23(4):376-7.

Indexed‎: PubMed 21876453

DOI‎: 10.1097/ANA.0b013e31822c804f

http://www.ncbi.nlm.nih.gov/pubmed/21876453

Recombinant activated factor VII usage in life threatening hemorrhage: a pediatric experience.

Bhat S, Yadav SP, Anjan M, Dinand V, Sachdeva A.

Source‎: Indian J Pediatr 2011;78(8):961-8.

Indexed‎: PubMed 21328080

DOI‎: 10.1007/s12098-011-0364-6

http://www.ncbi.nlm.nih.gov/pubmed/21328080

Recombinant activated factor VII (rFVIIa) treatment in infants with hemorrhage.

Brady KM, Blaine Easley R, Tobias JD.

Source‎: Paediatr Anaesth 2006;16(10):1042-6.

Indexed‎: PubMed 16972833

http://www.ncbi.nlm.nih.gov/pubmed/16972833

A Jehovah's Witness child with hemophilia B and factor IX inhibitors undergoing scoliosis surgery.

Chau A, Wu J, Ansermino M, Tredwell S, Purdy R.

Source‎: Can J Anaesth 2008;55(1):47-51.

Indexed‎: PubMed 18166748

DOI‎: 10.1007/BF03017597

http://www.ncbi.nlm.nih.gov/pubmed/18166748

Efficacy and safety of prophylactic large dose of tranexamic acid in spine surgery: a prospective, randomized, double-blind, placebo-controlled study.

Elwatidy S, Jamjoom Z, Elgamal E, Zakaria A, Turkistani A, El-Dawlatly A.

Source‎: Spine (Phila Pa 1976) 2008;33(24):2577-80.

Indexed‎: PubMed 19011538

DOI‎: 10.1097/BRS.0b013e318188b9c5

http://www.ncbi.nlm.nih.gov/pubmed/19011538

A randomized control trial to verify the efficacy of pre-operative intravenous tranexamic acid in the control of tonsillectomy bleeding.

George A, Kumar R, Kumar S, Shetty S.

Source‎: Indian J Otolaryngol Head Neck Surg 2011;63(1):20-6.

Indexed‎: PubMed 22319712

DOI‎: 10.1007/s12070-010-0095-4

http://www.ncbi.nlm.nih.gov/pubmed/22319712

Efficacy of tranexamic acid in pediatric craniosynostosis surgery: a double-blind, placebo-controlled trial.

Goobie SM, Meier PM, Pereira LM, McGowan FX, Prescilla RP, Scharp LA, Rogers GF, Proctor MR, Meara JG, Soriano SG, Zurakowski D, Sethna NF.

Source‎: Anesthesiology 2011;114(4):862-871.

Indexed‎: PubMed 21364458

DOI‎: 10.1097/ALN.0b013e318210fd8f

http://www.ncbi.nlm.nih.gov/pubmed/21364458

Differential effects of aprotinin and tranexamic acid on outcomes and cytokine profiles in neonates undergoing cardiac surgery.

Graham EM, Atz AM, Gillis J, Desantis SM, Haney AL, Deardorff RL, Uber WE, Reeves ST, McGowan FX Jr, Bradley SM, Spinale FG.

Source‎: J Thorac Cardiovasc Surg 2012;143(5):1069-76.

Indexed‎: PubMed 22075061

DOI‎: 10.1016/j.jtcvs.2011.08.051

http://www.ncbi.nlm.nih.gov/pubmed/22075061

Eltrombopag for children with chronic immune thrombocytopenia (PETIT2): a randomised, multicentre, placebo-controlled trial.

Grainger JD, Locatelli F, Chotsampancharoen T, Donyush E, Pongtanakul B, Komvilaisak P, Sosothikul D, Drelichman G, Sirachainan N, Holzhauer S, Lebedev V, Lemons R, Pospisilova D, Ramenghi U, Bussel JB, Bakshi KK, Iyengar M, Chan GW, Chagin KD, Theodore D

Source‎: Lancet 2015;386(10004):1649-58.

Indexed‎: PubMed 26231455

DOI‎: 10.1016/S0140-6736(15)61107-2.

http://www.ncbi.nlm.nih.gov/pubmed/26231455

Review of the off-label use of recombinant activated factor VII in pediatric cardiac surgery patients.

Guzzetta NA, Russell IA, Williams GD.

Source‎: Anesth Analg 2012;115(2):364-78.

Indexed‎: PubMed 22652310

DOI‎: 10.1213/ANE.0b013e31825aff10

http://www.ncbi.nlm.nih.gov/pubmed/22652310

Management of dilutional coagulopathy during pediatric major surgery.

Haas T, Mauch J, Weiss M, Schmugge M.

Source‎: Transfus Med Hemother 2012;39(2):114-9.

Indexed‎: PubMed 22670129

http://www.ncbi.nlm.nih.gov/pubmed/22670129

Endoscopic technique for sagittal synostosis.

Jimenez DF, Barone CM.

Source‎: Childs Nerv Syst 2012;28(9):1333-9.

Indexed‎: PubMed 22872245

DOI‎: 10.1007/s00381-012-1768-y

http://www.ncbi.nlm.nih.gov/pubmed/22872245

Tranexamic acid versus ɛ-aminocaproic acid: efficacy and safety in paediatric cardiac surgery.

Martin K, Breuer T, Gertler R, Hapfelmeier A, Schreiber C, Lange R, Hess J, Wiesner G.

Source‎: Eur J Cardiothorac Surg 2011;39(6):892-7.

Indexed‎: PubMed 21115357

DOI‎: 10.1016/j.ejcts.2010.09.041

http://www.ncbi.nlm.nih.gov/pubmed/21115357

Antifibrinolytic agents reduce blood loss during pediatric vertebral column resection procedures.

Newton PO, Bastrom TP, Emans JB, Shah SA, Shufflebarger HL, Sponseller PD, Sucato DJ, Lenke LG.

Source‎: Spine (Phila Pa 1976) 2012;37(23):E1459-63.

Indexed‎: PubMed 22872217

DOI‎: 10.1097/BRS.0b013e31826c9fe4

http://www.ncbi.nlm.nih.gov/pubmed/22872217

Cardiac surgery without blood products in a Jehovah's Witness child with factor VII deficiency.

Pérez-Ferrer A, Gredilla E, de Vicente J, Laporta Y.

Source‎: J Cardiothorac Vasc Anesth 2012;26(4):651-3.

Indexed‎: PubMed 21924639

DOI‎: 10.1053/j.jvca.2011.07.012

http://www.ncbi.nlm.nih.gov/pubmed/21924639

Use of recombinant activated factor VII for controlling refractory postoperative bleeding in children undergoing cardiac surgery with cardiopulmonary bypass.

Pychyńska-Pokorska M, Pągowska-Klimek I, Krajewski W, Moll JJ.

Source‎: J Cardiothorac Vasc Anesth 2011;25(6):987-94.

Indexed‎: PubMed 21835642

DOI‎: 10.1053/j.jvca.2011.05.012

http://www.ncbi.nlm.nih.gov/pubmed/21835642

The effect of aprotinin, tranexamic acid, and aminocaproic acid on blood loss and use of blood products in major pediatric surgery: a meta-analysis.

Schouten ES, van de Pol AC, Schouten AN, Turner NM, Jansen NJ, Bollen CW.

Source‎: Pediatr Crit Care Med 2009;10(2):182-90.

Indexed‎: PubMed 19188875

DOI‎: 10.1097/PCC.0b013e3181956d61

http://www.ncbi.nlm.nih.gov/pubmed/19188875

Strategic and operational aspects of a transfusion-free neonatal arterial switch operation.

Schweiger M, Dave H, Kelly J, Hübler M.

Source‎: Interact Cardiovasc Thorac Surg 2013;16(6):890-1.

Indexed‎: PubMed 23460601

DOI‎: 10.1093/icvts/ivt010

http://www.ncbi.nlm.nih.gov/pubmed/23460601

Recombinant activated factor VII for hemorrhage after pediatric cardiac surgery.

Singh SP, Chauhan S, Choudhary M, Vasdev S, Talwar S.

Source‎: Asian Cardiovasc Thorac Ann 2012;20(1):19-23.

Indexed‎: PubMed 22371937

DOI‎: 10.1177/0218492311432584

http://www.ncbi.nlm.nih.gov/pubmed/22371937

The role of Amicar in same-day anterior and posterior spinal fusion for idiopathic scoliosis.

Thompson GH, Florentino-Pineda I, Poe-Kochert C, Armstrong DG, Son-Hing JP.

Source‎: Spine (Phila Pa 1976) 2008;33(20):2237-42.

Indexed‎: PubMed 18794767

DOI‎: 10.1097/BRS.0b013e31817bd889

http://www.ncbi.nlm.nih.gov/pubmed/18794767

Does the intraoperative tranexamic acid decrease operative blood loss during posterior spinal fusion for treatment of adolescent idiopathic scoliosis?

Yagi M, Hasegawa J, Nagoshi N, Iizuka S, Kaneko S, Fukuda K, Takemitsu M, Shioda M, Machida M.

Source‎: Spine (Phila Pa 1976) 2012;37(21):E1336-42.

Indexed‎: PubMed 22772572

DOI‎: 10.1097/BRS.0b013e318266b6e5

http://www.ncbi.nlm.nih.gov/pubmed/22772572

Off-label use of rFVIIa in children with excessive bleeding: a consecutive study of 153 off-label uses in 139 children.

Young G, Wicklund B, Neff P, Johnson C, Nugent DJ.

Source‎: Pediatr Blood Cancer 2009;53(2):179-83.

Indexed‎: PubMed 19415741

DOI‎: 10.1002/pbc.22053

http://www.ncbi.nlm.nih.gov/pubmed/19415741


The medical section of jw.org is designed as an informational resource primarily for use by clinicians and other health-care professionals. It provides neither medical advice nor treatment recommendations and does not substitute for an appropriately qualified health-care provider. The clinical literature cited is not published by Jehovah’s Witnesses, but it outlines transfusion-alternative strategies that might be considered. It is the responsibility of each qualified health-care provider to maintain awareness of new information, discuss options for care, and assist patients in making choices in accord with their medical condition, wishes, values, and beliefs. Not all listed strategies are appropriate or acceptable to all patients.

Patients: Always seek the advice of your doctor or other qualified health-care provider regarding medical conditions or treatments. Check with a doctor if you suspect you are ill.

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