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Intensive and Critical Care

Anticoagulation Reversal

Four-factor prothrombin complex concentrate versus plasma for rapid vitamin K antagonist reversal in patients needing urgent surgical or invasive interventions: a phase 3b, open-label, non-inferiority, randomised trial.

Goldstein JN, Refaai MA, Milling TJ Jr, Lewis B, Goldberg-Alberts R, Hug BA, Sarode R.

Source‎: Lancet 2015;385(9982):2077-87.

Indexed‎: PubMed 25728933

DOI‎: 10.1016/S0140-6736(14)61685-8

http://www.ncbi.nlm.nih.gov/pubmed/25728933

Reversal of antithrombotic agents.

Bauer KA.

Source‎: Am J Hematol 2012;87 Suppl 1:S119-26.

Indexed‎: PubMed 22460529

DOI‎: 10.1002/ajh.23165

http://www.ncbi.nlm.nih.gov/pubmed/22460529

Reversal of warfarin-induced hemorrhage in the emergency department.

Zareh M, Davis A, Henderson S.

Source‎: West J Emerg Med 2011;12(4):386-92.

Indexed‎: PubMed 22224125

DOI‎: 10.5811/westjem.2011.3.2051

http://www.ncbi.nlm.nih.gov/pubmed/22224125

Reversal of clopidogrel-induced bleeding with rFVIIa in healthy subjects: a randomized, placebo-controlled, double-blind, exploratory study.

Skolnick BE, Shenouda M, Khutoryansky NM, Pusateri AE, Gabriel D, Carr ME.

Source‎: Anesth Analg 2011;113(4):703-10.

Indexed‎: PubMed 21890888

DOI‎: 10.1213/ANE.0b013e318228c690

http://www.ncbi.nlm.nih.gov/pubmed/21890888

Bleeding risk and reversal strategies for old and new anticoagulants and antiplatelet agents.

Levi M, Eerenberg E, Kamphuisen PW.

Source‎: J Thromb Haemost 2011;9(9):1705-12.

Indexed‎: PubMed 21729240

DOI‎: 10.1111/j.1538-7836.2011.04432.x

http://www.ncbi.nlm.nih.gov/pubmed/21729240

Emergency reversal of warfarin anticoagulation.

Lin Y, Callum J.

Source‎: CMAJ 2010;182(18):2004.

Indexed‎: PubMed 21078740

DOI‎: 10.1503/cmaj.100983

http://www.ncbi.nlm.nih.gov/pubmed/21078740

Prothrombin complex concentrate (Beriplex P/N) for emergency anticoagulation reversal: a prospective multinational clinical trial.

Pabinger I, Brenner B, Kalina U, Knaub S, Nagy A, Ostermann H; Beriplex P/N Anticoagulation Reversal Study Group.

Source‎: J Thromb Haemost 2008;6(4):622-31.

Indexed‎: PubMed 18208533

DOI‎: 10.1111/j.1538-7836.2008.02904.x

http://www.ncbi.nlm.nih.gov/pubmed/18208533


The medical section of jw.org is designed as an informational resource primarily for use by clinicians and other health-care professionals. It provides neither medical advice nor treatment recommendations and does not substitute for an appropriately qualified health-care provider. The clinical literature cited is not published by Jehovah’s Witnesses, but it outlines transfusion-alternative strategies that might be considered. It is the responsibility of each qualified health-care provider to maintain awareness of new information, discuss options for care, and assist patients in making choices in accord with their medical condition, wishes, values, and beliefs. Not all listed strategies are appropriate or acceptable to all patients.

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