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Jehovah’s Witnesses


Sickle Cell Disease (Adults)

Prevention of Sickle Cell Crises—Pharmacological Activation of Fetal Hemoglobin in Children and Infants

The effect of prolonged administration of hydroxyurea on morbidity and mortality in adult patients with sickle cell syndromes: results of a 17-year, single-center trial (LaSHS).

Voskaridou E, Christoulas D, Bilalis A, Plata E, Varvagiannis K, Stamatopoulos G, Sinopoulou K, Balassopoulou A, Loukopoulos D, Terpos E.

Source‎: Blood 2010;115(12):2354-63.

Indexed‎: PubMed 19903897

DOI‎: 10.1182/blood-2009-05-221333

Systematic review: hydroxyurea for the treatment of adults with sickle cell disease.

Lanzkron S, Strouse JJ, Wilson R, Beach MC, Haywood C, Park H, Witkop C, Bass EB, Segal JB.

Source‎: Ann Intern Med 2008;148(12):939-55.

Indexed‎: PubMed 18458272

Hydroxyurea for the treatment of sickle cell anemia.

Platt OS.

Source‎: N Engl J Med 2008;358(13):1362-9.

Indexed‎: PubMed 18367739

DOI‎: 10.1056/NEJMct0708272

Clinical effectiveness of decitabine in severe sickle cell disease.

Saunthararajah Y, Molokie R, Saraf S, Sidhwani S, Gowhari M, Vara S, Lavelle D, DeSimone J.

Source‎: Br J Haematol 2008;141(1):126-9.

Indexed‎: PubMed 18324975

DOI‎: 10.1111/j.1365-2141.2008.07027.x

Cost-effectiveness of hydroxyurea in sickle cell anemia. Investigators of the Multicenter Study of Hydroxyurea in Sickle Cell Anemia.

Moore RD, Charache S, Terrin ML, Barton FB, Ballas SK.

Source‎: Am J Hematol 2000;64(1):26-31.

Indexed‎: PubMed 10815784

The medical section of is designed as an informational resource primarily for use by clinicians and other health-care professionals. It provides neither medical advice nor treatment recommendations and does not substitute for an appropriately qualified health-care provider. The clinical literature cited is not published by Jehovah’s Witnesses, but it outlines transfusion-alternative strategies that might be considered. It is the responsibility of each qualified health-care provider to maintain awareness of new information, discuss options for care, and assist patients in making choices in accord with their medical condition, wishes, values, and beliefs. Not all listed strategies are appropriate or acceptable to all patients.

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