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Jehovah’s Witnesses


Beta Thalassemia (Pediatrics)

Beta Thalassemia Major—Pharmacological Induction of Fetal Hemoglobin Synthesis

Hydroxyurea can reduce or eliminate transfusion requirements in children with major and intermediate thalassemia.

Hashemi A, Abrishamkar M, Jenabzade AR, Eslami Z.

Source‎: Iran J Blood Cancer 2009;1(4):147-50.

Indexed‎: IMEMR 107228

Termination of transfusion dependence in beta-thalassemia: two-year experience with recombinant human erythropoietin.

Nişli G, Kavakli K, Aydinok Y, Oztop S, Cetingül N.

Source‎: Pediatr Hematol Oncol 1997;14(3):285-7.

Indexed‎: PubMed 9185215

Gγ-Xmn I polymorphism: a significant determinant of β-thalassemia treatment without blood transfusion.

Ansari SH, Shamsi TS, Munzir S, Khan MT, Erum S, Perveen K, Farzana T, Ashraf M, Mehboob T, Moinuddin M.

Source‎: J Pediatr Hematol Oncol 2013;35(4):e153-6.

Indexed‎: PubMed 23389500

DOI‎: 10.1097/MPH.0b013e31827e8662

Genotype-phenotype relationship of patients with β-thalassemia taking hydroxyurea: a 13-year experience in Iran.

Karimi M, Haghpanah S, Farhadi A, Yavarian M.

Source‎: Int J Hematol 2012;95(1):51-6.

Indexed‎: PubMed 22180324

DOI‎: 10.1007/s12185-011-0985-6

Efficacy of hydroxyurea in providing transfusion independence in β-thalassemia.

Ansari SH, Shamsi TS, Ashraf M, Perveen K, Farzana T, Bohray M, Erum S, Mehboob T.

Source‎: J Pediatr Hematol Oncol 2011;33(5):339-43.

Indexed‎: PubMed 21602718

DOI‎: 10.1097/MPH.0b013e31821b0770

Fetal globin gene inducers: novel agents and new potential.

Perrine SP, Castaneda SA, Chui DH, Faller DV, Berenson RJ, Siritanaratku N, Fucharoen S.

Source‎: Ann N Y Acad Sci 2010;1202:158-64.

Indexed‎: PubMed 20712788

DOI‎: 10.1111/j.1749-6632.2010.05593.x

Hydroxyurea therapy in 49 patients with major beta-thalassemia.

Zamani F, Shakeri R, Eslami SM, Razavi SM, Basi A.

Source‎: Arch Iran Med 2009;12(3):295-7.

Indexed‎: PubMed 19400608

Efficacy of hydroxyurea (HU) in reduction of pack red cell (PRC) transfusion requirement among children having beta-thalassemia major: Karachi HU trial (KHUT).

Ansari SH, Shamsi TS, Siddiqui FJ, Irfan M, Perveen K, Farzana T, Panjwani VK, Yousuf A, Mehboob T.

Source‎: J Pediatr Hematol Oncol 2007;29(11):743-6.

Indexed‎: PubMed 17984691

Decreased transfusion needs associated with hydroxyurea therapy in Algerian patients with thalassemia major or intermedia.

Bradai M, Pissard S, Abad MT, Dechartres A, Ribeil JA, Landais P, de Montalembert M.

Source‎: Transfusion 2007;47(10):1830-6.

Indexed‎: PubMed 17880608

Response to hydroxyurea treatment in Iranian transfusion-dependent beta-thalassemia patients.

Yavarian M, Karimi M, Bakker E, Harteveld CL, Giordano PC.

Source‎: Haematologica 2004;89(10):1172-8.

Indexed‎: PubMed 15477200

Hydroxyurea can eliminate transfusion requirements in children with severe beta-thalassemia.

Bradai M, Abad MT, Pissard S, Lamraoui F, Skopinski L, de Montalembert M.

Source‎: Blood 2003;102(4):1529-30.

Indexed‎: PubMed 12702505

Use of hydroxyurea and recombinant erythropoietin in management of homozygous ߺ thalassemia.

Kohli-Kumar M, Marandi H, Keller MA, Guertin K, Hvizdala E.

Source‎: J Pediatr Hematol Oncol 2002;24(9):777-8.

Indexed‎: PubMed 12468925

The medical section of is designed as an informational resource primarily for use by clinicians and other health-care professionals. It provides neither medical advice nor treatment recommendations and does not substitute for an appropriately qualified health-care provider. The clinical literature cited is not published by Jehovah’s Witnesses, but it outlines transfusion-alternative strategies that might be considered. It is the responsibility of each qualified health-care provider to maintain awareness of new information, discuss options for care, and assist patients in making choices in accord with their medical condition, wishes, values, and beliefs. Not all listed strategies are appropriate or acceptable to all patients.

Patients: Always seek the advice of your doctor or other qualified health-care provider regarding medical conditions or treatments. Check with a doctor if you suspect you are ill.

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