Optimierung der Hämostase

Antifibrinolytika

Alternatives to allogeneic platelet transfusion. (öffnet neues Fenster)

Desborough MJ, Smethurst PA, Estcourt LJ, Stanworth SJ.

Quelle‎: Br J Haematol 2016;175(3):381-92.

Tranexamic acid in patients undergoing noncardiac surgery. (öffnet neues Fenster)

Devereaux PJ, Marcucci M, Painter TW, Conen D, Lomivorotov V, Sessler DI, Chan MTV, Borges FK, Martínez-Zapata MJ, Wang CY, Xavier D, Ofori SN, Wang MK, Efremov S, Landoni G, Kleinlugtenbelt YV, Szczeklik W, Schmartz D, Garg AX, Short TG, Wittmann M, Meyhoff CS, Amir M, Torres D, Patel A, Duceppe E, Ruetzler K, Parlow JL, Tandon V, Fleischmann E, Polanczyk CA, Lamy A, Astrakov SV, Rao M, Wu WKK, Bhatt K, de Nadal M, Likhvantsev VV, Paniagua P, Aguado HJ, Whitlock RP, McGillion MH, Prystajecky M, Vincent J, Eikelboom J, Copland I, Balasubramanian K, Turan A, Bangdiwala SI, Stillo D, Gross PL, Cafaro T, Alfonsi P, Roshanov PS, Belley-Côté EP, Spence J, Richards T, VanHelder T, McIntyre W, Guyatt G, Yusuf S, Leslie K; POISE-3 Investigators

Quelle‎: N Engl J Med. 2022;386(21):1986-97.

Anti-fibrinolytic use for minimising perioperative allogeneic blood transfusion. (öffnet neues Fenster)

Henry DA, Carless PA, Moxey AJ, O'Connell D, Stokes BJ, Fergusson DA, Ker K.

Quelle‎: Cochrane Database Syst Rev 2011;(3):CD001886.

A single preoperative dose of tranexamic acid reduces perioperative blood loss: a meta-analysis. (öffnet neues Fenster)

Heyns M, Knight P, Steve AK, Yeung JK

Quelle‎: Ann Surg 2021;273(1):75-81.

Putting the record straight on aprotinin as safe and effective: results from a mixed treatment meta-analysis of trials of aprotinin. (öffnet neues Fenster)

Howell N, Senanayake E, Freemantle N, Pagano D.

Quelle‎: J Thorac Cardiovasc Surg 2013;145(1):234-40.

Effect of tranexamic acid on surgical bleeding: systematic review and cumulative meta-analysis. (öffnet neues Fenster)

Ker K, Edwards P, Perel P, Shakur H, Roberts I.

Quelle‎: BMJ 2012;344:e3054.

Systematic review, meta-analysis and meta-regression of the effect of tranexamic acid on surgical blood loss. (öffnet neues Fenster)

Ker K, Prieto-Merino D, Roberts I.

Quelle‎: Br J Surg 2013;100(10):1271-9.

Safety and efficacy of tranexamic acid in general surgery. (öffnet neues Fenster)

Park LJ, Marcucci M, Ofori SN, Borges FK, Nenshi R, Kanstrup CTB, Rosen M, Landoni G, Lomivorotov V, Painter TW, Xavier D, Martinez-Zapata MJ, Szczeklik W, Meyhoff CS, Chan MTV, Simunovic M, Bogach J, Serrano PE, Balasubramanian K, Cadeddu M, Yang I, Kim WH, Devereaux PJ

Quelle‎: JAMA Surg 2025;160(3):267-74.

Association of intravenous tranexamic acid with thromboembolic events and mortality: a systematic review, meta-analysis, and meta-regression. (öffnet neues Fenster)

Taeuber I, Weibel S, Herrmann E, Neef V, Schlesinger T, Kranke P, Messroghli L, Zacharowski K, Choorapoikayil S, Meybohm P

Quelle‎: JAMA Surg 2021;156(6):e210884.

Oral is as effective as intravenous tranexamic acid at reducing blood loss in thoracolumbar spinal fusions: a prospective randomized trial. (öffnet neues Fenster)

Yu CC, Fidai M, Washington T, Bartol S, Graziano G

Quelle‎: Spine 2022;47(2):91-8.

Rekombinanter Faktor VIIa (rFVIIa)

Aortic dissection and hypothermic arrest in a Jehovah's Witness patient: a case for recombinant factor VIIa? (öffnet neues Fenster)

Ballen J, Raabe M, Muirhead B.

Quelle‎: Can J Anaesth 2006;53(4):353-6.

The treatment of bleeding is to stop the bleeding! Treatment of trauma-related hemorrhage. (öffnet neues Fenster)

Boffard KD, Choong PI, Kluger Y, Riou B, Rizoli SB, Rossaint R, Warren B; NovoSeven Trauma Study Group.

Quelle‎: Transfusion 2009;49 Suppl 5:240S-7S.

Comprehensive Canadian review of the off-label use of recombinant activated factor VII in cardiac surgery. (öffnet neues Fenster)

Karkouti K, Beattie WS, Arellano R, Aye T, Bussieres JS, Callum JL, Cheng D, Heinrich L, Kent B, Lee TW, MacAdams C, Mazer CD, Muirhead B, Rochon AG, Rubens FD, Sawchuk C, Wang S, Waters T, Wong BI, Yau TM.

Quelle‎: Circulation 2008;118(4):331-8.

Recombinant factor VIIa as last-resort treatment of desperate haemorrhage. (öffnet neues Fenster)

Palmason R, Vidarsson B, Sigvaldason K, Ingimarsson JP, Gudbjartsson T, Sigurdsson GH, Onundarson PT.

Quelle‎: Acta Anaesthesiol Scand 2012;56(5):636-44.

Gerinnungsfaktorenkonzentrate

Prophylactic use of factor IX concentrate in a Jehovah's Witness patient. (öffnet neues Fenster)

Bolliger D, Sreeram G, Duncan A, Molinaro RJ, Szlam F, Chen EP, Tanaka KA.

Quelle‎: Ann Thorac Surg 2009;88(5):1666-8.

Bloodless orthotopic heart transplantation in a Jehovah's Witness. (öffnet neues Fenster)

Dallas T, Welsby I, Bottiger B, Milano C, Daneshmand M, Guinn N.

Quelle‎: A A Case Rep 2015;4(10):140-2.

Fibrinogen replacement therapy: a critical review of the literature. (öffnet neues Fenster)

Franchini M, Lippi G.

Quelle‎: Blood Transfus 2012;10(1):23-7.

First-line therapy with coagulation factor concentrates combined with point-of-care coagulation testing is associated with decreased allogeneic blood transfusion in cardiovascular surgery: a retrospective, single-center cohort study. (öffnet neues Fenster)

Görlinger K, Dirkmann D, Hanke AA, Kamler M, Kottenberg E, Thielmann M, Jakob H, Peters J.

Quelle‎: Anesthesiology 2011;115(6):1179-91.

Prophylactic fibrinogen infusion reduces bleeding after coronary artery bypass surgery. A prospective randomised pilot study. (öffnet neues Fenster)

Karlsson M, Ternström L, Hyllner M, Baghaei F, Flinck A, Skrtic S, Jeppsson A.

Quelle‎: Thromb Haemost 2009;102(1):137-44.

Fibrinogen as a therapeutic target for bleeding: a review of critical levels and replacement therapy. (öffnet neues Fenster)

Levy JH, Welsby I, Goodnough LT.

Quelle‎: Transfusion 2014;54(5):1389-405.

Effects of fibrinogen concentrate as first-line therapy during major aortic replacement surgery: a randomized, placebo-controlled trial. (öffnet neues Fenster)

Rahe-Meyer N, Solomon C, Hanke A, Schmidt DS, Knoerzer D, Hochleitner G, Sørensen B, Hagl C, Pichlmaier M.

Quelle‎: Anesthesiology 2013;118(1):40-50.

Bleeding in a Jehovah's Witness patient undergoing a redo aortic valve replacement controlled with cryoprecipitate and a prothrombin complex concentrate. (öffnet neues Fenster)

Robblee JA, Wilkes PR, Dickie SJ, Rubens FD, Bormanis J.

Quelle‎: Can J Anaesth 2012;59(3):299-303.

Desmopressin

Effects of desmopressin on platelet function under conditions of hypothermia and acidosis: an in vitro study using multiple electrode aggregometry. (öffnet neues Fenster)

Hanke AA, Dellweg C, Kienbaum P, Weber CF, Görlinger K, Rahe-Meyer N.

Quelle‎: Anaesthesia 2010;65(7):688-91.

Viskoelastische Tests zur Identifizierung chirurgischer oder koagulopathischer Blutungen

Management of severe perioperative bleeding: Guidelines from the European Society of Anaesthesiology. (öffnet neues Fenster)

Kozek-Langenecker SA, Afshari A, Albaladejo P, Santullano CA, De Robertis E, Filipescu DC, Fries D, Görlinger K, Haas T, Imberger G, Jacob M, Lancé M, Llau J, Mallett S, Meier J, Rahe-Meyer N, Samama CM, Smith A, Solomon C, Van der Linden P, Wikkelsø AJ, Wouters P, Wyffels P.

Quelle‎: Eur J Anaesthesiol 2013;30(6):270-382.

Use of rotation thromboelastometry (ROTEM) to achieve successful treatment of polytrauma with fibrinogen concentrate and prothrombin complex concentrate. (öffnet neues Fenster)

Schöchl H, Forster L, Woidke R, Solomon C, Voelckel W.

Quelle‎: Anaesthesia 2010;65(2):199-203.

Fachliteratur für Mediziner

Antifibrinolytika

Alternatives to allogeneic platelet transfusion. (öffnet neues Fenster)

Tranexamic acid in patients undergoing noncardiac surgery. (öffnet neues Fenster)

Anti-fibrinolytic use for minimising perioperative allogeneic blood transfusion. (öffnet neues Fenster)

A single preoperative dose of tranexamic acid reduces perioperative blood loss: a meta-analysis. (öffnet neues Fenster)

Putting the record straight on aprotinin as safe and effective: results from a mixed treatment meta-analysis of trials of aprotinin. (öffnet neues Fenster)

Effect of tranexamic acid on surgical bleeding: systematic review and cumulative meta-analysis. (öffnet neues Fenster)

Systematic review, meta-analysis and meta-regression of the effect of tranexamic acid on surgical blood loss. (öffnet neues Fenster)

Safety and efficacy of tranexamic acid in general surgery. (öffnet neues Fenster)

Association of intravenous tranexamic acid with thromboembolic events and mortality: a systematic review, meta-analysis, and meta-regression. (öffnet neues Fenster)

Oral is as effective as intravenous tranexamic acid at reducing blood loss in thoracolumbar spinal fusions: a prospective randomized trial. (öffnet neues Fenster)

Rekombinanter Faktor VIIa (rFVIIa)

Aortic dissection and hypothermic arrest in a Jehovah's Witness patient: a case for recombinant factor VIIa? (öffnet neues Fenster)

The treatment of bleeding is to stop the bleeding! Treatment of trauma-related hemorrhage. (öffnet neues Fenster)

Comprehensive Canadian review of the off-label use of recombinant activated factor VII in cardiac surgery. (öffnet neues Fenster)

Recombinant factor VIIa as last-resort treatment of desperate haemorrhage. (öffnet neues Fenster)

Gerinnungsfaktorenkonzentrate

Prophylactic use of factor IX concentrate in a Jehovah's Witness patient. (öffnet neues Fenster)

Bloodless orthotopic heart transplantation in a Jehovah's Witness. (öffnet neues Fenster)

Fibrinogen replacement therapy: a critical review of the literature. (öffnet neues Fenster)

First-line therapy with coagulation factor concentrates combined with point-of-care coagulation testing is associated with decreased allogeneic blood transfusion in cardiovascular surgery: a retrospective, single-center cohort study. (öffnet neues Fenster)

Prophylactic fibrinogen infusion reduces bleeding after coronary artery bypass surgery. A prospective randomised pilot study. (öffnet neues Fenster)

Fibrinogen as a therapeutic target for bleeding: a review of critical levels and replacement therapy. (öffnet neues Fenster)

Effects of fibrinogen concentrate as first-line therapy during major aortic replacement surgery: a randomized, placebo-controlled trial. (öffnet neues Fenster)

Bleeding in a Jehovah's Witness patient undergoing a redo aortic valve replacement controlled with cryoprecipitate and a prothrombin complex concentrate. (öffnet neues Fenster)

Desmopressin

Effects of desmopressin on platelet function under conditions of hypothermia and acidosis: an in vitro study using multiple electrode aggregometry. (öffnet neues Fenster)

Viskoelastische Tests zur Identifizierung chirurgischer oder koagulopathischer Blutungen

Management of severe perioperative bleeding: Guidelines from the European Society of Anaesthesiology. (öffnet neues Fenster)

Use of rotation thromboelastometry (ROTEM) to achieve successful treatment of polytrauma with fibrinogen concentrate and prothrombin complex concentrate. (öffnet neues Fenster)

Ansprechpartner des Krankenhaus-Verbindungskomitees vor Ort (KVK)

Informationen zum Herunterladen

Videos

Interview mit Dr. Pia Di Benedetto

Optimierung der Hämostase

Antifibrinolytika

Rekombinanter Faktor VIIa (rFVIIa)

Gerinnungsfaktorenkonzentrate

Desmopressin

Viskoelastische Tests zur Identifizierung chirurgischer oder koagulopathischer Blutungen

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