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Jehovah’s Witnesses


Perioperative Care

Anticoagulation Reversal

Four-factor prothrombin complex concentrate versus plasma for rapid vitamin K antagonist reversal in patients needing urgent surgical or invasive interventions: a phase 3b, open-label, non-inferiority, randomised trial.

Goldstein JN, Refaai MA, Milling TJ Jr, Lewis B, Goldberg-Alberts R, Hug BA, Sarode R.

Source‎: Lancet 2015;385(9982):2077-87.

Indexed‎: PubMed 25728933

DOI‎: 10.1016/S0140-6736(14)61685-8

Pharmacological prophylaxis of bleeding in surgical patients treated with aspirin.

Flordal PA.

Source‎: Eur J Anaesthesiol Suppl 1997;14:38-41.

Indexed‎: PubMed 9088834

Reversing the effects of antiplatelet agents in the setting of intracranial hemorrhage: a look at the literature.

Jaben EA, Mulay SB, Stubbs JR.

Source‎: J Intensive Care Med 2015;30(1):3-7.

Indexed‎: PubMed 25492811

DOI‎: 10.1177/0885066613487298

Long-term safety and efficacy of a pasteurized nanofiltrated prothrombin complex concentrate (Beriplex P/N): a pharmacovigilance study.

Hanke AA, Joch C, Görlinger K.

Source‎: Br J Anaesth 2013;110(5):764-72.

Indexed‎: PubMed 23335567

DOI‎: 10.1093/bja/aes501

Effect of non-specific reversal agents on anticoagulant activity of dabigatran and rivaroxaban. A randomised crossover ex vivo study in healthy volunteers.

Marlu R, Hodaj E, Paris A, Albaladejo P, Crackowski JL, Pernod G.

Source‎: Thromb Haemost 2012;108(2):217-24.

Indexed‎: PubMed 22627883

DOI‎: 10.1160/TH12-03-0179

Recombinant factor VIIa (rFVIIa) and hemodialysis to manage massive dabigatran-associated postcardiac surgery bleeding.

Warkentin TE, Margetts P, Connolly SJ, Lamy A, Ricci C, Eikelboom JW.

Source‎: Blood 2012;119(9):2172-4.

Indexed‎: PubMed 22383791

DOI‎: 10.1182/blood-2011-11-393587

Perioperative management of antithrombotic therapy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines.

Douketis JD, Spyropoulos AC, Spencer FA, Mayr M, Jaffer AK, Eckman MH, Dunn AS, Kunz R; American College of Chest Physicians.

Source‎: Chest 2012;141(2 Suppl):e326S-50S.

Indexed‎: PubMed 22315266

DOI‎: 10.1378/chest.11-2298

Emergency reversal of anticoagulation: from theory to real use of prothrombin complex concentrates. A retrospective Italian experience.

Barillari G, Pasca S, Barillari A, De Angelis V.

Source‎: Blood Transfus 2012;10(1):87-94.

Indexed‎: PubMed 22044952

DOI‎: 10.2450/2011.0030-11

Reversal of clopidogrel-induced bleeding with rFVIIa in healthy subjects: a randomized, placebo-controlled, double-blind, exploratory study.

Skolnick BE, Shenouda M, Khutoryansky NM, Pusateri AE, Gabriel D, Carr ME.

Source‎: Anesth Analg 2011;113(4):703-10.

Indexed‎: PubMed 21890888

DOI‎: 10.1213/ANE.0b013e318228c690

Bleeding risk and reversal strategies for old and new anticoagulants and antiplatelet agents.

Levi M, Eerenberg E, Kamphuisen PW.

Source‎: J Thromb Haemost 2011;9(9):1705-12.

Indexed‎: PubMed 21729240

DOI‎: 10.1111/j.1538-7836.2011.04432.x

How I treat warfarin-associated coagulopathy in patients with intracerebral hemorrhage.

Goodnough LT, Shander A.

Source‎: Blood 2011;117(23):6091-9.

Indexed‎: PubMed 21411756

DOI‎: 10.1182/blood-2010-11-316075

Emergency reversal of warfarin anticoagulation.

Lin Y, Callum J.

Source‎: CMAJ 2010;182(18):2004.

Indexed‎: PubMed 21078740

DOI‎: 10.1503/cmaj.100983

Oral anticoagulation in surgical procedures: risks and recommendations.

Torn M, Rosendaal FR.

Source‎: Br J Haematol 2003;123(4):676-82.

Indexed‎: PubMed 14616972

The medical section of is designed as an informational resource primarily for use by clinicians and other health-care professionals. It provides neither medical advice nor treatment recommendations and does not substitute for an appropriately qualified health-care provider. The clinical literature cited is not published by Jehovah’s Witnesses, but it outlines transfusion-alternative strategies that might be considered. It is the responsibility of each qualified health-care provider to maintain awareness of new information, discuss options for care, and assist patients in making choices in accord with their medical condition, wishes, values, and beliefs. Not all listed strategies are appropriate or acceptable to all patients.

Patients: Always seek the advice of your doctor or other qualified health-care provider regarding medical conditions or treatments. Check with a doctor if you suspect you are ill.

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