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Jehovah’s Witnesses


Intensive and Critical Care

Management and Optimization of Hemostasis

The importance of early treatment with tranexamic acid in bleeding trauma patients: an exploratory analysis of the CRASH-2 randomised controlled trial.

Roberts I, Shakur H, Afolabi A, Brohi K, Coats T, Dewan Y, Gando S, Guyatt G, Hunt BJ, Morales C, Perel P, Prieto-Merino D, Woolley T; CRASH-2 collaborators.

Source‎: Lancet 2011;377(9771):1096-1101.

Indexed‎: PubMed 21439633

DOI‎: 10.1016/S0140-6736(11)60278-X

Tranexamic acid: less bleeding and less thrombosis?

Godier A, Roberts I, Hunt BJ.

Source‎: Crit Care 2012;16(3):135.

Indexed‎: PubMed 22748073

DOI‎: 10.1186/cc11374

Selective angiographic embolization of blunt splenic traumatic injuries in adults decreases failure rate of nonoperative management.

Bhullar IS, Frykberg ER, Siragusa D, Chesire D, Paul J, Tepas JJ 3rd, Kerwin AJ.

Source‎: J Trauma Acute Care Surg 2012;72(5):1127-34.

Indexed‎: PubMed 22673236

DOI‎: 10.1097/TA.0b013e3182569849

Salvage use of activated recombinant factor VII in the management of refractory bleeding following cardiac surgery.

Barua A, Rao VP, Ramesh B, Barua B, El-Shafei H.

Source‎: J Blood Med 2011;2:131-4.

Indexed‎: PubMed 22287872

DOI‎: 10.2147/JBM.S21609

Strategies to reduce the use of blood products: a European perspective.

Theusinger OM, Felix C, Spahn DR.

Source‎: Curr Opin Anaesthesiol 2012;25(1):59-65.

Indexed‎: PubMed 22113184

DOI‎: 10.1097/ACO.0b013e32834dec98

Recombinant factor VIIa in trauma patients with the 'triad of death.'

Mitra B, Cameron PA, Parr MJ, Phillips L.

Source‎: Injury 2012;43(9):1409-14.

Indexed‎: PubMed 21345431

DOI‎: 10.1016/j.injury.2011.01.033

Antifibrinolytic drugs for acute traumatic injury.

Roberts I, Shakur H, Ker K, Coats T; CRASH‐2 Trial collaborators.

Source‎: Cochrane Database Syst Rev 2011;(1):CD004896.

Indexed‎: PubMed 21249666

DOI‎: 10.1002/14651858.CD004896.pub3

The treatment of bleeding is to stop the bleeding! Treatment of trauma-related hemorrhage.

Boffard KD, Choong PI, Kluger Y, Riou B, Rizoli SB, Rossaint R, Warren B; NovoSeven Trauma Study Group.

Source‎: Transfusion 2009;49 Suppl 5:240S-7S.

Indexed‎: PubMed 19954486

DOI‎: 10.1111/j.1537-2995.2008.01987.x

Transfusion in trauma: why and how should we change our current practice?

Theusinger OM, Spahn DR, Ganter MT.

Source‎: Curr Opin Anaesthesiol 2009;22(2):305-12.

Indexed‎: PubMed 19390257

DOI‎: 10.1097/ACO.0b013e3283212c7c

Low-dose recombinant factor VIIa for trauma patients with coagulopathy.

Stein DM, Dutton RP, Hess JR, Scalea TM.

Source‎: Injury 2008;39(9):1054-61.

Indexed‎: PubMed 18656871

DOI‎: 10.1016/j.injury.2008.03.032

Use of recombinant activated factor VII in patients without hemophilia: a meta-analysis of randomized control trials.

Hsia CC, Chin-Yee IH, McAlister VC.

Source‎: Ann Surg 2008;248(1):61-8.

Indexed‎: PubMed 18580208

DOI‎: 10.1097/SLA.0b013e318176c4ec

Treatment of excessive bleeding in Jehovah's Witness patients after cardiac surgery with recombinant factor VIIa (Novoseven®).

Tanaka KA, Waly AA, Cooper WA, Levy JH.

Source‎: Anesthesiology 2003;98(6):1513-5.

Indexed‎: PubMed 12766668

The medical section of is designed as an informational resource primarily for use by clinicians and other health-care professionals. It provides neither medical advice nor treatment recommendations and does not substitute for an appropriately qualified health-care provider. The clinical literature cited is not published by Jehovah’s Witnesses, but it outlines transfusion-alternative strategies that might be considered. It is the responsibility of each qualified health-care provider to maintain awareness of new information, discuss options for care, and assist patients in making choices in accord with their medical condition, wishes, values, and beliefs. Not all listed strategies are appropriate or acceptable to all patients.

Patients: Always seek the advice of your doctor or other qualified health-care provider regarding medical conditions or treatments. Check with a doctor if you suspect you are ill.

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