Crisis Prevention

Pharmacological Induction of Fetal Hemoglobin

Safety of hydroxyurea in pregnancy: a systematic review of the literature. (opens new window)

Al Sulaimani R, Zitoun N, Alothman H, Hutson JR, Garcia-Bournissen F

Source‎: J Obstet Gynaecol Can. 2025 Jul;47(7):102924.

Outcomes of pregnancies in sickle cell patients treated with hydroxyurea : findings from the escort-HU cohort studies. (opens new window)

Anoosha Habibi, Maryse Etienne-Julan, Maria Dimopoulou, Gylna Loko, Pagona Flevari, Narcisse Elenga, Sylvain LE Jeune, Estelle Jean, Laura Thomas-Bourgneuf, Jean-Benoit Arlet, Stephanie NGO, Emmanuelle Bernit, Corinne Charneau, Justine Dautremer, Laure Joseph, Giovanna Cannas, Pablo Bartolucci

Source‎: Blood 2025;146(Suppl 1):2-3.

Systematic review: hydroxyurea for the treatment of adults with sickle cell disease. (opens new window)

Lanzkron S, Strouse JJ, Wilson R, Beach MC, Haywood C, Park H, Witkop C, Bass EB, Segal JB.

Source‎: Ann Intern Med 2008;148(12):939-55.

Cost-effectiveness of hydroxyurea in sickle cell anemia. Investigators of the Multicenter Study of Hydroxyurea in Sickle Cell Anemia. (opens new window)

Moore RD, Charache S, Terrin ML, Barton FB, Ballas SK.

Source‎: Am J Hematol 2000;64(1):26-31.

Hydroxyurea for the treatment of sickle cell anemia. (opens new window)

Platt OS.

Source‎: N Engl J Med 2008;358(13):1362-9.

Clinical effectiveness of decitabine in severe sickle cell disease. (opens new window)

Saunthararajah Y, Molokie R, Saraf S, Sidhwani S, Gowhari M, Vara S, Lavelle D, DeSimone J.

Source‎: Br J Haematol 2008;141(1):126-9.

The effect of prolonged administration of hydroxyurea on morbidity and mortality in adult patients with sickle cell syndromes: results of a 17-year, single-center trial (LaSHS). (opens new window)

Voskaridou E, Christoulas D, Bilalis A, Plata E, Varvagiannis K, Stamatopoulos G, Sinopoulou K, Balassopoulou A, Loukopoulos D, Terpos E.

Source‎: Blood 2010;115(12):2354-63.

Prevention of Infections and Other Complications

Prophylactic antibiotics for preventing pneumococcal infection in children with sickle cell disease. (opens new window)

Hirst C, Owusu-Ofori S.

Source‎: Cochrane Database Syst Rev 2012;(9):CD003427.

Sickle cell disease. (opens new window)

Meremikwu MM, Okomo U.

Source‎: BMJ Clin Evid 2011;02:2402.

A phase 3 trial of l-glutamine in sickle cell disease. (opens new window)

Niihara Y, Miller ST, Kanter J, Lanzkron S, Smith WR, Hsu LL, Gordeuk VR, Viswanathan K, Sarnaik S, Osunkwo I, Guillaume E, Sadanandan S, Sieger L, Lasky JL, Panosyan EH, Blake OA, New TN, Bellevue R, Tran LT, Razon RL, Stark CW, Neumayr LD, Vichinsky EP

Source‎: N Engl J Med 2018;379(3):226-35.

Malaria chemoprophylaxis in sickle cell disease. (opens new window)

Oniyangi O, Omari AA.

Source‎: Cochrane Database Syst Rev 2006;(4):CD003489.

Medical Information for Clinicians

Pharmacological Induction of Fetal Hemoglobin

Safety of hydroxyurea in pregnancy: a systematic review of the literature. (opens new window)

Outcomes of pregnancies in sickle cell patients treated with hydroxyurea : findings from the escort-HU cohort studies. (opens new window)

Systematic review: hydroxyurea for the treatment of adults with sickle cell disease. (opens new window)

Cost-effectiveness of hydroxyurea in sickle cell anemia. Investigators of the Multicenter Study of Hydroxyurea in Sickle Cell Anemia. (opens new window)

Hydroxyurea for the treatment of sickle cell anemia. (opens new window)

Clinical effectiveness of decitabine in severe sickle cell disease. (opens new window)

The effect of prolonged administration of hydroxyurea on morbidity and mortality in adult patients with sickle cell syndromes: results of a 17-year, single-center trial (LaSHS). (opens new window)

Prevention of Infections and Other Complications

Prophylactic antibiotics for preventing pneumococcal infection in children with sickle cell disease. (opens new window)

Sickle cell disease. (opens new window)

A phase 3 trial of l-glutamine in sickle cell disease. (opens new window)

Malaria chemoprophylaxis in sickle cell disease. (opens new window)

Hospital Liaison Committee (HLC)

Medical Information Packets

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Crisis Prevention

Pharmacological Induction of Fetal Hemoglobin

Prevention of Infections and Other Complications

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