CARDIOTHORACIC AND VASCULAR SURGERY
Intraoperative Autologous Blood Management
English
Intraoperative Autologous Blood Management
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Cardiothoracic and Vascular Surgery

Intraoperative Autologous Blood Management

Blood Cell Salvage

Reduced use of allogeneic platelets through high-yield perioperative autologous plateletpheresis and reinfusion. (opens new window)

Alberts M, Bandarenko N, Gaca J, Lockhart E, Milano C, Alexander S, Linder D, Lombard FW, Welsby IJ.

Source‎: Transfusion 2014;54(5):1348-57.

The importance of cell saver usage in complex endovascular repair of thoraco-abdominal aortic aneurysms. (opens new window)

Ali AA, Hamwi T, Sikman L, Stana J, Abicht JM, Tsilimparis N, Prendes CF

Source‎: Ann Vasc Surg 2024:297-308.

Efficacy and cost-effectiveness of cell saver usage in the repair of thoracic aortic aneurysms and dissections. (opens new window)

Amanvermez Senarslan D, Yildirim F, Kurdal AT, Damar A, Ozturk T, Tetik O

Source‎: Perfusion. 2022;37(7):722-28. Epub 2021 Jun 30.

Preservation of platelet function after intraoperative cell salvage using the i-SEP Same device in cardiac surgery. (opens new window)

Blum LV, Sertdere F, Iken S, Lotz G, Nordine M, Hecker F, von Knethen A, Friedrichson B, Rausch J, Zacharowski K, Heinicke U

Source‎: J Cardiothorac Vasc Anesth 2026;40(1):38-48.

Cell salvage for minimising perioperative allogeneic blood transfusion. (opens new window)

Carless PA, Henry DA, Moxey AJ, O'Connell D, Brown T, Fergusson DA.

Source‎: Cochrane Database Syst Rev 2010;(4):CD001888.

Efficacy of intraoperative cell salvage in decreasing perioperative blood transfusion rates in first-time cardiac surgery patients: a retrospective study. (opens new window)

Côté CL, Yip AM, MacLeod JB, O'Reilly B, Murray J, Ouzounian M, Brown CD, Forgie R, Pelletier MP, Hassan A

Source‎: Can J Surg 2016;59(5):330-6.

Does washing swabs increase the efficiency of red cell recovery by cell salvage in aortic surgery? (opens new window)

Haynes SL, Bennett JR, Torella F, McCollum CN.

Source‎: Vox Sang 2005;88(4):244-8.

Transfusion requirements and outcomes in patients undergoing abdominal aortic surgery using intra-operative cell salvage. (opens new window)

Healy CF, Doyle M, Egan B, Hendrick B, O'Malley MK, O'Donohoe MK.

Source‎: Ir J Med Sci 2007;176(1):33-6.

Exploring myths of perioperative autologous red blood cell salvage. (opens new window)

Kaufman M, Jahr JS, Klompas AM, Perelman S, Raphael J, Tan GM, Frank SM, Waters JH, Warner MA

Source‎: Anesthesiology 2025;143(5):1357-70.

Direct reinfusion of unwashed shed autologous blood during thoracoabdominal aortic aneurysm repair: a retrospective analysis. (opens new window)

Powell TR, Khalifa A, Green SY, Tolpin DA, Staggers KA, Anton JM, LeMaire SA, Coselli JS, Pan W

Source‎: Anesth Analg 2025;140(3):527-36.

Impaired red blood cell deformability after transfusion of stored allogeneic blood but not autologous salvaged blood in cardiac surgery patients. (opens new window)

Salaria ON, Barodka VM, Hogue CW, Berkowitz DE, Ness PM, Wasey JO, Frank SM.

Source‎: Anesth Analg 2014;118(6):1179-87.

The role of cell salvage autotransfusion in abdominal aortic aneurysm surgery. (opens new window)

Shantikumar S, Patel S, Handa A.

Source‎: Eur J Vasc Endovasc Surg 2011;42(5):577-84.

Intraoperative cell salvage is associated with reduced postoperative blood loss and transfusion requirements in cardiac surgery: a cohort study. (opens new window)

Vonk AB, Meesters MI, Garnier RP, Romijn JW, van Barneveld LJ, Heymans MW, Jansen EK, Boer C.

Source‎: Transfusion 2013;53(11):2782-9.

The efficacy of an intraoperative cell saver during cardiac surgery: a meta-analysis of randomized trials. (opens new window)

Wang G, Bainbridge D, Martin J, Cheng D.

Source‎: Anesth Analg 2009;109(2):320-30.

Acute Normovolemic Hemodilution

Acute normovolemic hemodilution reduces allogeneic red blood cell transfusion in cardiac surgery: a systematic review and meta-analysis of randomized trials. (opens new window)

Barile L, Fominskiy E, Di Tomasso N, Alpìzar Castro LE, Landoni G, De Luca M, Bignami E, Sala A, Zangrillo A, Monaco F.

Source‎: Anesth Analg 2017;124(3):743-52.

Decreased transfusion requirements with use of acute normovolemic hemodilution in open aortic aneurysm repair. (opens new window)

Droz NM, Lin J, Beach J, Vo C, Morrow K, Lyden SP, Hardy DM, Caputo FJ, Rowse J, Kirksey L, Smolock CJ

Source‎: J Vasc Surg 2021;74(6):1885-93.

Greater volume of acute normovolemic hemodilution may aid in reducing blood transfusions after cardiac surgery. (opens new window)

Goldberg J, Paugh TA, Dickinson TA, Fuller J, Paone G, Theurer PF, Shann KG, Sundt TM 3rd, Prager RL, Likosky DS; PERForm Registry and the Michigan Society of Thoracic and Cardiovascular Surgeons Quality Collaborative.

Source‎: Ann Thorac Surg 2015;100(5):1581-7.

Impact of intraoperative high-volume autologous blood collection on allogeneic transfusion during and after cardiac surgery: a propensity score matched analysis. (opens new window)

Henderson RA, Mazzeffi MA, Strauss ER, Williams B, Wipfli C, Dawood M, Taylor BS, Tanaka KA

Source‎: Transfusion 2019;59(6):2023-9.

Cardioprotective effects of acute normovolemic hemodilution in patients undergoing coronary artery bypass surgery. (opens new window)

Licker M, Ellenberger C, Sierra J, Kalangos A, Diaper J, Morel D.

Source‎: Chest 2005;128(2):838-47.

Large volume acute normovolemic hemodilution in patients undergoing cardiac surgery with intermediate-high risk of transfusion: a randomized controlled trial. (opens new window)

Ming Y, Zhang F, Yao Y, Cheng Z, Yu L, Sun D, Sun K, Yu Y, Liu M, Ma L, HuangYang Y, Yan M

Source‎: J Clin Anesth. 2023;87:111082.

Hemodilution in high-risk cardiac surgery: Laboratory values, physiological parameters, and outcomes. (opens new window)

Mladinov D, Padilla LA, Leahy B, Norman JB, Enslin J, Camp RS, Eudailey KW, Tanaka K, Davies JE

Source‎: Transfusion 2022;62(4):826-37.

Acute normovolemic hemodilution in adult cardiac surgery. (opens new window)

Tanaka KA, Stewart KE, Vandyck KB, Burkhart HM, Garwe T, Kertai MD, Butt AL, Mazzeffi MA

Source‎: JAMA Surg 2025:e253238.

Acute normovolemic hemodilution and intraoperative cell salvage in aortic surgery. (opens new window)

Torella F, Haynes SL, Kirwan CC, Bhatt AN, McCollum CN.

Source‎: J Vasc Surg 2002;36(1):31-4.

The effect of acute normovolaemic haemodilution on blood transfusion requirements in abdominal aortic aneurysm repair. (opens new window)

Wolowczyk L, Lewis DR, Nevin M, Smith FC, Baird RN, Lamont PM.

Source‎: Eur J Vasc Endovasc Surg 2001;22(4):361-4.

Autologous versus allogeneic transfusion in aortic surgery: a multicenter randomized clinical trial. (opens new window)

Wong JC, Torella F, Haynes SL, Dalrymple K, Mortimer AJ, McCollum CN.

Source‎: Ann Surg 2002;235(1):145-51.

Retrograde Autologous Priming

Retrograde autologous priming in cardiac surgery: results from a systematic review and meta-analysis. (opens new window)

Hensley NB, Gyi R, Zorrilla-Vaca A, Choi CW, Lawton JS, Brown CH 4th, Frank SM, Grant MC, Cho BC

Source‎: Anesth Analg 2021;132(1):100-7.

Retrograde autologous priming of the cardiopulmonary bypass circuit reduces blood transfusion in small adults: a prospective, randomized trial. (opens new window)

Hou X, Yang F, Liu R, Yang J, Zhao Y, Wan C, Ni H, Gong Q, Dong P.

Source‎: Eur J Anaesthesiol 2009;26(12):1061-6.

Retrograde autologous priming reduces transfusion requirements in coronary artery bypass surgery. (opens new window)

Severdija EE, Heijmans JH, Theunissen M, Maessen JG, Roekaerts PH, Weerwind PW.

Source‎: Perfusion 2011;26(4):315-21.

Retrograde autologous priming as a safe and easy method to reduce hemodilution and transfusion requirements during cardiac surgery. (opens new window)

Trapp C, Schiller W, Mellert F, Halbe M, Lorenzen H, Welz A, Probst C.

Source‎: Thorac Cardiovasc Surg 2015;63(7):628-34.

The effect of retrograde autologous priming volume on haemodilution and transfusion requirements during cardiac surgery. (opens new window)

Vandewiele K, Bové T, De Somer FM, Dujardin D, Vanackere M, De Smet D, Moerman AT, Bouchez S, François K.

Source‎: Interact Cardiovasc Thorac Surg 2013;16(6):778-83.

Ultrafiltration

Ultrafiltration reduces blood transfusions following cardiac surgery: a meta-analysis. (opens new window)

Boodhwani M, Williams K, Babaev A, Gill G, Saleem N, Rubens FD.

Source‎: Eur J Cardiothorac Surg 2006;30(6):892-7.

Novel ultrafiltration technique for blood conservation in cardiac operations. (opens new window)

Gunaydin S, Gourlay T.

Source‎: Ann Thorac Surg 2013;95(6):2148-51.

Use of the Hemobag® for modified ultrafiltration in a Jehovah's Witness patient undergoing cardiac surgery. (opens new window)

Moskowitz DM, Klein JJ, Shander A, Perelman SI, McMurtry KA, Cousineau KM, Ergin MA.

Source‎: J Extra Corpor Technol 2006;38(3):265-70.

Miniaturized Cardiopulmonary Bypass (Perfusion) Circuits

Use of minimal extracorporeal circulation improves outcome after heart surgery; a systematic review and meta-analysis of randomized controlled trials. (opens new window)

Anastasiadis K, Antonitsis P, Haidich AB, Argiriadou H, Deliopoulos A, Papakonstantinou C.

Source‎: Int J Cardiol 2013;164(2):158-69.

Minimized perfusion circuits: an alternative in the surgical treatment of Jehovah's Witnesses. (opens new window)

El-Essawi A, Breitenbach I, Ali K, Jungebluth P, Brouwer R, Anssar M, Harringer W.

Source‎: Perfusion 2013;28(1):47-53.

Significant reduction in blood loss in patients undergoing minimal extracorporeal circulation. (opens new window)

Gerritsen WB, van Boven WJ, Wesselink RM, Smelt M, Morshuis WJ, van Dongen HP, Haas FJ, Aarts LP.

Source‎: Transfus Med 2006;16(5):329-34.

Is microplegia really superior to standard blood cardioplegia? The results from a meta-analysis. (opens new window)

Gong B, Ji B, Sun Y, Wang G, Liu J, Zheng Z.

Source‎: Perfusion 2015;30(5):375-82.

Impact of minimized extracorporeal circulation on outcome in patients with preoperative anemia undergoing coronary artery bypass surgery. (opens new window)

Haneya A, Philipp A, Von Suesskind-Schwendi M, Diez C, Hirt SW, Kolat P, Attmann T, Schoettler J, Zausig Y, Ried M, Schmid C.

Source‎: ASAIO J 2013;59(3):269-74.

Total cavopulmonary connection in a 35-month-old Jehovah's Witness child. (opens new window)

Hörer J, Schreiber C, Prodan Z, Zaccaria F, Cleuziou J, Böckler U, Kühn A, Tassani-Prell P, Lange R.

Source‎: J Cardiothorac Vasc Anesth 2008;22(1):108-10.

Miniaturized versus conventional cardiopulmonary bypass in high-risk patients undergoing coronary artery bypass surgery. (opens new window)

Koivisto SP, Wistbacka JO, Rimpiläinen R, Nissinen J, Loponen P, Teittinen K, Biancari F.

Source‎: Perfusion 2010;25(2):65-70.

Transfusion-free anesthetic management for open heart surgery in a neonate—a case report. (opens new window)

Lee JM, Byon HJ, Kim JT, Kim HS, Kim CS.

Source‎: Korean J Anesthesiol 2010;59 Suppl:S141-5.

Perfusion approaches to blood conservation. (opens new window)

McKay C.

Source‎: Semin Cardiothorac Vasc Anesth 2007;11(4):252-5.

Minimized extracorporeal circulation system in coronary artery bypass surgery: a 10-year single-center experience with 2243 patients. (opens new window)

Puehler T, Haneya A, Philipp A, Zausig YA, Kobuch R, Diez C, Birnbaum DE, Schmid C.

Source‎: Eur J Cardiothorac Surg 2011;39(4):459-64.

Coronary artery bypass grafting with a minimized cardiopulmonary bypass circuit: a prospective, randomized trial. (opens new window)

Sakwa MP, Emery RW, Shannon FL, Altshuler JM, Mitchell D, Zwada D, Holter AR.

Source‎: J Thorac Cardiovasc Surg 2009;137(2):481-5.

Minimised closed circuit coronary artery bypass grafting in the elderly is associated with lower levels of organ-specific biomarkers: a prospective randomised study. (opens new window)

van Boven WJ, Gerritsen WB, Driessen AH, van Dongen EP, Klautz RJ, Aarts LP.

Source‎: Eur J Anaesthesiol 2013;30(11):685-94.

Miniaturized cardiopulmonary bypass improves short-term outcome in cardiac surgery: a meta-analysis of randomized controlled studies. (opens new window)

Zangrillo A, Garozzo FA, Biondi-Zoccai G, Pappalardo F, Monaco F, Crivellari M, Bignami E, Nuzzi M, Landoni G.

Source‎: J Thorac Cardiovasc Surg 2010;139(5):1162-9.