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Trauma and Emergency Medicine

Management and Optimization of Hemostasis

Antifibrinolytic drugs for acute traumatic injury.

Ker K, Roberts I, Shakur H, Coats TJ

Source‎: Cochrane Database Syst Rev 2015;5:CD004896.

Indexed‎: PubMed 25956410

DOI‎: 10.1002/14651858.CD004896.pub4

http://www.ncbi.nlm.nih.gov/pubmed/25956410

The importance of early treatment with tranexamic acid in bleeding trauma patients: an exploratory analysis of the CRASH-2 randomised controlled trial.

Roberts I, Shakur H, Afolabi A, Brohi K, Coats T, Dewan Y, Gando S, Guyatt G, Hunt BJ, Morales C, Perel P, Prieto-Merino D, Woolley T; CRASH-2 collaborators.

Source‎: Lancet 2011;377(9771):1096-1101.

Indexed‎: PubMed 21439633

DOI‎: 10.1016/S0140-6736(11)60278-X

http://www.ncbi.nlm.nih.gov/pubmed/21439633

Efficacy of recombinant activated Factor VII in patients with massive uncontrolled bleeding: a retrospective observational analysis.

Berkhof FF, Eikenboom JC.

Source‎: Transfusion 2009;49(3):570-7.

Indexed‎: PubMed 19040498

DOI‎: 10.1111/j.1537-2995.2008.02001.x

http://www.ncbi.nlm.nih.gov/pubmed/19040498

Association of cryoprecipitate and tranexamic acid with improved survival following wartime injury: findings from the MATTERs II Study.

Morrison JJ, Ross JD, Dubose JJ, Jansen JO, Midwinter MJ, Rasmussen TE.

Source‎: JAMA Surg 2013;148(3):218-25.

Indexed‎: PubMed 23670117

DOI‎: 10.1001/jamasurg.2013.764

http://www.ncbi.nlm.nih.gov/pubmed/23670117

The exclusive use of coagulation factor concentrates enables reversal of coagulopathy and decreases transfusion rates in patients with major blunt trauma.

Innerhofer P, Westermann I, Tauber H, Breitkopf R, Fries D, Kastenberger T, El Attal R, Strasak A, Mittermayr M.

Source‎: Injury 2013;44(2):209-16.

Indexed‎: PubMed 23000050

DOI‎: 10.1016/j.injury.2012.08.047

http://www.ncbi.nlm.nih.gov/pubmed/23000050

The treatment of bleeding is to stop the bleeding! Treatment of trauma-related hemorrhage.

Boffard KD, Choong PI, Kluger Y, Riou B, Rizoli SB, Rossaint R, Warren B; NovoSeven Trauma Study Group.

Source‎: Transfusion 2009;49 Suppl 5:240S-7S.

Indexed‎: PubMed 19954486

DOI‎: 10.1111/j.1537-2995.2008.01987.x

http://www.ncbi.nlm.nih.gov/pubmed/19954486

Successful rotational thromboelastometry-guided treatment of traumatic haemorrhage, hyperfibrinolysis and coagulopathy.

Brenni M, Worn M, Brüesch M, Spahn DR, Ganter MT.

Source‎: Acta Anaesthesiol Scand 2010;54(1):111-7.

Indexed‎: PubMed 19860752

DOI‎: 10.1111/j.1399-6576.2009.02132.x

http://www.ncbi.nlm.nih.gov/pubmed/19860752


The medical section of jw.org is designed as an informational resource primarily for use by clinicians and other health-care professionals. It provides neither medical advice nor treatment recommendations and does not substitute for an appropriately qualified health-care provider. The clinical literature cited is not published by Jehovah’s Witnesses, but it outlines transfusion-alternative strategies that might be considered. It is the responsibility of each qualified health-care provider to maintain awareness of new information, discuss options for care, and assist patients in making choices in accord with their medical condition, wishes, values, and beliefs. Not all listed strategies are appropriate or acceptable to all patients.

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