TRAUMA AND EMERGENCY MEDICINE
Management and Optimization of Hemostasis
English
Management and Optimization of Hemostasis
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Trauma and Emergency Medicine

Management and Optimization of Hemostasis

Antifibrinolytic Agents

Strategies to prevent blood loss and reduce transfusion in emergency general surgery, WSES-AAST consensus paper. (opens new window)

Coccolini F, Shander A, Ceresoli M, Moore E, Tian B, Parini D, Sartelli M, Sakakushev B, Doklestich K, Abu-Zidan F, Horer T, Shelat V, Hardcastle T, Bignami E, Kirkpatrick A, Weber D, Kryvoruchko I, Leppaniemi A, Tan E, Kessel B, Isik A, Cremonini C, Forfori F, Ghiadoni L, Chiarugi M, Ball C, Ottolino P, Hecker A, Mariani D, Melai E, Malbrain M, Agostini V, Podda M, Picetti E, Kluger Y, Rizoli S, Litvin A, Maier R, Beka SG, De Simone B, Bala M, Perez AM, Ordonez C, Bodnaruk Z, Cui Y, Calatayud AP, de Angelis N, Amico F, Pikoulis E, Damaskos D, Coimbra R, Chirica M, Biffl WL, Catena F

Source‎: World J Emerg Surg 2024;19(1):26.

Alternatives to allogeneic platelet transfusion. (opens new window)

Desborough MJ, Smethurst PA, Estcourt LJ, Stanworth SJ.

Source‎: Br J Haematol 2016;175(3):381-92.

Antifibrinolytic drugs for acute traumatic injury. (opens new window)

Ker K, Roberts I, Shakur H, Coats TJ.

Source‎: Cochrane Database Syst Rev 2015;(5):CD004896.

Association of cryoprecipitate and tranexamic acid with improved survival following wartime injury: findings from the MATTERs II Study. (opens new window)

Morrison JJ, Ross JD, Dubose JJ, Jansen JO, Midwinter MJ, Rasmussen TE.

Source‎: JAMA Surg 2013;148(3):218-25.

The importance of early treatment with tranexamic acid in bleeding trauma patients: an exploratory analysis of the CRASH-2 randomised controlled trial. (opens new window)

Roberts I, Shakur H, Afolabi A, Brohi K, Coats T, Dewan Y, Gando S, Guyatt G, Hunt BJ, Morales C, Perel P, Prieto-Merino D, Woolley T; CRASH-2 collaborators.

Source‎: Lancet 2011;377(9771):1096-101, 1101.e1-2.

Recombinant Activated Factor VII (rFVIIa)

The treatment of bleeding is to stop the bleeding! Treatment of trauma-related hemorrhage. (opens new window)

Boffard KD, Choong PI, Kluger Y, Riou B, Rizoli SB, Rossaint R, Warren B; NovoSeven Trauma Study Group.

Source‎: Transfusion 2009;49 Suppl 5:240S-7S.

Coagulation Factor Concentrates

The exclusive use of coagulation factor concentrates enables reversal of coagulopathy and decreases transfusion rates in patients with major blunt trauma. (opens new window)

Innerhofer P, Westermann I, Tauber H, Breitkopf R, Fries D, Kastenberger T, El Attal R, Strasak A, Mittermayr M.

Source‎: Injury 2013;44(2):209-16.

Desmopressin

Strategies to prevent blood loss and reduce transfusion in emergency general surgery, WSES-AAST consensus paper. (opens new window)

Coccolini F, Shander A, Ceresoli M, Moore E, Tian B, Parini D, Sartelli M, Sakakushev B, Doklestich K, Abu-Zidan F, Horer T, Shelat V, Hardcastle T, Bignami E, Kirkpatrick A, Weber D, Kryvoruchko I, Leppaniemi A, Tan E, Kessel B, Isik A, Cremonini C, Forfori F, Ghiadoni L, Chiarugi M, Ball C, Ottolino P, Hecker A, Mariani D, Melai E, Malbrain M, Agostini V, Podda M, Picetti E, Kluger Y, Rizoli S, Litvin A, Maier R, Beka SG, De Simone B, Bala M, Perez AM, Ordonez C, Bodnaruk Z, Cui Y, Calatayud AP, de Angelis N, Amico F, Pikoulis E, Damaskos D, Coimbra R, Chirica M, Biffl WL, Catena F

Source‎: World J Emerg Surg 2024;19(1):26.

Desmopressin is a transfusion sparing option to reverse platelet dysfunction in patients with severe traumatic brain injury. (opens new window)

Furay EJ, Daley MJ, Satarasinghe P, Lara S, Aydelotte JD, Teixeira PG, Coopwood TB, Ali S, Brown CVR

Source‎: J Trauma Acute Care Surg 2020;88(1):80-6.

Viscoelastic Tests to Identify Surgical or Coagulopathic Bleeding

Successful rotational thromboelastometry-guided treatment of traumatic haemorrhage, hyperfibrinolysis and coagulopathy. (opens new window)

Brenni M, Worn M, Brüesch M, Spahn DR, Ganter MT.

Source‎: Acta Anaesthesiol Scand 2010;54(1):111-7.

Hospital Liaison Committee (HLC)

Contact local representatives who provide free assistance to clinicians treating Jehovah’s Witnesses.

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Medical Information Packets

Subjects include: Clinical strategies for managing hemorrhage and anemia without blood transfusion, the religious and ethical position of Jehovah’s Witnesses on medical therapy, and the services Witnesses offer to the medical community through their worldwide network of Hospital Liaison Committees.

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Videos

Treatment options as well as medical and ethical considerations for clinicians who treat Jehovah’s Witnesses.

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