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Jehovah’s Witnesses


Trauma and Emergency Medicine

Anticoagulation Reversal

Four-factor prothrombin complex concentrate versus plasma for rapid vitamin K antagonist reversal in patients needing urgent surgical or invasive interventions: a phase 3b, open-label, non-inferiority, randomised trial.

Goldstein JN, Refaai MA, Milling TJ Jr, Lewis B, Goldberg-Alberts R, Hug BA, Sarode R.

Source‎: Lancet 2015;385(9982):2077-87.

Indexed‎: PubMed 25728933

DOI‎: 10.1016/S0140-6736(14)61685-8

Management of anticoagulation agents in trauma patients.

McCoy CC, Lawson JH, Shapiro ML.

Source‎: Clin Lab Med 2014;34(3):563-74.

Indexed‎: PubMed 25168942

DOI‎: 10.1016/j.cll.2014.06.013

Rapid warfarin reversal in the setting of intracranial hemorrhage: a comparison of plasma, recombinant activated factor VII, and prothrombin complex concentrate.

Woo CH, Patel N, Conell C, Rao VA, Faigeles BS, Patel MC, Pombra J, Akins PT, Axelrod YK, Ge IY, Sheridan WF, Flint AC.

Source‎: World Neurosurg 2014;81(1):110-5.

Indexed‎: PubMed 23220122

DOI‎: 10.1016/j.wneu.2012.12.002

Guidance on the emergent reversal of oral thrombin and factor Xa inhibitors.

Kaatz S, Kouides PA, Garcia DA, Spyropolous AC, Crowther M, Douketis JD, Chan AK, James A, Moll S, Ortel TL, Van Cott EM, Ansell J.

Source‎: Am J Hematol 2012;87 Suppl 1:S141-5.

Indexed‎: PubMed 22473649

DOI‎: 10.1002/ajh.23202

Reversal of clopidogrel-induced bleeding with rFVIIa in healthy subjects: a randomized, placebo-controlled, double-blind, exploratory study.

Skolnick BE, Shenouda M, Khutoryansky NM, Pusateri AE, Gabriel D, Carr ME.

Source‎: Anesth Analg 2011;113(4):703-10.

Indexed‎: PubMed 21890888

DOI‎: 10.1213/ANE.0b013e318228c690

Bleeding risk and reversal strategies for old and new anticoagulants and antiplatelet agents.

Levi M, Eerenberg E, Kamphuisen PW.

Source‎: J Thromb Haemost 2011;9(9):1705-12.

Indexed‎: PubMed 21729240

DOI‎: 10.1111/j.1538-7836.2011.04432.x

Emergency reversal of warfarin anticoagulation.

Lin Y, Callum J.

Source‎: CMAJ 2010;182(18):2004.

Indexed‎: PubMed 21078740

DOI‎: 10.1503/cmaj.100983

The medical section of is designed as an informational resource primarily for use by clinicians and other health-care professionals. It provides neither medical advice nor treatment recommendations and does not substitute for an appropriately qualified health-care provider. The clinical literature cited is not published by Jehovah’s Witnesses, but it outlines transfusion-alternative strategies that might be considered. It is the responsibility of each qualified health-care provider to maintain awareness of new information, discuss options for care, and assist patients in making choices in accord with their medical condition, wishes, values, and beliefs. Not all listed strategies are appropriate or acceptable to all patients.

Patients: Always seek the advice of your doctor or other qualified health-care provider regarding medical conditions or treatments. Check with a doctor if you suspect you are ill.

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