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Jehovah’s Witnesses


Sickle Cell Disease (Adults)

Management of Vaso-Occlusive Crisis and Acute Chest Syndrome—Antibiotic and Respiratory Therapy

Incentive spirometry to prevent acute pulmonary complications in sickle cell diseases.

Bellet PS, Kalinyak KA, Shukla R, Gelfand MJ, Rucknagel DL.

Source‎: N Engl J Med 1995;333(11):699-703.

Indexed‎: PubMed 7637747

Continuous inhaled nitric oxide therapy in a case of sickle cell disease with multiorgan involvement.

Chang WL, Corate LM, Sinclair JM, van der Heyde HC.

Source‎: J Investig Med 2008;56(8):1023-7.

Indexed‎: PubMed 19050460

DOI‎: 10.231/JIM.0b013e31818cb612

Safety of purified poloxamer 188 in sickle cell disease: phase I study of a non-ionic surfactant in the management of acute chest syndrome.

Ballas SK, Files B, Luchtman-Jones L, Benjamin L, Swerdlow P, Hilliard L, Coates T, Abboud M, Wojtowicz-Praga S, Grindel JM.

Source‎: Hemoglobin 2004;28(2):85-102.

Indexed‎: PubMed 15182051

Causes and outcomes of the acute chest syndrome in sickle cell disease. National Acute Chest Syndrome Study Group.

Vichinsky EP, Neumayr LD, Earles AN, Williams R, Lennette ET, Dean D, Nickerson B, Orringer E, McKie V, Bellevue R, Daeschner C, Manci EA.

Source‎: N Engl J Med 2000;342(25):1855-65.

Indexed‎: PubMed 10861320

The medical section of is designed as an informational resource primarily for use by clinicians and other health-care professionals. It provides neither medical advice nor treatment recommendations and does not substitute for an appropriately qualified health-care provider. The clinical literature cited is not published by Jehovah’s Witnesses, but it outlines transfusion-alternative strategies that might be considered. It is the responsibility of each qualified health-care provider to maintain awareness of new information, discuss options for care, and assist patients in making choices in accord with their medical condition, wishes, values, and beliefs. Not all listed strategies are appropriate or acceptable to all patients.

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